Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.We explore (...) what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking. (shrink)

If a man born blind were to gain his sight in later life would he be able to identify the objects he saw around him? Would he recognise a cube and a globe on the basis of his earlier tactile experiences alone? This was William Molyneux's famous question to John Locke and it was much discussed by English and French empiricists in the eighteenth century as part of the controversy over innatism and abstract ideas. Dr Morgan examines the whole history (...) of this debate: Locke's own (negative) answer to the question, the contributions of Berkeley, Condillac, Diderot and Voltaire and the factual accounts of early cataract operations and modern laboratory studies. He shows how this debate is involved in the development and eventual separation of philosophy and experimental psychology after the eighteenth century and considers why the original question is effectively still unanswered. This is one problem-area with its intricate cluster of connected conceptual and technical difficulties which suggests the need for some reunion or at least collaboration between the two subjects. (shrink)

There is currently an explosion of interest in grounding. In this article we provide an overview of the debate so far. We begin by introducing the concept of grounding, before discussing several kinds of scepticism about the topic. We then identify a range of central questions in the theory of grounding and discuss competing answers to them that have emerged in the debate. We close by raising some questions that have been relatively neglected but which warrant further attention.

This paper focuses on the inheritance of human handedness and cerebral lateralization within the more general context of structural biological asymmetries. The morphogenesis of asymmetrical structures, such as the heart in vertebrates, depends upon a complex interaction between information coded in the cytoplasm and in the genes, but the polarity of asymmetry seems to depend on the cytoplasmic rather than the genetic code. Indeed it is extremely difficult to find clear-cut examples in which thedirectionof an asymmetry is under genetic control. (...) As one possible case, there is some evidence that the direction, clockwise or counterclockwise, of rotation of the abdomen in certain mutant strains ofDrosophilais controlled by a particular gene locus, although there appears to be some degree of confusion on this point. By contrast, it is much easier to find examples in which thedegreebut not the direction of asymmetry is under genetic control. For instance, there is a mutant strain of mice in which half of the animals displaysitus inversusof the viscera. The proportion has remained at one half despite many years of inbreeding, suggesting that the mutant allele effectively cancels the normalsitusand allows the asymmetry to be specified in random fashion.Although this account does not deny that the right hemisphere of humans may be the more specialized for certain functions, it does attribute a leading or dominant role to the left hemisphere (at least in most individuals). We suggest that so-called “right-hemisphere” functions are essentially acquired by default, due to the left hemisphere's prior involvement with speech and skilled motor acts; we note, for instance, that these right-hemisphere functions include rather elementary perceptual processes. But perhaps the more critical prediction from our account is that the phenomenon of equipotentiality should be unidirectional: the right (lagging) hemisphere should be more disposed to take over left-hemisphere functions following early lesions than is the left (leading) hemisphere to take over right-hemisphere functions. We note preliminary evidence that this may be so. (shrink)

I argue that plausible claims in the logic of partial grounding, when combined with a plausible analysis of that concept, entail the falsity of plausible grounding claims. As our account of the concept of partial grounding and its logic should be consistent with plausible grounding claims, this is problematic. The argument hinges on the idea that some facts about what grounds what are grounded in others, which is an idea the paper aims to motivate.

Philosophical discussions of the morality of suicide have tended to focus on its justifiability from an agent’s point of view rather than on the justifiability of attempts by others to intervene so as to prevent it. This paper addresses questions of suicide intervention within a broadly Kantian perspective. In such a perspective, a chief task is to determine the motives underlying most suicidal behaviour. Kant wrongly characterizes this motive as one of self-love or the pursuit of happiness. Psychiatric and scientific (...) evidence suggests that suicide is instead motivated by a nihilistic disenchantment with the possibility of happiness which, at its apex, results in the loss of the individual’s conception of her practical identity. Because of this, methods of intervention that appeal to agents’ happiness, while morally benign, will prove ineffective in forestalling suicide. At the same time, more aggressive methods violate the Kantian concern for autonomy. This apparent dilemma can be resolved by seeing suicide intervention as an action undertaken in non-ideal circumstances, where otherwise unjustified manipulation, coercion, or paternalism are morally permitted. (shrink)

