Commonly, a switch between networks mediating memory encoding and those mediating retrieval is observed. This may not only be due to differential involvement of neural resources due to distinct cognitive processes but could also reflect the formation of new memory traces and their dynamic change during consolidation. We used resting state fMRI to measure functional connectivity (FC) changes during post-encoding rest, hypothesizing that during this phase, new functional connections between encoding- and retrieval-related regions are created. Interfering and reminding tasks served (...) as experimental modulators to corroborate that the observed FC differences indeed reflect changes specific to post-encoding rest. The right inferior occipital and fusiform gyri (active during encoding) showed increased FC with the left inferior frontal gyrus and the left middle temporal gyrus (MTG) during post-encoding rest. Importantly, the left MTG subsequently also mediated successful retrieval. This finding might reflect the formation of functional connections between encoding- and retrieval-related regions during undisturbed post-encoding rest. These connections were vulnerable to experimental modulation: Cognitive interference disrupted FC changes during post-encoding rest resulting in poorer memory performance. The presentation of reminders also inhibited FC increases but without affecting memory performance. Our results contribute to a better understanding of the mechanisms by which post-encoding rest bridges the gap between encoding- and retrieval-related networks. (shrink)

The psychedelic psilocybin has shown promise both as treatment for psychiatric conditions and as a means of improving well-being in healthy individuals. In some jurisdictions (e.g., Oregon, USA), psilocybin use for both purposes is or will soon be allowed and yet, public attitudes toward this shift are understudied. We asked a nationally representative sample of 795 US Americans to evaluate the moral status of psilocybin use in an appropriately licensed setting for either treatment of a psychiatric condition or well-being enhancement. (...) Showing strong bipartisan support, participants rated the individual’s decision as morally positive in both contexts. These results can inform effective policy-making decisions around supervised psilocybin use, given robust public attitudes as elicited in the context of an innovative regulatory model. We did not explore attitudes to psilocybin use in unsupervised or non-licensed community or social settings. (shrink)

2007 will be remembered as the year in which the Tour de France died. Race leader and likely eventual winner, Michael Rasmussen, was eliminated near the end on an allegation of doping. Since the 1960s, the idealistic drug crusaders have been on a mission to reverse the course of history, and eliminate drugs from the sport. But this “zero tolerance” strategy to drugs has failed, as 2007's Tour spectacularly showed. Only around 10–15% of professional athletes are drug tested. Currently, it (...) is illegal to use erythropoietin (EPO) or blood doping to move your haematocrit from 48 to 49% even though some people will have a normal level of 49%. A regulated permissive policy would paradoxically reduce risk to athletes. The present system creates an environment of risk to the athlete. A rational policy on doping would allow safe performance‐enhancing interventions which are consistent with the spirit of a particular sport. (shrink)

Some of my colleagues will sadly not be attending the IAB World Congress in Qatar. Amongst other things, they wish to take a stand against Qatar’s human rights record and the treatment of women and...

Julian Wolfreys starts with loss. All memory is the memory of loss... All that we are, all we experience, all we remember, all that we forget but which leaves nevertheless a trace on us, in us, a trace that countersigns and writes us as who we are (in effect the constellated matrix of Being's becoming): this is a process of loss. This just is loss. Loss is who we are. Loss is authentically the necessary and inescapable inessential essence of (...) Being. Loss names the ghosts, the revenants of Being, Being's others. Neither there nor not there, loss persists as the always already becoming of the thinking of Being. There is more than one loss. There is no one loss. Loss never arrives for a first time. All loss is the return of what is lost to Being's being in the world. From that starting point, the author explores the nature of being and dwelling... of memory and the nature of the traces of the past... of apparition and appearance and perception... of touch and being touched... of the material and the (a)material. In a book that draws in multiple threads from 19th- and 20th-century European literature, he references extensively Heidegger, Derrida, Lacan, Cixous, Celan, Husserl, Woolf, Joyce, Hegel, Badiou, Rilke, Merleau-Ponty, Winterson, Stockhausen and True Detective in an impressive and eclectic tour of the being-becoming-loss.". (shrink)

First impressions -- Sheep -- Counting sheep in the belly of the wolf -- What was pastoral (again)? more versions (otium for sheep) -- Oranges -- Invisible Inc. (time for oranges) -- Gold you can eat (on theft) -- Yeast -- Bread and stones (on bubbles) -- Erasures.

