Few topics have intrigued biologists as much as the evolution of sex. Understanding why sex persists despite its costs requires not just rigorous theoretical study, but also empirical data on related fundamental issues, including the nature of genetic variance for fitness, patterns of genetic interactions, and the dynamics of adaptation. The increasing feasibility of examining genomes in an experimental context is now shedding new light on these problems. Using this approach, McDonald et al. recently demonstrated that sex uncouples beneficial and (...) deleterious mutations, allowing selection to proceed more effectively with sex than without. Here we discuss the insights provided by this study, along with other recent empirical work, in the context of the major theoretical models for the evolution of sex. (shrink)

An accurate classification of bacteria is essential for the proper identification of patient infections and subsequent treatment decisions. Multi-Locus Sequence Typing (MLST) is a genetic technique for bacterial classification. MLST classifications are used to cluster bacteria into clonal complexes. Importantly, clonal complexes can serve as a biological species concept for bacteria, facilitating an otherwise difficult taxonomic classification. In this paper, we argue for the inclusion of terms relating to clonal complexes in biomedical ontologies.

The Simple Counterfactual Analysis (SCA) was once considered the most promising analysis of disposition ascriptions. According to SCA, disposition ascriptions are to be analyzed in terms of counterfactual conditionals. In the last few decades, however, SCA has become the target of a battery of counterexamples. In all counterexamples, something seems to be interfering with a certain object’s having or not having a certain disposition thus making the truth-values of the disposition ascription and of its associated counterfactual come apart. Intuitively, however, (...) it would seem that, if all interferences were absent, the disposition ascription and its associated conditional would have the same truth-value. Although this idea may seem obvious, it is far from obvious how to implement it. In fact, it has become widely assumed that the content of qualifying ceteris paribus clauses (such as ‘if all interferences were absent’) cannot be specified in a clear and non-circular manner. In this paper, I will argue that this assumption is wrong. I will develop an analysis of disposition ascriptions, the Interference-Free Counterfactual Analysis, which relies on a clear and non-circular definition of the notion of interference and avoids the standard counterexamples to SCA while vindicating the intuition that disposition ascriptions and counterfactual conditionals are intimately related. (Please note that an erratum has been issued for the published version of this paper. It is recommended to read the self-archived version of the paper.). (shrink)

The innovation of the deep learning modeling scheme plays an important role in promoting the research of complex problems handled with artificial intelligence in smart cities and the development of the next generation of information technology. With the widespread use of smart interactive devices and systems, the exponential growth of data volume and the complex modeling requirements increase the difficulty of deep learning modeling, and the classical centralized deep learning modeling scheme has encountered bottlenecks in the improvement of model performance (...) and the diversification of smart application scenarios. The parallel processing system in deep learning links the virtual information space with the physical world, although the distributed deep learning research has become a crucial concern with its unique advantages in training efficiency, and improving the availability of trained models and preventing privacy disclosure are still the main challenges faced by related research. To address these above issues in distributed deep learning, this research developed a clonal selective optimization system based on the federated learning framework for the model training process involving large-scale data. This system adopts the heuristic clonal selective strategy in local model optimization and optimizes the effect of federated training. First of all, this process enhances the adaptability and robustness of the federated learning scheme and improves the modeling performance and training efficiency. Furthermore, this research attempts to improve the privacy security defense capability of the federated learning scheme for big data through differential privacy preprocessing. The simulation results show that the proposed clonal selection optimization system based on federated learning has significant optimization ability on model basic performance, stability, and privacy. (shrink)

Masks, interferers, finks, reverse finks, and mimickers are troublesome for powers metaphysics insofar as the latter concedes that there are powers with essential stimuli/activation conditions. In this article, I aim at offering a novel approach for solving this problem. In Section 1, I shall present the problem; and in Section 2, I shall briefly show how it also arises within non‐reductive views of powers. Subsequently, in Section 3, I shall examine the failure of the ceteris paribus solution. The pars construens (...) will begin in Section 4, where I shall distinguish between the activation conditions, the background conditions, and the possession conditions of a power. Within each category, I shall draw further distinctions. In Section 5, I shall demonstrate how such distinctions may ground a solution to our problem. Finally, in Section 6, I shall anticipate and reply to four objections. (shrink)

The widespread distribution of fibroblasts underlines their central role in mammalian physiology, development and ageing. The existence of developmentally regulated and site‐specific phenotypic variation in fibroblasts is well documented. Recent evidence has revealed heterogeneity within the fibroblast population of a given tissue at a specified development stage. The relative proportion and tissue distribution of distinct fibroblast subsets must have important consequences in the control of connective tissue and adjacent epithelial functions in health and disease.

