The Groundwork of the Metaphysics of Morals is Kant's central contribution to moral philosophy, and has inspired controversy ever since it was first published in 1785. Kant champions the insights of 'common human understanding' against what he sees as the dangerous perversions of ethical theory. Morality is revealed to be a matter of human autonomy: Kant locates the source of the 'categorical imperative' within each and every human will. However, he also portrays everyday morality in a way that many readers (...) find difficult to accept. The Groundwork is a short book, but its argument is dense, intricate and at times treacherous. This commentary explains Kant's arguments paragraph by paragraph, and also contains an introduction, a synopsis of the argument, six short interpretative essays on key topics of the Groundwork, and a glossary of key terms. It will be an indispensable tool for anyone wishing to study the Groundwork in detail. (shrink)

Section I of Kant's Groundwork of the Metaphysics of Morals is meant to lead us from our everyday conception of morality to the supreme principle of all moral action, officially christened the ‘categorical imperative’ some twenty Academy pages further into the treatise. It is quite striking that in this first section Kant dispenses with the notorious technical language that pervades not just other parts of the Groundwork but also most of the remaining philosophical writings of the critical period. The mere (...) fact that Groundwork I is comparatively accessible does not, of course, make it straightforward or uncontroversial. Kant's readers are faced with, amongst other things, four unconvincing paragraphs on the natural purpose of practical reason (G IV 394–6), a crucial change of topic from good volition to acting from duty (G IV 397), an unstated ‘first proposition’ about moral value that has baffled generations of interpreters (presumably G IV 397–9), and a contentious shift from an allegedly unproblematic principle of practical universalizability to a substantive moral command (G IV 402). (shrink)

The essays in this volume, by international Kant scholars and moral philosophers, discuss Kant's philosophical development and his rejection of earlier moral theories, the role of happiness and inclination in the Groundwork, Kant's moral ...

The traditional possible-worlds model of belief describes agents as ‘logically omniscient’ in the sense that they believe all logical consequences of what they believe, including all logical truths. This is widely considered a problem if we want to reason about the epistemic lives of non-ideal agents who—much like ordinary human beings—are logically competent, but not logically omniscient. A popular strategy for avoiding logical omniscience centers around the use of impossible worlds: worlds that, in one way or another, violate the laws (...) of logic. In this paper, we argue that existing impossible-worlds models of belief fail to describe agents who are both logically non-omniscient and logically competent. To model such agents, we argue, we need to ‘dynamize’ the impossible-worlds framework in a way that allows us to capture not only what agents believe, but also what they are able to infer from what they believe. In light of this diagnosis, we go on to develop the formal details of a dynamic impossible-worlds framework, and show that it successfully models agents who are both logically non-omniscient and logically competent. (shrink)

Drawing together the ideas, practices, and techniques associated with the subject, this book puts them in historical context and demonstrates their relevance to ...

Giambattista Vico gilt als Begründer der Kulturwissenschaft, obwohl er Jurist war und Rhetorik lehrte. Der Autor führt die juristische Provenienz mit Vicos kulturgeschichtlichen Entdeckungen zusammen und begründet diese in Verbindung mit jener. Durch diese Rückbesinnung auf Vicos Theorie kann womöglich auch die Rechtswissenschaft als Kulturwissenschaft begriffen werden.

Jens Timmermann provides a detailed philosophical, developmental and historical analysis of Immanuel Kant's 1797 essay 'On a Supposed Right to Lie from Love of Humanity', in which Kant argues that it is criminally wrong to lie to protect a friend from being murdered.