Enhancing Human Capacities is the first to review the very latest scientific developments in human enhancement. It is unique in its examination of the ethical and policy implications of these technologies from a broad range of perspectives. Presents a rich range of perspectives on enhancement from world leading ethicists and scientists from Europe and North America The most comprehensive volume yet on the science and ethics of human enhancement Unique in providing a detailed overview of current and expected scientific advances (...) in this area Discusses both general conceptual and ethical issues and concrete questions of policy Includes sections covering all major forms of enhancement: cognitive, affective, physical, and life extension. (shrink)

There are 4 main arguments for euthanasia: (1) arguments appealing to consistency (e.g., from passive to active euthanasia); (2) the argument from respect for autonomy; (3) appeals to justice; and (4) the argument from interests (mercy or relief of suffering). I will argue that only the last is directly relevant to active euthanasia as a medical intervention, though arguments together from autonomy and justice can in practice (through the backdoor) provide a ground for voluntary active medical euthanasia (AME).

Current and future possibilities for enhancing human physical ability, cognition, mood, and lifespan raise the ethical question of whether we should enhance normal human capacities in these ways. This chapter offers such an account of enhancement. It begins by reviewing a number of suggested accounts of enhancement, and points to their shortcomings. The chapter then identifies two key senses of “enhancement”: functional enhancement, the enhancement of some capacity or power (e.g. vision, intelligence, health) and human enhancement, the enhancement of a (...) human being's life. The latter notion is the notion of enhancement most relevant to ethical debate. The chapter argues that it is best understood in welfarist terms. It illustrates this welfarist approach to enhancement by applying it to the case of cognitive enhancement. Unlike the sociological pragmatic and functional approaches, the welfarist account is inherently normative. It ties enhancement to the value of well‐being. (shrink)

Voici une dition qui contribuera sans doute clairer une activit encore mal connue de Voltaire, celle d' diteur. Car de cette uvre composite qu'est le Discours de l'empereur Julien Voltaire se veut avant tout et reste bien l'organisateur, empruntant l'empereur du IVe si cle le r quisitoire qu'il a dress dans son Contre les Galil ens et au marquis d'Argens, son moderne et premier traducteur, la 'belle infid le' qu'il a donn e lire cinq ans plus t t ceux qui (...) n'entendaient ni le grec ni le latin. Voltaire n'a cependant conserv le joyau que pour le servir dans une monture toute nouvelle: d'Argens avait accompagn sa traduction d'une substantielle pr face et d'une annotation abondante; mais Voltaire a cart la premi re et retenu un tiers seulement de la seconde, encadrant d sormais le Discours de ses propres textes; en pr faces un 'Avis au lecteur' suivi d'un 'Portrait de l'empereur Julien' et d'un 'Examen du Discours'; en postface un virulent 'Suppl ment au Discours'. A quoi l'on ajoutera les quarante-quatre notes r dig es par l' diteur et qui s'adjoignent aux treize notes de d'Argens qu'il a conserv es; ce sont les 'nouvelles notes de divers auteurs' annonc s par la page de titre et dont quatre sont sign es Damilaville, Boulanger, Bolingbroke et 'le th ologien Th ro': sous ces noms d'emprunt, l' diteur ne s'est pas fait scrupule de r utiliser certains de ses textes ant rieurs, pas plus qu'il n'a craint, par de simples coupes habilement op r es dans certaines notes de d'Argens, de d figurer l'occasion la pens e du marquis quand elle se trouve contraire la sienne. Ainsi voit-on clairer sous ses diff rents aspects une activit ditoriale dont il fallait aussi p n trer les motifs. (shrink)

