The distribution of scarce healthcare resources is an increasingly important issue due to factors such as expensive ‘high tech’ medicine, longer life expectancies and the rising prevalence of chronic illness. Furthermore, in the current healthcare context lifestyle-related factors such as high blood pressure, tobacco use and obesity are believed to contribute significantly to the global burden of disease. As such, this paper focuses on an ongoing debate in the academic literature regarding the role of responsibility for illness in healthcare resource (...) allocation: should patients with self-caused illness receive lower priority in access to healthcare resources? This paper critically describes the lower priority debate's 12 key arguments and maps out their relationships. This analysis reveals that most arguments have been refuted and that the debate has stalled and remains unresolved. In conclusion, we suggest progression could be achieved by inviting multidisciplinary input from a range of stakeholders for the development of evidence-based critical evaluations of existing arguments and the development of novel arguments, including the outstanding rebuttals. (shrink)

Context: In 2015, we are surrounded by tools and technologies for creating and making, thinking and learning. But classroom “learning” is often focused on learning about the tool/technology itself, rather than learning with or through the technology. Problem: A constructionist theory of learning offers useful ways for thinking about how technology can be included in the service of learning in K-12 classrooms. To support constructionism in the classroom, we need to focus on supporting teachers, who necessarily serve as the agents (...) of classroom-level innovations. This article explores a central question: How can we support teachers to engage with constructionism as a way to think beyond a technocentric view in the classroom? Method: I approach this work from the perspective of a designer, using the process of supporting teachers working with the Scratch programming language in K-12 classrooms as a central example. I draw on reflections from six years of the ScratchEd project, which includes interviews with 30 teachers, and observations from teacher professional development events and an online community of educators. Results: I describe five sets of tensions that I encountered while designing the ScratchEd model of professional development: tensions between tool and learning, direction and discovery, individual and group, expert and novice, and actual and aspirational. I describe how these tensions are negotiated within the elements of the PD model (an online community, participatory meetups, and an online workshop. Implications: The tensions I describe are not specific to Scratch, and can serve as a more general model for PD designers to scrutinize and critique. Constructivist content: This work contributes to ongoing conversations and questions about how to support constructivist/constructionist approaches in classrooms. (shrink)

Background and objectives Conscientious refusal of abortion has been discussed widely by medical ethicists but little information on practitioners' opinions exists. The American College of Obstetricians and Gynecologists (ACOG) issued recommendations about conscientious refusal. We used a vignette experiment to examine obstetrician-gynecologists' (OB/GYN) support for the recommendations. Design A national survey of OB/GYN physicians contained a vignette experiment in which an OB/GYN doctor refused a requested elective abortion. The vignette varied two issues recently addressed by the ACOG ethics committee—whether the (...) doctor referred and whether the doctor disclosed their objection to the abortion. Participants and setting 1800 OB/GYN randomly selected physicians were asked to complete a mail survey containing the vignette. The response rate was 66% (n=1154) after excluding 40 ineligible cases. Measurement Physicians indicated their approval for the vignette doctor's decision. Main results Overall, 43% of OB/GYN physicians responded that the conscientious refusal exercised by the vignette physician was appropriate. 70% rated the vignette doctor as acting appropriately when a referral was made. This dropped to 51% when the doctor disclosed objections to the patient, and to 12% when the doctor disclosed objections and refused to make a referral. Consistent with previous research, males were more likely to support disclosure and refusal to refer. Highly religious physicians supported non-referral but not disclosure. Conclusion OB/GYN physicians are less likely to support conscientious refusal of abortion if physicians disclose their objections to patients. This is at odds with ACOG recommendations and with some models of the doctor–patient relationship. (shrink)

In the current study, we aimed at understanding the effect of exposure to complex input on speech sound development, by conducting a systematic meta-analysis review of the existing treatment-based studies employing complex input in children with speech sound disorders. In the meta-analysis review, using a list of inclusion criteria, we narrowed 280 studies down to 12 studies. Data from these studies were extracted to calculate effect sizes that were plotted as forest plots to determine the efficacy of complexity-based treatment approaches. (...) The outcome variables of interest were improvement on the treated and generalization to the untreated sounds. Meta-analysis revealed that the exposure to complex input not only promoted improvement in production of complex speech sounds but also facilitated the production of untreated simple speech sounds. Overall, the current findings revealed that the exposure to complex input promotes acquisition of both complex and simple speech sounds. The current findings are in line with the models of language learnability. The current findings have implications in the treatment of speech sound disorders. (shrink)

SummaryAs part of a prospective controlled study of the psychosomatic effects of elective tubal sterilization, 138 women were questioned about their menstrual functioning before sterilization, and again 6 months and 12 months post-operatively, using standardized interviewing procedures. Adverse changes, including increased menstrual loss, shorter menstrual cycles and greater use of pads or tampons were reported by sterilized subjects at both of the post-operative interviews. Control subjects reported several comparable effects, although adverse changes overall were reported more commonly by sterilized women (...) than by control subjects. However, many of the reported changes appeared to be related to pre-operative contraceptive methods, although consistent increases in use of pads or tampons were found in women who had pre-operatively used neither the pill nor the IUD. (shrink)

BACKGROUND: Health-based journal clubs have been in place for over 100 years. Participants meet regularly to critique research articles, to improve their understanding of research design, statistics and critical appraisal. However, there is no standard process of conducting an effective journal club. We conducted a systematic literature review to identify core processes of a successful health journal club. METHOD: We searched a range of library databases using established keywords. All research designs were initially considered to establish the body of evidence. (...) Experimental or comparative papers were then critically appraised for methodological quality and information was extracted on effective journal club processes. RESULTS: We identified 101 articles, of which 21 comprised the body of evidence. Of these, 12 described journal club effectiveness. Methodological quality was moderate. The papers described many processes of effective journal clubs. Over 80% papers reported that journal club intervention was effective in improving knowledge and critical appraisal skills. Few papers reported on the psychometric properties of their outcome instruments. No paper reported on the translation of evidence from journal club into clinical practice. CONCLUSION: Characteristics of successful journal clubs included regular and anticipated meetings, mandatory attendance, clear long- and short-term purpose, appropriate meeting timing and incentives, a trained journal club leader to choose papers and lead discussion, circulating papers prior to the meeting, using the internet for wider dissemination and data storage, using established critical appraisal processes and summarizing journal club findings. (shrink)

Retractions are rare in science, but there is growing concern about the impact retracted papers have. We present data on the retractions in the journal Science, between 1983 and 2017. Each year, approximately 2.6 papers are retracted; that is about 0.34% of the papers published in the journal. 30% of the retracted papers are retracted within 1 year of publication. Some papers are retracted almost 12 years after publication. 51% of the retracted papers are retracted due to honest mistakes. Smaller (...) research teams of 2–4 scientists are responsible for a disproportionately larger share of the retracted papers especially when it comes to retractions due to honest mistakes. In 60% of the cases all authors sign the retraction notice. (shrink)