Feminist Policymaking in Turbulent Times offers a unique and timely reflection of the critical debates around the institutionalisation of feminist and gender-focused ideas and norms into policy. Many states and non-governmental organisations are increasingly invested in 'feminist policymaking' at the domestic and international levels. Yet, this liberal (feminist) agenda is also vastly disputed by critical, intersectional and decolonial voices on the one hand, and by anti-gender movements around the world on the other. Indeed, while opposition to 'gender ideology' is mounting (...) from reactionary, religious and secular forces, feminist policymaking is also being challenged in important ways from within. Thus, this book situates feminist policymaking in a challenging and 'turbulent', global context. This book explores feminist policymaking in multiple areas of policy, examining various gender-focused programmes that states and international organisations have undertaken in the last decade, offering critical interventions and rethinking the relationship between feminism and policy. The book not only reflects on the advances of feminist policymaking globally, but also critically assesses the intersectional challenges embedded within it and lying ahead. It moves the field forward by creating opportunities, based on lived experiences, for re-imagining the transformative potential of the nexus between feminism and policymaking. Interdisciplinary in scope and bringing to the fore the voices of both academics and practitioners, the book is the product of an international collaboration, forging links and dialogue that are increasingly necessary to question some of the exclusionary, militaristic and hierarchical assumptions of policymaking which is labelled as feminist. Feminist Policymaking in Turbulent Times will be of interest to all scholars, students and practitioners interested in the role of gender in policymaking and concerned with contestations around gender-focused projects. (shrink)

Blaise Pascal (1623-1662) gehort zu den grossten Geistern, die je auf Erden gelebt haben. Der vorliegende Band versucht eine Verbindungslinie zwischen seiner Rechtsphilosophie und seiner Religionsphilosophie herzustellen, indem er Pascals Gedanken uber die Gerechtigkeit zu seiner beruhmten Lehre von den drei Ordnungen ins Verhaltnis setzt. ".

Das Buch zeichnet Schopenhauers individualistisches Rechtsdenken nach und verteidigt seinen methodischen Individualismus namentlich gegen Carl Schmitt. Soweit ersichtlich erstmals wird Schopenhauers Idee der ewigen Gerechtigkeit der Kritik Friedrich Nietzsches gegenübergestellt.

English summary: How do our perceptions come about? If our ways of forming them is deterministically given, skeptical objections can no longer be warded off. We might as well be calibrated for errors. If, instead, our cognition works unbounded and free, there is no compulsion to fall prey to error. It is therefore advisable to understand cognitive formation as a plurimodal interaction of activities of perception, imagination and verbalization, the course of which is never determined by the conditions under which (...) it currently stands. Further, we should not describe ourselves as mere "res cogitans," no matter what the philosophical intentions: there is no sense in assuming that we are determined to perform activities of cognition only. In dealing with two major historical examples, these assumptions are developed and tested. It is shown why Rene Descartes unexpectedly champions them, and which consequences ensue from John Locke's disregarding them. German description: Wie kommen unsere Erkenntnisse zustande? Ist deterministisch festgelegt, wie wir sie bilden, lassen sich skeptische Einwande nicht mehr abwehren. Wir konnten auf Irrtumer geeicht sein. Verlauft unsere Erkenntnisbildung stattdessen ungebunden und frei, entfallt jeglicher Zwang zum Irrtum. Deshalb empfiehlt es sich, Erkenntnisbildung als plurimodales Zusammenwirken von Tatigkeiten der Wahrnehmung, Imagination und Verbegrifflichung zu verstehen, deren Verlauf nie durch die Bedingungen festgelegt ist, unter denen er gerade steht. Ferner sollten wir uns deshalb nicht als blosse "res cogitans" beschreiben, ganz gleich in welcher philosophischen Absicht: Wir konnen in keiner Hinsicht darauf festgelegt sein, nur Tatigkeiten der Erkenntnisbildung auszuuben. In der Auseinandersetzung mit zwei grossen historischen Beispielen werden diese Thesen entwickelt und erprobt. Es wird gezeigt, warum Rene Descartes sie unerwartet vertritt und mit welchen Folgen John Locke sie ausser Acht lasst. (shrink)

Astonishingly, despite the vast amount of scholarship on Machiavelli, no study exists on his theory of legislation, which runs through his celebrated work The Prince, the three-volume Discourses on Livy, the History of Florence, and many of his shorter writings. Jens Petersen's work fills this gap and applies his insights to contemporary legislation.

