Background: SNOMED CT is a large terminology system designed to represent all aspects of healthcare. Its current form and content result from decades of bottom-up evolution. Due to SNOMED CT’s formal descriptions, it can be considered an ontology. The Basic Formal Ontology (BFO) is a foundational ontology that proposes a small set of disjoint, hierarchically ordered classes, supported by relations and axioms. In contrast, as a typical top-down endeavor, BFO was designed as a foundational framework for domain ontologies in the (...) natural sciences and related disciplines. Whereas it is mostly assumed that domain ontologies should be created as extensions of foundational ontologies, a post-hoc harmonization of consolidated domain ontologies in use, such as SNOMED CT, is known to be challenging. Methods: We explored the feasibility of harmonizing SNOMED CT with BFO, with a focus on the SNOMED CT Clinical Finding hierarchy. With more than 100,000 classes, it accounts for about one third of SNOMED CT’s content. In particular, we represented typical SNOMED CT finding/disorder concepts using description logics under BFO. Three representational patterns were created and the logical entailments analyzed. Results: Under a first scrutiny, the clinical intuition that diseases, disorders, signs and symptoms form a homogeneous ontological upper-level class appeared incompatible with BFO’s upper-level distinction into continuants and occurrents. The Clinical finding class seemed to be an umbrella for all kinds of entities of clinical interest, such as material entities, processes, states, dispositions, and qualities. This suggests the conclusion that Clinical finding would not be a suitable upper-level class from an BFO perspective. On closer inspection of the taxonomic links within this hierarchy and the implicit meaning derived thereof, it became clear that Clinical finding classes do not characterize the entity (e.g. a fracture, allergy, tumor, pain, hemorrhage, seizure, fever) in a literal sense but rather the condition of a patient having that fracture, allergy, pain etc. This gives sense to the current characteristic of the Clinical Finding hierarchy, in which complex classes are modeled as subclasses of their constituents. Most of these taxonomic links are inferred, as the consequence of the ‘role group’ design pattern, which is ubiquitous in SNOMED CT and has often been subject of controversy regarding its semantics. Conclusion: Our analyses resulted in the proposal of (i) equating SNOMED CT’s ‘role group’ property with the reflexive and transitive BFO relation ‘has occurrent part’; and (ii) reinterpreting Clinical Findings as Clinical Occurrents, i.e. temporally extended entities in an organism, having one or more occurrents as temporal parts that occur in continuants. This re-interpretation was corroborated by a manual analysis of classes under Clinical Finding, as well as the identification of similar modeling patterns in other ontologies. As a result, SNOMED CT does not require any content redesign to establish compatibility with BFO, apart from this re-interpretation, and a suggested re-labeling. Regarding the feasibility of harmonizing terminologies with principled foundational ontologies post-hoc, our results provide support to the assumption that this does not necessarily require major redesign efforts, but rather a careful analysis of the implicit assumptions of terminology curators and users. (shrink)

At the heart of ethics reside the concepts of good and bad; they are at work when we assess whether a person is virtuous or vicious, an act right or wrong, a decision defensible or indefensible, a goal desirable or undesirable. But there are many varieties of goodness and badness. At their core lie intrinsic goodness and badness, the sort of value that something has for its own sake. It is in virtue of intrinsic value that other types of value (...) may be understood, and hence that we can begin to come to terms with questions of virtue and vice, right and wrong, and so on. This book investigates the nature of intrinsic value: just what it is for something to be valuable for its own sake, just what sort of thing can have such value, just how such a value is to be computed. In the final chapter, the fruits of this investigation are applied to a discussion of pleasure, pain, and displeasure and also of moral virtue and vice, in order to determine just what value lies within these phenomena. (shrink)

In this paper I propose to shed new light on the role of feeling in Kant’s psychology of moral motivation by focusing on the concept of an incentive (Triebfeder), a term he borrowed from one of his most important rationalist predecessors, Alexander Gottlieb Baumgarten. I argue that, similar to Baumgarten, Kant understands an incentive to refer to the ground of desire and that feelings function as a specific kind of ground within Kant’s psychology of moral action, namely as the ‘impelling (...) cause’ of desire. I claim that this interpretation has several advantages over the alternatives currently on offer in the literature. (shrink)