Recently, Kroedel and Schulz have argued that the exclusion problem—which states that certain forms of non-reductive physicalism about the mental are committed to systematic and objectionable causal overdetermination—can be solved by appealing to grounding. Specifically, they defend a principle that links the causal relations of grounded mental events to those of grounding physical events, arguing that this renders mental–physical causal overdetermination unproblematic. Here, we contest Kroedel and Schulz’s result. We argue that their causal-grounding principle is undermotivated, if not outright false. (...) In particular, we contend that the principle has plausible counterexamples, resulting from the fact that some mental states are not fully grounded by goings on ‘in our heads’ but also require external factors to be included in their full grounds. We draw the sceptical conclusion that it remains unclear whether non-reductive physicalists can plausibly respond to the exclusion argument by appealing to considerations of grounding. (shrink)

Legal statutes prohibiting felons from voting result in nearly 4 million Americans, disproportionately African-American and male, being unable to vote. These felony disenfranchisement (FD) statutes have a long history and apparently enjoy broad public support. Here I argue that despite the popularity and extensive history of these laws, denying felons the right to vote is an unjust form of punishment in a democratic state. FD serves none of the recognized purposes of punishment and may even exacerbate crime. My strategy is (...) not to argue for this conclusion directly. Rather, I consider seven arguments for the moral legitimacy of FD, each of which will be found lacking. My emphasis falls not on the legal or constitutional questions associated with FD, but with its moral justification within a broadly liberal political framework. These arguments draw upon a variety of philosophical outlooks; three justify FD by appealing to justice or desert, three others justify FD based on its allegedly beneficial social consequences, and a final argument is a hybrid of both sorts of considerations. Not only do all these arguments fail, but eliminating FD could have salutary effects on our present climate of political discourse. -/- . (shrink)

If there are facts about what grounds what, are there any grounding relations between them? This paper suggests so, arguing that transitivity and amalgamation principles in the logic of grounding yield facts of grounding that are grounded by others. I develop and defend this view and note that combining it with extant accounts of iterated grounding commits us to seemingly problematic instances of ground-theoretic overdetermination. Taking the superinternality thesis as a case study, I discuss how defenders of this thesis should (...) respond. It emerges that our discussion puts pressure on superinternalists to make an interesting qualification to their view: to only regard as a fundamental metaphysical law a version of the superinternality thesis that is restricted to minimal and immediate grounding. (shrink)

Beginning at the end of the nineteenth century, systematic scientific abstracting played a crucial role in reconfiguring the sciences on an international scale. For mathematicians, the 1931 launch of the Zentralblatt für Mathematik and 1940 launch of Mathematical Reviews marked and intensified a fundamental transformation, not just to the geographic scale of professional mathematics but to the very nature of mathematicians’ research and theories. It was not an accident that mathematical abstracting in this period coincided with an embrace across mathematical (...) research fields of a distinctive form of symbolic and conceptual abstraction. This essay examines the historical, institutional, embodied, and conceptual bases of mathematical abstracting and abstraction in the mid-twentieth century, placing them in historical context within the first half of the twentieth century and then examining their consequences and legacies for the second half of the twentieth century and beyond. Focused on scale, media, and the relationship between mathematical knowledge and its forms of articulation, my analysis connects the changing social structure of modern mathematical research communities to their changing domains of investigation and resources for representation and collective understanding. (shrink)

A systematic approach to the development of an applied scientific research program to meet a developing country's future technological needs is briefly described. The essential features common to all applied science programs are discussed, and approaches to the special problems of a developing country suggested.

