Envelhecer traz em si significações negativas que se agravam em situação de reclusão. Os procedimentos metodológicos pautaram-se em estudo bibliográfico e pesquisa em banco de dados. Os artigos encontrados foram organizados, analisados, chegando à conclusões como a falta de pesquisas sobre a mulher idosa encarcerada. Por isso, foi realizada a entrevista semi-estruturada com uma senhora sentenciada à privação de liberdade em São Paulo, Brasil. Os dados da pesquisa revelaram que a vida em regime fechado é precária para a mulher idosa (...) e, que se faz necessário repensar as políticas públicas priorizando medidas educativas e artísticas no ambiente prisional. (shrink)

Fibromyalgia is a chronic pain syndrome characterized by dysfunctional processing of nociceptive stimulation. Neuroimaging studies have pointed out that pain-related network functioning seems to be altered in these patients. It is thought that this clinical symptomatology may be maintained or even strengthened because of an enhanced expectancy for painful stimuli or its forthcoming appearance. However, neural electrophysiological correlates associated with such attentional mechanisms have been scarcely explored. In the current study, expectancy processes of upcoming laser stimulation (painful and non-painful) and (...) its further processing were explored by event-related potentials (ERPs). Nineteen fibromyalgia patients and twenty healthy control volunteers took part in the experiment. Behavioral measures (reaction times and subjective pain perception) were also collected. We manipulated the pain/no pain expectancy through an S1–S2 paradigm (cue-target). S1 (image: triangle or square) predicted the S2 appearance (laser stimulation: warmth or pinprick sensation). Laser stimuli were delivered using a CO2 laser device. Temporal and spatial principal component analyses were employed to define and quantify the ERP component reliability. Statistical analyses revealed the existence of an abnormal pattern of pain expectancy in patients with fibromyalgia. Specifically, our results showed attenuated amplitudes at posterior lCNV component in anticipation of painful stimulation that was not found in healthy participants. In contrast, although larger P2 amplitudes to painful compared to innocuous events were shown, patients did not show any amplitude change in this laser-evoked response as a function of pain predictive cues (as occurred in the healthy control group). Additionally, analyses of the subjective perception of pain and reaction time indicated that laser stimuli preceded by pain cues were rated as more painful than those signaling non-pain expectancy and were associated with faster responses. Differences between groups were not found. The present findings suggest the presence of dysfunction in pain expectation mechanisms in fibromyalgia that eventually may make it difficult for patients to correctly interpret signs that prevent pain symptoms. Furthermore, the abnormal pattern in pain expectancy displayed by fibromyalgia patients could result in ineffective pain coping strategies. Understanding the neural correlates of pain processing and its modulatory factors is crucial to identify treatments for chronic pain syndromes. (shrink)

Este ensayo busca examinar en qué medida el modelo de interpretación constructiva, sustentado por Ronald Dworkin en el ámbito de su teoría del derecho como integridad, se ajusta y permite explicar las experiencias jurídicas que se desarrollan bajo los sistemas de derecho de la tradición jurídica romano-canónica. Lo que se intenta demostrar es que no obstante el modelo de Dworkin no se ajuste bien a nuestras experiencias jurídicas, algunos de los argumentos centrales de su crítica al modelo positivista constituyen una (...) importante contribución a la teoría del enjuiciamiento y, con algunos ajustes, efectivamente ayudan a comprender y explicar nuestras prácticas jurídicas. Con todo, el modelo de interpretación constructiva no parece constituir una alternativa, sino más bien un complemento necesario a una teoría positivista moderada como la de H. L. A. Hart. (shrink)

The elite theory of Max Weber has recently been rediscovered by political scientists and political theorists who have sought to explore both the heuristic and the normative potential of plebiscitary leader democracy. Notwithstanding the merits of this wave of studies, this paper argues that attention should be shifted from Weber's context-specific defence of plebiscitary leadership in post-WWI Germany to his broader conception of charisma as an attempt to grasp the enigma of significant social and political change. Contemporary democratic theory, this (...) paper contends, can fruitfully draw on Weber to sink into the antinomies and ambiguities of a transformative democratic politics. (shrink)

. Introductory Remarks THEODOSIUS DOBZHANSKY The problems of reduction in biology are currently of considerable theoretical interest and practical ...