Wilhelm von Humboldts Rechtsphilosophie ist bei weitem nicht so bekannt wie seine Sprachphilosophie oder gar seine Rolle als Bildungsreformer. Der Autor untersucht zu diesem Zweck Humboldts "Ideen zu einem Versuch, die Grenzen der Wirksamkeit des Staates zu bestimmen".

Indem Montaigne die Jurisprudenz von Grund auf anzweifelte, hat er ihr zugleich die Grundlagen des Rechts in einer spezifisch neuzeitlichen Weise erschlossen. Obwohl er nichts weniger suchte, entdeckte Montaigne beiläufig die Grundlagen des Rechts in ihrer Gesamtheit.

Advanced AI systems are rapidly making their way into medical research and practice, and, arguably, it is only a matter of time before they will surpass human practitioners in terms of accuracy, reliability, and knowledge. If this is true, practitioners will have a prima facie epistemic and professional obligation to align their medical verdicts with those of advanced AI systems. However, in light of their complexity, these AI systems will often function as black boxes: the details of their contents, calculations, (...) and procedures cannot be meaningfully understood by human practitioners. When AI systems reach this level of complexity, we can also speak of black-box medicine. In this paper, we want to argue that black-box medicine conflicts with core ideals of patient-centered medicine. In particular, we claim, black-box medicine is not conducive for supporting informed decision-making based on shared information, shared deliberation, and shared mind between practitioner and patient. (shrink)

Die Tiefe Hirnstimulation hat sich in den vergangenen Jahren bei der Behandlung schwer ausgepragter neurologischer Storungen wie dem Morbus Parkinson bewahrt. WEgen dieses Erfolges werden neue therapeutische Anwendungsmoglichkeiten intensiv erforscht. AUssichtsreiche Ergebnisse liefern dabei auch die ersten Studien an Patienten mit verschiedenen psychiatrischen Erkrankungen, bei denen alle anderen Therapieansatze erfolglos geblieben sind. DIe Tiefe Hirnstimulation weckt jedoch auch Angste. DIese beziehen sich zum Teil auf den fur ihre Anwendung erforderlichen neurochirurgischen Eingriff, bei dem Elektroden dauerhaft in das Gehirn implantiert werden, (...) die uber eine ebenfalls implantierte Stimulatoreinheit mit Strom versorgt werden. ALlerdings wirft insbesondere die Moglichkeit, mit einer neurotechnischen Intervention Einfluss auf das Verhalten bzw. Die Psyche von Menschen nehmen zu konnen, neben medizinethischen auch viele Fragen grundsatzlicher philosophischer Natur auf. IN diesem Sachstandsbericht wird der Stand der medizinischen Anwendung und Erforschung der Tiefen Hirnstimulation in einem neurologischen und einem psychiatrischen Teil zusammengefasst, gefolgt von einer ausfuhrlichen Auswertung der philosophischen Literatur zum Thema. (shrink)

The Oxford Handbook of Carl Schmitt collects thirty original chapters on the diverse oeuvre of one of the most controversial thinkers of the twentieth century. Carl Schmitt was a German theorist whose anti-liberalism continues to inspire scholars and practitioners on both the Left and the Right. Despite Schmitt's rabid anti-semitism and partisan legal practice in Nazi Germany, the appeal of his trenchant critiques of, among other things, aestheticism, representative democracy, and international law as well as of his theoretical justifications of (...) dictatorship and rule by exception is undiminished. Uniquely located at the intersection of law, the social sciences, and the humanities, this volume brings together sophisticated yet accessible interpretations of Schmitt's sprawling thought and complicated biography. The contributors hail from diverse disciplines, including art, law, literature, philosophy, political science, and history. In addition to opening up exciting new avenues of research, The Oxford Handbook of Carl Schmitt provides the intellectual foundations for an improved understanding of the political, legal, and cultural thought of this most infamous of German theorists. A substantial introduction places the trinity of Schmitt's thought in a broad context. (shrink)