After clarifying the concepts of "science" and of "planning" six aspects of planning are discussed, dealing with the time scale, with the interdependence of various systems, with the probability Interpretation of plans, with the dichotomy of quantity and quality, with who should plan, and with the balance between planning, decision making, and implementation. This is followed by an overview of input planning for manpower, finances, buildings and equipment, organizations, research, assessment and evaluation, and the linking of science with its environment. (...) Then output planning is discussed and some of the main difficulties in it are listed. The discussion ends with a "checklist" of 16 features of planning that often go wrong in practice and which therefore should be paid attention to in order to make planning a creative component in the development of science, especially in the Third World. (shrink)

Pseudonymous mathematician Nicolas Bourbaki and his lesser-known counterpart E.S. Pondiczery, devised respectively in France and in Princeton in the mid-1930s, together index a pivotal moment in the history of modern mathematics, marked by international infrastructures and institutions that depended on mathematicians’ willingness to play along with mediated personifications. By pushing these norms and practices of personification to their farcical limits, Bourbaki’s and Pondiczery’s impersonators underscored the consensual social foundations of legitimate participation in a scientific community and the symmetric fictional character (...) of both fraud and integrity in scientific authorship. To understand authorial identity and legitimacy, individual authors’ conduct and practices matter less than the collective interpersonal relations of authorial assertion and authentication that take place within disciplinary institutions. (shrink)

Research into the work of UK estate agents reveals a love‐hate attitude on the part of the public and profound ethical ambivalences. Dr Clarke is a member of the Department of Sociology, Social Policy and Social Work Studies, The University of Liverpool, POB 147, Liverpool L69 3BX. This article draws on his study Slippery Customers: Estate Agents, The Public and Regulation, Blackstone Press 1994, co‐authored with D. Smith and M. McConville.

Christine Korsgaard has argued recently that the thesis that reasons are "essentially public" undermines the distinction between agent-neutral and agent-relative reasons, thus refuting egoism by rejecting its commitment to the universal availability of agent-relative reasons. I conclude that Korsgaard's invocation of the essential publicity of reasons trades on ambiguities concerning the "sharing" of reasons and so does not refute egoism and does not ground moral normativity. Her account of the publicity of reasons shows that solipsism is incoherent, but the egoist (...) need not be a solipsist, nor is she an incompetent user of moral language or the language of reasons. (shrink)

We conducted focus groups with 47 potential jurors who were presented with diferent scenarios in a hypothetical malpractice case involving failure to order a PSA test. Better documentation that a patient made an informed decision to decline a PSA test appeared to provide more medical-legal protection for physicians, especially with the use of a decision aid.

Screening for prostate cancer with the prostate-specific antigen blood test is controversial, as evidence to date has not demonstrated such screening does more good than harm. While the potential benefit of PSA screening on reducing prostate cancer mortality has not been documented in randomized trials, many risks of PSA screening have been well documented. These risks include a substantially higher risk of a prostate cancer diagnosis over a screenee’s lifetime, false-positive and false-negative test results, possible complications from biopsies done in (...) response to suspicious test results, and substantial risks of side effects from subsequent prostate cancer treatments. Nevertheless, PSA screening is widespread in the United States, and many physicians in a national survey reported supporting routine PSA screening as well as getting PSA tests themselves, despite the lack of evidence. (shrink)

Comparing my historical account of the early years of Laurent Schwartz’s theory of distributions with number theorist Michael Harris’s narrative of the early years of Peter Scholze’s perfectoid theory, I develop a perspective on change and temporality in mathematics that emphasizes the relationships between concepts, expectations, and communities of practice. Contemporary mathematics, understood as mathematics imbued with temporality, reflects the dynamic relationship between the people, ideas, pasts, and prospects of mathematical knowledge. Studying these historically may offer critical perspectives on (...) the social and political conditions and implications of mathematical research and the communities that practice it. (shrink)

