Determination of the structure of the nucleic acids involved inter alia identification of the ring atom of the purines to which ribose or deoxyribose was attached. This in turn depended on knowledge of the ring atoms that could be so substituted and hence that were bonded to replaceable hydrogens. In 1897 E. Fischer adopted a convention of depicting this hydrogen at position 7 of the purine ring, although he was aware that it was equally correct to depict it at position (...) 9. Many later workers apparently came to believe that the 7H structure was more than just a convention, and considered that the sugar was attached solely at position 7 and could not be attached to position 9. When evidence was presented in 1933 that the sugar was in fact attached to position 9, the force of this convention apparently was so strong that many were reluctant to accept this evidence. More than 20 years was required for complete acceptance of the new view, and Fischer's convention was still being used in other contexts until at least 1967. (shrink)

Implicit in the theoretical chemical writings of Antoine Laurent Lavoisier is a theory of language that is not in complete harmony with the philosopher of language whom he takes as his explicit authority, Condillac. Lavoisier's reform of the nomenclature of chemistry leads to his dividing scientific language into two sets with different properties: a denotative artificial nomenclature and connotative natural language. This division supposedly permits knowledge to be stored in the nomenclature while the natural language retains (...) the rhetorical tools necessary for creative thought and argument. The consequences of this reform of scientific language are, however, the opposite of what Lavoisier had intended. (shrink)

Chemical elements are the bricks with which Chemistry is build. Their names had a history, but part of it is forgotten or barely known. In this article the forgotten, no more used, never used, and alternatively used names and symbols of the elements are reviewed, bringing to us some surprises and deeper knowledge about the richness of Chemistry. It should be stressed that chemical elements are important not only for chemists but for all people dealing with science. As (...) in any other aspect of our lives, we tend to better understand something by knowing his history. By knowing them we can have a deeply understanding of how science evolves and how it is influenced by our human aspects. (shrink)

This Brief presents an historical investigation into the reaction between ferric ions and thiocyanate ions, which has been viewed in different ways throughout the last two centuries. Historically, the reaction was used in chemical analysis and to highlight the nature of chemical reactions, the laws of chemistry, models and theories of chemistry, chemical nomenclature, mathematics and data analysis, and instrumentation, which are important ingredients of what one might call the nature of chemistry. Using the history of (...) the iron thiocyanate reaction as a basis, the book’s main objective is to explore how chemistry develops its own knowledge base; how it assesses the reliability of that base; and how some important tools of the trade have been brought to bear on a chemical reaction to achieve understanding, a worthwhile goal of any historical investigation. (shrink)

In this paper we present a semantic analysis of the application of didactic constructivism to chemical education. We show that the psychological basis of constructivism yield, when applied to chemistry, an internalist semantics for the chemical names. Since these names have been presented as typical examples of an externalism for kind terms, a fundamental incompatibility ensues. We study this situation, to conclude that it affects chemical education at every level. Finally, we present a preliminary analysis of this (...) problem from the point of view of physics. (shrink)

This paper explores the origins of the analytical definition of simple substance, a concept whose central importance in the new chemistry of Lavoisier and his colleagues is now widely recognized. I argue that this notion derived from the practical activities of metallurgists and mineral assayers, and that the theoretical elaboration necessary for the analytical concept to be understood as relevant to chemistry was inspired by the efforts of enlightened rulers in Sweden and Germany to turn chemical science to the (...) benefit of mining—and thus of the various state treasuries. The involvement of chemically-literate mineralogists in the mining industry led them to adopt the principle that analytically-determined composition was a far more essential aspect of minerals than any mere congeries of properties. The same men who pioneered the analytical notion of simple substance also inaugurated the attempt to define a nomenclature for chemistry based exclusively on composition, as determined in the laboratory. -/- . (shrink)

The aim of the series of the three articles entitled “Name game…” is to present the historical information about nomenclature history of every known chemical element. The process of naming each chemical element is analyzed, with particular emphasis on the first publication with a given name. It turned out that in many cases this information is not obvious and unambiguous, and the published data are even contradictory. In a few cases, the names of the elements were changed (...) even several times. Moreover, even when the author of a given element name is known, it is sometimes not entirely clear in which publication he/she first used it. Therefore, the series of three articles are an attempt to sort out the issue of first publishing of the names of all 118 chemical elements known so far, based on original source texts, available thanks to the digitization of a number of collections of scientific literature. The articles are divided according to the time of discoveries: (1) research till the end of the 18th century, (2) discoveries in the 19th century, (3) discoveries and syntheses of elements in the 20th and 21st centuries. This particular article presents the history of naming of the first 37 elements: known from antiquity, discovered in nature and named in 17th and 18th century. (shrink)

