Consumer involvement in clinical research is an essential component of a comprehensive response during emergent health challenges. During the COVID-19 pandemic, the moderation of research policies and regulation to facilitate research may raise ethical issues. Meaningful, diverse consumer involvement can help to identify practical approaches to prioritize, design, and conduct rapidly developed clinical research amid current events. Consumer involvement might also elucidate the acceptability of flexible ethics review approaches that aim to protect participants whilst being sensitive to the challenging context (...) in which research is taking place. This article describes the main ethical challenges arising from pandemic research and how involving consumers and the community could enable resolution of such issues. (shrink)

Philosophers and other scholars have often claimed that the arts are not only cognitively valuable but also morally improving (e.g., Nussbaum, 1997). However, their arguments often proceed with little attention to empirical evidence. At the same time, filmmakers and media creators deliberately use devices to direct their audience’s attention, with the intention of impacting viewers’ cognitive, affective, and neurological responses in meaningful ways (Carroll & Seeley, 2013). Whether these devices have the desired effects, and on whom, also remains largely untested. (...) If we want to understand the ways that film and media can have moral impacts, we must step out of our disciplinary siloes. It is not enough for film experts, philosophers, and experimentalists to merely take note of each other’s work; collaborative interdisciplinary research is required, both to improve methods and to examine questions that have not yet been empirically explored. In this article we propose a model for this kind of research, focusing on how media can influence moral understanding. We first outline the challenges that must be met for such research to be successful, including clarifying and operationalizing concepts, measuring moral understanding, and applying empirical methods to media and the arts. We then describe the advantages of interdisciplinary collaboration for meeting these challenges, in the context of some recent examples of interdisciplinary projects on related themes. (shrink)

It is generally believed that an invariant notion of a global present or "Now" cannot be defined in special relativity, because of the relativity of optical simultaneity. I argue that this may be a non sequitur since it is not necessarily the case that the psychological "Now" should be thought of as associated with constant time slices in spacetime. By considering a science fictional version of the Twin Paradox due to Robert A. Heinlein, I argue that it is psychologically plausible (...) to associate the common specious present of several observers in relative motion with certain hypersurfaces of proper time of those observers corrected for acceleration history and relative motion in an obvious way. If this is correct then the relativity of optical simultaneity may be simply irrelevant to the question of the relativity of a globally distinguished "present". (shrink)

In their forthcoming article, ‘What makes a medical intervention invasive?’ De Marco, Simons, and colleagues explore the meaning and usage of the term ‘invasive’ in medical contexts. They describe a ‘Standard Account’, drawn from dictionary definitions, which defines invasiveness as ‘incision of the skin or insertion of an object into the body’. They then highlight cases wherein invasiveness is employed in a manner that is inconsistent with this account (eg, in describing psychotherapy) to argue that the term invasiveness is often (...) used to explicitly or implicitly reference interventions that do not fall under the standard account. The authors offer an alternative ‘schematic’ definition of invasiveness, whereby medical interventions entail an underlying context-independent property of ‘basic invasiveness’ and may be understood both relative to each other and to a context-specific threshold of what is ‘invasive’.1 We propose that the meaning of terms such as ‘invasiveness’ is necessarily heterogeneous, and that what is implied by its usage will certainly depend on context, particularly in medical settings. Hence, the creation of a unifying definition is less critical than clarification of the implied and intended meanings of each instance of the term’s use. We further argue that interpreting the use of terms like ‘invasiveness’ in medical practice is complicated by the embedding of each use of this term in a different ‘language game’, whereby words and their meanings are understood by an in-group familiar with …. (shrink)

I present a thought experiment in quantum mechanics and tease out some of its implications for the doctrine of “peaceful coexistence”, which, following Shimony, I take to be the proposition that quantum mechanics does not force us to revise or abandon the relativistic picture of causality. I criticize the standard arguments in favour of peaceful coexistence on the grounds that they are question-begging, and suggest that the breakdown of Lorentz-invariant relativity as a principle theory would be a natural development, given (...) the general trend of physics in this century. (shrink)