T.M. Scanlon (1998) proposes that promise breaking is wrong because it shows manipulative disregard for the expectations for future behavior created by promising. I argue that this account of promissory obligation is mistaken in it own right, as well as being at odds with Scanlon's contractualism. I begin by placing Scanlon's account of promising within a tradition that treats the creation of expectations in promise recipients as central to promissory obligation. However, a counterexample to Scanlon's account, his case of the (...) "Profligate Pal," will show that this view of promissory obligation, which I call the Expectations View, is incorrect. In its place, I propose an account of promissory obligation I call Promising as Accountability, according to which promising is a way of making oneself accountable to others for a future act. Not only is Promising as Accountability a more defensible approach to promissory obligation, it also better fits with certain general features of Scanlon's contractualism. (shrink)

E. Beltrami in 1868 did not intend to prove the consistency of non-euclidean plane geometry nor the independence of the euclidean parallel postulate. His approach would have been unsuccessful if so intended. J. Hoüel in 1870 described the relevance of Beltrami's work to the issue of the independence of the euclidean parallel postulate. Hoüel's method is different from the independence proofs using reinterpretation of terms deployed by Peano about 1890, chiefly in using a fixed interpretation for non-logical terms. Comparing the (...) work of Beltrami and Hoüel with the treatment of non-euclidean geometry after the development of the axiomatic method in the 1890s indicates an important shift in mathematicians? attitudes towards mathematical theories. (shrink)

Ockham appeared to maintain that God necessarily knows all true propositions, including future contingent propositions, despite the fact that such propositions have determinate truth values. While some commentators believe that Ockham’s attempt to reconcile divine omniscience with the contingency of true future propositions amounts to little more than a simple-minded assertion of Ockham’s Christian faith, I argue that Ockham’s position is more sophisticated than this and rests on attributing to God a dual knowledge property: God not only knows every true (...) proposition, but knows its modal properties as well. Future contingent propositions are determinately true when actualized, not timelessly, and God’s knowledge of their truth values is knowledge of when the truth value of a proposition is actually determined. (shrink)

Evidence from the Apology, Crito, Protagoras, and Gorgias is mustered in defense of the claim that for Socrates, dialectic typifies just punishment: Dialectic benefits the punished by making her more just, since it disabuses her of the false beliefs that stand in the way of her acquiring knowledge of justice. Though painful and disorienting to the interlocutor, having one’s opinions refuted by Socrates—who is wiser than his interlocutors due to his awareness of the vastness of his ignorance—is in fact a (...) benefit. Socrates’ attitude toward his own pending death sentence, his claim that the virtues are unified around wisdom, and his opposition to vengeance or retaliation as a moral motive, all underscore how dialectical engagement is a paradigm instance of just Socratic punishment. (shrink)

Evidence from the Apology, Crito, Protagoras, and Gorgias is mustered in defense of the claim that for Socrates, dialectic typifies just punishment: Dialectic benefits the punished by making her more just, since it disabuses her of the false beliefs that stand in the way of her acquiring knowledge of justice. Though painful and disorienting to the interlocutor, having one’s opinions refuted by Socrates—who is wiser than his interlocutors due to his awareness of the vastness of his ignorance—is in fact a (...) benefit. Socrates’ attitude toward his own pending death sentence, his claim that the virtues are unified around wisdom, and his opposition to vengeance or retaliation as a moral motive, all underscore how dialectical engagement is a paradigm instance of just Socratic punishment. (shrink)

Increasing frauds in insurance and mortgage‐lending illustrate the dilemma for companies between tackling fraud in the public interest and retaining customer confidence and competitive position.

Book Reviewed in this article: Multinationals as Moral Agents George Goyder Meeting Customer Expectations Sheila M. Evers E PLURIBUS UNUM?! Tim Traverse‐Healy The Impacts of Tourism Marion Wheeler.

Most large frauds develop only gradually and incidentally. When things fall apart it is politic to call it anything but fraud. The author is a member of the Department of Sociology, University of Liverpool, POB 147, Liverpool L69 3BX.

Most large frauds develop only gradually and incidentally. When things fall apart it is politic to call it anything but fraud. The author is a member of the Department of Sociology, University of Liverpool, POB 147, Liverpool L69 3BX.