The traditional Lewis–Stalnaker semantics treats all counterfactuals with an impossible antecedent as trivially or vacuously true. Many have regarded this as a serious defect of the semantics. For intuitively, it seems, counterfactuals with impossible antecedents—counterpossibles—can be non-trivially true and non-trivially false. Whereas the counterpossible "If Hobbes had squared the circle, then the mathematical community at the time would have been surprised" seems true, "If Hobbes had squared the circle, then sick children in the mountains of Afghanistan at the time would (...) have been thrilled" seems false. Many have proposed to extend the Lewis–Stalnaker semantics with impossible worlds to make room for a non-trivial or non-vacuous treatment of counterpossibles. Roughly, on the extended Lewis–Stalnaker semantics, we evaluate a counterfactual of the form "If A had been true, then C would have been true" by going to closest world—whether possible or impossible—in which A is true and check whether C is also true in that world. If the answer is "yes", the counterfactual is true; otherwise it is false. Since there are impossible worlds in which the mathematically impossible happens, there are impossible worlds in which Hobbes manages to square the circle. And intuitively, in the closest such impossible worlds, sick children in the mountains of Afghanistan are not thrilled—they remain sick and unmoved by the mathematical developments in Europe. If so, the counterpossible "If Hobbes had squared the circle, then sick children in the mountains of Afghanistan at the time would have been thrilled" comes out false, as desired. In this paper, I will critically investigate the extended Lewis–Stalnaker semantics for counterpossibles. I will argue that the standard version of the extended semantics, in which impossible worlds correspond to maximal, logically inconsistent entities, fails to give the correct semantic verdicts for many counterpossibles. In light of the negative arguments, I will then outline a new version of the extended Lewis–Stalnaker semantics that can avoid these problems. (shrink)

We argue that stereotypes associated with concepts like he-said–she-said, conspiracy theory, sexual harassment, and those expressed by paradigmatic slurs provide “normative inference tickets”: conceptual permissions to automatic, largely unreflective normative conclusions. These “mental shortcuts” are underwritten by associated stereotypes. Because stereotypes admit of exceptions, normative inference tickets are highly flexible and productive, but also liable to create serious epistemic and moral harms. Epistemically, many are unreliable, yielding false beliefs which resist counterexample; morally, many perpetuate bigotry and oppression. Still, some normative (...) inference tickets, like some activated by sexual harassment, constitute genuine moral and hermeneutical advances. For example, our framework helps explain Miranda Fricker’s notion of “hermeneutical lacunae”: what early victims of “sexual harassment” — as well as their harassers — lacked before the term was coined was a communal normative inference ticket — one that could take us, collectively, from “this is happening” to “this is wrong.”. (shrink)

Possible-worlds accounts of mental or linguistic content are often criticized for being too coarse-grained. To make room for more fine-grained distinctions among contents, several authors have recently proposed extending the space of possible worlds by "impossible worlds". We argue that this strategy comes with serious costs: we would effectively have to abandon most of the features that make the possible-worlds framework attractive. More generally, we argue that while there are intuitive and theoretical considerations against overly coarse-grained notions of content, the (...) same kinds of considerations also prohibit an overly fine-grained individuation of content. An adequate notion of content, it seems, should have intermediate granularity. However, it is hard to construe a notion of content that meets these demands. Any notion of content, we suggest, must be either implausibly coarse-grained or implausibly fine-grained (or both). (shrink)

This paper argues in favor of a hybrid conception of identity. A common conception of identity in datafied society is a split between a digital self and a real self, which has resulted in concepts such as the data double, algorithmic identity, and data shadows. These data-identity metaphors have played a significant role in the conception of informational privacy as control over information—the control of or restricted access to your digital identity. Through analyses of various data-identity metaphors as well as (...) philosophical accounts of identity, we argue in favor of a hybrid conception of identity that emphasizes the relations between the ‘real’ and the ‘digital’. A hybrid conception of identity—where the digital is an aspect on par with social relations, self-understanding, and values—ultimately calls for an understanding of privacy as the right to influence one’s own identity. (shrink)