This paper is a report on the viability, both technical and ethical, of negative emissions technologies (NETs) in climate change mitigation. Given present levels of atmospheric carbon dioxide, NETs are almost certainly required in order to avoid the most serious consequences of anthropogenic carbonization. Critics argue that we should not rely on the promise of future NETs because that could be taken as an excuse to avoid decarbonization in the near term. The concern is genuine, but if the prima facie (...) arguments for drawing down carbon as soon as possible are correct, ways must be found to counter the incentives to defer the immediate deployment of NETs and other forms of mitigation. A policy instrument is sketched which could help accomplish that task. (shrink)

James Hansen and others have argued that climate scientists are often reluctant to speak out about extreme outcomes of anthropogenic carbonization. According to Hansen, such reticence lessens the chance of effective responses to these threats. With the collapse of the West Antarctic Ice Sheet as a case study, reasons for scientific reticence are reviewed. The challenges faced by scientists in finding the right balance between reticence and speaking out are both ethical and methodological. Scientists need a framework within which to (...) find this balance. Such a framework can be found in the long-established practices of professional ethics. (shrink)

ABSTRACTJames Hansen and others have argued that climate scientists are often reluctant to speak out about extreme outcomes of anthropogenic carbonization. According to Hansen, such reticence lessens the chance of effective responses to these threats. With the collapse of the West Antarctic Ice Sheet as a case study, reasons for scientific reticence are reviewed. The challenges faced by scientists in finding the right balance between reticence and speaking out are both ethical and methodological. Scientists need a framework within which to (...) find this balance. Such a framework can be found in the long-established practices of professional ethics. (shrink)

The twilight of certainty -- Einstein and light -- The Bohr atom and old quantum theory -- Uncertain synthesis -- Dualities -- Elements of physical reality -- Creation and annihilation -- Quantum mechanics goes to work -- Symmetries and resonances -- "The most profound discovery of science" -- Bits, qubits, and the ultimate computer -- Unfinished. business.

It seems to me that it is among the most sure-footed of quantum physicists, those who have it in their bones, that one finds the greatest impatience with the idea that the ‘foundations of quantum mechanics’ might need some attention. Knowing what is right by instinct, they can become a little impatient with nitpicking distinctions between theorems and assumptions. —John Stewart Bell [4, p. 33].

This is a review of those key thought experiments in physics from the late 19th century onward that seem to have played a particular role in the process of the discovery or advancement of theory. Among others the paper discusses Maxwell's demon, several of Einstein's thought experiments in relativity, Heisenberg's microscope, the Einstein-Schrödinger cat, and the EPR thought experiment.

Psychopaths constitute less than 1% of the general population, but they commit a much larger proportion of crime and violence in society. This volume chronicles the latest science of psychopathy, various ways that psychopaths challenge the criminal justice system, and the major ethical issues arising from this fascinating condition.

The purpose of the current study was to examine the reliability and validity of the RESTQ-Sport-36 for use in the collegiate student-athlete population. A total of 494 collegiate student-athletes competing in National Collegiate Athletic Association Division I, II, or III sanctioned sport completed the RESTQ-Sport-36 and Brief Profile of Mood States. Structural equation modeling procedures were used to compare first order to hierarchical model structures. Results of a confirmatory factor analysis and exploratory structural equation modeling analysis indicated that the first (...) order 12-factor structure demonstrated the best fit of all models tested. Support was not observed for the fit of any hierarchical model. Moderate to strong correlations were observed between stress and recovery subscales and mood states, thus supporting the construct validity of the abbreviated RESTQ measurement model. The current findings provide support for the measure’s use in this population and give pause as it relates to the scoring and interpretation of hierarchical factors such as Total Stress and Total Recovery. Overall, the current results indicate that the RESTQ-Sport-36 may be a useful tool for collegiate student-athlete training load and competition monitoring. (shrink)