The ethical issues concerning the use of PGD to select embryos of a particular HLA type are numerous. They arise from the potentially conflicting interests between those of the pre-existing child, the subject of a treatment which may be curative, and those of the sibling to be created, who cannot give consent to the donation, together with the problem of the destruction of potentially healthy embryos. This essay focuses on the web of vulnerabilities affecting the parents, the sick child and (...) the “saviour sibling,” while addressing three areas: science, bioethics and literature. The novel My Sister’s Keeper, by Jodi Picoult, provides the reader with an in-depth view of the conflicting interests and emotional problems that affect the Fitzgeralds, a family experiencing the pain of seeing one of their children dying while facing the tragic consequences of trying to save this child by having another offspring. (shrink)

Culling is used in traditional public health policies to control animal populations. These policies aim primarily to protect human interests but often fail to provide scientific evidence of effectiveness. In this article, we defend the need to move from a strictly anthropocentric approach to disease control towards a One Health ethics, using culling practices as an example. We focus on the recent badger culls in the UK, claiming that, based on data provided by the English Government, these culls may be (...) unjustified, all thing considered. We highlight the relevance of ethical reasoning rooted in One Health for this discussion, and make several suggestions including a moratorium on culling until data are provided to support the effectiveness of culling; to conduct a randomized trial to compare proactive culling with alternative methods; to apply deliberative democratic methods to assess public opinion towards the culls, and to find in Brexit an opportunity for aiming for more effective control measures. (shrink)

Presentism: Essential Readings contains writings—classic and contemporary—that acquaint the reader with different versions of presentism, standard philosophical and scientific objections to presentism, and their attempted solutions. Detailed introductions to each part of the book make the discussions accessible to students and those unfamiliar with this fascinating and controversial philosophy.

This article observes the imagination of the end of the world in the Anthropocene era and, at the same time, intends, from an anthropological turn that considers other possibilities of human existence on Earth, to imagine how Amerindian cosmovision can promote not only an ontological but also an epistemological turn in the field of contemporary law and politics. A conflicted but not impossible dialogue between the naturalistic matrix of Western thought and Amerindian multinaturalism, in search of “ideas to postpone the (...) end of the world”. (shrink)

The distributed temporal logic (DTL) is a logic for reasoning about temporal properties of distributed systems from the local point of view of the system’s agents, which are assumed to execute sequentially and to interact by means of synchronous event sharing. Different versions of DTL have been provided over the years for a number of different applications, reflecting different perspectives on how non-local information can be accessed by each agent. In this paper, we propose an automata-theoretic model checking algorithm for (...) DTL. To this end, we propose a notion of distributed transition system that will be used to specify the system to be verified. The properties that the system should meet are specified in DTL. In order to capture the models of these properties, we propose the notions of generalized distributed Büchi automaton and of distributed Büchi automaton. With these concepts, we are able to adapt results from automata-theoretic approaches to model checking in LTL to the distributed case. (shrink)

This essay addresses the moral nature of corporate social media platforms through the lenses of Axel Honneth’s concept of justice, according to which relations of mutual recognition must be institutionalized into spheres of social freedom to claim a just society. This perspective allows us to observe how platforms configure a symmetrically inverted form of ethical sphere, in which users are led to formulate non-autonomous desires that can only be realized socially. We characterize this as social unfreedom. A just platform ought (...) to be the one in which rights and self-legislation capabilities enable users to have a stake in governing how these digital spaces can be designed to foster the practical realization of users’ autonomous aims, the essay argues. (shrink)