Wolff's book defends the Kantian idea of a "general logic" whose principles underlie special systems of deductive logic. It thus undermines "logical pluralism," which tolerates the co-existence of divergent systems of modern logic without asking for consistent common principles. Part I of Wolff’s book identifies the formal language in which the most general principles of logic must be expressed. This language turns out to be a version of syllogistic language already used by Aristotle. The universal validity of logical principles, as (...) well as the translatability of other logical languages into this language, are shown to depend only on the meanings of its logical vocabulary. Part II of the book answers the metalogical question concerning the deductive relation between general logic and special logical systems, which also have their own (less general) principles. This part identifies the rules according to which logical rules can be derived from principles. The main result of the book is that the highest principles of logic and metalogics are provided by the syllogistic, when properly understood. (shrink)

Current pharmacopoeias invariably refer to a category of ‘alkylating drugs’, still among the most widely used in cancer chemotherapy. They are described as acting through their ability to damage DNA, thus interfering with cell replication. Unfortunately, this mode of action implicates these drugs as carcinogens. Thus the early studies recalled in this essay proved to be relevant to our understanding of both the main problems with which cancer research concerns itself: the causation of cancer and possible methods of treatment of (...) this group of diseases. (shrink)

Neuropsychiatrist Michael T. H. Wong argues that the notions of soul, mind, brain, self and consciousness are no longer adequate on their own to explain humanity. He formulates a “third discourse” that brings philosophy neuroscience theology and psychiatry together as an innovative multilayered narrative for the person in the twenty-first century.

This chapter offers an account of Crusius’ conception of freedom. In the first part of the chapter I sketch Crusius’ understanding of ‘Thelematology’ or ‘science of the will’ and his conception of the will itself. In the second part of the paper I provide an account of Crusius’ conception of freedom of the will and I focus on two topics: his understanding of freedom as self-determination and his conception of free choice. Contrary to how some of the secondary literature portrays (...) his view, I argue that freedom of the will, for Crusius, is not best described as the freedom to choose otherwise or liberty of indifference. On the contrary, Crusius argues that free choice is rarely indifferent to its choices and is most often strongly inclined towards certain ends that free choice must overcome and choose against. (shrink)

Inspired by the work of Wilfrid Sellars, Michael Williams launches an all-out attack on what he calls "phenomenalism," the idea that our knowledge of the world rests on a perceptual or experiential foundation. The point of this wider-than-normal usage of the term "phenomenalism," according to which even some forms of direct realism deserve to be called phenomenalistic, is to call attention to important continuities of thought between theories often thought to be competitors. Williams's target is not phenomenalism in its (...) classical sense-datum and reductionist form but empiricism generally. Williams examines and rejects the idea that, unless our beliefs are answerable to a "given" element in experience, objective knowledge will be impossible. Groundless Belief was first published in 1977. This second edition contains a new afterword in which Williams places his arguments in the context of some current discussions of coherentism versus the Myth of the Given and explains their relation to subsequent developments in his own epistemological views. (shrink)

The fact that Gilbert Ryle and J.L. Austin seem to disagree about the ordinary use of words such as ‘voluntary’, ‘involuntary’, ‘voluntarily’, and ‘involuntarily’ has been taken to cast doubt on the methods of ordinary language philosophy. As Benson Mates puts the worry, ‘if agreement about usage cannot be reached within so restricted a sample as the class of Oxford Professors of Philosophy, what are the prospects when the sample is enlarged?’ (Mates, Inquiry 1:161–171, 1958, p. 165). In this chapter, (...) we evaluate Mates’s criticism alongside Ryle’s and Austin’s specific claims about the ordinary use of these words, assessing these claims against actual examples of ordinary use drawn from the British National Corpus (BNC). Our evaluation consists in applying a combination of methods: first aggregating judgments about a large set of samples drawn from the corpus, and then using a clustering algorithm to uncover connections between different types of use. In applying these methods, we show where and to what extent Ryle’s and Austin’s accounts of the use of the target terms are accurate as well as where they miss important aspects of ordinary use, and we demonstrate the usefulness of this new combination of methods. At the heart of our approach is a commitment to the idea that systematically looking at actual uses of expressions is an essential component of any approach to ordinary language philosophy. (shrink)