Background and objectives: There are few insights from sub-Saharan Africa on research participants’ experiences of the informed consent process, particularly in the context of randomised controlled trials, where issues of randomisation and the use of placebos may be confusing concepts for participants. This study investigated the knowledge and perceptions of the informed consent process among individuals participating in influenza vaccine trials in two disadvantaged communities in South Africa.Method: Four to 12 months after completion of the trials, participants were contacted to (...) return to participate in the informed consent study. The semistructured questionnaire administered to assess recall of trial procedures and the informed consent process covered key issues including: purpose of the study; awareness that the study was not part of routine treatment; voluntary nature of participation and freedom to withdraw; randomisation; placebos; and remuneration.Results: A total of 334 participants completed the questionnaire. Only 21% were able to recall that they were allocated randomly to the different treatment arms. Only 19% of those involved in the placebo controlled study had interpreted the concept of placebo as an inactive medication.Conclusion: Although a good general recall of trial concepts was demonstrated, only a small proportion of the participants correctly interpreted and recalled the concepts of randomisation and placebos. Informed consent in this and similarly disadvantaged communities may often be inadequate and new ways to improve understanding of the research process should be explored. (shrink)

The aim of this research is to find the operating level manager’s interpersonal competence. The total subjects of this research are 139 operating level managers. The subjects of this research are divided by the big-five personality trait, such as openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism. Researcher used questionnaire which is based on Likert scale to collect the data of this research. The data was analyzed by descriptive statistics with SPSS program 12 th version. The result of this research (...) shows that openness to experience and neuroticism tipe of personality has higher interpersonal competence score than the other personality tipes.  . (shrink)

Indexes to the Dhammapada. Compiled by Moriichi Yamazaki, Yumi Ousaka and Masahiro Miyao. Pali Text Society, Oxford 1995. vii, 139 pp. £12. ISBN 0-86013-337-0.

We examined unconscious priming in a stem-completion task with both identity and form-related primes. Participants were given exclusion instructions to avoid completing a stem with a briefly flashed masked word . In Experiment 1, priming of around 7% occurred for both identity and form-based primes at a 33 ms exposure duration. When examining only trials in which the participants failed to identify the prime, this effect increased to 12% for identity primes, but remained the same for form-based primes. In Experiment (...) 2, priming without prime identification was 9% for identity primes, 4% for homophone primes, and 3% for orthographic control primes. Although identity priming was greater than form priming in both experiments, regression analyses revealed that orthographic and phonological overlap alone between the flashed primes and targets could completely account for unconscious identity priming. Hence, we conclude that masked words may only activate their sublexical orthographic and phonological representations and not their lexical representations. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

Recent years have seen an increasing interest in the study of continuous-time computational models. However, not so much has been done with respect to setting up a complexity theoretic framework for such models. The present paper intends to go a step into this direction. We consider problems over the real numbers which we try to relate to Lyapunov theory for dynamical systems: The global minimizers of particular energy functions are supposed to give solutions of the problem. The structure of such (...) energy functions leads to the introduction of problem classes U and NU; for the systems we are considering they parallel the classical complexity classes P and NP. We then introduce a notion of reducibility among problems and show existence of complete problems for NU and for PU, a polynomial hierarchy of continuous-time problems.For previous work on the computational capabilities of continuous-time systems see the surveys by Cris Moore [9] and by Pekka Orponen [10]. Our paper presents a step into the direction of creating a general framework for a complexity theory of continuous-time systems as outlined in [10]. It is closely related to work done by A. Ben-Hur, H. Siegelmann, and S. Fishman [12, 11]. (shrink)

Immediately after the publication of Darwin's book on the origin of species, Engels, having familiarized himself with it, wrote to Marx on December 12, 1859: "All in all, Darwin, whom I am reading right now, is superb. Teleology had hitherto not yet been destroyed in one of its aspects, and now this has been done. Moreover, hitherto there has never been so sweeping an attempt to prove historical development in nature, especially with such success." Soon Marx enlarged upon the evaluation (...) of Darwinism. In his letter of December 19, 1860, he commented that this theory "provides a foundation in natural history for our views." It is therefore no accident that Engels, in developing the principles of dialectical materialism and problems of the dialectics of nature, interested himself so deeply and comprehensively in the theory of evolution. (shrink)

John Gray, Professor of European Thought at the London School of Economics and the author of the book under review should not be confused with the John Gray who thinks that men are from Mars and women from Venus. Our man is a political philosopher, best known for a string of books on liberalism and a lot less sanguine about the prospects for humanity than his New Age namesake. In fact, perhaps on account of his earlieRAffection for Margaret Thatcher, he (...) concludes: ' Humanity does not exist. There are only humans . . .' . If Gray's reclassification of homo sapiens as homo rapiens and his ecological pessimism are right, humans are unlikely to be around for much longer either. John Gray, Straw Dogs: Thoughts on Humans and Other animals, London: Granta Publications, 2002, ?12.99, ISBN 1862075123. (shrink)

This chapter reviews the work and influence of Donald Davidson across all the areas to which he contributed.