The path taken by German philosophy in the twentieth century is one of the most exciting and controversial in the history of human thought, by turns radical and conservative and secular and religious. In this outstanding introduction, German Philosophy in the Twentieth Century: Dilthey to Honneth--the third and final volume in his trilogy, Julian Young examines the work of eight German philosophers and theologians of the period. He shows how they engaged with profound existential questions about individual and collective (...) lives, criticised the increasing rationalisation and mechanisation characteristic of modernity, and committed themselves to varying forms of liberalism, socialism and democracy. Young introduces and assesses the thought of the following figures: Wilhelm Dilthey, the encroachment of the natural sciences upon the study of humanity and his distinction between 'explanation' and 'understanding'; Karl Jaspers, existentialism, the challenge of nihilism and the turn to theology; Edith Stein, our understanding of other people and the philosophy of empathy from a phenomenological standpoint; Paul Tillich, philosophical theology and the 'theonomous' life; Martin Buber, Recovering the 'I-Thou' relationship in the face of modernity and religious socialism; Hans Jonas, responsibility, selfhood and threats to humanity in the twentieth century; Erich Fromm, the 'art of loving' as a bulwark against totalitarianism and the replacement of capitalism by communitarian socialism; Axel Honneth, contemporary Hegelianism and the ethics and politics of recognition. Lucidly and engagingly written, German Philosophy in the Twentieth Century: Dilthey to Honneth is essential reading for students of German philosophy, phenomenology and theology and will also be of interest to students in related fields such as literature, political theory and sociology. (shrink)

Radical empiricists at the turn of the twentieth century described organisms as experiencing the relations they maintain with their surroundings prior to any analytic separation from their environment. They notably avoided separating perception of the material environment from social life. This perspective on perceptual experience was to prove the inspiration for Gibson’s ecological approach to perceptual psychology. Gibson provided a theory of how the direct perception of the organism-environment relation is possible. Central to his account was the notion of a (...) medium for direct perception. However Gibson provided two mutually inconsistent accounts of the medium leading to problems for his radical empiricism. We develop an account of the medium that does justice to ecological psychology’s radical empiricist roots. To complement this account of the medium we detail a usage-based account of information. Together they allow us to propose a novel radical empiricist view of direct perception. We then return to the notion of medium and expand it to include sociomaterial practices. We show how direct perception happens in the midst of social life, and is made possible by an active achieving and maintaining of a pragmatic relation with the environment. (shrink)

The blossoming literature on genealogy in recent years has come as somewhat of a pleasant surprise to the historically inclined among us. It has not, however, come without its difficulties. As I see it, the literature on genealogy is guilty of two conflations, what I call the “debunking/problematizing conflation” and the “problematizing/rationalizing conflation.” Both are the result of the inadequate typological maps currently used to organize the literature. As a result, what makes many genealogies philosophically interesting often remains obscure. In (...) response, I propose a new two-dimensional typology that avoids these conflations and outfits us with a richer conceptual vocabulary with which to understand and organize the genealogies which populate the literature. By identifying a second dimension of analysis which has thus far gone untheorized, my typology enables us to elucidate the various normative objectives and objects of investigation structuring a literature which is more diverse than previously acknowledged. We can thus get a clearer understanding of the problems those genealogies face, of their critical potential, and of their implications for our conception of critique. (shrink)

"Roger Garaudy was for many years at the centre of the French Communist Party but was eventually expelled for his liberal views. In the Seventies he developed a project to bring Marxism and Christianity together, to include all humanity in a project to set all people free. What emerges from Garaudy's project is a very modern Marxism, with its emphasis on the individual, its ecological politics, and in its insistence on religion as central to human emancipation. Although Garaudy himself became (...) frustrated by the West and converted to Islam in 1982, ending his life discredited in the West, it is certainly possible that Garaudy's project represents a good, perhaps even the best, starting point for Marxism in today's world"--. (shrink)

This volume reviews and takes stock of legal ethics, at a time when the legal profession globally is experiencing considerable change and challenges, through a re-evaluation of writings that are in some way foundational to the field. Legal ethics, understood here as the study of the ethics and professional regulation of lawyers, has emerged as a novel and important field of study over the last 50 years. It is also one that displays considerable diversity in its scholarship, with distinctive philosophical (...) and interdisciplinary approaches emerging over the years to underpin and supplement the doctrinal 'law on lawyering'. With contributions from leading and emerging scholars from the United States, Australia, Canada, the Netherlands, New Zealand and the United Kingdom, this collection offers not just critical insights into the authors' chosen texts, but a thought-provoking commentary on the current state of legal ethics scholarship and its future directions. In addition to being an essential resource for scholars and students of legal ethics theory, it will also be of interest to academics and researchers in legal theory, the philosophy of law, and applied ethics. (shrink)

In a revolutionary new book, a theoretical physicist attacks the foundations of modern scientific theory, including the notion of time, as he shares evidence of ...

