Nel 1589 Hercole Filogenio scrisse un discorso che intitolò _Dell’eccellenza della donna_, con l’intento di allinearsi “all’opinione di coloro che si sforzano scoprire l’errore di molti, quali tanto si affannano in avilire il feminil sesso” e dedicò il suo scritto a Flavia Peretti Orsina, donna distinta e dallo spirito inquieto, che con i suoi interessi contribuì allo sviluppo della società dell’epoca. Nel suo tentativo di preservare le donne dal biasimo manifestato dal maschilismo egemone e, allo stesso tempo, elogiare le loro (...) virtù, Filogenio propone due conclusioni, l’analisi e l’approfondimento delle quali, per mezzo di un’argomentazione valida, costituiscono il nucleo testuale della sua opera. L’articolo presenta e analizza i ragionamenti che Filogenio sviluppa nella seconda parte del suo discorso sui quali intende imperniare la dimostrazione della seconda conclusione: che la Donna non è superiore né inferiore all’Uomo, ma simile e uguale per nobiltà, eccellenza e perfezione. (shrink)

RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated (...) in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned. BioEssays 21:546–557, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Addison and Steele’s legacy on polite manners has been widely acknowledged as a hallmark of the Scottish Enlightenment’s tradition. On the other hand the place of courtly, ‘French’ politeness within the Scottish Enlightenment is much less debated. Conceiving the European Enlightenment as a status quo built on ‘French manners and English liberty’, as Pocock perfectly synthesizes1, points out to the restrictions imposed on religious fanaticism and warfare by the ‘jus gentium’ and European civility. In my paper I aim to shift (...) the attention to the seemingly obvious fact that manners, the backbone of European civility, originate in court, and Versailles was the court par excellence. In this context I explore Adam Smith’s struggle to strip politeness and civility of its aristocratic components. In the heart of the matter lies the strange idea of courtoisie without a court, of propriety that should overcome formal politeness i.e. imitation of aristocratic manners. (shrink)

Based on A. P. D. Mourelatos's "Events, Processes, and States", an overview of the literature on „verb types‟ is provided in this paper;the basic conceptual, logical and grammatical tests for the identification of different verb types are also briefly reviewed.Such tests, it is argued, reveal variations in a verb’s grammatical and/or lexical aspect; accordingly, verb types should be viewed as regularities governing aspectual variation within and across sentences. Verb types are not associated with particular verbs, predicates or sentences; rather, a (...) verb type is the sum of ways in which a verb‟s aspect may vary. In other words, verb types describe the possibilities for a verb to appear in one or another of a series of interrelated constructions. Verb types are verbal possibilities or, to use B. L. Whorf‟s apt term, fashions of speaking which cut across typical grammatical classifications. It is further argued that verb types, as “mere” fashions of speaking, cannot provide a firm basis for any metaphysics of „situation types‟; i.e., the metaphysics of verb types cannot be founded on their linguistics. (shrink)

Adam Smith not only champions commerce, he also criticizes it. In this criticism Smith draws critically upon a long-standing concern in enlightenment’s culture about the proper basis of political and moral life. For the purposes of this chapter, we can identify two interrelated dimensions in Smith’s analysis of the relation between corruption and commerce. He focuses on atavistic remainders of pre-modern, feudal, or aristocratic aspects of behaviour within the heart of commercial society and considers obsequiousness as emblematic of dependent socio-economic (...) relationships while, simultaneously, he raises the issue of distinct socio-economic, moral and political forms of commercial corruption, endemic to the core of commercial polity. (shrink)

Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF-2. In this review, we summarize the (...) signaling pathways that activate ATF-2, as well as its downstream targets. We examine the role of ATF-2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design. (shrink)

In this article I consider the normative and axiological dimension of Simmel’s thought. Building on previous interpretations, I argue that although Simmel cannot be interpreted as a systematic normative theorist, the issue of values and the normative standpoint can nevertheless be traced in various aspects of his multifarious work. This interpretive turn attempts to link Simmel’s obscure theory of value with his epistemological relationism. Relationism may offer a counterweight to Simmel’s value-pluralism, since it points to normative elements (e.g. internal teleology, (...) justice) that can contribute to the reconciliation between incommensurablity of forms and totality. Axiological and normative concerns (of a Hegelian source) survive also in his metaphysics of life, pointing beyond a merely Bergsonian and conservative Lebensphilosophie. I conclude with some thoughts on how this normative rethinking of Simmel’s thought can contribute towards more adequate appreciations of Simmel’s overall theory. (shrink)