Adam Smith was not just a pioneer of political economy; he was also a moral philosopher who aspired to write a systematic theory of law. Though he never completed the project - he asked the executors of his estate to burn his notes - his major published works contain a multitude of passages from which significant portions of his legal theory can be reconstructed. Many of Smith's views are of great relevance to present-day issues. He proposed financial regulation restricting the (...) freedom of individuals, which he likened to the necessity of equipping buildings with firewalls. In light of the global firestorm caused by the most recent banking crisis, Smith's ideas appear strikingly modern. (shrink)

My goal in what follows is to argue that Astell endorses what I call the admonisher conception of a friend. For I will argue that, according to Astell, a sufficient condition for whether someone is our friend is that they admonish us in her technical sense. So anyone who admonishes us in this sense—be they Mother Teresa, the sinner sitting in confession, or our professional rival—is a friend to us. Put simply, an Astellian friend is an admonisher. The paper is (...) divided into four sections. Having motivated my reading in section one, section two develops and defends my thesis that admonishment is a sufficient condition for someone to be our Astellian friend. With Astell’s admonisher conception on the table, the balance of the paper shows how Astell might have persuaded us to accept her severe-sounding view by sketching the goods that she thinks flow from having an admonisher as a friend. Section three thus contends that, on Astell’s view, there is a class of deep truths about who we are that only our admonishing friends can reliably access; section four sketches how admonishment enhances our moral reasoning skills on Astell’s picture. Published on 2022-12-12 11:42:32. (shrink)

Why, then, has Anglo-American jurisprudence remained staunchly indifferent to history? How has it been able to maintain its confident assumption that the analytical and the historical can be neatly...

In this paper, I investigate whether we can use a world-involving framework to model the epistemic states of non-ideal agents. The standard possible-world framework falters in this respect because of a commitment to logical omniscience. A familiar attempt to overcome this problem centers around the use of impossible worlds where the truths of logic can be false. As we shall see, if we admit impossible worlds where “anything goes” in modal space, it is easy to model extremely non-ideal agents that (...) are incapable of performing even the most elementary logical deductions. A much harder, and considerably less investigated challenge is to ensure that the resulting modal space can also be used to model moderately ideal agents that are not logically omniscient but nevertheless logically competent. Intuitively, while such agents may fail to rule out subtly impossible worlds that verify complex logical falsehoods, they are nevertheless able to rule out blatantly impossible worlds that verify obvious logical falsehoods. To model moderately ideal agents, I argue, the job is to construct a modal space that contains only possible and non-trivially impossible worlds where it is not the case that “anything goes”. But I prove that it is impossible to develop an impossible-world framework that can do this job and that satisfies certain standard conditions. Effectively, I show that attempts to model moderately ideal agents in a world-involving framework collapse to modeling either logical omniscient agents, or extremely non-ideal agents. (shrink)

How can work be a genuine good in life? I argue that this requires overcoming a problem akin to that studied by Marx scholars as the problem of work, freedom and necessity: how can work be something we genuinely want to do, given that its content is not up to us, but is determined by necessity? I argue that the answer involves valuing contributing to the good of others, typically as valuing active pro-sociality – that is, valuing actively doing something (...) good for others. This makes work better in one way, and may even make work something we are genuinely glad to have in our lives. Contemporary philosophical thinking about good work tends to focus on how work can be good for the person doing it, by providing, for example, self-realization or social relationships, while underappreciating the special importance of valuing social contribution. People will typically only really want work if they want a part of their lives to be about the good of others. This also means that work may be a part of the best life, something we should take into account when discussing work-related policies and the desirability of a ‘post-work’ future. (shrink)

In this paper, we present and defend an analysis of harm that we call the Negative Influence on Well-Being Account (NIWA). We argue that NIWA has a number of significant advantages compared to its two main rivals, the Counterfactual Comparative Account (CCA) and the Causal Account (CA), and that it also helps explain why those views go wrong. In addition, we defend NIWA against a class of likely objections, and consider its implications for several questions about harm and its role (...) in normative theorizing. (shrink)

While philosophers generally accept some version of the principle ‘ought’ implies ‘can’, recent work in experimental philosophy and cognitive science provides evidence against a presupposition or a conceptual entailment from ‘ought’ to ‘can’. Here, we review some of this evidence, its effect on particular formulations of the principle, and future directions for cognitive scientists and philosophers.