Self-monitoring theory explains the individual differences in using interpersonal adjustment techniques like self-control, self-regulation, and self-presentation. Self-monitoring plays a key role for understanding the social life. Therefore, it has been one of most popular research topics in social psychology. The aim of this study is to find out if there is a meaningful relationship between religious orientation and self-monitoring, and to determine the direction of the relationship if it exists. Besides, examining the effect of religious group membership on self-monitoring is (...) another aim of this study. In accordance with this purpose, Religious Orientation Scale and Revised Self-Monitoring Scale are applied to sample group which consists of 437 female and 369 male participants aged16 to 65+ living in Bursa. The results has revealed that there is a meaningful positive correlation between intrinsic religious orientation and self-monitoring. In addition, no meaningful relationship between religious group membership and self-monitoring has been confirmed.Summary: The adaptation process of the human being as a social creature starts in a mother's womb and becomes more complicated in consequence of coming into the world which is full of stimulus. In the beginning, this process has only a physical aspect, but with the inclusion of emotional, cognitive, and social factors over time turns into developmental tasks that people will struggle throughout their lives. The social development involves the process of becoming of the individual as an organic part of the society. As the individual realizes the existence of the other, he/she develops similar patterns of behavior that can be approved by the other. Because the meaningful relationships that form the backbone of social development constitute an important part of the self. Belonging is one of the main needs, that the individual shapes his emotions, actions, and decisions more or less in line with this need in order not to encounter the possibility of social exclusion. While belonging is a universal need for every healthy individual, there are differences between individuals in terms of directing the course of the relationship, role sharing, and using situational clues. Individual differences in how people construct interpersonal processes led Mark Snyder to systematize and theorize the concept of self-monitoring. Self-monitoring is a concept that expresses individuals' control of self-presentation, expressive behavior, and non-verbal emotional expression and their regulation. Accordingly, individuals with a high tendency to shape their behavior according to the context are classified as high self-monitors and those with low tendency are classified as low self-monitors. It can be said that adherence to religion, which is one of the determinants of social behavior, is related to self-monitoring. In this context, the main subject of this study is the relationship between self-monitoring and religiosity. The study aims to examine the effect of intrinsic-extrinsic religiosity on individuals' self-monitoring levels. Besides, as a form of religiosity, to reveal whether religious group religiosity affects self-monitoring, the study examines also self-monitoring levels of individuals belonging to the religious group and those who are not.The sample of the study was selected by a simple random sampling method and it consists of 806 participants aged 16 to 65+ living in Bursa in 2017. 437 (54.2%) of the participants in the research are women and 369 (45.8%) are men. In this study, a relational screening model was used for determining the presence, direction, and degree of the relationship between the variables. The questionnaire technique was preferred as the method of gathering information. The questionnaire was arranged in a way that does not require asking the participant any other questions apart from the questions on the form. The questionnaire form used in this research consists of 43 items. At the beginning of the questionnaire, there is a 9-item personal information form that includes demographic items consisting of age, gender, educational status, marital status, occupation, place of residence, socio-economic status, levels of subjective religious involvement, and religious group membership. For the measurement of self-monitoring, a 12-item "Self-Monitoring Scale", which was developed by Mark Snyder, revised by Richard Lennox and Raymond Wolfe and adapted by İlknur Özalp Türetgen and Sevim Cesur to Turkish (α =.80) was used. For the measurement of religious orientation, a 22-item “Religious Orientation Scale” developed by Gordon Allport and Michael Ross and adapted to Turkish by Fatma Gül Cirhinlioğlu was used (α =.90). Data collected through scales were processed by One Way Variance Analysis (ANOVA), t-Test, Pearson Correlation Analysis, and Simple Linear Regression Analysis and turned into research findings.According to the results of the simple linear correlation analysis conducted to reveal whether there is a relationship between the self-monitoring scores of the participants and the intrinsic religious orientation scores, there is a positive and significant relationship between the variables (r = 0.102, p = 0.004 0.05). The result of the correlation analysis between self-monitoring and the level of subjective religious involvement shows that no significant relationship is found (r = 0.051, p = 0.146> 0.05).This research expected that there was a negative relationship between self-monitoring and intrinsic religious orientation. However, the analyses has not reported anticipated results as addressed in the previous research. Therefore, this study opens the door for asking new questions about the subject. Religious groups, by their very nature, can refer the individual to self-presentation control, obedience, to act as deemed appropriate by the group, to adapt to the group, to change behavior without attitude change, and therefore, to attitude-behavior inconsistency. It can be argued that not only religious groups but, by their nature, all social groups create harmony-oriented pressure on the individual. Therefore, it can be predicted that belonging to a group, in general, may have a significant effect on the level of self-monitoring. The high self-monitoring scores of the participants, whether religious or non-religious group members of this study may have reduced the observability of the difference between the two groups. Therefore, repeating the study on a different sample may produce different results. (shrink)

Anger, indignation, guilt, rumination, victim compensation, and perpetrator punishment are considered primary responses associated with justice sensitivity. However, injustice and high JS may predispose to further responses. We had N = 293 adults rate their JS, 17 potential responses toward 12 unjust scenarios from the victim’s, observer’s, beneficiary’s, and perpetrator’s perspectives, and several control variables. Unjust situations generally elicited many affective, cognitive, and behavioral responses. JS generally predisposed to strong affective responses toward injustice, including sadness, pity, disappointment, and helplessness. It (...) impaired trivialization, victim-blaming, or justification, which may otherwise help cope with injustice. It predisposed to conflict solutions and victim compensation. Particularly victim and beneficiary JS had stronger effects in unjust situations from the corresponding perspective. These findings add to a better understanding of the main and interaction effects of unjust situations from different perspectives and the JS facets, differences between the JS facets, as well as the links between JS and behavior and well-being. (shrink)

This research focused on one of the messages in the Lord’s Prayer, particularly Matthew 6:12 about prayer for forgiveness and forgiveness to others in order to suggest a concept revision for the sake of a rather normative modern Arabic audience. In the Smith-Van Dyck version, asking God for forgiveness serves as the basis for forgiving sinners by using the present and future form of the verb نغفر كما (as we will forgive). This translation is in contrast to 1881 Jesuit Arabic (...) Bible, which used the past tense غفرنا كما and أعفينا فقد (as we have forgiven) as written in the Greek Bible as ὀφειλήματα ‘debts’ by referring to the debt metaphor. This study examined the Arabic translation of Matthew 6:12 in the perspective of Nida and Taber’s semantic adjustments. In light of the research findings, it was clear that the semantic adjustment and grammatical adjustment in the translation did not run on the grammatical structure of the Arabic language. The translation into Arabic also did not comply with the original source of the text, but it was accentuated by the interpretation of ‘debts’ into ‘sins’. Contribution: In conclusion, this fact can be seen from the choice of the word ‘نغفر’ and the use of the future tense ( fi’l muḍār’i ) as opposed to the source text that uses the past tense ( fi’l māḍy ). (shrink)