Lavoisier sistematizou a nomenclatura química com base na Lógica de Condillac, e ambos os autores foram inspirados por John Locke. Atacou persistentemente a teoria flogística até a sua derrocada e conseguiu a adesão de vários cientistas a sua teoria do oxigênio. O uso da nova nomenclatura química implicava a aceitação dessa última teoria. Escreveu várias obras, entre elas Méthode de nomenclature chimique e Traité élémentaire de chimie, nas quais divulgou a nova nomenclatura química por toda a Europa. Assumindo que (...) a ciência é um produto cultural, tecemos considerações a luz do pensamento de Thomas Kuhn e Ludwik Fleck. (shrink)

During the summer of 1900, the Chemical Section of the Society for the Promotion of Russian Industry and Commerce in Warsaw published a very special booklet in which prominent philologists debated proposals concerning adjustments to chemical nomenclature. Several issues were discussed, including systems of classification of chemical compounds, new specialist terms, and which element names to select among the many then in use. Chemists translated and modified these proposals while strongly disagreeing with using philological expertise. But (...) both the booklet and the debate were novelties within discussions on chemical terminology, which provides an opportunity to examine the peculiarities of such endeavors. This article examines this special moment in the history of chemistry when chemists ceded (partially) their authority over their subject to philologists. I discuss how this episode was shaped by the low grade of academic professionalization in the Polish-language scholarly community and the practical needs of industry, which engendered different habitus among scholars debating chemical issues. This paper asks what language was for chemists and philologists and which epistemic ideals were linked with it. I argue that this episode was a form of interdisciplinary interrogation in which philologists and their arguments were instrumentalized for the needs of chemists. (shrink)

The focus of this contribution lies on eighteenth-century chemistry up to Lavoisier’s anti-phlogistic chemical system. Some main features of chemistry in this period will be examined by discussing classificatory practices and the understanding of the substances these practices imply. In particular, the question will be discussed of whether these practices can be regarded as natural historical practices and, hence, whether chemistry itself was a special natural history (part I). Furthermore, discussion of the famous Methode de nomenclature chimique (1787) (...) raises the question of what modes of classification tell us about chemists’ understanding of the substances they deal with (part II). Finally, in investigating what taxonomic orders reveal about deep structures of chemists’ understanding of the world of substances, the contribution will examine the question of whether Lavoisier’s anti-phlogistic chemical system was a revolution on the level of a deep structure or a revision within the untouched frame of such a structure (part III). (shrink)

This paper examines the negative response to Dalton’s atomic symbols by situating them in the context of the normative eighteenth-century representational system of affinity tables. Aesthetic analysis of the affinity tables reveals them as schema embedded with a potent functionalist empiricism. In contrast, the aesthetics of Dalton's symbols is associated with hypothetico-deductivism and alchemical iconicism.

We analyze the connections of Lavoisier system of nomenclature with Leibniz’s philosophy, pointing out to the resemblance between what we call Leibnizian and Lavoisian programs. We argue that Lavoisier’s contribution to chemistry is something more subtle, in so doing we show that the system of nomenclature leads to an algebraic system of chemical sets. We show how Döbereiner and Mendeleev were able to develop this algebraic system and to find new interesting properties for it. We pointed out (...) the resemblances between Leibniz program and Lavoisier legacy, particularly regarding the lingua philosophica for understanding and thinking Nature, in this particular case, chemistry. In the second part we discuss, from the linguistic viewpoint, how Lavoisian algebraic system may be taken further to build a language. We study the constituents of such a chemical language. Finally, we formalize some of the ideas here presented by using elements of network theory and discrete mathematics. (shrink)

