BackgroundThe role of consent for research use of health information is contentious. Most discussion has focused on when project-specific consent may be waived but, recently, a broader range of consent options has been entertained, including broad opt-in for multiple studies with restrictions and notification with opt-out. We sought to elicit public values in this matter and to work toward an agreement about a common approach to consent for use of personal information for health research through deliberative public dialogues.MethodsWe conducted seven (...) day-long public dialogues, involving 98 participants across Canada. Immediately before and after each dialogue, participants completed a fixed-response questionnaire rating individuals' support for 3 approaches to consent in the abstract and their consent choices for 5 health research scenarios using personal information. They also rated how confident different safeguards made them feel that their information was being used responsibly.ResultsBroad opt-in consent for use of personal information garnered the greatest support in the abstract. When presented with specific research scenarios, no one approach to consent predominated. When profit was introduced into the scenarios, consent choices shifted toward greater control over use. Despite lively and constructive dialogues, and considerable shifting in opinion at the individual level, at the end of the day, there was no substantive aggregate movement in opinion. Personal controls were among the most commonly cited approaches to improving people's confidence in the responsible use of their information for research.ConclusionBecause no one approach to consent satisfied even a simple majority of dialogue participants and the importance placed on personal controls, a mechanism should be developed for documenting consent choice for different types of research, including ways for individuals to check who has accessed their medical record for purposes other than clinical care. This could be done, for example, through a web-based patient portal to their electronic health record. Researchers and policy makers should continue to engage the public to promote greater public understanding of the research process and to look for feasible alternatives to existing approaches to project-specific consent for observational research. (shrink)

Using the artificial language paradigm, we studied the acquisition of morphophonemic alternations with exceptions by 160 German adult learners. We tested the acquisition of two types of alternations in two regularity conditions while additionally varying length of training. In the first alternation, a vowel harmony, backness of the stem vowel determines backness of the suffix. This process is grounded in substance, and this universal phonetic factor bolsters learning a generalization. In the second alternation, tenseness of the stem vowel (...) determines backness of the suffix vowel. This process is not based in substance, but it reflects a phonotactic property of German and our participants benefit from this language-specific factor. We found that learners use both cues, while substantive bias surfaces mainly in the most unstable situation. We show that language-specific and universal factors interact in learning. (shrink)

Using the artificial language paradigm, we studied the acquisition of morphophonemic alternations with exceptions by 160 German adult learners. We tested the acquisition of two types of alternations in two regularity conditions while additionally varying length of training. In the first alternation, a vowel harmony, backness of the stem vowel determines backness of the suffix. This process is grounded in substance (phonetic motivation), and this universal phonetic factor bolsters learning a generalization. In the second alternation, tenseness of the (...) stem vowel determines backness of the suffix vowel. This process is not based in substance, but it reflects a phonotactic property of German and our participants benefit from this language-specific factor. We found that learners use both cues, while substantive bias surfaces mainly in the most unstable situation. We show that language-specific and universal factors interact in learning. (shrink)

I construe Relevant Alternatives Theory (RAT) as an abstract combination of anti-skepticism and epistemic modesty, then re-evaluate the challenge posed to it by the missed clue counter-examples of Schaffer [2001]. The import of this challenge has been underestimated, as Schaffer’s specific argument invites distracting objections. I offer a novel formalization of RAT, accommodating a suitably wide class of concrete theories of knowledge. Then, I introduce abstract missed clue cases and prove that every RA theory, as formalized, admits such a case. (...) This yields an argument - in Schaffer’s spirit - that resists easy dismissal. (shrink)

Recent evidence suggests that probabilistic grammars may be modulated by communication mode and genre. Accordingly, the question arises how complex language users’ lectal competence is, where complexity is proportional to the extent to which choice-making processes depend on the situation of language use. Do probabilistic constraints vary when we talk to a friend compared to when we give a speech? Are differences between spoken and written language larger than those within each mode? In the present study, we aim to approach (...) these questions systematically. Guided by theorizing in cognitive (socio)linguistics and using logistic regression based on corpus materials, we analyzed the dative alternation with give (The government gives farmers money vs. The government gives money to farmers) in four broad registers of English: spoken informal, spoken formal, written informal, and written formal. Corpus analysis was supplemented with a scalar rating experiment. Results suggest that language users’ probabilistic grammars vary as a function of register. (shrink)

Things we can say, and the ways in which we can say them, compete with one another. And this has consequences: words we decide not to pronounce have critical effects on the messages we end up conveying. For instance, in saying Chris is a good teacher, we may convey that Chris is not an amazing teacher. How this happens is an unsolvable problem, unless a theory of alternatives indicates what counts, among all the things that have not been pronounced. It (...) is sometimes assumed, explicitly or implicitly, that any word counts, as long as that word could have replaced one that was actually pronounced. We review arguments for going beyond this powerful idea. In doing so, we argue that the level of words is not the right level of analysis for alternatives. Instead, we capitalize on recent conceptual and associated methodological advances within the study of the so-called “language of thought” to reopen the problem from a new perspective. Specifically, we provide theoretical and experimental arguments that the relation between alternatives and words may be indirect, and that alternatives are not merely linguistic objects in the traditional sense. Rather, we propose that competition in language is significantly determined by general reasoning preferences, or thought preferences. We propose that such non-linguistic preferences can be measured and that these measures can be used to explain linguistic competition, non-linguistically, and more in depth. (shrink)

With its provocative title, Blumenthal-Barby’s (2024) Target Article is an important addition to the critical work on using ‘personhood’ in bioethics. I suggest it bears on any philosophical discus...