This research focused on one of the messages in the Lord’s Prayer, particularly Matthew 6:12 about prayer for forgiveness and forgiveness to others in order to suggest a concept revision for the sake of a rather normative modern Arabic audience. In the Smith-Van Dyck version, asking God for forgiveness serves as the basis for forgiving sinners by using the present and future form of the verb نغفر كما (as we will forgive). This translation is in contrast to 1881 Jesuit Arabic (...) Bible, which used the past tense غفرنا كما and أعفينا فقد (as we have forgiven) as written in the Greek Bible as ὀφειλήματα ‘debts’ by referring to the debt metaphor. This study examined the Arabic translation of Matthew 6:12 in the perspective of Nida and Taber’s semantic adjustments. In light of the research findings, it was clear that the semantic adjustment and grammatical adjustment in the translation did not run on the grammatical structure of the Arabic language. The translation into Arabic also did not comply with the original source of the text, but it was accentuated by the interpretation of ‘debts’ into ‘sins’.Contribution: In conclusion, this fact can be seen from the choice of the word ‘نغفر’ and the use of the future tense (fi’l muḍār’i) as opposed to the source text that uses the past tense (fi’l māḍy). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.2 (2003) 267-268 [Access article in PDF] Myles Burnyeat. A Map of "Metaphysics" Zeta. Pittsburgh, PA: Mathesis Publications, 2001. Pp. x + 176. Paper, $25.00. Burnyeat's map is an ambitious attempt to establish two claims about Zeta: that Aristotle employs an unusual, non-linear form of argument in Zeta, and that the discussion in Zeta is on two levels, one abstract and "logical" and (...) another specific and "metaphysical." In addition to looking at Zeta, chapter by chapter, Burnyeat examines the other works that provide the context for Zeta—the Organon for the logical level of explanation and the rest of the Metaphysics for the metaphysical level. Burnyeat argues that Aristotle's metaphysical project culminates in the theology of'Lambda, for which the metaphysics of Zeta has prepared us. The goal is to "map" or sketch the evidence for these claims rather than provide definitive arguments for them.A brief introductory chapter presents the main themes of the book. This is followed by an even briefer chapter that sets out the four routes (or independent sections of Zeta), viz. Z 3; Z 4-6, 10-11 with Z 7-9, 12; Z 13-6; and Z 17 with H 1. On all four routes, a logical discussion moves to a metaphysical discussion of form and matter.The third chapter on "signposts" is the lengthiest of all and takes the reader through the chapters of Zeta in order. It is also the most map-like of the chapters, as it requires that the reader have a copy of the Metaphysics ready to hand. Burnyeat follows other commentators in treating Zeta 7-9 and Zeta 12 as later insertions; he does, however, argue that the former and probably the latter were added by Aristotle. Chapters 7-9 are integral to the argument of Zeta, as they provide a diachronic view of artifacts and substantial beings (37). [End Page 267] Rejecting the prominence assigned Z 13 by several recent commentators, Burnyeat reads Z 13 in context with chapters 14-6. "The task of Z 13-6 is to show how the idea that substantial being is a universal such as human leads eventually, after suitable refinements and restrictions, to the conclusion that substantial being is form" (54). Wrapping up the discussion of Zeta, Burnyeat concludes that the goal of Zeta's two-level approach has been to show how logical concepts should be used to search for form.This leads directly to a chapter on the Organon. Burnyeat argues that none of the treatises making up the Organon are metaphysical; all employ an abstract (logical) mode of analysis. Even if written at different times, these treatises belong together because they are all methodological. Since form and matter belong to the metaphysical level, in the Analytics Aristotle "follows a deliberate policy of excluding form and matter" (97).In the final chapter, Burnyeat returns to the Metaphysics and considers Zeta in the context of the other books. Three "chunks," viz. books ABGE, ZHQ, and MN are briefly surveyed. The topics of Zeta are then considered in relation to Lambda. Several chapters, viz. D1 and Z1; D3 and Z 7-9, are found to have the same concerns. Burnyeat concludes with a fanciful muqo~ (story) about a dying Aristotle hastily writing a culminating metaphysical treatise.Burnyeat gives us a map—a map to prompt questions; he does not attempt to delve into many of the interpretative puzzles that have exercised other interpreters of Zeta. Thus, this book stands as a helpful counterbalance to a certain kind of scholarship on Zeta. The two interpretative claims, however, that are at the heart of Burnyeat's enterprise stand in need of further justification. One of these, the non-linearity of Zeta, seems to be too weak to support substantive claims. Burnyeat defines non-linearity as holding when "it is not the case that the successive chapters build continuously upon the results of their predecessors" (4). He then cites a few examples of linearity, e.g., Physics II. Yet the vast majority of Aristotelian... (shrink)

We sought to identify emotional reactions to a partner's sexual infidelity and emotional infidelity. In a preliminary study, 53 participants nominated emotional reactions to a partner's sexual and emotional infidelity. In a second study, 655 participants rated each emotion for how likely it was to occur following sexual and emotional infidelity. Principal components analysis revealed 15 emotion components, including Hostile/Vengeful, Depressed, and Sexually aroused. We conducted repeated measures analyses of variance on the 15 components, with participant sex as the between-subjects (...) factor and infidelity type as the within-subjects factor. A main effect for sex obtained for 9 components. For example, men scored higher on Homicidal/Suicidal, whereas women scored higher on Undesirable/Insecure. A main effect for infidelity type obtained for 12 components. For example, participants endorsed Nauseated/Repulsed as more likely to follow sexual infidelity and Undesirable/Insecure as more likely to follow emotional infidelity. Discussion addresses limitations of this research, and highlights the need for an integrative theory of emotional reactions to infidelity. (shrink)

BackgroundGenetics and genomics research (GGR) is increasingly being conducted around the world; yet, researchers and research oversight entities in many countries have struggled with ethical challenges. A range of ethics and regulatory issues need to be addressed through comprehensive policy frameworks that integrate with local environments. While important efforts have been made to enhance understanding and awareness of ethical dimensions of GGR in Africa, including through the H3Africa initiative, there remains a need for in-depth policy review, at a country-level, to (...) inform and stimulate local policy development and revision on the continent.MethodsTo identify and characterize existing ethics-related guidelines and laws applicable to GGR across much of Africa, we conducted a scoping review of English language policy documents identified through databases, repositories, and web searches. Thirty-six documents were included and coded using a framework that contained a range of themes across five analytical categories: (1) respect, (2) beneficence, (3) justice, (4) independent oversight, and (5) bans and prohibitions. Data analysis software (NVivo 12) was used to organize, code, and tabulate information according to document characteristics and topics. Illustrative examples of policy requirements were selected for inclusion.ResultsDocuments that met inclusion criteria spanned 20 years; published between 1996 and 2018, with the majority (58%) published after 2009. About two-thirds were denoted as “guidelines,” and slightly more than half were non-exclusive to GGR. Very few (six) country-level documents identified were specific to GGR. Requirements related to the principle of “respect” appeared most often across all documents, relative to other principles and processes. The most commonly stated ban was on reproductive cloning. Other prohibitions applied to germline editing, undue inducements in research, sample use for commercial purposes, employee mandatory DNA testing, fetal sex selection, stem cell use, eugenics, and research without public health benefits.ConclusionsEnforceable policies that are indispensable to the ethical conduct and review of GGR are either deficient or missing in many African countries. Existing international, GGR-specific ethics guidelines can be used to inform GGR policy development at a country-level, in conjunction with insight from country specific ethics committees and other local stakeholders. (shrink)

BackgroundThe return of genetics and genomics research results has been a subject of ongoing global debate. Such feedback is ethically desirable to update participants on research findings particularly those deemed clinically significant. Although there is limited literature, debate continues in African on what constitutes appropriate practice regarding the return of results for genetics and genomics research. This study explored perspectives and ethical considerations of Ugandan genomics researchers regarding the return of genetics and genomics research results.MethodsThis was a qualitative study that (...) employed in-depth interviews. Thirty participants were purposively selected based on their expertise as genomics researchers in Uganda. Data were analysed through content analysis along the main themes of the study using a comprehensive thematic matrix, to identify common patterns arising from the narratives. NVivo software 12 was used to support data analysis.ResultsThe return of genetics and genomics research results was generally acceptable to researchers, and some indicated that they had previously returned individual or aggregate results to participants and communities. The main reasons cited for sharing research results with participants included their clinical utility, actionability and overall benefit to society. Ethical considerations for appropriate return of results included a need for effective community engagement, genetic counselling prior to disclosure of the results, adequate informed consent, and proper assessment of the implications of, or consequences of returning of results. However, the approaches to return of results were perceived as unstandardized due to the lack of appropriate regulatory frameworks.ConclusionsThe return of genetic and genomic research results is generally acceptable to researchers despite the lack of appropriate regulatory frameworks. Ethical considerations for return of genetics and genomics research results are highly divergent, hence the need for national ethical guidelines to appropriately regulate the practice. (shrink)

The American Journal of Bioethics, Volume 12, Issue 4, Page 12-13, April 2012.