Lavoisier defined an element as a chemicalsubstance that cannot be decomposed usingcurrent analytical methods. Mendeleev saw anelement as a substance composed of atoms of thesame atomic weight. These `definitions' doquite different things: Lavoisier'sdistinguishes the elements from the compounds,so that the elements may form the basis of acompositional nomenclature; Mendeleev's offersa criterion of sameness and difference forelemental substances, while Lavoisier's doesnot. In this paper I explore the historical andtheoretical background to each proposal.Lavoisier's and Mendeleev's explicitconceptions of elementhood differed from eachother, (...) and from the official IUPAC definitionof `element' of the 1920s. However, Lavoisierand Mendeleev both subscribed to – andemployed – a deeper notion of a chemicalelement as the component of compound substancesthat (i) can survive chemical change, and (ii)explains the chemical behaviour of itscompounds. (shrink)

The growth of botany following European expansion and the consequent increase of plants necessitated significant development in classification methodology, during the key decades spanning the late 17th to the mid-18th century, leading to the emergence of a “natural method.” Much of this development was driven by the need to accurately identify medicinal plants, and was founded on the principle of analogy, used particularly in relation to properties. Analogical reasoning established correlations (affinities) between plants, moreover between their external and internal characteristics (...) (here, medicinal properties). The diversity of plants, names, and botanical information gathered worldwide amplified confusion. This triggered the systematisation of the collection and referencing of data, prioritizing the meticulous observation of plant characteristics and the recording of medicinal properties as established by tradition: it resulted in principled methods of natural classification and nomenclature, represented by the _genus_, to enhance reliability of plant knowledge, which was crucial in medical contexts. The scope of botany increased dramatically, with new methods broadening studies beyond traditional medicinal plants. The failure of chemical methods to predict properties, particularly of unknown flora, amplified the reliance on analogy and on natural affinities. (shrink)

The ArgumentThis paper charts eighteenth-century chemistry's transition from its definition as an art to its proclaimed status as a science. Both the general concept of art and specific practices of eighteenth-century chemists are explored to account for this transition. As a disciplined activity, art orients practitioners' attention toward particular directions and away from others, providing a structured space of possibilities within which their discipline develops. Consequently, while chemists throughout the eighteenth century aspired to reveal nature's “true voice,” the path of (...) their investigations was directed by and toward their laboratory manipulations. So long as the chemical community maintained an ethos of polite cooperation and eschewed theoretical wrangling, this point was hidden by a rhetoric of “matter of fact” reporting. But as “facts” mounted in the 1770s and 1780s, especially in pneumatic chemistry, cooperation gave way to contention as chemists sought to name and organize their findings without the guidance of a communally accepted “natural” system. Lavoisier and his fellow “new” chemists offered a forceful solution to this dilemma by introducing a revolutionary network of theories, nomenclature, and instruments that unabashedly fused the productive manipulation of their laboratory work with what they claimed as the structure and activity of nature. (shrink)

Until the 1860s, science in Russia was principally conducted in Latin, French, and German. In the years leading up to and following the creation of the Russian Chemical Society in 1868, Russian chemists – treated in this article as both a representative sample of Russian scientists and also practitioners of the flagship science of the period – debated both the merits of developing a nomenclature that would enable Russian to “hold” modern inorganic and organic chemistry, and the practicability (...) of doing so. The article explores debates over whether Russian syntax could be adapted to represent chemical compounds according to emerging western conventions or in a sui generis manner, as well as the struggles of Russian scientists to use French and German to communicate with their foreign counterparts, arguing that the details of these debates highlight both the fruitfulness and the limits of using “standardization” as a framework for linguistic codification. (shrink)

In the 18th century, the concept of ‘affinity’, ‘principle’ and ‘element’ dominated chemical discourse, both inside and outside the laboratory. Although much work has been done on these terms and the methodological commitments which guided their usage, most studies over the past two centuries have concentrated on their application as relevant to Lavoisier's oxygen theory and the new nomenclature. Kim's affinity challenges this historiographical trajectory by looking at several French chemists in the light of their private thoughts, public (...) disputations and communal networks. In doing so, she tells a complex story which points to the methodological and practical importance of industrial and medical chemistry. The following review highlights the advantages and snares of such an approach and makes a few historiographical points along the way. (shrink)