We propose a non-representationalist framework for deep learning relying on a novel method computational phenomenology, a dialogue between the first-person perspective (relying on phenomenology) and the mechanisms of computational models. We thereby propose an alternative to the modern cognitivist interpretation of deep learning, according to which artificial neural networks encode representations of external entities. This interpretation mainly relies on neuro-representationalism, a position that combines a strong ontological commitment towards scientific theoretical entities and the idea that the brain operates on symbolic (...) representations of these entities. We proceed as follows: after offering a review of cognitivism and neuro-representationalism in the field of deep learning, we first elaborate a phenomenological critique of these positions; we then sketch out computational phenomenology and distinguish it from existing alternatives; finally we apply this new method to deep learning models trained on specific tasks, in order to formulate a conceptual framework of deep-learning, that allows one to think of artificial neural networks’ mechanisms in terms of lived experience. (shrink)

Standard, linguistic means of specifying the content of mental states do so by expressing the content in question. Such means fail when it comes to capturing non-conceptual aspects of visual experience, since no linguistic expression can adequately express such content. One alternative is to use depictions: images that either evoke (reproduce in the recipient) or refer to the content of the experience. Practical considerations concerning the generation and integration of such depictions argue in favour of a synthetic approach: the generation (...) of depictions through the use of an embodied, perceiving and acting agent, either virtual or real. This paper takes the first steps in an investigation as to how one might use a robot to specify the non-conceptual content of the visual experience of an (hypothetical) organism that the robot models. (shrink)

Explanations in the life sciences frequently involve presenting a model of the mechanism taken to be responsible for a given phenomenon. Such explanations depart in numerous ways from nomological explanations commonly presented in philosophy of science. This paper focuses on three sorts of differences. First, scientists who develop mechanistic explanations are not limited to linguistic representations and logical inference; they frequently employ diagrams to characterize mechanisms and simulations to reason about them. Thus, the epistemic resources for presenting mechanistic explanations are (...) considerably richer than those suggested by a nomological framework. Second, the fact that mechanisms involve organized systems of component parts and operations provides direction to both the discovery and testing of mechanistic explanations. Finally, models of mechanisms are developed for specific exemplars and are not represented in terms of universally quantified statements. Generalization involves investigating both the similarity of new exemplars to those already studied and the variations between them. (shrink)

Guessing is a familiar activity, one we engage in when we are uncertain of the answer to a question under discussion. It is also an activity that lends itself to normative evaluation: some guesses are better than others. The question that interests me here is what makes for a good guess. In recent work, Dorst and Mandelkern have argued that good guesses are distinguished from bad ones by how well they optimize a tradeoff between accuracy and specificity. Here I (...) argue that Dorst and Mandelkern’s implementation of this idea fails to satisfy some plausible constraints on good guesses, and I develop an alternative implementation that satisfies the relevant constraints. The result is a new account of good guesses which retains the positive aspects of Dorst and Mandelkern’s proposal, but without the drawbacks. (shrink)

Alternative cleavage and polyadenylation (APA) can diversify coding and non‐coding regions, but has particular impact on increasing 3′ UTR diversity. Through the gain or loss of regulatory elements such as RNA binding protein and microRNA sites, APA can influence transcript stability, localization, and translational efficiency. Strikingly, the central nervous systems of invertebrate and vertebrate species express a broad range of transcript isoforms bearing extended 3′ UTRs. The molecular mechanism that permits proximal 3′ end bypass in neurons is mysterious, and only (...) beginning to be elucidated. This landscape of neural 3′ UTR extensions, many reaching unprecedented lengths, may help service the unique post‐transcriptional regulatory needs of neurons. A combination of approaches, including transcriptome‐wide profiling, genetic screening to identify APA factors, biochemical dissection of alternative 3′ end formation, and manipulation of individual neural APA targets, will be necessary to gain fuller perspectives on the mechanism and biology of neural‐specific 3′ UTR lengthening. (shrink)

Amid the many food safety scandals that have erupted in recent years, Chinese food activists and consumers are turning to the creation of alternative food networks to ensure better control over their food. These Chinese AFNs have not been documented in the growing literature on food studies. Based on in-depth interviews and case studies, this paper documents and develops a typology of AFNs in China, including community supported agriculture, farmers’ markets, buying clubs, and recreational garden plot rentals. We unpacked the (...) four standard dimensions of alternativeness of AFNs into eight elements and used these to examine the alternativeness of AFNs in China. We argue first that the landscape of alternativeness varies among different networks but the healthfulness of food is the most prominent element. Second, there is an inconsistency in values between AFN initiators and customers, which contributes to the uneven alternativeness of Chinese AFNs. Third, Chinese AFNs are strongly consumer driven, a factor that constrains their alternativeness at present. The inclusion of “real” peasants in the construction of AFNs in China is minimal. This paper adds to the existing literature on AFNs with an analysis of recent initiatives in China that have not been well documented before. By unpacking the dimensions of alternativeness into specific elements, this paper also provides an analytical framework for examining the alternativeness of AFNs especially nascent ones that have not developed a full spectrum of alternativeness. (shrink)

