Results for 'retroviral silencing'

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  1.  13
    Stanley Cavell.Silences Noises Voices - 2001 - In Juliet Floyd & Sanford Shieh (eds.), Future Pasts: The Analytic Tradition in Twentieth-Century Philosophy. Oxford University Press.
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  2. Courtney S. Campbell.Sounds Of Silence - 1991 - Theological Developments in Bioethics, 1988-1990 1:23.
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  3.  11
    authoritative General Handbook of Instructions (hereafter Instructions), these initial documents addressed such· problems· as abortion, artificial.Courtneys Campbell & Sounds Of Silence - forthcoming - Bioethics Yearbook.
  4.  15
    Abstain or die: The development of hiv/aids policy in botswana.Suzette Heald - 2006 - Journal of Biosocial Science 38 (1):29-41.
    This paper traces the development of policies dealing with HIV/AIDS in Botswana from their beginning in the late 1980s to the current programme to provide population-wide anti-retroviral therapy (ARV). Using a variety of source material, including long-term ethnographic research, it seeks to account for the failure of Western-inspired approaches in dealing with the pandemic. It does this by looking at the cultural and institutional features that have created resistance to the message and inhibited effective implementation. The negative response to (...)
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  5.  10
    Do repeated arrays of regulatory small‐RNA genes elicit genomic imprinting?Stéphane Labialle & Jérôme Cavaillé - 2011 - Bioessays 33 (8):565-573.
    The basic premise of the host‐defense theory is that genomic imprinting, the parent‐of‐origin expression of a subset of mammalian genes, derives from mechanisms originally dedicated to silencing repeated and retroviral‐like sequences that deeply colonized mammalian genomes. We propose that large clusters of tandemly‐repeated C/D‐box small nucleolar RNAs (snoRNAs) or microRNAs represent a novel category of sequences recognized as “genomic parasites”, contributing to the emergence of genomic imprinting in a subset of chromosomal regions that contain them. Such a view (...)
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  6.  34
    Death by transposition – the enemy within?John M. Sedivy, Jill A. Kreiling, Nicola Neretti, Marco De Cecco, Steven W. Criscione, Jeffrey W. Hofmann, Xiaoai Zhao, Takahiro Ito & Abigail L. Peterson - 2013 - Bioessays 35 (12):1035-1043.
    Here we present and develop the hypothesis that the derepression of endogenous retrotransposable elements (RTEs) – “genomic parasites” – is an important and hitherto under‐unexplored molecular aging process that can potentially occur in most tissues. We further envision that the activation and continued presence of retrotransposition contribute to age‐associated tissue degeneration and pathology. Chromatin is a complex and dynamic structure that needs to be maintained in a functional state throughout our lifetime. Studies of diverse species have revealed that chromatin undergoes (...)
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  7.  15
    Retroviral integration: Site matters.Jonas Demeulemeester, Jan De Rijck, Rik Gijsbers & Zeger Debyser - 2015 - Bioessays 37 (11):1202-1214.
    Here, we review genomic target site selection during retroviral integration as a multistep process in which specific biases are introduced at each level. The first asymmetries are introduced when the virus takes a specific route into the nucleus. Next, by co‐opting distinct host cofactors, the integration machinery is guided to particular chromatin contexts. As the viral integrase captures a local target nucleosome, specific contacts introduce fine‐grained biases in the integration site distribution. In vivo, the established population of proviruses is (...)
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  8.  6
    Retroviral elements and suppressor genes in Drosophila.Susan M. Parkhurst & Victor G. Corces - 1986 - Bioessays 5 (2):52-57.
    The phenotype of some spontaneous mutations in Drosophila can be modified by mutations at unlinked loci. The affected alleles are caused by the insertion of retroviral transposable elements. The idiosyncratic functional and structural properties of these elements play a key role in determining the expression characteristics of the genes into which they are inserted. These phenotypes are reversed or intensified by the allelic state of suppressor and enhancer loci through changes in the transcriptional properties of the transposable elements.
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  9.  10
    Retroviral DNA integration.Anna Marie Skalka & Jonathan Leis - 1984 - Bioessays 1 (5):206-210.
    The synthesis and integration of DNA into the genome of its host cell is a normal step in the replication of the retroviruses. Previous studies have provided details concerning the structure of viral DNA and viral and host integration sites. More recent genetic and biochemical results have expanded our understanding considerably: it should soon be possible to describe the exact viral DNA sequence recognized during the integration reaction for several viruses. In addition, at least one of the viral proteins and (...)
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  10. Silencing and assertion.Alessandra Tanesini - 2018 - In Sanford C. Goldberg (ed.), The Oxford Handbook of Assertion. Oxford University Press. pp. 749-769.
    Theories of assertion must explain how silencing is possible. This chapter defends an account of assertion in terms of normative commitments on the grounds that it provides the most plausible analysis of how individuals might be silenced when attempting to make assertions. The chapter first offers an account of the nature of silencing and defends the view that it can occur even in contexts where speakers’ communicative intentions are understood by their audience. Second, it outlines some of the (...)
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  11.  33
    Anti‐retrovirals for treatment and prevention – time for new paradigms in our response to the HIV/AIDS epidemic?Quarraisha Abdool Karim & Ronald Bayer - 2013 - Developing World Bioethics 13 (2):ii-iii.
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  12. Silencing the experience of change.Sebastian Watzl - 2013 - Philosophical Studies 165 (3):1009-1032.