Current treatments for chronic pain have limited benefit. We describe a resilience intervention for individuals with chronic pain which is based on a model of viewing chronic pain as dysregulated homeostasis and which seeks to restore homeostatic self-regulation using strategies exemplified by survivors of extreme environments. The intervention is expected to have broad effects on well-being and positive emotional health, to improve cognitive functions, and to reduce pain symptoms thus helping to transform the suffering of pain into self-growth. A total (...) of 88 Veterans completed the pre-assessment and were randomly assigned to either the treatment intervention or control. Fifty-eight Veterans completed pre- and post-testing. The intervention covered resilience strengths organized into four modules: engagement, social relatedness, transformation of pain and building a good life. A broad set of standardized, well validated measures were used to assess three domains of functioning: health and well-being, symptoms, and cognitive functions. Two-way Analysis of Variance was used to detect group and time differences. Broadly, results indicated significant intervention and time effects across multiple domains: Pain decreased in present severity [F = 5.02, p < 0.05, η2p = 0.08], total pain over six domains [F = 14.52, p < 0.01, η2p = 0.21], and pain interference [F = 6.82, p < 0.05, η2p = 0.11]; Affect improved in pain-related negative affect [F = 7.44, p < 0.01, η2p = 0.12], fear [F = 7.70, p < 0.01, η2p = 0.12], and distress [F = 10.87, p < 0.01, η2p = 0.16]; Well-being increased in pain mobility [F = 5.45, p < 0.05, η2p = 0.09], vitality [F = 4.54, p < 0.05, η2p = 0.07], and emotional well-being [F = 5.53, p < 0.05, η2p = 0.09] Mental health symptoms and the cognitive functioning domain did not reveal significant effects. This resilience intervention based on homeostatic self-regulation and survival strategies of survivors of extreme external environments may provide additional sociopsychobiological tools for treating individuals with chronic pain that may extend beyond treating pain symptoms to improving emotional well-being and self-growth.Clinical Trial Registration: Registered with ClinicalTrials.gov. (shrink)

Against a background of increasing regulation regarding access to medical information and the presentation of patients' confidentiality, the case of genetic information raises interesting questions about whether the application of general rules is appropriate in all situations. Whilst all genetic information is not equally sensitive, some of it is highly predictive. It also allows deductions to be made about other family members. It may not be regarded as particularly sensitive when compared to other types of medical information and those to (...) whom it applies may not be as anxious about preserving their confidentiality as compared with—for example, the prospect of seeing research into cause and cures for rare diseases put in hand. These distinctions also find resonance with the general public. Resolving conflicting tensions will require subtlety, not a blunt “one size fits all” model. (shrink)

This volume collects essays which are thematically connected through the work of Kent Emery Jr., to whom the volume is dedicated. A main focus lies on the attempts to bridge the gap between mysticism and a systematic approach to medieval philosophical thought.

RésuméCet article défend une approche à la philosophic et à l'éthique environnementale qui a originalement été avancée par Aldo Leopold. Selon cet auteur, l'éthique peut être comprise, d'un point de vue biologique, comme la forme spécifiquement humaine de la symbiose. La question cruciate de notre époque est de savoir si les humains peuvent coexister avec l'environnement global en un état de symbiose. La philosophie et les sciences humaines en général peuvent contribuer grandement à l'atteinte de ce but, à cause de (...) la façon très spéciale dont le caractère même des actions et des æuvres humaines peut être amplifié par l'écosystème. Je critique un argument thermodynamique qui a été formulé contre la possibilité de la symbiose humaine; et je mets en garde contre les tendances à l'autoritarisme et è l'évasion par l'introspection qui sont typiques des cultures en état de crise écologique. (shrink)

How do we understand the agency and significance of material forces and their interface with human bodies? What does it mean to be human in these times, with bodies that are inextricably interconnected with our physical world? Bodily Natures considers these questions by grappling with powerful and pervasive material forces and their increasingly harmful effects on the human body. Drawing on feminist theory, environmental studies, and the sciences, Stacy Alaimo focuses on trans-corporeality, or movement across bodies and nature, which has (...) profoundly altered our sense of self. By looking at a broad range of creative and philosophical writings, Alaimo illuminates how science, politics, and culture collide, while considering the closeness of the human body to the environment. (shrink)

The essays evaluate Woods' work and celebrate the generous contribution that he has made to Canada?s intellectual development over the past forty years.