Orphan drug policy often gives ‘special treatment’ to rare diseases, by giving additional priority or making exceptions to specific drugs, based on the rarity of the conditions they aim to treat. This essay argues that the goal of orphan drug policy should be to make prevalence irrelevant to funding decisions. It aims to demonstrate that it is severity, not prevalence, which drives our judgments that important claims are being overlooked when treatments for severe rare diseases are not funded. It shows (...) that prioritising severity avoids problems caused by prioritising rarity, and that it is compatible with a range of normative frameworks. The implications of a severity-based view for drug development are then derived. The severity-based view also accounts for what is wrong with how the current system of drug development unfairly neglects common diseases that burden the developing world. Lastly, the implications of a severity-based view for current orphan drug policies are discussed. There are no data in this work. (shrink)

The moral enhancement of human beings is a constant theme in the history of humanity. Today, faced with the threats of a new, globalised world, concern over this matter is more pressing. For this reason, the use of biotechnology to make human beings more moral has been considered. However, this approach is dangerous and very controversial. The purpose of this article is to argue that the use of another new technology, AI, would be preferable to achieve this goal. Whilst several (...) proposals have been made on how to use AI for moral enhancement, we present an alternative that we argue to be superior to other proposals that have been developed. (shrink)

This article discusses some of the claims of the earlier and later versions of the Contemporary Theory of Metaphor (CTM) and addresses some of the criticism that has been leveled against it. It is argued that much of this criticism arises from common misconceptions as to the real claims made by the theory. However, CTM is still in need of further exploration and empirical support. In this connection, we identify some areas where research is still needed and supply our own (...) developments. We argue for a more complex classification of metaphor types, which takes into account various complementary taxonomic perspectives, including the nature of source and target and the genericity and complexity of the metaphoric operation. We also explore metaphor in relation to cognitive prominence and conceptual interaction issues. Finally, we deal with the problem of constraints on metaphor and make a proposal for three complementary kinds of constraint. (shrink)

In theory, a human rights framework should protect and guarantee the equal provision of care and rights of all people. In practice, however, the universality that underlies human rights is enacted through citizenship rights, which rely on the individual politically ‘belonging’ to a nation-state.

Este estudo resulta de uma investigação sobre as aproximações teóricas entre o pensamento de Willard Van Omar Quine e o pragmatismo filosófico de John Dewey. O enfoque desta abordagem é a concepção naturalista e realista de conhecimento desenvolvida por estes dois teóricos. Busca-‑se compreender as conexões conceituais presentes na epistemologia de ambos, sobretudo, as referências de Quine a um empirismo radical e sem dogmas. O critério de análise comparatória será as seguintes teses: a ruptura com a filosofia apriorística, o naturalismo (...) realista, a crítica aos dogmas do empirismo, a defesa do holismo como alternativa à visão tradicional do conhecimento. (shrink)

El artículo deriva de un estudio de caso cualitativo realizado en 2019 que analiza los testimonios de 30 mujeres bolivianas aymara empleadas mayormente en la agricultura o en el comercio agrícola en el valle de Azapa, en las inmediaciones de la ciudad chilena de Arica. Se enfoca específicamente en sus relatos sobre las relaciones de género en sus familias de origen, indagando sobre su impacto (o su vinculación) con los desplazamientos que las mujeres emprenden en sus vidas adultas. El objetivo (...) central es mostrar cómo las relaciones de género en estos entornos familiares ayudaron a configurar los procesos de movilidad transfronteriza femenina y cómo ambos elementos están atravesados por las múltiples desigualdades entre hombres y mujeres en las comunidades de origen de las migrantes. Los marcos conceptuales aplicados a este estudio devienen de dos grandes campos teóricos. Primero, para conceptualizar las relaciones de género y las desigualdades de poder que caracterizan las trayectorias familiares de nuestras entrevistadas en sus localidades de origen, nos apoyamos en las reflexiones antropológicas del feminismo crítico sobre los sistemas de dominación masculina. En segundo lugar, nos apoyamos también en la amplia producción antropológica sobre las asimetrías de género en los grupos sociales aymara, que permiten complementar el marco anterior desde las dimensiones simbólicas y relacionales propias de estos pueblos originarios. (shrink)