For most of its history, the psychology of reasoning was dominated by binary extensional logic. The so-called “new paradigm” instead puts subjective degrees of belief center stage, often represented as probabilities. We argue that the “new paradigm” is too vaguely defined and therefore does not allow a clear decision about what falls within its scope and what does not. We also show that there was not one settled theoretical “old” paradigm, before the new developments emerged, and that the alleged new (...) paradigm is less revolutionary as the term suggests. A more veridical view is that current progress is developing in continuities where rival research programs can thrive or fail in the face of new experimental findings. The article closes with some topics where more connections between competing research programs are likely to promote progress in our understanding of human reasoning. (shrink)

According to widespread opinion, the meaning of body part terms is determined by salient discontinuities in the visual image; such that hands, feet, arms, and legs, are natural parts. If so, one would expect these parts to have distinct names which correspond in meaning across languages. To test this proposal, we compared three unrelated languages—Dutch, Japanese, and Indonesian—and found both naming systems and boundaries of even basic body part terms display variation across languages. Bottom-up cues alone cannot explain natural language (...) semantic systems; there simply is not a one-to-one mapping of the body semantic system to the body structural description. Although body parts are flexibly construed across languages, body parts semantics are, nevertheless, constrained by non-linguistic representations in the body structural description, suggesting these are necessary, although not sufficient, in accounting for aspects of the body lexicon. (shrink)

There is a persisting debate about what chemical bonds are and whether they exist. I argue that chemical bonds are real patterns of interactions between subatomic particles. This proposal resolves the problems raised in the context of existing understandings of the chemical bond and provides a novel way to defend the reality of chemical bonds.

According to widespread opinion, the meaning of body part terms is determined by salient discontinuities in the visual image; such that hands, feet, arms, and legs, are natural parts. If so, one would expect these parts to have distinct names which correspond in meaning across languages. To test this proposal, we compared three unrelated languages—Dutch, Japanese, and Indonesian—and found both naming systems and boundaries of even basic body part terms display variation across languages. Bottom‐up cues alone cannot explain natural language (...) semantic systems; there simply is not a one‐to‐one mapping of the body semantic system to the body structural description. Although body parts are flexibly construed across languages, body parts semantics are, nevertheless, constrained by non‐linguistic representations in the body structural description, suggesting these are necessary, although not sufficient, in accounting for aspects of the body lexicon. (shrink)

In this paper I investigate the relationship between vernacular kind terms and specialist scientific vocabularies. Elsewhere I have developed a defence of realism about the chemical elements as natural kinds. This defence depends on identifying the epistemic interests and theoretical conception of the elements that have suffused chemistry since the mid-eighteenth century. Because of this dependence, it is a discipline-specific defence, and would seem to entail important concessions to pluralism about natural kinds. I argue that making this kind of (...) concession does not imply that vernacular kind terms have independent application conditions. Nor does it preclude us saying that chemists, with their particular epistemic interests, have discovered the underlying nature of water, the stuff that is named and thought about in accordance with the practical interests of everyday life. There are limits to pluralism. (shrink)

Following Kripke and Putnam, the received view of chemical kinds has been a microstructuralist one. To be a microstructuralist about chemical kinds is to think that membership in said kinds is conferred by microstructural properties. Recently, the received microstructuralist view has been elaborated and defended, but it has also been attacked on the basis of complexities, both chemical and ontological. Here, I look at which complexities really challenge the microstructuralist view; at how the view itself might be (...) made more complicated in order to accommodate such challenges; and finally, at what this increasingly complicated picture implies for our standard assessment of chemical kindhood—primarily, for the widespread assumption that chemical kinds in general are more neat and tidy than those messy biological ones. _1_ The Received View _2_ A Taxonomy of Chemical Kinds _3_ Atomic Number _4_ H2O, H3O+, OH−, and More _5_ Complicating the Microstructuralist Picture _6_ Concrete and Other Mixtures _7_ Macromolecules, Especially Proteins _8_ Abandoning Sameness of Elemental Composition _9_ Not So Different after All. (shrink)

Long-standing neglect of the chemical senses in the philosophy of perception is due, mostly, to their being regarded as ‘lower’ senses. Smell, taste, and chemically irritated touch are thought to produce mere bodily sensations. However, empirically informed theories of perception can show how these senses lead to perception of objective properties, and why they cannot be treated as special cases of perception modelled on vision. The senses of taste, touch, and smell also combine to create unified perceptions of flavour. (...) The nature of these multimodal experiences and the character of our awareness of them puts pressure on the traditional idea that each episode of perception goes one or other of the five senses. Thus, the chemical senses, far from being peripheral to the concerns of the philosophy of perception, may hold important clues to the multisensory nature of perception in general. (shrink)