Instead of investigating the interference between two stationary, rectilinear wave functions in a trajectory representation by examining the trajectories of the two rectilinear wave functions individually, we examine a dichromatic wave function that is synthesized from the two interfering wave functions. The physics of interference is contained in the reduced action for the dichromatic wave function. As this reduced action is a generator of the motion for the dichromatic wave function, it determines the dichromatic wave function’s trajectory. The (...) quantum effective mass renders insight into the behavior of the trajectory. The trajectory in turn renders insight into quantum nonlocality. (shrink)

Three‐ to 4‐month‐old infants show asymmetric exclusivity in the acquisition of cat and dog perceptual categories. The cat perceptual category excludes dog exemplars, but the dog perceptual category does not exclude cat exemplars. We describe a connectionist autoencoder model of perceptual categorization that shows the same asymmetries as infants. The model predicts the presence of asymmetric retroactive interference when infants acquire cat and dog categories sequentially. A subsequent experiment conducted with 3‐ to 4‐month‐olds verifies the predicted pattern of looking (...) time behaviors. We argue that bottom‐up, associative learning systems with distributed representations are appropriate for modeling the operation of short‐term visual memory in early perceptual category learning. (shrink)

We propose a new principle of 'non-interference' applied to social welfare orderings. The principle, together with two other standard requirements, implies a strong egalitarian conclusion: the ordering must lexicographically maximize the welfare of the worst off.

Performance of bimanual motor actions requires coordinated and integrated bilateral communication, but in some bimanual tasks, neural interactions and crosstalk might cause bilateral interference. The level of interference probably depends on the proportions of bilateral interneurons connecting homologous areas of the motor cortex in the two hemispheres. The neuromuscular system for proximal muscles has a higher number of bilateral interneurons connecting homologous areas of the motor cortex compared to distal muscles. Based on the differences in neurophysiological organization for (...) proximal vs. distal effectors in the upper extremities, the purpose of the present experiment was to evaluate how the level of bilateral interference depends on whether the bilateral interference task is performed with homologous or non-homologous effectors as the primary task. Fourteen participants first performed a unilateral primary motor task with the dominant arm with proximal and distal controlled joysticks. Performance in the unilateral condition with the dominant arm was compared to the same effector’s performance when two different bilateral interference tasks were performed simultaneously with the non-dominant arm. The two different bilateral interference tasks were subdivided into homologous and non-homologous effectors. The results showed a significant decrease in performance for both proximal and distal controlled joysticks, and this effect was independent of whether the bilateral interference tasks were introduced with homologous or non-homologous effectors. The overall performance decrease as a result of bilateral interference was larger for proximal compared to distal controlled joysticks. Furthermore, a proximal bilateral interference caused a larger performance decrement independent of whether the primary motor task was controlled by a proximal or distal joystick. A novel finding was that the distal joystick performance equally interfered with either homologous or non-homologous interference tasks performed simultaneously. The results indicate that the proximal–distal distinction is an important organismic constraint on motor control and for understanding bilateral communication and interference in general and, in particular, how bilateral interference caused by homologous vs. non-homologous effectors impacts motor performance for proximal and distal effectors. The results seem to map neuroanatomical and neurophysiological differences for these effectors. (shrink)

I discuss the interpretation of a recent experiment showing quantum interference in time. It is pointed out that the standard nonrelativistic quantum theory does not have the property of coherence in time, and hence cannot account for the results found. Therefore, this experiment has fundamental importance beyond the technical advances it represents. Some theoretical structures which consider the time as an observable, and thus could, in principle, have the required coherence in time, are discussed briefly, and the application of (...) Floquet theory and the manifestly covariant quantum theory of Stueckelberg are treated in some detail. In particular, the latter is shown to account for the results in a simple and consistent way. (shrink)