ResumoAlguns leitores de Nietzsche podem admitir certa dificuldade em reconhecer os limites entre a crítica, a genealogia e o filosofar com o martelo. Tais limites existem e podem ser delineados se buscarmos o elemento no qual cada uma dessas investidas atua. Este artigo procura elaborar a ideia de que a noção nietzschiana de crítica envolve o desprezo afirmativo, o riso e a zombaria. Ligada, portanto, a uma condição valorativa, a crítica é mais ofensiva, exigente e assumidamente tendenciosa do que se (...) poderia conceber a partir da tradição kantiana.AbstractSome readers of Nietzsche may admit some difficulty in recognizing the boundaries between criticism, genealogy, and philosophizing with the hammer. However, such limits exist if one seek the element that produces each one. This article tries to elaborate the idea that the affirmative contempt, laughter, mockery, for Nietzsche, defines the critic. Related, therefore, to an evaluative (and physiological) condition, criticism is more virulent, offensive, demanding and biased than one might think from a Kantian tradition. (shrink)

Resumo Qual o papel da religião numa sociedade secularizada? Qual o papel da Igreja? O artigo propõe uma reflexão sobre essas questões a partir de um "diálogo virtual" entre o teólogo alemão Dietrich Bonhoeffer (1906-1945) e o filósofo italiano contemporâneo Gianni Vattimo. Esses dois autores, separados pelo tempo e pela geografia, aproximam-se, no entanto, na forma de pensar o fenômeno da secularização - ambos a entendem como algo intrínseco ao Ocidente cristão. A dissolução do sacro e o movimento em direção (...) à autonomia humana foram percebidos por esses dois pensadores não como ameaças à religião cristã, mas como possibilidades de sua plena realização, concretizada por meio do engajamento social. Diante do fim das certezas e das verdades absolutas - quadro pós-moderno que já se delineava na década de 1940 e ganha contornos mais precisos no princípio do século XXI, tanto Bonhoeffer quanto Vattimo pensaram uma teologia capaz de abrir mão dos pressupostos metafísicos. Palavras-chave: Filosofia; Teologia; Pós-modernidade; Secularização; Eclesiologia.What is the role of religion in a secularized society? What is the role of the Church? This article suggests a reflection on these questions based on a "virtual dialogue" between German theologian Dietrich Bonhoeffer (1906-1945) and contemporary Italian philosopher Gianni Vattimo. Though separated by time and geography, those authors are close to each other in the way they view the secularization phenomenon - both understand it as intrinsic to the Christian West. The dissolution of the sacred and the movement towards human autonomy were perceived by the two thinkers not as threats to the Christian religion, but as possibilities of its full accomplishment, made real by social commitment. Facing the end of certainties and absolute truths - a postmodern framework that starts to take shape in the 1940s and acquires more definite contours in the beginning of the 21st century - Bonhoeffer and Vattimo were able to think a theology capable of giving up its metaphysical presuppositions. Key words: Philosophy; Theology; Postmodernity; Secularization; Ecclesiology. (shrink)

Child poly-victimization is a risk factor for psychopathology in adulthood, such as anxiety and depression. Despite that, there is minus investment regarding psychotic symptoms and the mechanisms explaining the relationship between poly-victimization and psychoticism. The purpose of this study is to investigate these variables and explain how they might be associated. A sample of 246 adults participated in this study, aged between 18 and 68 years (M = 37.5, SD = 12.5) and mostly females (76.8%). The results revealed a significant (...) mediating effect of anxiety and depression in the relationship between childhood victimization and psychoticism (b =.12, p =.011), but not a significant moderating effect of gender, Δχ2(5) = 3.87, p =.568. The affective pathway was supported by our findings. These results suggest the need of additional efforts on prevention of child victimization, as well as of intervention programs aiming to prevent its cumulative effect. (shrink)