Many healthcare practices expose people to risks of harmful outcomes. However, the major theories of moral philosophy struggle to assess whether, when and why it is ethically justifiable to expose individuals to risks, as opposed to actually harming them. Sven Ove Hansson has proposed an approach to the ethical assessment of risk imposition that encourages attention to factors including questions of justice in the distribution of advantage and risk, people’s acceptance or otherwise of risks, and the scope individuals have to (...) influence the practices that generate risk. This paper investigates the ethical justifiability of preventive healthcare practices that expose people to risks including overdiagnosis. We applied Hansson’s framework to three such practices: an ‘ideal’ breast screening service, a commercial personal genome testing service, and a guideline that lowers the diagnostic threshold for hypertension. The framework was challenging to apply, not least because healthcare has unclear boundaries and involves highly complex practices. Nonetheless, the framework encouraged attention to issues that would be widely recognised as morally pertinent. Our assessment supports the view that at least some preventive healthcare practices that impose risks including that of overdiagnosis are not ethically justifiable. Further work is however needed to develop and/or test refined assessment criteria and guidance for applying them. (shrink)

(2002). Bub and the barriers to quantum ontology. International Studies in the Philosophy of Science: Vol. 16, No. 3, pp. 285-289. doi: 10.1080/0269859022000013346.

Objectives: To test the range of beliefs regarding the ethics of testing, in resource poor settings, new therapies that are less efficacious but more affordable and feasible than the best current therapeutic standard. Design: Using a web-based survey, we presented a hypothetical scenario proposing to test a therapy for HIV disease ("therapeutic inoculation") known to be less efficacious than highly active antiretroviral therapy (HAART). Respondents evaluated various trial designs as ethical or unethical. Participants: 604 subscribers to two listservs for individuals (...) interested in international health research ethics. Main outcome measures: Proportion of respondents endorsing trials testing this "substandard" therapy, and proportion endorsing placebo-controlled trials. Results: There were 215 respondents from 47 countries. Forty-five percent of respondents were from low or middle income countries; 96% devoted at least some time to research activities; and 75% had "some" or "considerable" research experience in developing countries. Of respondents, 97% (95% CI 94.7 to 99.4) endorsed testing therapeutic inoculation, without HAART, in patients with HIV disease; 86% (95% CI 81.4% to 90.7%) endorsed testing against placebo. Sixty-eight percent explicitly endorsed principles where the standard of care for subjects in clinical trials is determined by local, not universal, standards. There were no differences in responses based on respondent education-level or the income-level of their country of citizenship. Conclusion: There was broad agreement that a therapy of potential local benefit may be tested, even when that therapy is known to be inferior to the standard of care in wealthy countries. Most agreed that a placebo control may be used in some circumstances. (shrink)

This paper argues that fitness is most usefully understood as those properties of organisms that are explanatory of survival in the broadest sense, not merely descriptive of reproductive success. Borrowing from Rosenberg and Bouchard , fitness in this sense is ecological in that it is defined by the interactions between organisms and environments. There are three sorts of ecological fitness: the well-documented ability to compete, the ability to cooperate , and a third sense of fitness that has received insufficient attention (...) in evolutionary theory, the ability to construct. Following Lotka, it can be understood thermodynamically as the ability to maintain or enlarge the energy-circulating capacity of an ecosystem. An organism that does this could end with its gene frequency unchanged but its probability of survival enhanced since it would sustain or increase the total carrying capacity of its ecosystem. Photosynthesizers and other autotrophs are obvious candidates for organisms that are fit in the constructive sense, but any organisms, including heterotrophs, can exhibit constructive fitness if they have some mechanism for channeling external flows of free energy into their ecosystems. I will briefly examine the prospects for the human species in the light of these considerations. (shrink)