The paper’s target is the historically influential betting interpretation of subjective probabilities due to Ramsey and de Finetti. While there are several classical and well-known objections to this interpretation, the paper focuses on just one fundamental problem: There is a sense in which degrees of belief cannot be interpreted as betting rates. The reasons differ in different cases, but there’s one crucial feature that all these cases have in common: The agent’s degree of belief in a proposition A does not (...) coincide with her degree of belief in a conditional that A would be the case if she were to bet on A, where the belief in this conditional itself is conditioned on the supposition that the agent will have an opportunity to make such a bet. Even though the two degrees of belief sometimes can coincide (they will coincide in those cases when the bet has no expected causal bearings on the proposition A and the opportunity to bet have no evidential bearings on that proposition), it is the latter belief rather than the former that guides the agent’s rational betting behaviour. The reason is that this latter belief takes into consideration potential interferences that bet opportunities and betting itself might create with regard to the proposition to be betted on. It is because of this interference problem that the agent’s degree of belief in A cannot be interpreted as her betting rate for A. (shrink)

BackgroundTemporal interference (TI) stimulation is a novel technique that enables the non-invasive modulation of deep brain regions. However, the implementation of this technology in humans has not been well-characterized or examined, including its safety and feasibility.ObjectiveWe aimed to examine the feasibility, safety, and blinding of using TI on human participants in this pilot study.Materials and methodsIn a randomized, single-blinded, and sham-controlled pilot study, healthy young participants were randomly divided into four groups [TI and transcranial alternating current stimulation (tACS) targeting (...) the right frontoparietal region, TI-sham, and tACS-sham]. Each participant was asked to complete N-back (N = 1 to 3) tasks before, during, and after one session of stimulation to assess their working memory (WM). The side effects and blinding efficacy were carefully assessed. The accuracy, reaction time (RT), and inverse efficiency score (IES, reaction time/accuracy) of the N-back tasks were measured.ResultsNo severe side effects were reported. Only mild-to-moderate side effects were observed in those who received TI, which was similar to those observed in participants receiving tACS. The blinding efficacy was excellent, and there was no correlation between the severity of the reported side effects and the predicted type of stimulation that the participants received. WM appeared to be only marginally improved by TI compared to tACS-sham, and this improvement was only observed under high-load cognitive tasks. WM seemed to have improved a little in the TI-sham group. However, it was not observed significant differences between TI and TI-sham or TI and tACS in all N-back tests.ConclusionOur pilot study suggests that TI is a promising technique that can be safely implemented in human participants. Studies are warranted to confirm the findings of this study and to further examine the effects of TI-sham stimulation as well as the effects of TI on deeper brain regions. (shrink)

From carrots to frogs to sheep and finally to humans, the history of cloning is a fascinating study of the interplay between science and popular culture. Imagination and discovery provide mutual impetus in the evolving science and cultural phenomenon of cloning. Its history is a paradigm of science unfiction: What once belonged unequivocally on the pages of science fiction is now emerging in flesh and blood. Writers, movie producers, ethicists, and all manner of social commentators, no less than scientists, have (...) all participated in the creation of the human clone as an idea and as a biological entity. While the clone stands apart as having only one genetic parent, it truly is a brainchild of multifarious origins. (shrink)

It is held by some philosophers that it is possible that x has a disposition D but, if the stimulus condition obtains, it won’t manifest D because of an intrinsic interference. I will criticize this position on the ground that it has a deeply sceptical consequence, for instance, that, assuming that I am not well informed of the micro-properties of a metal coin, I do not know that it is not water-soluble. But I urge that this is beyond the (...) pale, especially in light of the weight of the practical considerations we take when we use dispositional concepts in everyday life or science. In doing so, further, I will formulate a type of belief-forming inference and claim that it confers justification on commonsensical dispositional beliefs like the one that a metal coin isn’t water-soluble. (shrink)

I present the current experimental and theoretical work on interference in complementary spaces. These ideas are applicable to both light and matter waves. I give a detailed treatment for classical light beams in frequency and time domains. I also present a description which gives the totality of interferences.