The American Journal of Bioethics, Volume 12, Issue 6, Page 46-47, June 2012.

Alternatives to convenience sampling (CS) are needed for HIV/STI surveillance of most-at-risk populations in Latin America. We compared CS, time space sampling (TSS), and respondent driven sampling (RDS) for recruitment of men who have sex with men (MSM) and transgender women (TW) in Lima, Peru. During concurrent 60-day periods from June-August, 2011, we recruited MSM/TW for epidemiologic surveillance using CS, TSS, and RDS. A total of 748 participants were recruited through CS, 233 through TSS, and 127 through RDS. The TSS (...) sample included the largest proportion of TW (30.7 %) and the lowest percentage of subjects who had previously participated in HIV/STI research (14.9 %). The prevalence of newly diagnosed HIV infection, according to participants' self-reported previous HIV diagnosis, was highest among TSS recruits (17.9 %) compared with RDS (12.6 %) and CS (10.2 %). TSS identified diverse populations of MSM/TW with higher prevalences of HIV/STIs not accessed by other methods. (shrink)

The word stigma comes from ancient Greece, and was initially used in reference to signs or symbols physically cut into or burned onto the bodies of those deemed to be of an inferior status. It was a marking of one's tarnished and flawed character. Today, stigma is more often attached to one's social standing, personality traits, or psychological makeup. "People are no longer physically branded; instead they are societally labeled—as poor, as criminal, homosexual, mentally ill, and so on. These labels (...) influence public perceptions and behavior and lead to devaluation and denigration of those who are so labeled" (Wahl 1999, 11–12).The modern usage of the term stigma and contemporary focus on the concept as a topic of .. (shrink)

A growing interest has been observed among K-12 school educators to incorporate maker pedagogy into science, technology, engineering, and mathematics education to engage students in the design and making process. Both cognitive engagement and emotional engagement of students can be promoted through satisfying the psychological need of relatedness that concerns a sense of connection and belonging. How to support relatedness would influence the effective development of students’ cognitive competencies, namely creativity and critical thinking, and non-cognitive characteristics, namely interest and identity. (...) Therefore, the present study investigated how two relatedness support strategies—real-world problems and mentoring influence the development of student’s STEM-related cognitive competencies and non-cognitive characteristics in STEM marker activities. We implemented a 7-week intervention study with three classes of Grade 9 students in Hong Kong. Three intervention conditions were designed in the experiment, comprising textbook problem, RWP, and RWP with mentoring. Our analysis showed that the differences in creativity among the three groups were non-significant, the RWP and RWPM groups showed stronger critical thinking than the TBP group, and the RWPM group exhibited stronger STEM interest and identity than the other two groups. This study revealed the effectiveness of adopting RWP strategy in developing secondary students’ perceived cognitive competencies and the feasibility of employing a mentoring mechanism for cultivating learners’ perceived non-cognitive characteristics. Hence, we also offered practical suggestions for teachers. (shrink)

This thesis investigates Hume’s philosophy of external existence in relation to, and within the context of, his philosophy of scepticism. In his two main works on metaphysics – A Treatise of Human Nature (1739–40) and the first Enquiry (first ed. 1748) – Hume encounters a predicament pertaining to the unreflective, ‘vulgar’ attribution of external existence to mental perceptions and the ‘philosophical’ distinction between perceptions and objects. I argue that we should understand this predicament as follows: the vulgar opinion is our (...) natural and default belief for Hume, but causal reasoning reveals it to be false, and the philosophical alternative is a confabulation that we cannot permanently believe and is devoid of justification. Hume uses the fact that we cannot have a satisfactory account of belief in external existence as a sceptical consideration to motivate his wider philosophical scepticism. Hume’s response to his predicament about external existence is found in the context of his confrontation with other sceptical worries (Treatise 1.4.7 and Enquiry 12), in which Hume also reflects generally on the nature and implications of scepticism. I argue that we should characterise Hume’s position as residually sceptical. This means that, while Hume accepts the unanswerability of some sceptical problems, he denies that it is possible to eradicate all belief as a result (and denies that it is practically useful to even try) and instead uses sceptical problems as a motivation to adopt a moderately sceptical position. While we inevitably return to entertaining the vulgar belief, there is no solution to the sceptical predicament; Hume does not endorse the vulgar belief, or the philosophical system, or indeed any alternative system of the external world that might extinguish the predicament. Sceptical doubt, for Hume, does not derail intellectual pursuits, but rather modifies our attitudes in those very pursuits. (shrink)

Our tendency is not to read Romantic poetry as alluding to the texts it reminds us of. We think of the Augustans as the author of what Reuben Brower calls "the poetry of allusion."5 We envision Romantic poets carrying on their work in reaction to these Augustans and in mysterious awe, whether fearful or admiring, of most other poets—sometimes even of each other. No self-respecting Romantic, it is usually assumed, will deliberately send his reader elsewhere for a meaning to complement (...) the effect of his own words. If a reader's mind wanders to an earlier poem, that is not the Romantic poet's fault but a matter of accident or perhaps of cruel destiny. The Romantic wants to keep the poem an intimate affair—just the two of us—and does what he can to keep his reader's attention on himself.[…]What follows is an effort to test the applicability of Wasserman's Augustan hypothesis to the poetic mode of high Romanticism. This effort should not be taken to imply either that the Romantics simply continue in the allusive mode of the Augustans or that the assumptions that lead Bloom and others to read Romantic poetry as they do are utterly mistaken. I will in fact be arguing quite otherwise. Nor must there be any confusion about Wasserman's conception of the Augustan mode. Some of the language of his summary, for example where he speaks of "the rich interplay between the author's text and the full contexts it allusively arouses," might lead one to liken his work to the criticism now associated with the notion of "intertextuality." For the practitioners of this criticism, as Jonathan Culler explains, "to read is to place a work in a discursive space, relating it to other texts and to other codes of that space, and writing is a similar activity."8 Writing and reading a poem are in this account both acts of "intertextual location," if you will, but the reader of the poem need not concern himself with the aims and circumstances of its writer's "similar activity." The decisive difference between this view and the one Wasserman offers for the Augustans is that Wasserman's is intentionalist and historicist. This shows plainly in his exegetical commentary on the Rape, where his characteristic claim follows the formula: "Pope [expects, invites, prods, wants] his reader to [discover, exercise his wit on, recognize, see] X in his allusion to such-and-such a text." And to support his claim he repeatedly brings his historicist scholarship to bear on questions about "the kind of ready knowledge Pope demands of his reader" and what "facts [were] known to any serious reader" of the time.95. See Reuben Brower, Alexander Pope: The Poetry of Allusion , esp. pp. 1-14.8. Jonathan Culler, "Presupposition and Intertextuality," MLN 91 : 1382-3; Culler refers primarily to the work of Roland Barthes and Julia Kristeva but notes that Bloom himself occasionally sounds curiously like an intertextualist critic.9. Wasserman, "Limits of Allusion," pp. 427, 429. For a response to Wasserman less sympathetic than mine, see Irvin Ehrenpreis, Literary Meaning and Augustan Values , pp. 12-15.James K. Chandler, an assistant professor of English at the University of Chicago, has published work on Wordsworth's poetry and politics and is currently completing a book on the subject. (shrink)