I use some recent formal work on measuring causation to explore a suggestion by James Woodward: that the notion of causal specificity can clarify the distinction in biology between permissive and instructive causes. This distinction arises when a complex developmental process, such as the formation of an entire body part, can be triggered by a simple switch, such as the presence of particular protein. In such cases, the protein is said to merely induce or "permit" the developmental process, whilst (...) the causal "instructions" for guiding that process are already prefigured within the cells. I construct a novel model that expresses in a simple and tractable way the relevant causal structure of biological development and then use a measure of causal specificity to analyse the model. I show that the permissive-instructive distinction cannot be captured by simply contrasting the specificity of two causes as Woodward proposes, and instead introduce an alternative, hierarchical approach to analysing the interaction between two causes. The resulting analysis highlights the importance of focusing on gene regulation, rather than just the coding regions, when analysing the distinctive causal power of genes. (shrink)

The suggestion of seeking specificity in a higher-order array is attractive, but Stoffregen & Bardy fail to provide a compelling empirical basis to their claim that specificity exists solely in the global array. Using the example of relative motion, the alternate hypotheses that must be considered are presented.

The paper discusses the similarity between geometry, arithmetic, and logic, specifically with respect to the question of whether applied theories of each may be revised. It argues that they can - even when the revised logic is a paraconsistent one, or the revised arithmetic is an inconsistent one. Indeed, in the case of logic, it argues that logic is not only revisable, but, during its history, it has been revised. The paper also discusses Quine's well known argument against the possibility (...) of logical deviancy. (shrink)

Neuronal signalling involves multiple neuropeptides that are diverse in structure and function. Complex patterns of tissue‐specific expression arise from alternate RNA splicing of neuropeptide‐encoding gene transcripts. The pattern of expression and its role in cell signalling is diffecult to study at the level of single neurons in the complex vertebrate brain. However, in the model molluscan system, Lymnaea, it is possible to show that alternate mRNA expression of the FMRFamide gene is specific to single identified neurons. Two different transcripts are (...) expressed in a mutually exclusive manner in different neurons. Post‐translational processing of the two precursor proteins leads to completely distinct sets of neuropeptide transmitters. The function of these transmitter cocktails, resulting from alternate mRNA splicing, was studied physiologically in identified neurons forming part of a behaviourally important network regulating heartbeat. (shrink)

In this paper we extend the NeutroAlgebra & AntiAlgebra to the geometric spaces, by founding the NeutroGeometry & AntiGeometry. While the Non-Euclidean Geometries resulted from the total negation of one specific axiom (Euclid’s Fifth Postulate), the AntiGeometry results from the total negation of any axiom or even of more axioms from any geometric axiomatic system (Euclid’s, Hilbert’s, etc.) and from any type of geometry such as (Euclidean, Projective, Finite, Affine, Differential, Algebraic, Complex, Discrete, Computational, Molecular, Convex, etc.) Geometry, and the (...) NeutroGeometry results from the partial negation of one or more axioms [and no total negation of no axiom] from any geometric axiomatic system and from any type of geometry. Generally, instead of a classical geometric Axiom, one may take any classical geometric Theorem from any axiomatic system and from any type of geometry, and transform it by NeutroSophication or AntiSophication into a NeutroTheorem or AntiTheorem respectively in order to construct a NeutroGeometry or AntiGeometry. Therefore, the NeutroGeometry and AntiGeometry are respectively alternatives and generalizations of the Non-Euclidean Geometries. In the second part, we recall the evolution from Paradoxism to Neutrosophy, then to NeutroAlgebra & AntiAlgebra, afterwards to NeutroGeometry & AntiGeometry, and in general to NeutroStructure & AntiStructure that naturally arise in any field of knowledge. At the end, we present applications of many NeutroStructures in our real world. (shrink)

This paper aspires to show the often-obscured structure of alternatives in education. Alternative education is generally understood as an umbrella term for educational thought and practice for and in schools differing from an assumed ‘mainstream’, where ‘alternative’ is often taken to mean ‘better’. In many cases, ‘mainstream’ serves as an empty signifier that can be substituted by various forms of criticism. Just as progressive education is supposed to remedy all the ills of traditional education, alternative education is often positioned as (...) a safe place to retreat to, away from the mainstream. I argue that this leads to a dichotomous structure. The mainstream, however, is not an empirical reality, for example, a specific form of curriculum, differentiation of different types of schooling, or anything else. ‘Mainstream’ serves as a generic critical reference point. My argument is developed through a series of historical discussions around alternative education explored through the lens of contemporary analysis of the category. I then offer a more systematic account of the terminology in order to establish a perspective from which to assess the flaws and problems of alternative education alongside its potential virtues and benefits. (shrink)

The paper discusses the similarity between geometry, arithmetic, and logic, specifically with respect to the question of whether applied theories of each may be revised. It argues that they can - even when the revised logic is a paraconsistent one, or the revised arithmetic is an inconsistent one. Indeed, in the case of logic, it argues that logic is not only revisable, but, during its history, it has been revised. The paper also discusses Quine's well known argument against the possibility (...) of “logical deviancy”. (shrink)

Initially proposed as rivals of classical logic, alternative logics have become increasingly important in sciences such as quantum physics, computer science, and artificial intelligence. The contributions collected in this volume address and explore the question whether the usage of logic in the sciences, especially in modern physics, requires a deviation from classical mathematical logic. The articles in the first part of the book set the scene by describing the context and the dilemma when applying logic in science. In part II (...) the authors offer several logics that deviate in different ways from classical logics. The twelve papers in part III investigate in detail specific aspects such as quantum logic, quantum computation, computer-science considerations, praxic logic, and quantum probability. Most of the contributions are revised and partially extended versions of papers presented at a conference of the same title of the Académie Internationale de Philosophie des Sciences held at the Internationales Forschungszentrum Salzburg in May 1999. Others have been added to complete the picture of recent research in alternative logics as they have been developed for applications in the sciences. (shrink)

Is alternative mathematics possible? More specifically,is it possible to imagine that mathematics could havedeveloped in any other than the actual direction? Theanswer defended in this paper is yes, and the proofconsists of a direct demonstration. An alternativemathematics that uses vague concepts and predicatesis outlined, leading up to theorems such as ``Smallnumbers have few prime factors''.