The issue as to whether an atomistic or holistic viewof knowledge and meaning is correct relies on the way part/whole relationships is analysed,exactly as the issue as to whether a constructive or realistic view of knowledge and meaningis correct relies on the way internal/external relationships is analysed. Both theprinciple of compositionality and the context principle depend on how finely the constituents,the nature and the size of the context are identified; both the notion of meaning andthe notion of truth depend on (...) the resources of internalisation/externalisation. Thus thespectrum of semantic and epistemological theories varies from (global) atomismto (global) holism, and from minimal to maximal internalisation. Are compositionaltheories necessarily extensional? Does formal semantics necessarily rely on set theory?Does the domain-specific character of the notions of element, part and whole prevent anygeneral, non-trivial account? The aim of the present paper is to provide a negative answerto these questions by exploring some of the features a theory covering the phenomenologyof part and whole should have. This phenomenology will only be sketched through a fewparadigmatic examples, showing how the reference of notions of part and wholevaries and which are the constraints inherentin such variation. Categorytheory provides the tools for fashioning this framework, since it allows describing any coherentcollection of objects (with actions defined over them) and (action preserving) maps betweenthe objects, as well as the variation of such collections in terms of suitablefunctors, coding the ways parts and wholes undergo co-variation. The main thesis is thatthere are interference patterns between the two pairs Local/Global and Internal/External,only in terms of which the above phenomenology can be properly described.Se mai tu diventeraimetá di te stesso, e te l''auguro, ragazzo, capirai cose al di lá della comune intelligenza dei cervelli interi.Avrai perso metá di te e del mondo, ma la realtá rimasta sará mille volte piú profonda e preziosa. E tupure vorrai che tutto sia dimezzato e straziato a tua immagine, perchè bellezza e sapienza e giustizia ci sono soloin ció che é fatto a brani. (shrink)

The Sustained Attention to Response Task is a Go–No-Go signal detection task developed to measure lapses of sustained conscious attention. In this study, we examined the impact global interference and spatial uncertainty has on SART performance. Ten participants performed either a SART or a traditionally formatted version of a global–local stimuli detection task with spatially certain and uncertain signals. Reaction time in the SART was insensitive to global interference and spatial uncertainty, whereas reaction time in the low-Go task (...) was sensitive. Spatial uncertainty increased errors of omission in the SART, which was not expected if the SART measures mindlessness. There was a high correlation between participants’ errors of commission rate and their reaction time in the SART. The results, overall, support the view that the SART is a better measure of response strategy than lapses in sustained attention or mindlessness. (shrink)

Our current society seems to require a sharp separation between what can be tolerated in public and what must remain hidden. There is explicit and implicit censorship of both the subject of death and of the crying and suffering of surviving relatives and friends. Medieval literature and literary studies, however, show how the experience of dying and its appropriate manifestations of grief seemed to be more integrated into everyday life, as opposed to the apparent “disintegration” of nowadays. It is possible (...) to begin to detect this evolution already in medieval Hispanic literature itself, from an apparently more public, visible and integrated death in 13th-century Hispanic literature to a more private, concealed and disintegrated death in 15th-century Hispanic literature. This process will continue its journey to the present society of eternal springs and summers from which we have eradicated autumns and winters, seasons as necessary for the cycle of life – for personal, psychological and social balance – as the first two. Keywords: death; mourning; crying; medieval literature. Resumen Nuestra sociedad actual parece presentar una tajante separación entre lo que puede ser tolerado en público y lo que debe permanecer oculto. Hay una censura explícita e implícita tanto del tema de la muerte como del llanto y el sufrimiento de los familiares y amigos supervivientes. Sin embargo, la literatura medieval y los estudios literarios sobre la misma muestran cómo la experiencia del morir y sus apropiadas manifestaciones de dolor parecían estar más integradas en la vida cotidiana en contraposición a la aparente “desintegración” actual. Es posible comenzar a detectar esta evolución ya en la propia literatura hispánica medieval, desde una muerte aparentemente más pública, visible e integrada en la literatura hispánica del siglo XIII hasta una muerte más privada, oculta y desintegrada en la literatura hispánica del siglo XV. Este proceso continuará su recorrido hasta una sociedad actual de eternas primaveras y veranos de la que hemos erradicado los otoños e inviernos, estaciones tan necesarias para el ciclo de la vida —para el equilibrio personal, psicológico y social— como las dos primeras. Palabras clave: muerte; duelo; llanto; literatura medieval. (shrink)

This paper discusses the so-called non-interference assumption (NIA) grounding causal inference in trials in both medicine and the social sciences. It states that for each participant in the experiment, the value of the potential outcome depends only upon whether she or he gets the treatment. Drawing on methodological discussion in clinical trials and laboratory experiments in economics, I defend the necessity of partial forms of blinding as a warrant of the NIA, to control the participants’ expectations and their strategic (...) interactions with the experimenter. (shrink)