This book examines the way in which Robert Boyle seeks to accommodate his complex chemical philosophy within the framework of a mechanistic theory of matter. More specifically, the book proposes that Boyle regards chemical qualities as properties that emerged from the mechanistic structure of chymical atoms. Within Boyle’s chemical ontology, chymical atoms are structured concretions of particles that Boyle regards as chemically elementary entities, that is, as chemical wholes that resist experimental analysis. Although this interpretation of (...) Boyle’s chemical philosophy has already been suggested by other Boyle scholars, the present book provides a sustained philosophical argument to demonstrate that, for Boyle, chemical properties are dispositional, relational, emergent, and supervenient properties. This argument is strengthened by a detailed mereological analysis of Boylean chymical atoms that establishes the kind of theory of wholes and parts that is most consistent with an emergentist conception of chemical properties. The emergentist position that is being attributed to Boyle supports his view that chemical reactions resist direct explanation in terms of the mechanistic properties of fundamental particles, as well as his position regarding the scientific autonomy of chymistry from mechanics and physics. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Given the rich diversity of research fields usually ascribed to chemistry in a broad sense, the present paper tries to dig our characteristic parts of chemistry that can be conceptually distinguished from interdisciplinary, applied, and specialized subfields of chemistry, and that may be called chemistry in a very narrow sense, or 'the chemical core of chemistry'. Unlike historical, ontological, and 'anti-reductive' approaches, I use a conceptual approach together with some methodological implications that allow to develop step by step a (...) kind of cognitive architecture for chemistry, which basically contains: (1) systematic chemical knowledge on the experimental level; (2) clarification of chemical species; (3) chemical classification systems; (4) theoretical foundation through the chemical theory of structural formulas. In a succeeding paper the results will be checked for resisting physicalistic reduction. (shrink)

What is it that turns a new observation into a true scientific discovery? And who may claim the credit? Theoreticians of science, the foremost thinkers of their times among them, have tried to answer these fundamental questions about the nature of scientific progress and discovery. With clear insight and the chemical as well as philosophical wisdom gained from over fifty years as a practising chemist, Jerome Berson puts their theories to the test. The development of chemistry into a "modern" (...) science during the last two centuries provides him with ample cases to illustrate the way scientific progress really happens. Kekul?'s struggle to arrive at a structure for benzene, the paradigm change that was necessary to accept the reality of molecular rearrangements, and other episodes are retold here from the philosopher's as well as from the practitioner's perspective, shedding light on the way scientists think and act. Berson's account of the rather unphilosophical way in which scientific discoveries are made includes the realization that even a false hypothesis, such as Woodward's ideas about the biosynthesis of strychnine, may help rather than hinder scientific progress. Scientists of all ages, as well as many non-scientists, will find this a highly readable and unusual book. (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused (...) review of what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

Quine, taking the molecular constitution of matter as a paradigmatic example, offers an account of the relation between theory confirmation and ontology. Elsewhere, he deploys a similar ontological methodology to argue for the existence of mathematical objects. Penelope Maddy considers the atomic/molecular theory in more historical detail. She argues that the actual ontological practices of science display a positivistic demand for “direct observation,” and that fulfillment of this demand allows us to distinguish molecules and other physical objects from mathematical abstracta. (...) However, the confirmation of the atomic/molecular theory and the development of scientists’ ontological attitudes towards atoms was more complicated and subtle than even Maddy supposes. The present paper argues that the history of the theory in fact supports neither Quine’s and Maddy’s accounts of scientific ontology. There was no general demand from scientists to “see” atoms before they were reckoned to be real; but neither did the indispensable appearance of atoms in the best theory of chemical combination suffice to convince scientists of their reality. (shrink)