The notion of specification plays a key role in the developing science of computing. It is typically considered to be the keystone in the software development process. However, there is no single, generally agreed meaning of specification that bears close scrutiny. Instead there is a variety of different, although partially interlocking and overlapping interpretations of the term.We catalogue this varietal profusion and attempt to lay bare both the sources and consequences of each major alternative. We attempt to present the full (...) range of possibilities, and the biases inherent in each style of interpretation. (shrink)

The main objective of this study is to propose, from a theoretical approach, an alternative model of the communication process that includes intentionality, interest, identification, and exchange as part of the internal process of decoding the message experienced by the receiver. The proposal includes the subdivision of the responses offered by the receiver into two possible categories: one simple, which can mean the programmed response to a specific code; and another complex, which can mean a change and/or significant transformation in (...) different aspects associated with the recipient. Through a qualitative methodology, with emphasis on documentary review, and inferential and deductive reasoning, the proposed theoretical model has been developed and explained, highlighting the added value that it could offer to the understanding of communication. (shrink)

This article analyses and reflects missiologically on the City of Tshwane's economy, in terms of its priorities and strategies. It points out that it is to the detriment of local communities that Tshwane's economy has become a replica of the national economy which is essentially growth-focused and structured to service the global market. It also discusses possibilities for the urban church to be involved in addressing this situation as it wrestles with the question: What role can the church play towards (...) fostering a grass roots, 'glocal' alternative vision to the current local economic system? Responding to this question, this article argues that the church, drawing from theological/missiological resources and hermeneutic insights on biblical texts, such as Luke 16:19-31, and on the concept of God's economy, can steer such an alternative vision for the economy of the City of Tshwane. It ends by demonstrating how the church can engage the issues of local economic development in a practical way, which will lead to an alternative reality where shared prosperity and inclusion are attained. (shrink)

A major strategy in the creation of sustainable economies is the establishment of alternative market institutions, such as fair trade and local market systems. However, the dynamics of these alternative markets are poorly understood. What are the rules of behavior by which these markets function? How do these markets maintain their separate identity as “alternative”: apart from the conventional (“free”) market system? Building on Lyson’s notion of civic agriculture, we argue that alternative markets maintain themselves through civic engagement. However, we (...) argue that the civically-engaged practices of alternative markets are poorly understood. We seek, therefore, to begin a conversation about the everyday forms of civic engagement in alternative practice and to do this we introduce a few useful conceptual tools. Building upon ideas in science studies about the collaboration of scientists (Hess, Alternative pathways in science and industry, 2007) we argue that civic markets have their own “market fields” and “modes of governance” (Bulkeley et al., Environment and Planning A 39:2733–2753, 2007), their own fields of social interaction in which rules of behavior become stabilized and determine how the market works. The creation of a social field also requires the demarcation of boundaries, referred to in the science studies literature as “boundary work” (Gieryn, Cultural boundaries of science: Credibility on the line, 1999). We apply the idea of boundary work to understand how alternative market actors maintain boundaries between alternative and conventional markets. Finally, studies of collaboration in science have often centered on the object created through these interactions, an object that is partially material and partially a product of knowledge, what (Rheinberger, Toward a history of epistemic things: Synthesizing proteins in the test tube, 1997) calls an “epistemic object.” We use this idea to understand that the creation of alternative objects of exchange, such as organic food, are epistemic objects in that they combine both particular materialities and particular ways of knowing. Using these concepts, we will carry out a close analysis of the mode of governance in the national organic market, looking specifically a recent governance crisis in organic agriculture known as the Harvey lawsuit. (shrink)

Frankfurt-style cases (FSCs) have famously served as counterexamples to the Principle of Alternative Possibilities (PAP). The fine-grained version of the flicker defense has become one of the most popular responses to FSCs. Proponents of this defense argue that there is an alternative available to all agents in FSCs such that the cases do not show that PAP is false. Specifically, the agents could have done otherwise than decide on their own, and this available alternative is robust enough to ground moral (...) responsibility. In this paper, I argue that, when relying on definitions of ‘on one’s own’ within the literature on FSCs, a case can be constructed in which the agent could not have done otherwise than make a decision on his own. Insofar as this new case is successful, it will be able to avoid arguments about robustness while showing that moral responsibility does not require alternative possibilities of the type argued for by proponents of the fine-grained version of the flicker defense. (shrink)