ExcerptVassilios Paipais, ed. Theology and World Politics: Metaphysics, Genealogies, Political Theologies. Cham: Palgrave Macmillan, 2020. Pp. xiv + 349. Political theology represents one of the most fundamental subfields of contemporary political theory and international political theory. Since the 1920s, when Carl Schmitt introduced the respective terminology in the broader field of social and political sciences, political theology has developed in a dynamic way, composing, one way or another, a broader interdisciplinary field in which philosophy, theology, and politics are fruitfully interconnected.

This article reports data collected from 385 performing arts professionals using the HEartS Professional Survey during the COVID-19 Lockdown 1.0 in the United Kingdom. Study 1 examined characteristics of performing arts professionals’ work and health, and investigated how these relate to standardized measures of wellbeing. Study 2 examined the effects of the lockdown on work and wellbeing in the respondents’ own words. Findings from Study 1 indicate a substantial reduction in work and income. 53% reported financial hardship, 85% reported increased (...) anxiety, and 63% reported being lonelier than before the crisis. 61% sought support on finances while only 45% did so on health and wellbeing. Multiple regression analyses, using the Mental Health Continuum-Short Form, Center for Epidemiologic Studies Depression Scale, Social Connectedness Scale, and Three-Item Loneliness Scale as outcome variables, indicate that perceived financial hardship was associated with lower wellbeing and higher depression and loneliness scores. Higher self-rated health was associated with higher wellbeing and lower depression scores. More physical activity before lockdown was associated with higher wellbeing and social connectedness scores, as well as lower loneliness scores, and an increase in physical activity during lockdown compared with before, as well as older age, were associated with higher wellbeing and social connectedness scores, and lower depression and loneliness scores. Thematic inductive analysis of 341 open responses in Study 2 identified five overarching themes characterizing the effects of Lockdown 1.0: lost or uncertain work and income, including canceled work, financial concerns, and uncertainties for the future; constraints of lockdown working, including challenges of working at home, struggles with online work and skill maintenance, and caring responsibilities; loss and vulnerability, including reduced social connections, lack of support, vulnerability, feelings of loss and grief, and concern for others; detrimental effects on health and wellbeing, including anxiety, low or unstable mood, poorer physical health, and lack of motivation; and professional and personal opportunities, including coping well or living more healthily, more time and less pressure, new possibilities and activities, enhanced social connections, and new skills. Lockdown 1.0 had profound effects on performing arts professionals, but our findings reveal some opportunities and compelling links between positive wellbeing and physical activity. (shrink)

A simple, fact-filled introduction for the smallest citizen on the judicial branch of the government.

The research presented in this paper was motivated by our aim to study a problem due to J. Bourgain [3]. The problem in question concerns the uniform boundedness of the classical separation rank of the elements of a separable compact set of the first Baire class. In the sequel we shall refer to these sets (separable or non-separable) as Rosenthal compacta and we shall denote by ∝(f) the separation rank of a real-valued functionfinB1(X), withXa Polish space. Notice that in [3], (...) Bourgain has provided a positive answer to this problem in the case ofKsatisfyingwithXa compact metric space. The key ingredient in Bourgain's approach is that whenever a sequence of continuous functions pointwise converges to a functionf, then the possible discontinuities of the limit function reflect a local ℓ1-structure to the sequence (fn)n. More precisely the complexity of this ℓ1-structure increases as the complexity of the discontinuities offdoes. This fruitful idea was extensively studied by several authors (c.f. [5], [7], [8]) and for an exposition of the related results we refer to [1]. It is worth mentioning that A.S. Kechris and A. Louveau have invented the rank rND(f) which permits the link between thec0-structure of a sequence (fn)nof uniformly bounded continuous functions and the discontinuities of its pointwise limit. Rosenthal'sc0-theorem [11] and thec0-index theorem [2] are consequences of this interaction.Passing to the case where either (fn)nare not continuous orXis a non-compact Polish space, this nice interaction is completely lost. (shrink)