Science and Community: Ending Obesity Improving Health (S&C) aimed to reduce obesity in Houston by developing community partnerships to identify research priorities and develop a sustainable obesity reduction program. Partnership members were recruited from S&C events and invited to participate in in‐depth interviews to gain insight into obesity prevalence, causes, and solutions. Members (n = 22) completed a 60–90‐min in‐depth interview. The interview guide consisted of 30 questions about pressing health problems in the community, potential solutions to health problems and (...) obesity and how the environment has impacted obesity and health behaviors in the community. Interviewees (n = 12 women and 10 men) were mostly Hispanic/Latino (n = 9) and African American (n = 7). Common problems identified were childhood obesity, balancing a healthy diet and physical inactivity. Interviewees identified obesity as a major problem in their communities and cited access to quality food and physical activity resources as both a problem and a solution. Additional emergent themes focused on solutions, including increasing awareness and education, coordinated efforts among organizations and using an ecologic approach to combat obesity. Community insight gleaned from this study may be used to enhance relevance and sustainability of programs developed to reduce obesity and suggests possible avenues for participatory research and intervention. (shrink)

The Vatican palimpsest omits the word enthymemate and leaves a lacuna, thus showing that the scribe found it written as Greek in his exemplar. Now A has been shown to belong to the fourth century, and therefore its authority must be greater than that of the other manuscripts available for this part of Gellius. The same problem occurs in 12.2.14, non pro enthymemate aliquo, where Hertz goes against the Greek of the manuscripts and adopts the reading of Carrio. Yet an (...) examination of the use of the Greek dative in Cicero's Letters will show that it can be used fully as the equivalent of a Latin ablative, can be governed by prepositions taking the ablative in Latin, and can be qualified by a Latin adjective in the ablative. (shrink)

The Vatican palimpsest omits the word enthymemate and leaves a lacuna, thus showing that the scribe found it written as Greek in his exemplar. Now A has been shown to belong to the fourth century, and therefore its authority must be greater than that of the other manuscripts available for this part of Gellius. The same problem occurs in 12.2.14, non pro enthymemate aliquo, where Hertz goes against the Greek of the manuscripts and adopts the reading of Carrio. Yet an (...) examination of the use of the Greek dative in Cicero's Letters will show that it can be used fully as the equivalent of a Latin ablative, can be governed by prepositions taking the ablative in Latin, and can be qualified by a Latin adjective in the ablative. (shrink)

Developmental coordination disorder is a neurodevelopmental disorder that significantly impairs a child’s ability to learn motor skills and to perform everyday activities. The cause of DCD is unknown; however, evidence suggests that children with DCD have altered brain structure and function. While the cerebellum has been hypothesised to be involved in developmental coordination disorder, no studies have specifically examined cerebellar structure in this population. The purpose of our study was to examine cerebellar differences in children with DCD compared to typically-developing (...) children. Using voxel-based morphometry, we assessed cerebellar morphology in children 8–12 years of age. Forty-six children were investigated using high resolution T1-weighted images, which were then processed using the spatially unbiased atlas template of the cerebellum and brainstem toolbox for a region of interest-based examination of the cerebellum. Results revealed that children with DCD had reduced grey matter volume in several regions, namely: the brainstem, right/left crus I, right crus II, left VI, right VIIb, and right VIIIa lobules. Further, Pearson correlations revealed significant positive associations between the total motor percentile score on the Movement Assessment Battery for Children-2 and regions that had reduced grey matter volume in our cohort. These findings indicate that reductions in cerebellar grey matter volume are associated with poorer motor skills. Given the cerebellum’s involvement in internal models of movement, results of this study may help to explain why children with DCD struggle to learn motor skills. (shrink)

In EN II.1, Aristotle claims that our nature is inadequate for moral virtue. We are not, he says, in the same relation to virtue as a stone falling to earth; moral excellence is neither by nature nor contrary to our nature but reached by habituation . Other texts such as Pol. I.13 and Pol. VII.12 about natural capacities, as well as those like Phys. II.1 and Meta. V.4 about physis in general, complicate the picture concerning the bases for moral excellence (...) in EN. This essay considers the range of applications of physis, focusing on the practical works, so as to examine the extent to which Aristotle thinks moral and political nature is amenable to external determinants such as cultural education. (shrink)

Objective: To compare the attitudes of patients with cancer toward making changes in lifestyle, according to their awareness of the diagnosis.Method: Personal interviews with 50 patients with breast cancer, 24 patients with prostate cancer and 50 patients with colorectal cancer were conducted in a cancer hospital in Athens, Greece.Analysis: Multiple logistic regression models were used to estimate the odds ratio as a measure of the association of the characteristics of participants with changes in lifestyle.Results: Overall, 22.6% of the patients were (...) not aware of the diagnosis. Among the changes in lifestyle, 41.1% reported changing their diet to a healthier one, 22.6% of the smokers reduced or stopped smoking and 13.7% added new physical activity. Compared with uninformed patients, those who were aware of the diagnosis, after adjusting for the confounding effect of educational status , were 2.5 times as likely to make dietary changes . Among the other characteristics under study, older patients were less likely to add new physical activity than younger ones , and newly diagnosed patients were more likely to stop or reduce smoking than patients with a diagnosis made more than 12 months previously.Conclusion: Patients with cancer are motivated to attempt changes in lifestyle and can benefit from more factual information about the diagnosis. (shrink)