The concept of food sovereignty is primarily taken as an alternative to the prevailing neoliberal food security model. However, the approach has hitherto not received adequate attention from policy makers. This could be because the discourse is marked by controversies and contradictions, particularly regarding its ability to address the challenges of feeding a rapidly growing global population. In response to these criticisms, this paper argues that the principles of food sovereignty, such as democratic and transparent food systems, agroecology, and local (...) market prioritization, should be fundamental pillars for achieving sustainable food security. It acknowledges that neither food sovereignty nor food security models alone can guarantee long-term food security, thus advocating for a blended approach that integrates these perspectives into a complex and interconnected system. This paper makes three significant contributions to the existing literature. Firstly, it emphasizes that food sovereignty should be seen as an integral component of transforming food systems towards sustainability, rather than a complete departure from neoliberal food systems. Secondly, it highlights the importance of adopting a multi-scalar approach, where decisions and policies for transforming food systems are context-specific and tailored to local circumstances. Lastly, the paper recognizes the necessity of institutional transformations that involve nation-states, social movements, and civil society organizations as key actors in the process of food system transformation. By reframing the discussion on food sovereignty and its relationship with food security, this paper provides insights into how these concepts can be mutually reinforcing, leading to more sustainable and equitable food systems. (shrink)

Serial homology is widespread in organismal design, but the origin and individuation of these repeated structures appears to differ with the different types of serial homologues, and remains an intriguing and exciting topic of research. Here I focus on the evolution of the serially repeated eyespots that decorate the margin of the wings of nymphalid butterflies. In this system, unresolved questions relate to the evolutionary steps that lead to the appearance of these serial homologues and how their separate identities evolved. (...) I present and discuss two alternative hypotheses. The first proposes that eyespots first appeared as a row of undifferentiated repeated modules, one per wing compartment, that later become individuated. This individuation allowed eyespots to appear and disappear from specific wing compartments and also allowed eyespots to acquire different morphologies. The second hypothesis proposes that eyespots first appeared as individuated single units, or groups of units, that over evolutionary time were co‐opted into new compartments on the wing. I discuss the merits of each of these alternate hypotheses by finding analogies to other systems and propose research avenues for addressing these issues in the future. BioEssays 30:358–366, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In this brief discussion, we explicate and evaluate Heyes and colleagues’ deflationary approach to interpreting apparent evidence of domain-specific processes for social percep- tion. We argue that the deflationary approach sheds important light on how functionally specific processes in social perception can be subserved at least in part by domain-general processes. On the other hand, we also argue that the fruitfulness of this approach has been unnecessarily hampered by a contrastive conception of the relationship between domain- general and domain-specific processes. (...) As an alternative, we propose a complementary conception: the identification of domain-general processes that are engaged in instances of social perception can play a positive, structuring role by adding additional constraints to be accounted for in modelling the domain-specific processes that are also involved in such instances. (shrink)

Informed consent is recognized as a primary ethical requirement to conduct research involving humans. In the investigations with the use of human biological material, informed consent (IC) assumes a differentiated condition on account of the many future possibilities. This work presents suitable alternatives for IC regarding the storage and use of human biological material in research, according to new Brazilian regulations. Both norms – Resolution 441/11 of the National Health Council, approved on 12 May 2011, and Ordinance 2.201 (NATIONAL GUIDELINES (...) FOR BIOREPOSITORIES AND BIOBANKS OF HUMAN BIOLOGICAL MATERIAL FOR RESEARCH PURPOSE) of the Brazil Ministry of Health, approved on 14 September 2011 – state that the consent of subjects for the collection, storage and use of samples stored in Biobanks is necessarily established by means of a Free and Informed Consent Form (ICF). In order to obtain individual and formal statements, this form should contain the following two mutually exclusive options: an explanation about the use of the stored material in each research study, and the need for new consent or the waiver thereof when the material is used for a new study. On the other hand, ICF suitable for Biorepositories must be exclusive and related to specific research. Although Brazilian and international regulations identify the main aspects to be included in the IC, efforts are still necessary to improve the consent process, so that the document will become a bond of trust between subject and researcher. (shrink)

This article answers the question raised by the special issue of this journal in a positive way: managerial practices do need philosophy. In particular, it argues for a more concrete claim: managerial practices have needed philosophy in the past to develop some important intellectual tools, and today they still need to be open to the continuous conceptual and methodological innovations introduced by competing philosophical research programmes, because loyalty to just one favourite philosophical paradigm can hinder the ability of managerial practices (...) to express their full potential, whereas openness to philosophical innovation can help managers keep their conceptual tools up to their tasks. The authors argue for this thesis in concreto: they discuss a specific branch of managerial practice—marketing—and illustrate that a preeminent form thereof, i.e. Experiential Marketing, has needed philosophy, and still needs it nowadays, in order to achieve its goals and overcome certain problems. They also point out that Experiential Marketing needs to renew and integrate some of its philosophical assumptions and conceptual tools in the light of innovations brought about by a recent philosophical turn. In particular, the authors argue that philosophy has provided essential conceptual tools for the articulation of the notions of experience and authenticity used in Experiential Marketing; they claim that the excessive reliance of Experiential Marketing upon a problematic and somewhat outdated ontology produces paradoxes with important repercussions upon managerial practice; and they show that those problems can be overcome by integrating and partially renewing its assumptions and conceptual tools, in the light of a fresher philosophical framework. Shortcomings and solutions are discussed with reference to a specific case study: Venice as an experientially rewarding and authentic tourist destination during the Covid19 crisis, but also as a World Heritage property whose management entails difficult choices. The fruitfulness of the paradigm revision is shown also by integrating the conceptual toolkit of Experiential Marketing with three relatively new notions, deriving from a new realist framework: independence, attrition and perception. (shrink)