Should we allow performance-enhancing substances in competitive athletics? The first book of its kind, Well Played answers this question by urging us to a deeper appreciation for the purpose of sport. Giving special reference to performance-enhancing substances, Shafer challenges the incompleteness of the ethical arguments and contributes a Christian voice to the discussion. He initiates a theological conversation that is both scholarly and accessible, arguing that a distinctively Christian understanding of sport will have far-reaching implications for how we treat ethical (...) issues like doping. The values, beliefs, and practices within the Christian tradition show an alternative that prioritizes humility and friendship, grace and gratitude over the "win at all costs" mentality that drives the use of performance-enhancing substances for a competitive advantage. This groundbreaking book ventures into new theological territory as it explores the intersections of theology, philosophy of sport, and the ethics of doping. Theologians, ethicists, and pastors, as well as coaches, athletes, and sports fans will benefit from this book's thoughtful reflection on how Christians can play well in the modern sports culture. (shrink)

Arguments from perceptual variation challenge the view that colors are objective properties of objects, properties that objects have independent of how they are perceived. This paper attempts, first, to diagnose one central reason why arguments from perceptual variation seem especially challenging for objectivists about color. Second, we offer a response to this challenge, claiming that once we focus on determinate colors rather than the determinables they determine, a response to arguments from perceptual variation becomes apparent. Third, our nominal opponents are (...) relationalist (like Cohen in The red and the real: an essay on color ontology, Oxford University Press, Oxford, 2009) and we will argue that the main argument for rejecting objectivism commits the relationalist to a position that is more radical than the one he would wish to endorse. Fourth, we suggest that insight into which properties could be relational may be found by looking to our best scientific theories. (shrink)

According to Darwinian thinking, organisms are (for the most part) designed by natural selection, and so are (for the most part) integrated collections of adaptations, where an adaptation is a phenotypic trait that is a specialized response to a particular selection pressure. For animals that make their living in the Arctic, one adaptive problem is how to maintain body temperature above a certain minimum level necessary for survival. Polar bears' thick coats are a response to that selection pressure (surviving in (...) extreme cold). A thick coat makes a positive difference to a polar bear's fitness, since polar bears with very thin coats left fewer offspring than those with thicker coats. The foundational idea ofevolutionary psychologyis that brains are no different from any other organ with an evolutionary function, insofar as brains too are systems shaped by natural selection to solve adaptive problems. Thus brains have a particular functional organization because their behavioural effects tend, or once tended, to help maintain or increase the fitness of organisms with those brains. Prominent evolutionary psychologists (for example: Cosmides and Tooby, 1987; Cosmides and Tooby, 1994 and Symons, 1992) have endorsed the view that the last time any significant modifications were made by natural selection to the human brain's functional architecture, we were hunter-gatherers, inhabiting a world quite different from that which we now inhabit. That world was the Pleistocene epoch, between about 2 million years ago and 10 thousand years ago. On this view, then, the Pleistocene constitutes what evolutionary psychologists often call ourenvironment of evolutionary adaptedness(or EEA), and the information- processing structure and organization of our present-day cognitive architecture is no different from that of our recent huntergatherer ancestors. (shrink)

This volume unites Peter Winch's previously unpublished work on Baruch de Spinoza. The primary source for the text is a series of seminars on Spinoza that Winch gave, first at the University of Swansea in 1982 and then at King's College London in 1989. What emerges is an original interpretation of Spinoza's work that demonstrates his continued relevance to contemporary issues in metaphysics, epistemology and ethics, and establishes connections to other philosophers - not only Spinoza's predecessors such as René Descartes, (...) but also important 20th Century philosophers such as Ludwig Wittgenstein and Simone Weil. Alongside Winch's lectures, the volume contains an interpretive essay by David Cockburn, and an introduction by the editors. (shrink)

The threat of terrorism once again raises some of the classic questions about constitutionalism: is it possible for constitutions to do what they aim to do—channel and control political power in such a way as to make it safe and beneficent for those under its rule but also competent to govern? Does not terrorism reraise the Schmittian problem of “the exception”, i.e., the situation of emergency that necessarily escapes all constitutional limitations? Although they did not face the problem of terrorism (...) as we know it, the American founders developed three different models of constitutionalism, embodying three different ways of responding to emergent circumstances and yet remaining bound to the constitutionalist aspiration. We develop the main outlines of the three models both conceptually and historically and show how they continue to be relevant to current discussions of constitutionalism in the age of terror. Finally, we make a tentative effort to judge which of the three models is most able to do what constitutions should do in difficult times. (shrink)