ABSTRACT Background: The doctrine of informed consent (IC) exists to protect individuals from exploitation or harm. This study into IC was carried out to investigate how different researchers perceived the process whereby researchers obtained consent. It also examined researchers’ perspectives on what constituted IC, and how different settings influenced the process. Methods: The study recorded in‐depth interviews with 12 lecturers and five doctoral students, who had carried out research in developing countries, at a leading school of public health in the (...) United Kingdom. A purposive, snowballing approach was used to identify interviewees. Results: Although the concept and application of the doctrine of IC should have been the same, irrespective of where the research was carried out, the process of obtaining it had to be different. The setting had to be taken into consideration and the autonomy of the subject had to be respected at all times. In areas of high illiteracy, and where understanding of the subject was likely to be a problem, there was an added responsibility placed on the researcher to devise innovative ways of carrying out the study, taking into consideration the peculiarities of the environment. Conclusion: The ethical issues for IC were the same, irrespective of where the research was conducted. However, because the backgrounds, setting, and knowledge of populations differed, there was the need to be similarly sensitive in obtaining consent. The problems of obtaining genuine IC were not limited to developing countries. (shrink)

The open practice of euthanasia in The Netherlands stood alone in the world until the government of the Northern Territories in Australia accepted the possibility of physician-assisted suicide. Even though the active ending of lives in The Netherlands is still a crime by law, the current practice allows it and acquits physicians if certain conditions have been met. Of the many facets of euthanasia, the teaching of this practice represents a further logical step. In this contribution, we intend to describe (...) the comprehensive teaching program of euthanasia of the Free University of Amsterdam's Postgraduate Family Medicine Program. Here students receive university-based training for 1 day a week in a cohort of 12 and on the job training for 4 days with individual family physicians for 2 consecutive years. We especially intend to portray the integration of euthanasia into the wider teaching of the process of counseling and aid of the dying. (shrink)

Featuring an 18.0 megapixel CMOS sensor and DIGIC 4 image processor for high image quality and speed, ISO 100-6400 for shooting from bright to dim light, and many more great features, the Canon EOS Rebel T2i brings professional features into an entry-level digital SLR. The Canon EOS Rebel T2i/550D Digital Field Guide will teach you how to get the most out of these impressive features so you can improve your photography skills. CHAPTER 1: Setting Up the EOS Rebel T2i/550D. – (...) This chapter will help you set up your T2i so you can get the best image quality from your Canon T2i. It will also cover different ways to review your images and protect them from accidental deletion. CHAPTER 2: Controlling Exposure and Focus. – Learn about the different types of shooting modes on your T2i, as well as image exposure and how to modify it for individual shooting scenarios. CHAPTER 3: Getting Great Color. – This chapter explores the concepts of light and color, and teaches you how to select a white balance and picture style on your T2i for maximum color rendering. CHAPTER 4: Customizing the EOS Rebel T2i/550D. – Learn how to set up your T2i for common and uncommon shooting situations. CHAPTER 5: Shooting in Live View and Tethered. – This chapter explains the T2i’s Live View feature and how to shoot tethered to a computer. CHAPTER 6: Using Movie Mode. – A great starting point for any photographer to explore the world of digital video with the T2i, this chapter will teach you how to shoot and playback video on the T2i. CHAPTER 7: Using Flash. – This chapter explores flash technology, and how to use the T2i’s on board flash and menu options for the built-in flash and for EX-Series Speedlites. CHAPTER 8: Exploring Canon Lenses and Accessories. This chapter covers popular T2i lenses and how they impact the images you capture with your T2i. CHAPTER 9: The Elements of Exposure and Composition. – Learn how aperture, shutter speed, and ISO affect your images, and how they work together to determine exposure. This chapter also covers the basics of composing images with your T2i. CHAPTER 10: Event and Action Photography. – Learn how to capture action in your images, plus some tips and tricks for general event photography, including how to capture great photos in low lighting. CHAPTER 11: Nature and Landscape Photography. – This chapter explores how to approach shooting nature and landscape images with your T2i. CHAPTER 12: Portrait Photography. – Learn how to set up the T2i for portrait shooting, plus information on choosing backgrounds, lighting, and other tips and tricks for taking great portraits. APPENDIX A: Exploring RAW Capture. – This chapter contains an overview of RAW capture as well as a brief walk-through on converting RAW images into a final image. APPENDIX B: How to Use the Gray and Color Checker cards. – Learn how to produce photos with accurate color and exposure with these free-inside-the-book tools. A full-color, portable-trim book with beautiful photography for photographers on the go, the Canon EOS Rebel T2i/550D Digital Field Guide includes a free Grey/Color checker card to help you achieve accurate white balance and color. With the Canon EOS Rebel T2i/550D Digital Field Guide, you will gain a thorough understanding of the T2i dSLR, as well as the basic fundamentals of capturing the best possible photos. (shrink)

Your Digital Rebel XSi/450D, with its 12.2 megapixel resolution, 3-inch view screen, and the option for "Live View" shooting, is designed for simplicity without sacrificing creative freedom. This guide is ideal for helping you use that creative control and get great shots anywhere, anytime. If you’re new to dSLRs, it makes the transition easy. If you’re already comfortable with the various modes and settings, the book helps you make the most of every one. Set up your camera and learn when (...) to choose automatic, semi-automatic, and manual modes Understand the camera's controls, menus, and when to use different metering and autofocus modes Explore Canon Picture Styles and custom functions Learn to manipulate ISO, exposure, depth of field, and shutter speed Create intriguing night and low-light images, capture sports action, portraits, and get tips for better macro photography. (shrink)

Caring for critically ill and dying patients often triggers both professional and personal growth for physician trainees. In pediatrics, the neonatal intensive care unit is among the most distressing settings for trainees. We used longitudinal narrative writing to gain insight into how physician trainees are challenged by and make sense of repetitive, ongoing conflicts experienced as part of caring for very sick and dying babies. The study took place in a 45-bed, university-based NICU in an urban setting in the United (...) States. From November 2009 to June 2010 we enrolled pediatric residents and neonatology fellows at the beginning of their NICU rotations. Participants were asked to engage in individual, longitudinal narrative writing about their “experience in the NICU.” Thematic narrative analysis was performed. Thirty-seven physician trainees participated in the study. The mean number of narratives per trainee was 12; a total of 441 narratives were available for analysis. Conflict was the most pervasive theme in the narratives. Trainees experienced conflicts with families and conflicts with other clinicians. Trainees also described multiple conflicts of identity as members of the neonatology team, as members of the medical profession, as members of their own families, and as members of society. Physician trainees experience significant conflict and distress while learning to care for critically ill and dying infants. These conflicts often led them to question their own morals and their role in the medical profession. Physician trainees should be educated to expect various types of distress during intensive care rotations, encouraged to identify their own sources of distress, and supported in mitigating their effects. (shrink)