To reconcile the standard possible worlds model of knowledge with the intuition that ordinary agents fall far short of logical omniscience, a Stalnakerian strategy appeals to two components. The first is the idea that mathematical and logical knowledge is at bottom metalinguistic knowledge. The second is the idea that non-ideal minds are often fragmented. In this paper, we investigate this Stalnakerian reconciliation strategy and argue, ultimately, that it fails. We are not the first to complain about the Stalnakerian strategy. But (...) in contrast to existing complaints, we want to cause trouble for the strategy directly on its home turf. That is, we will advance our objection while granting both the plausibility of the fragmentation component—save for an extreme version of it—and that of the metalinguistic component. Once our central objection to the Stalnakerian strategy is in place, we will show how it negatively affects Adam Elga and Augustín Rayo’s recent attempt to apply the Stalnakerian strategy in the context of Bayesian decision theory. (shrink)

This paper analyzes the internet policy discourse regarding the German Network Enforcement Act (NetzDG) in different media settings. We examine the conversation about this highly controversial anti-hate speech law on IT blogs, websites, and in daily German newspapers. We compare the positions brought forward in these different media environments concerning one of the most important topics within the discussion about the NetzDG, specifically the question of whether or not the law will result in censorship, limiting users’ freedom of expression. We (...) employ pretrained transformer-based language models to detect and quantify recurring arguments in the debate. (shrink)

Taboo terms offer a playground for linguistic creativity in language after language, and sign languages form no exception. The present paper offers the first investigation of taboo terms in sign languages from a cognitive linguistic perspective. We analyze the linguistic mechanisms that introduce offense, focusing on the combined effects of cognitive metonymy and iconicity. Using the Think Aloud Protocol, we elicited offensive or crass signs and dysphemisms from nine signers. We find that German Sign Language uses a variety of linguistic (...) means to introduce and enhance offense, many of which rely on iconic properties of the taboo sign. In conjunction with cross-linguistically common metonymic word-formation strategies, the degree of visual explicitness of a sign increases its potential to offend. Semantically similar taboo signs based on the same metonymic anchor but differing in their degree of iconicity also differ in offensiveness. This allows for creating dysphemisms and euphemisms via phonological changes to a sign. We further show that embodiment creates modality-enhanced ‘vicarious embarrassment’ in the viewer that results in the respective signs being judged obscene or offensive. Further, lexical blending and non-manual enhancement play a role in the creation of dysphemisms in DGS. Lastly, we propose that iconicity as a cognitive structuring principle of linguistic expressions constrains the possible semantic extensions of iconic taboo terms. (shrink)

Slurs have been standardly assumed to bear a very direct, very distinctive semantic relationship to what philosophers have called “neutral counterpart” terms. I argue that this is mistaken: the general relationship between paradigmatic slurs and their “neutral counterparts” should be assumed to be the same one that obtains between ‘chick flick’ and ‘romantic comedy’, as well a huge number of other more prosaic pairs of derogatory and “less derogatory” expressions. The most plausible general relationship between these latter expressions — and (...) thus, I argue, between paradigmatic slurs and “neutral counterpart” terms — is one of overlap in presumed extension, grounded in overlap in associated stereotypes. The resulting framework has the advantages of being simple, unified, and, unlike its orthodox rivals, neatly accommodating of a much wider range of data than has previously been considered. More importantly, it positions us to better understand, identify, and confront the insidious mechanisms of ordinary bigotry. (shrink)