Informed consent is recognized as a primary ethical requirement to conduct research involving humans. In the investigations with the use of human biological material, informed consent (IC) assumes a differentiated condition on account of the many future possibilities. This work presents suitable alternatives for IC regarding the storage and use of human biological material in research, according to new Brazilian regulations. Both norms – Resolution 441/11 of the National Health Council, approved on 12 May 2011, and Ordinance 2.201 (NATIONAL GUIDELINES (...) FOR BIOREPOSITORIES AND BIOBANKS OF HUMAN BIOLOGICAL MATERIAL FOR RESEARCH PURPOSE) of the Brazil Ministry of Health, approved on 14 September 2011 – state that the consent of subjects for the collection, storage and use of samples stored in Biobanks is necessarily established by means of a Free and Informed Consent Form (ICF). In order to obtain individual and formal statements, this form should contain the following two mutually exclusive options: an explanation about the use of the stored material in each research study, and the need for new consent or the waiver thereof when the material is used for a new study. On the other hand, ICF suitable for Biorepositories must be exclusive and related to specific research. Although Brazilian and international regulations identify the main aspects to be included in the IC, efforts are still necessary to improve the consent process, so that the document will become a bond of trust between subject and researcher. (shrink)

Fibronectin (FN) is a multi‐functional extracellular matrix protein required for cell adhesion and migration, blood clotting, wound healing, and oncogenic transformation. The functional complexity is paralleled by structural diversity in that multiple forms of FN are generated by cell type‐specific alternative splicing. In the rat, up to 12 different combinations of the three alternatively spliced segments (EIIIA, EIIIB, and the V region) are produced. What effects do these segments have on FN function? Recently, progress has been made in the identification (...) of specific activities for the three Variants of the V region, V120, V95, and V0. FN‐mediated cell adhesion, FN synthesis and secretion, and incorporation into blood clots are differentially affected by these isoforms. These results suggest that cellular behavior is modulated by environmental cues provided by different types and proportions of alternatively spliced FN variants. (shrink)

In a recent paper, Negri and Pavlović (Studia Logica 1–35, 2020) have formulated a decidable sequent calculus for the logic of agency, specifically for a deliberative see-to-it-that modality, or dstit. In that paper the adequacy of the system is demonstrated by showing the derivability of the axiomatization of dstit from Belnap et al. (Facing the future: agents and choices in our indeterminist world. Oxford University Press, Oxford, 2001). And while the influence of the latter book on the study of logics (...) of agency cannot be overstated, we note that this is not the only axiomatization of that modality available. In fact, an earlier (and arguably purer) one was offered in Xu (J Philosophical Logic 27(5):505–552, 1998). In this article we fill this lacuna by proving that this alternative axiomatization is likewise readily derivable in the system of Negri and Pavlović (Studia Logica 1–35, 2020). (shrink)

Based on his experimental studies, Libet claims that voluntary actions are initiated by unconscious brain activities well before intentions or decisions to act are consciously experienced by people. This account conflicts with our common-sense conception of human agency, in which people consciously and intentionally exert volitions or acts of will to initiate voluntary actions. This paper offers an alternative interpretation of Libet's experiment. The cause of the intentional acts performed by the subjects in Libet's experiment should not be exclusively attributed (...) to special cerebral processes; conscious intentions formed at the beginning of the experiment, when the subjects received experimental instructions, must be taken into account. In addition, what the subjects were required to report was not a conscious intention or decision to act that conventionally figures in the etiology of voluntary action, but rather a perceived effective urge to move induced by specific experimental instructions. According to the alternative interpretation, the most suitable mental term correlated with the specific brain activity that precedes conscious, self-initiated voluntary bodily movements is volition. This account is supported by recent theories of function of the supplementary motor area . Therefore, the notion that we are the authors or originators of our own actions, which is fundamental to our common understanding of free will, moral responsibility and human dignity, can be preserved. (shrink)

The computation of both Scalar Implicatures (SI) and Association with Focus (AF) is characterized with reference to sets of alternatives. However, it has generally been assumed that the relevant alternatives are determined in different ways for the two processes. Specifically, it has been assumed that the alternatives for SI – scalar alternatives – are computed by a special procedure specifically designed for implicatures, whereas the alternatives for AF – focus alternatives – are determined by the general theory of association with (...) focus – focus semantics. As far as we know, the only attempt to connect the two is Krifka (1995), under which scalar alternatives and focus alternatives are identical and determined by focus semantics. However, Krifka’s result is based on a specific stipulation about scalar items, which he borrows from Horn and incorporates into focus semantics, namely that scalar items are inherently focused and have their Horn Scale as their lexically specified focus values. (shrink)

Griffiths et al. (2015) have proposed a quantitative measure of causal specificity and used it to assess various attempts to single out genetic causes as being causally more specific than other cellular mechanisms, for example, alternative splicing. Focusing in particular on developmental processes, they have identified a number of important challenges for this project. In this discussion note, I would like to show how these challenges can be met.