Voor de tweede keer in onze geschiedenis heeft technologie onze manier van samenleven radicaal veranderd. Na de 'eerste vervreemding', die er kwam als gevolg van de exponentiële bevolkingsgroei na de landbouwrevolutie, voltrekt zich nu een 'tweede vervreemding': de groepen waarin we samenleven staan niet langer los van elkaar. Door de globalisering zijn ze steeds meer met elkaar versmolten. Om wereldproblemen zoals klimaatverandering of overbevolking aan te pakken, moeten we voor het eerst op wereldschaal samenwerken.0Gelukkig is de mens geprogrammeerd om samen (...) te werken. Het zit in zijn natuur. Maar om wereldwijd samen te werken moet hij wel voorbij gaan aan zijn aangeboren 'tribalisme'. De huidige politieke context waarin vrijbuitersgedrag hoogtij viert, toont dat dat niet eenvoudig is. Michael Vlerick argumenteert dat er wel degelijk een weg is, dat efficiënt en legitieme wereldwijde samenwerking geen naïeve droom is. 0Meer nog, de tijd is er rijp voor. De mens kan voor het eerst in de geschiedenis haar evolutie in eigen handen nemen. We moeten die kans grijpen en een nieuw globaal sociaal contract in het leven te roepen. Een wereldwijd samenwerkingsmodel waarin burgers het écht voor het zeggen hebben. (shrink)

English summary: In twenty lectures and essays, many of which are published here for the first time, Michael Zank looks at modern Jewish philosophy of religion as an apologetics of the Mosaic faith. He approaches the subject from thematic as well as historical angles and shows how Hermann Cohen, Franz Rosenzweig, Martin Buber, Leo Strauss and others wrestled with the Christian and philosophical legacies of Europe. He also offers reflections on what we can learn from these philosophical efforts for (...) today, aiming to introduce the reader to the field of modern Jewish philosophy. The author first developed the idea for this book when he taught in Frankfurt as Martin Buber Professor of Jewish Philosophy of Religion at Johann Wolfgang Goethe University. German description: In zwanzig, hier zum grossen Teil erstmals veroffentlichten, Aufsatzen und Vortragen stellt Michael Zank die moderne judische Religionsphilosophie unter das Motto einer Apologie des Mosaismus. Er geht dabei sowohl thematisch als auch historisch vor und zeigt, wie sich Hermann Cohen, Franz Rosenzweig, Martin Buber, Leo Strauss und andere mit dem christlichen und philosophischen Erbe Europas auseinandergesetzt haben. Er denkt ausserdem daruber nach, was wir aus jenen Auseinandersetzungen heute noch lernen konnen. Das Buch versteht sich als eine Einfuhrung in die judische Religionsphilosophie. Die Idee fur dieses Buch entstand, als der Autor als Martin Buber Professor fur judische Religionsphilosophie an der Goethe Universitat Frankfurt lehrte. (shrink)

Collected essays on the topic of nature in the thought of St. Thomas Aquinas. Introduction by Ralph McInerny.

Die Begriffe Körper und Gesundheit sind (nicht erst) seit dem sogenannten body-, corporeal- oder somatic-turn Gegenstand sehr unterschiedlicher Disziplinen und Perspektiven: Die Komplexität der Zusammenhänge, Verschränkungen, Bedingungen des Gegenstandspaares Körper-Gesundheit bis hin zur Identifikation macht es erforderlich, multidisziplinär und multiperspektivisch vorzugehen. In diesem Band sind unterschiedliche Disziplinen und Perspektiven versammelt, die sich aus ihrer Fachgenese und wissenschaftlichen Position heraus mit Körper, Leib und Gesundheit beschäftigen, um v.a. Forschungsfelder zu erschließen und praxeologische Konsequenzen zu benennen.