Objectives To characterize the prevalence and content of pediatric triage policies.Methods We surveyed and solicited policies from U.S. hospitals with pediatric intensive care units. Policies were analyzed using qualitative methods and coded by 2 investigators.Results Thirty-four of 120 institutions (28%) responded. Twenty-five (74%) were freestanding children’s hospitals and 9 (26%) were hospitals within a hospital. Nine (26%) had approved policies, 9 (26%) had draft policies, 5 (14%) were developing policies, and 7 (20%) did not have policies. Nineteen (68%) institutions shared (...) their approved or draft policy. Eight (42%) of those policies included neonates. The polices identified 0 to 5 (median 2) factors to prioritize patients. The most common factors were short- (17, 90%) and long- (14, 74%) term predicted mortality. Pediatric scoring systems included Pediatric Logistic Organ Dysfunction-2 (12, 63%) and Score for Neonatal Acute Physiology and Perinatal Extensions-II (4, 21%). Thirteen (68%) policies described a formal algorithm. The most common tiebreakers were random/lottery (10, 71%) and life cycles (9, 64%). The majority (15, 79%) of policies specified the roles of triage team members and 13 (68%) precluded those participating in patient care from making triage decisions.Conclusions While many institutions still do not have pediatric triage policies, there appears to be a trend among those with policies to utilize a formal algorithm that focuses on short- and long-term predicted mortality and that incorporates age-appropriate scoring systems. Additional work is needed to expand access to pediatric-specific policies, to validate scoring systems, and to address health disparities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Confessions of a Poisoner, Written by HerselfGail K. Hart (bio)Confessions of a Poisoner, Written by Herself. Translated and introduced by Raleigh Whitinger and Diana Spokiene. New York: MLA, 2009. xliii + 196 pp. $12.95.Confessions of a Poisoner is an epistolary, autobiographical novel, first published anonymously in German as Bekenntnisse einer Giftmischerin in 1803. Lurid accounts of sex, incest, murder, and other crimes contributed to its status as a (...) sensational document in its day, especially in light of the illicit activities of the Countess Charlotte Ursinus, who was arrested and prosecuted for multiple poisonings allegedly committed between 1779 and 1803. Readers were eager for details of the countess's affairs and crimes, and the novel can indeed be read as an account, perhaps her account, of a very busy life of iniquity.The book is extremely engaging, and absorbing because our autobiographical narrator has unusually acute insight into human affairs and human character. From early youth, she finds pleasure in the art of seeming and she is proud of the skill with which she reads those who have something to offer her. Indeed the book could double as a seminar in social manipulation as the narrator negotiates her culture's obstacles to women's self-fulfillment. One is often reminded of George Lillo's murderous Millwood from The London Merchant, who in 1731 made the observation:It is a general maxim among the knowing part of mankind that a woman without virtue, like a man without honor or honesty, is capable of any action, though never [End Page 68] so vile. And yet what pains will they not take, what arts not use, to seduce us from our innocence and make us contemptible and wicked, even in their own opinions?(I:3)The narrator of Poisoner, though she might agree with Millwood, sees her part in the vile actions as both determined and chosen. The early steps of corruption were abetted by passion (incited with some calculation by early lovers) but also by the education she received, which she describes as being more masculine than feminine. Her father's failure to guide and restrain her thirst for knowledge has apparently left her with the ambitions of a conquerer and the social duties of an aristocratic woman—and, as Countess Orsina would have it, where men use daggers, women use poison. Yet she also accepts responsibility for all that she has done, quite convinced that most of it was wrong. The moral philosophy of the piece is somewhat peculiar, but she strives in the space of the one long letter that makes up the book to give an honest account of her duplicitous deeds.This intriguing life story also has significant scholarly value, and the editors/translators, Raleigh Whitinger and Diana Spokiene, have appended an excellent introduction that examines the poisoner's confessions as a document of its time. Our narrator is both wise and well-educated, and she discourses frequently on contemporary literature and philosophy, inserting herself into a variety of cultural debates. For example, her opinions on the value of Richardson's novels for the education and protection of young woman—that Richardson's ideals of virtue are delusional and therefore dangerous—run counter to prevailing wisdom on what young ladies should read. Her struggles with Kant and critical philosophy, which, she claims, diminished her pulchritude, are also instructive. Additionally, the editors make a very convincing case for the authorship of Friederike Helene Unger, whose husband was the publisher, and whose other works bear certain strong resemblances to the prose and the ideas of Poisoner.All of this excitement and knowledge comes to us in a supremely lucid and readable translation. I rarely read fiction in translation without being regularly reminded in some way of the translator. One sees an odd word, puzzles out a sentence and thinks about how one might have done that differently—and one gets distracted. That is not the case with this text, and this is especially surprising because the original German is that "of an era both culturally and historically distant" (xxvii). Whitinger and Spokiene have done a superb job of resurrecting a forgotten German text, embedding it in... (shrink)

Retractions are rare in science, but there is growing concern about the impact retracted papers have. We present data on the retractions in the journal Science, between 1983 and 2017. Each year, approximately 2.6 papers are retracted; that is about 0.34% of the papers published in the journal. 30% of the retracted papers are retracted within 1 year of publication. Some papers are retracted almost 12 years after publication. 51% of the retracted papers are retracted due to honest mistakes. Smaller (...) research teams of 2–4 scientists are responsible for a disproportionately larger share of the retracted papers especially when it comes to retractions due to honest mistakes. In 60% of the cases all authors sign the retraction notice. (shrink)

In the de Anima, Aristotle outlines a theory of perception. In de Anima II, 5-12, he considers the basic kinds of sensory perception — seeing, hearing, touching, tasting and smelling. He uses a few basic elements, viz., the five senses and their proper, common and incidental objects, and a few explanatory principles to explain sensory perception. In de Anima III, 1–2, Aristotle turns to apperception, viz. perceptual selfawareness. He considers several basic cases of apperception – the selfconscious awareness of occurrent (...) perceptions and the awareness that the objects of different senses are different. (shrink)

One of the most noticeable features of the book of Revelation is the ubiquity of arithmetic in the text. In this article, I survey the arithmetical functions found in the text (not only numbers but functions such as multiplication and applied mathematics, such as measurements), and note some patterns in John’s use of numbers. Then the article explores precedents in the Hebrew Scriptures, Hellenistic culture (including astrology) and Jewish apocalyptic literature. I argue rhetorical criticism helps us identify what John is (...) trying to do with his apocalyptic arithmetic. I draw on theological analysis, literary analysis (particularly the “writerly” nature of the text with its missing pieces for the audience to fill in) and especially intertextuality to understand his rhetorical strategy. I discuss various numbers but focus especially on ten and two passages (Rev 14:20 and 12:1-6) as examples of John’s use of numbers and arithmetical functions. I conclude that John uses arithmetic to support his Christocentric narrative and worldview in addressing his Jewish and Greek audience. (shrink)