Harold Kincaid in Individualism and the Unity of Science postulates a model of unity-without-reduction in order to accurately describe the relation between individualism and macroeconomics. I present this model and apply it to the description of the relation between chemistry and quantum mechanics. I argue that, when it comes to the description of molecular structure, chemistry and quantum mechanics are unified in Kincaid’s sense. Specifically, the two disciplines contribute to the formation of a unified body of knowledge with respect to (...) molecular structure. (shrink)

One of the reasons for relativistic attitudes toward science is the impossibility of justifying scientists’ decisions in the face of alternative theories. According to this paper, an alternative theory can challenge scientific rationality only if the conditions of “methodological shortcomings of scientists” and the “existence of alternative theories” are met at a specific time. A commonly used technique to counter relativism is to try to supplement and equip scientists’ methodologies when confronted with alternative theories. However, this paper focuses on evaluating (...) the possibility of “existence an alternative theory.” To this end, by referring to the different definitions of being alternative, we try to show that only “after the decision” and “the conversion of the scientific community” can a theory be considered justifiably “alternative.” Therefore, the relativistic claim is inconsistent because relativists must first accept the validity of scientists’ decisions to attribute being alternative to a theory. In this work, we provide evidence for our claim using a historical example. We also defend conservatism as a corollary of our discussion. (shrink)

In spite of the wide variety of approaches to ethics training it is still debatable which approach has the highest potential to enhance professionals’ integrity. The current effort assesses a novel curriculum that focuses on metacognitive reasoning strategies researchers use when making sense of day-to-day professional practices that have ethical implications. The evaluated trainings effectiveness was assessed by examining five key sensemaking processes, such as framing, emotion regulation, forecasting, self-reflection, and information integration that experts and novices apply in ethical decision-making. (...) Mental models of trained and untrained graduate students, as well as faculty, working in the field of physical sciences were compared using a think-aloud protocol 6 months following the ethics training. Evaluation and comparison of the mental models of participants provided further validation evidence for sensemaking training. Specifically, it was found that trained students applied metacognitive reasoning strategies learned during training in their ethical decision-making that resulted in complex mental models focused on the objective assessment of the situation. Mental models of faculty and untrained students were externally-driven with a heavy focus on autobiographical processes. The study shows that sensemaking training has a potential to induce shifts in researchers’ mental models by making them more cognitively complex via the use of metacognitive reasoning strategies. Furthermore, field experts may benefit from sensemaking training to improve their ethical decision-making framework in highly complex, novel, and ambiguous situations. (shrink)

Branching-time temporal logics have proved to be an extraordinarily successful tool in the formal specification and verification of distributed systems. Much of their success stems from the tractability of the model checking problem for the branching time logic CTL, which has made it possible to implement tools that allow designers to automatically verify that systems satisfy requirements expressed in CTL. Recently, CTL was generalised by Alur, Henzinger, and Kupferman in a logic known as Alternating-time Temporal Logic (ATL). The key insight (...) in ATL is that the path quantifiers of CTL could be replaced by cooperation modalities, of the form , where is a set of agents. The intended interpretation of an ATL formula is that the agents can cooperate to ensure that holds (equivalently, that have a winning strategy for ). In this paper, we extend ATL with knowledge modalities, of the kind made popular in the work of Fagin, Halpern, Moses, Vardi and colleagues. Combining these knowledge modalities with ATL, it becomes possible to express such properties as group can cooperate to bring about iff it is common knowledge in that . The resulting logic — Alternating-time Temporal Epistemic Logic (ATEL) — shares the tractability of model checking with its ATL parent, and is a succinct and expressive language for reasoning about game-like multiagent systems. (shrink)

Wood, Kressel, Joshi, and Louie report that published, but not unpublished, studies of masculinity, dominance, symmetry, and health preferences show significant overall effects of cycle phase. They interpret this as evidence that reports of cyclic shifts in mate preferences are artifacts of publication bias. I will first discuss why these conclusions do not necessarily follow straightforwardly from their results. I will then discuss their findings for health preferences specifically, concluding that their dismissal of a significant overall effect of cycle phase (...) is unreasonable. (shrink)

This paper contributes to the semantic typology of dependent indefinites, by accounting for the distribution and interpretation of the Romanian indefinite vreun. It is shown that its occurrences are restricted to negative polarity and a subset of modal contexts. More specifically, the study of its behavior in intensional environments reveals that vreun is systematically incompatible with non-epistemic operators, a restriction we capture by proposing a novel empirical generalization (‘the epistemic constraint’). To account for the observed pattern, we adopt the unitary (...) approach to polarity in Chierchia (Logic in Grammar: polarity, free choice and intervention, 2013a; in: Fălăuş (ed.) Alternatives in semantics, 2013b) and derive the properties of vreun from its obligatory association with alternatives. Its distributional restrictions are argued to follow from the interplay between the types of alternatives it activates (scalar and subdomain alternatives), the way these alternatives are factored into meaning (via an independently motivated mechanism of exhaustification) and the lexical semantics of the operators in the context of occurrence. We propose that the epistemic constraint arises from the lexicalization of an inference (anti-total variation) that non-epistemic operators can never satisfy. (shrink)

Our concept of choice is integral to the way we understand others and ourselves, especially when considering ourselves as free and responsible agents. Despite the importance of this concept, there has been little empirical work on it. In this paper we report four experiments that provide evidence for two concepts of choice—namely, a concept of choice that is operative in the phrase having a choice and another that is operative in the phrase making a choice. The experiments indicate that the (...) two concepts of choice can be differentiated from each other on the basis of the kind of alternatives to which each is sensitive. The results indicate that the folk concept of choice is more nuanced than has been assumed. This new, empirically informed understanding of the folk concept of choice has important implications for debates concerning free will, responsibility, and other debates spanning psychology and philosophy. -/- Specifically, 'having a choice' appears to require genuinely open alternatives, or alternative possibilities that are actually realizable, while 'making a choice' appears to only require psychological open alternatives, or the ability to consider alternatives independent of whether these alternatives are actually realizable. We argue that these findings are relevant to the free will debate because choice is central to the folk concept of free will and many philosophical analysis of free will. The kinds of alternatives required for having a choice appear to be incompatibilist in nature, while the kinds of alternatives required for making a choice appear to be compatibilist in nature. If free will requires having choices, then this is perhaps evidence against compatibilism. If free will requires making choices, then this is perhaps evidence in favor of--or at least consistent with--compatibilism. (shrink)