A chemical substance is instantiated in the material world by a number of quantities of such substance, placed in different locations. A change of location implies a change in the net of relationships entertained by the QCS with the region wherein it is found. This fact entails changes of the ontological status of the CS, as this is not fully determined by the inherent features of the CS and includes a relevant relational contribution. In order to demonstrate this thesis, (...) we have chosen to analyse the status of quantities of a same CS that are synchronically located in different spacetime regions: a synthetic lab, a lab where the QCS is turned into a material, an industrial plant, the market where the QCS gets a price and a dump waste where the QCS is discarded, respectively: Chemical substance Open image in new window material Open image in new window product Open image in new window goods Open image in new window wasteThe use of first-order predicate logic, mereology and locative logic allows carrying out a regimentation process that highlights the ontological commitments implied by the formal expressions through which each element of the aforementioned series can be described. The presence of relational properties discloses the systemic nature of the CS instantiated within a spacetime region. The implications of such an aspect are discussed. (shrink)

Surgical castration of sex offenders has been used in several countries to prevent sexual recidivism and is still practiced in several states in the United States. In Europe, it has remained in limited use in Germany and in the Czech Republic (Douglas et al. 2013). Since the 1960s, most jurisdictions have replaced irreversible surgical castration of sex offenders with reversible chemical castration with anti-androgen drugs. In Denmark, use of surgical castration was stopped in 1970, and since the late 1980s, (...) serious sex offenders have on a trial basis been treated with anti-androgen drugs (Hansen and Lykke-Olesen 1997). In 1997, an official treatment program for sex offenders was introduced on a trial basis, and in 2011 this scheme was made permanent (Nielsen 2001).The first part of the scheme covers persons with a suspended sentence with conditions of sexological treatment. This program serves as an alternative to suspended sentences of up to one and a half years of prison for crimina. (shrink)

Crutchfield and Redinger (2024) argue that, ceteris paribus, it is morally worse to deploy a restraint that undermines a basic liberty than one that does not.1 This is a plausible view, and is like...

From the perspective of successive events, chemical reactions are expressed or thought about, in terms of the cause-effect category. In this work, I will firstly discuss some aspects of causation and interaction in chemistry, argue for the interaction, and propose an alternative or complementary representation scheme called “interaction diagram”, that allows representing chemical reactions through a geometric diagram. The understanding of this diagram facilitates the analysis of reactions in terms of the interaction, or reciprocal action, among the participating (...) entities. Secondly, I will describe the model and provide examples and finally, I will discuss the scope and limitations of the current development status of the model. (shrink)

In several jurisdictions, sex offenders may be offered chemical castration as an alternative to further incarceration. In some, agreement to chemical castration may be made a formal condition of parole or release. In others, refusal to undergo chemical castration can increase the likelihood of further incarceration though no formal link is made between the two. Offering chemical castration as an alternative to further incarceration is often said to be partially coercive, thus rendering the offender’s consent invalid. (...) The dominant response to this objection has been to argue that any coercion present in such cases is compatible with valid consent. In this article, we take a different tack, arguing that, even if consent would not be valid, offering chemical castration will often be supported by the very considerations that underpin concerns about consent: considerations of autonomy. This is because offering chemical castration will often increase the offender’s autonomy, both at the time the offer is made and in the future. (shrink)

The chemical characterization of the substance responsible for the phenomenon of “transformation” of pneumococci was presented in the now famous 1944 paper by Avery, MacLeod, and McCarty. Reception of this work was mixed. Although interpreting their results as evidence that deoxyribonucleic acid (DNA) is the molecule responsible for genetic changes was, at the time, controversial, this paper has been retrospectively celebrated as providing such evidence. The mixed and changing assessment of the evidence presented in the paper was due to (...) the work’s interpretive flexibility – the evidence was interpreted in various ways, and such interpretations were justified given the neophytic state of molecular biology and methodological limitations of Avery’s transformation studies. I argue that the changing context in which the evidence presented by Avery’s group was interpreted partly explains the vicissitudes of the assessments of the evidence. Two less compelling explanations of the reception are a myth-making account and an appeal to the wartime historical context of its publication. (shrink)

The paper surveys the origins of chemical engineering in England in the late nineteenth and early twentieth centuries. It deals particularly with the recognition of the field as an independent discipline, its relations with chemistry and mechanical engineering, and the influence on its growth of industrial ‘demand’. The position of chemical engineering in public discourse, in the City and Guilds Central Institution, and at Imperial College of Science and Technology and University College London are discussed, together with the (...) creation of the Institution of Chemical Engineers in 1922. The idea that the discipline grew merely in response to the demands of industrial capitalists is rejected, and a variety of other interest groups is shown to have participated. (shrink)