Philosophie ist der Versuch, durch überzeugendes und durchsichtiges Argumentieren bestimmte Fragen zu lösen. Philosophische Grundthemen sind Fragen nach dem Verständnis der Welt im Ganzen und unserer Stellung in ihr. Diese Fragen können prinzipiell nur kontrovers beantwortet werden. Die Reihe Grundthemen Philosophie möchte der Diskussion solcher philosophischen Grundthemen einen Ort geben. Anstelle einer umfassenden einführenden Darstellung werden in den einzelnen Bänden in Auseinandersetzung mit ausgewählten historischen Positionen die jeweiligen Probleme analysiert und Lösungsmöglichkeiten diskutiert. Dabei setzt der Verfasser/die Verfasserin eigene Akzente und (...) bezieht Stellung, so dass sich nicht bloß ein Blick auf die Geschichte der Philosophie, sondern zugleich auch ein systematischer Beitrag zur Problemdiskussion ergibt. Zur Zeit sind weitere Bände zu den Themen Beziehungen, Kultur, Wissenschaft und Moralbegründung geplant. Die Bände der Reihe richten sich gleichermaßen an Studierende der Philosophie und anderer Fächer sowie an professionelle Philosophen. Außerdem wendet sich die Reihe an alle, die an Grundthemen der Philosophie interessiert sind. (shrink)

In this paper, we outline how one might conduct a comprehensive ethical evaluation of human brain organoid transplantation in animals. Thus far, ethical concerns regarding this type of research have been assumed to be similar to those associated with other transplants of human cells in animals, and have therefore not received significant attention. The focus has been only on the welfare, moral status, or mental capacities of the host animal. However, the transplantation of human brain organoids introduces several new ethical (...) issues. Many of these are related to uncertainty regarding whether or not brain organoids might be conscious. While these concerns might not be immediately relevant, they warrant closer scrutiny. We discuss how various ethical issues are relevant to different stages of human brain organoid transplantation and can guide the ethical evaluation of research. Our examination would broaden the horizons of the debate on the transplantation of brain organoids. (shrink)

This chapter contains sections titled: Nietzsche's Conversion The Impact of Lange Criticising Schopenhauer Reconstructing Schopenhauer Postscript References.

Principles of distributive justice are normative principles designed to guide the allocation of the benefits and burdens of economic activity.

Introduction -- The type/token theory introduced -- Motivating the type/token theory : repeatability -- Nominalist approaches to the ontology of music -- Musical anti-realism -- The type/token theory elaborated -- Types I : abstract, unstructured, unchanging -- Types introduced and nominalism repelled -- Types as abstracta -- Types as unstructured entities -- Types as fixed and unchanging -- Types II : platonism -- Introduction : eternal existence and timelessness -- Types and properties -- The eternal existence of properties reconsidered -- (...) Types and patterns -- Defending the type/token theory I -- Unstructuredness and analogical predication -- Musical works as fixed and unchanging -- Abstractness and audibility (again) -- Works and interpretations -- Conclusion and resumé -- Defending the type/token theory II : musical platonism -- Platonism it is : replies to Anderson and Levinson -- The existence conditions of works of music -- Composition as creative discovery -- The nature of the compositional process : replies to objections -- Composition and aesthetic appraisal : a reply to Levinson -- Composition and aesthetic appraisal : understanding, interpretation, and correctness -- Musical works as continuants : a theory rejected -- A theory introduced -- Explicating and motivating the continuant view -- The continuant view and repeatability -- Further objections to the continuant view -- Musical works as compositional actions : a critique -- Currie's action-type hypothesis -- Davies's performance theory -- Sonicism I : against instrumentalism -- Sonicism introduced -- Sonicism motivated : moderate empiricism -- Instrumentation : timbral sonicism introduced -- Scores -- Instrumentation, artistic properties, and aesthetic content -- Levinson's rejoinder -- Sonicism II : against contextualism -- Introduction : formulating contextualism -- Contextualist ontological proposals -- Levinson's doppelgänger thought-experiments -- Artistic, representational, and object-directed expressive properties -- Aesthetic and non-object-directed expressive properties -- Conclusion : the place of context. (shrink)