In a rich and thought-provoking paper, Lambros Malafouris argues that taking material culture seriously means to be ‘systematically concerned with figuring out the causal efficacy of materiality in the enactment and constitution of a cognitive system or operation’ (Malafouris 2004, 55). As I understand this view, there are really two intertwined claims to be established. The first is that the things beyond the skin that make up material culture (in other words, the physical objects and artefacts in which cultural networks (...) and systems of human social relations are realized) may be essential to the enactment of, and be partly constitutive of, certain cognitive systems or operations. The consequence of establishing this claim is supposed to be that we have a mandate to recast the boundaries of the mind so as to include, as proper parts of the mind, things located beyond the skin. Thus, in talking about the contribution of the world to cognition, Malafouris (2004, 58) concludes that ‘what we have traditionally construed as an active or passive but always clearly separated external stimulus for setting a cognitive mechanism into motion, may be after all a continuous part of the machinery itself; at least ex hypothesi’. This is the position that, in philosophical circles, is known increasingly as the extended mind hypothesis (Clark & Chalmers 1998; Menary forthcoming). Henceforth I shall refer to this hypothesis as EM. A stock example will help bring the idea into view. Rumelhart et al. (1986) note that most of us solve difficult multiplication problems by using ‘pen and paper’ as an external resource. This environmental prop enables us to transform a difficult cognitive problem into a set of simpler ones, and to temporarily store the results of certain intermediate calculations. For the fan of EM, the distributed combination of this external resource and certain inner psychological processes constitutes a cognitive system in its own right. (shrink)

This article reports on Clean Language Interviewing (CLI), a rigorous, recently developed 'content-empty' (non-leading) approach to second-person interviewing in the science of consciousness. Also presented is a new systematic third-person method of validation that evaluates the questions and other verbal interventions by the interviewer to produce an adherence-to-method or 'cleanness' rating. A review of 19 interviews from five research studies provides a benchmark for interviewers seeking to minimize leading questions. The inter-rater reliability analysis demonstrates substantial agreement among raters with an (...) average intraclass correlation coefficient of 0.72 (95% CI). We propose that this method of validation is applicable not only to CLI but to second-person interviews more generally. (shrink)

This chapter contains sections titled: Introduction McDowell Sellars and McDowell: Convergence Sellars and McDowell: Divergence Above the Line …and Below It Philosophy and Modern Science Notes References.

Formalised public participation in project approval procedures is rarely addressed in technology assessment. Empirical data about public participation processes are taken into account even more rarely. This article explores the practice of public participation in infrastructure projects in the Federal Republic of Germany on the basis of empirical data from the period of 1990 to 2010. The author compares the empirical data about participation processes with the targets of the public participation and asks for the reasons for the lack of (...) participation in formalised approval procedures. Furthermore, the author contrasts participation formats used in technology assessment with formalised public participation. In his conclusions, he advocates for a stronger combination of formalised and informal public participation in technology assessment. (shrink)

In this article, I examine Thomas Aquinas's teaching on the light of glory (lumen gloriae), and attempt to resolve several problems that arise within this teaching.

The author identifies four possible attitudes of tolerance toward groups with different ways of life: resignation, indifference, curiosity and enthusiasm. He explores the potential for these attitudes and concludes by discussing the role of boundaries within communities in modernism and postmodernism. The author is not going to focus on toleration of eccentric or dissident individuals in civil society; he is interested in individual rights primarily when they are exercised in common—in the course of voluntary association or religious worship or cultural (...) elaboration—or when they are claimed by groups on behalf of their members. (shrink)

Boethius's Consolation of Philosophy was one of the most widely read and influential texts in medieval Europe, considering questions such as: how can evil exist in a world governed by God? And how is happiness still attainable despite the vicissitudes of fortune? Written as a dialogue between Boethius and Lady Philosophy, and alternating between poetry and prose, the Consolation is of interest not only to philosophers, but to students of classics and literature as well. In this Critical Guide, the first (...) collection of philosophical essays devoted exclusively to the Consolation, thirteen new essays demonstrate its ongoing vitality and break open its riches for a new generation of readers. The essays reflect the diverse array of approaches in contemporary scholarship and attend to both the literary features and the philosophical content of the Consolation. The volume will be invaluable for scholars of medieval philosophy, medieval literature, and the history of ideas. (shrink)

One of the world's most influential political theorists reflects on justice, on war and on the key political issues of our time.

A particular feature of this book is substantial "Stretch and Challenge" material throughout which allows students to develop further.