It has recently been argued that a sensitivity theory of knowledge cannot account for intuitively appealing instances of higher-order knowledge. In this paper, we argue that it can once careful attention is paid to the methods or processes by which we typically form higher-order beliefs. We base our argument on what we take to be a well-motivated and commonsensical view on how higher-order knowledge is typically acquired, and we show how higher-order knowledge is possible in a sensitivity theory once this (...) view is adopted. (shrink)

This paper explores the possibility of moral conflict in Kant’s ethics. An analysis of the only explicit discussion of the topic in his published writings confirms that there is no room for genuine moral dilemmas. Conflict is limited to nonconclusive ‘grounds’ of obligation. They arise only in the sphere of ethical duty and, though defeasible, ought to be construed as the result of valid arguments an agent correctly judges to apply in the situation at hand. While it is difficult to (...) determine in theory what makes some of them stronger than others, these ‘grounds’ can account for practical residue in conflict cases and for a plausible form of agent regret. The principle that ‘ought implies can’ survives intact. (shrink)

According to the standard version of the counterfactual comparative account of harm, an event is overall harmful for an individual if and only if she would have been on balance better off if it had not occurred. This view faces the “preemption problem.” In the recent literature, there are various ingenious attempts to deal with this problem, some of which involve slight additions to, or modifications of, the counterfactual comparative account. We argue, however, that none of these attempts work, and (...) that the preemption problem continues to haunt the counterfactual comparative account. (shrink)

Epigenetic control of gene expression by chromatin remodeling is critical for adult stem cell function. A decline in stem cell function is observed during aging, which is accompanied by changes in the chromatin structure that are currently unexplained. Here, we hypothesize that these epigenetic changes originate from the limited cellular capability to inherit epigenetic information. We suggest that spontaneous loss of histone modification, due to fluctuations over short time scales, gives rise to long‐term changes in DNA methylation and, accordingly, in (...) gene expression. These changes are assumed to impair stem cell function and, thus, to contribute to aging. We discuss cell replication as a major source of fluctuations in histone modification patterns. Gene silencing by our proposed mechanism can be interpreted as a manifestation of the conflict between the stem cell plasticity required for tissue regeneration and the permanent silencing of potentially deleterious genomic sequences. (shrink)

The Groundwork of the Metaphysics of Morals is Kant's central contribution to moral philosophy, and has inspired controversy ever since it was first published in 1785. Kant champions the insights of 'common human understanding' against what he sees as the dangerous perversions of ethical theory. Morality is revealed to be a matter of human autonomy: Kant locates the source of the 'categorical imperative' within each and every human will. However, he also portrays everyday morality in a way that many readers (...) find difficult to accept. The Groundwork is a short book, but its argument is dense, intricate and at times treacherous. This commentary explains Kant's arguments paragraph by paragraph, and also contains an introduction, a synopsis of the argument, six short interpretative essays on key topics of the Groundwork, and a glossary of key terms. It will be an indispensable tool for anyone wishing to study the Groundwork in detail. (shrink)

Meaningful work is an important ideal, but it seems hard to give an adequate account of meaningful work. In this article, I conduct a revisionary conceptual analysis of ‘meaningful work’, i.e. a conceptual analysis that aims at finding a better and more useful way to use this term. I argue for a distinction between cases where work itself is meaningful and cases where other sources of meaning are found at work. The term ‘meaningful work’ is most useful for the former (...) cases. I then argue for the reasons account of what makes work itself meaningful: work is meaningful if (and to the extent that) there are good reasons to do it. I compare this to established accounts of meaningful work, such as subjective meaningfulness, self-realization, alienation, the unity of conception and execution, autonomy, social contribution, and Veltman’s four-dimensional account. None of these capture the distinct concern that the concept ‘meaningful work’ should capture, or they do so less well than the reasons account. This also shows that work can be meaningful regardless of whether it is good in other respects, such as in inherent interest or opportunities for self-realization. (shrink)