Lewisian reference magnetism about linguistic content determination [Lewis 1983 has been defended in recent work by Weatherson [2003] and Sider [2009], among others. Two advantages claimed for the view are its capacity to make sense of systematic error in speakers' use of their words, and its capacity to distinguish between verbal and substantive disagreements. Our understanding of both error and disagreement is linked to the role of usage and first order intuitions in semantics and in linguistic theory more generally. I (...) argue, partially on the basis of these more general considerations, that reference magnetism delivers implausible results. Specifically, I argue that the proponent of reference magnetism maintains her analysis of genuinely systematic error at the cost of an empirically unjustifiable error theory regarding ordinary usage. In response, I describe an alternative view of content determination—MUMPS, or Meaning is Use Minus Pragmatics—which is not committed to such error theories. Despite this advantage, MUMPS has high prima facie costs. On such a view, there is a great deal of variation in linguistic meaning across speakers and times. As a result, a large number of seemingly mistaken claims are analysed as expressing true propositions. Correspondingly, a large number of seemingly substantive disagreements are analysed as terminological. However, I argue that these consequences are not as costly as they seem. Despite appearances, MUMPS is consistent with objective, metaphysically realist adjudication of disagreements, even in cases where meanings are not shared and where both parties to a dispute speak truly. MUMPS thus allows for a more nuanced understanding of linguistic usage, change, and variation, without imposing a commitment to any form of metaphysical anti-realism. (shrink)

Concerns about the unsustainability of the conventional food system have brought attention to so called alternative food networks, which are widely thought to be more sustainable. However, claims made about AFNs’ sustainability have been subject to a range of criticisms. Some of them present counterevidence, while others have pointed to problematic underlying features in the academic literature and popular discourse that may hamper our understanding of AFNs’ sustainability. Considering these criticisms, together with the fact that the literature often addresses a (...) specific type of AFN or a specific sustainability-related issue, it is hard to form a clear overall picture of the sustainability promise of AFNs. In this article, we seek to contribute to a clearer understanding of this promise through a structured review, focusing on links between AFN characteristics and sustainability. Through an analysis of AFN conceptualizations reflected in the literature, we identify and consolidate their key characteristics. We then synthesize claims of how these characteristics may translate into sustainability, finding a wide range of potential direct and indirect impacts. Examining these from different angles, we find that the sustainability promise of AFNs found in these claims is qualified by the presence of potentially unaddressed issues, by criticisms regarding for example the evidence base of the assumed impacts and their power in addressing sustainability, and by considerations of how these impacts might play out in actual, real-life food networks. Indirect impacts of learning and participation may be highly significant for sustainability. We conclude with recommendations for research and practice. (shrink)

Studies of chimeras and in vivo development demonstrate that cell lineages are often quite variable, apparently in response to chance perturbations. This points to an apparent contradiction: although individual cells are the units of genetic information and differentiation, not all cellular events need be precise for the development of functional organisms. The social organization of ants can serve as a metaphor that helps understand the mechanisms that underlie such development. Ants suggest that continued cellular interactions and environmental conditions could specify (...) the proportion and general location of specialized units. Leaf venation is used as a concrete example of this general principle. A signal produced continuously by all cells specifies a requirement for vein differentiation. The cells that respond by differentiation then transport the signal away from the leaf; this removal acting as a feedback indicating that the requirement is being met. Because transport increases during vein differentiation, early initiation occurs in excess and vein ‘competition’ for the signal assures an acceptable outcome. Such specification would be robust since it does not depend on events in any single cell, and chance events, rather than being corrected or reversed, may be built upon in reaching an expected, collective phenotype. The absence of detailed information preceding development distinguishes this hypothesis from the common alternatives of a program or blueprint. Collective specification would have important implications for developmental plasticity and evolution. BioEssays 25:897–903, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In a recent paper, Martin Hackl and I identified a variety of circumstances where scalar implicatures, questions, definite descriptions, and sentences with the focus particle only are absent or unacceptable (Fox and Hackl 2006, henceforth F&H). We argued that the relevant effect is one of maximization failure (MF): an application of a maximization operator to a set that cannot have the required maximal member. We derived MF from our hypothesis that the set of degrees relevant for the semantics of degree (...) constructions is always dense (the Universal Density of Measurement, UDM). The goal of this paper is to present an apparent shortcoming of F&H and to argue that it is overcome once certain consequences of the proposal are shown to follow from more general properties of MF. Specifically, the apparent problem comes from evidence that the core generalizations argued for in F&H extend to areas for which an account in terms of density is unavailable. Nevertheless, I will argue that the account could still be right. Certain dense sets contain "too many alternatives" for there to be a maximal member, thus leading to MF. But, there are other sets that lead to the same predicament. My goal will be to characterize a general signature of MF in the hope that it could be used to determine the identity of alternatives in areas where their identity is not clear on independent grounds. (shrink)