The evolution and biodiversity of ageing have long fascinated scientists and the public alike. While mammals, including long‐lived species such as humans, show a marked ageing process, some species of reptiles and amphibians exhibit very slow and even the absence of ageing phenotypes. How can reptiles and other vertebrates age slower than mammals? Herein, I propose that evolving during the rule of the dinosaurs left a lasting legacy in mammals. For over 100 million years when dinosaurs were the dominant predators, (...) mammals were generally small, nocturnal, and short‐lived. My hypothesis is that such a long evolutionary pressure on early mammals for rapid reproduction led to the loss or inactivation of genes and pathways associated with long life. I call this the ‘longevity bottleneck hypothesis’, which is further supported by the absence in mammals of regenerative traits. Although mammals, such as humans, can evolve long lifespans, they do so under constraints dating to the dinosaur era. (shrink)

Provocatively, David Armstrong's properties are supposed to be both universals and spatio-temporal. What does this amount to? I consider four of Armstrong's views, in order of ascending plausibility: (1) the exemplification account, on which universals are exemplified by space-times; (2) the location account, on which universals are located at space-times; (3) the first constituent account, on which spatio-temporal relations are elements of what I call the form of time; and, the true view, (4) the second constituent account, on which universals (...) are spatio-temporal only 'derivatively' by being constituents of states of affairs which are so 'primarily'. The first two accounts are rejected because they entail that space-times must be substantival. In making plausible the second constituent account, I distinguish primitive and derivative spatio-temporality. Something is primitively spatio-temporal when it is at a space-time, or stands in spatio-temporal relations. Something is derivatively spatio-temporal when it is a constituent of something primitively spatio-temporal. (shrink)

Despite recent progress in the identification of genes that regulate longevity, aging remains a mysterious process. One influential hypothesis is the idea that the potential for cell division and replacement are important factors in aging. In this work, we review and discuss this perspective in the context of interventions in mammals that appear to accelerate or retard aging. Rather than focus on molecular mechanisms, we interpret results from an integrative biology perspective of how gene products affect cellular functions, which in (...) turn impact on tissues and organisms. We review evidence suggesting that mutations that give rise to features resembling premature aging tend to be associated with cellular phenotypes such as increased apoptosis or premature replicative senescence. In contrast, many interventions in mice that extend lifespan and might delay aging, including caloric restriction, tend to either hinder apoptosis or result in smaller animals and thus may be the product of fewer cell divisions. Therefore, it appears plausible that changes in the number of times that cells, and particularly stem cells, divide during an organism's lifespan influence longevity and aging. We discuss possible mechanisms related to this hypothesis and propose experimental paradigms. BioEssays 30:567–578, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

As questões que norteiam esta reflexão se colocam no entrecruzamento da Arte com a Educação bem como na inserção destas no mercado influenciado pelo poder midiático. A intervenção do educador apresenta-se como mediação que irá se contrapor à velocidade técnica imposta e buscar na interação logos/pathos a experiência do olhar pensante sobre a obra de arte.

Num mundo onde tudo se tornou imagem, parece da maior importância investigar filosoficamente as conexões entre imagens e educação. As imagens-marketing, compondo desejos capturados por um capitalismo que já traz prontos os mundos e seus sentidos, assumiram o status de arte e impregnam tudo - os sentidos, os raciocínios, a imaginação… elas educam. Ora, se é mesmo assim, interessa investigar as relações possíveis entre filosofia e imagem e educação. É o que propõe este dossiê.

Despite having been solved numerous times, the surprise quiz paradox persists in the intellectual imagination as a riddle. This dialogue aims to dispel the fallacies of the paradox in an intuitive way through the causal format of a dialogue. Along the way, two contributions are made to the literature. Even if the student knew there would be a quiz at the end of a quizless Thursday, the fact that the quiz will be a surprise Friday would provide a Gettier-style defeater (...) for his supposed knowledge that he will have a quiz Friday. In addition, pace Sorensen (1988), the dialogue explains why the temporal retention of knowledge is essential to the puzzle and not a mere accident. (shrink)