    Perceptual illusions have often served as an important tool in the study of perceptual experience. In this paper I argue that a recently discovered set of visual illusions sheds new light on the nature of time consciousness. I suggest the study of these silencing illusions as a tool kit for any philosopher interested in the experience of time and show how to better understand time consciousness by combining detailed empirical investigations with a detailed philosophical analysis. In addition, and more (...)
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  13. Silence Perception and Spatial Content.Błażej Skrzypulec - 2022 - Australasian Journal of Philosophy 100 (3):524-538.
    It seems plausible that visual experiences of darkness have perceptual phenomenal content that clearly differentiates them from absences of visual experiences. I argue, relying on psychological results concerning auditory attention, that the analogous claim is true about auditory experiences of silence. More specifically, I propose that experiences of silence present empty spatial directions like ‘right’ or ‘left’, and so have egocentric spatial content. Furthermore, I claim that such content is genuinely auditory and phenomenal in the sense that one can, in (...)
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  14.  40
    Silence in Philosophy, Literature, and Art.Steven Bindeman - 2017 - Boston: Brill | Rodopi.
    _Silence in Philosophy, Literature, and Art_ demonstrates how silence as a form of indirect discourse provides us with access to hitherto inaccessible aspects of human experience.
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  15. When silence may mean derision.Varol Akman - 1994 - Journal of Pragmatics 22 (2):211-212.
    In a paper published in 1992, Dennis Kurzon shows that silence does not necessarily mean lack of power: the silent response to a question may well be aiming at gaining control of a situation, viz. exercising power. I would like to extend Kurzon's analysis and argue that at times silence may mean derision or ridicule.
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  16. Philosophical Silences: Race, Gender, Disability, and Philosophical Practice.Robert A. Wilson - 2023 - Journal of Philosophy of Education 57 (4):1004-1024.
    Who is recognised as a philosopher and what counts as philosophy influence both the content of a philosophical education and academic philosophy’s continuing demographic skew. The “philosophical who” and the “philosophical what” themselves are a partial function of matters that have been passed over in collective silence, even if that now feels to some like a silence belonging to the distant past. This paper discusses some philosophical silences regarding race, gender, and disability in the context of reflection on philosophical education (...)
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  17. Silence: The Phenomenon and Its Ontological Significance.Bernard P. Dauenhauer - 1982 - International Journal for Philosophy of Religion 13 (4):229-230.
  18. Confronting Silences.Robert A. Wilson - 2023 - Tapuya: Latin American Science, Technology and Society 6 (1):1-5.
    This open-access editorial discusses confronting silences in different disciplinary contexts, such as science and technology studies, cultural anthropology, and philosophy. It has a focus on race and concludes with thoughts about Indigenous expertise, the Australian referendum on the Indigenous Voice, to parliament, and racism.
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  19. Silencing without Convention.Elmar Unnsteinsson - 2019 - Pacific Philosophical Quarterly 100 (2):573-598.
    Silencing is usually explained in terms of conventionalism about the nature of speech acts. More recently, theorists have tried to develop intentionalist theories of the phenomenon. I argue, however, that if intentionalists are to accommodate the conventionalists' main insight, namely that silencing can be so extreme as to render certain types of speech act completely unavailable to victims, they must take two assumptions on board. First, it must be possible that speakers' communicative intentions are opaque to the speakers (...)
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  20.  13
    The Silences of Feeling.Naomi Waltham-Smith - 2022 - Philosophy Today 66 (2):287-306.
    In Le différend Lyotard evocatively describes what remains to be heard as “the silence of feeling.” Setting Lyotard’s différend among a differentiated set of incommensurable family resemblances, including Rancière’s mésentente and Derrida’s différance, this paper argues that le différend même, far from coinciding with itself, points to the re-marks and differs from itself, silencing itself by putting itself under a conditional. This is what gives its particular affective quality that is bound up with address and listening. From this perspective, (...)
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  21.  8
    Ethical Silence: Kierkegaard on Communication, Education, and Humility.Sergia Hay - 2020 - Lanham: Lexington Books.
    This book analyzes Søren Kierkegaard’s message about the ethical necessity of silence in the context of our current information age flooded with sound and words. The author investigates the question of how being silent can make us more ethical.
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  22. Breaking Silence: The Quality of Life, Experiences, and Challenges of Balik Aral Grade 12 Students (17th edition).Mark Anthony Polinar - 2024 - Psychology and Education: A Multidisciplinary Journal 17 (7):710-719.
    The growth of individuals and society heavily relies on education. Certain hindrances may prompt some students to halt their academic pursuits temporarily. This is known as "Balik-aral." The exploration of the quality of life, lived experiences, and challenges of grade 12 Balik-aral students was undertaken by the authors to break their silence and help them by developing recommendations that could be presented to the school's key stakeholders. A phenomenological approach was used to understand the phenomenon in a study involving five (...)
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  23.  8
    Silence et sagesse: de la musique à la métaphysique, les anciens Grecs et leur héritage.Laurence Boulègue, Pierre Caye, Florence Malhomme, Sylvie Perceau & Catherine Flament (eds.) - 2014 - Paris: Classiques Garnier.
    Silence et sagesse montre combien les innombrables expériences et ascèses du silence, à travers la littérature ou les arts aussi bien que la philosophie ou la théologie, ont contribué à la constitution de la culture des hommes et de leur hominisation, au-delà ou en deça du logos et de son primat.
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  24.  66
    Experiencing Silence.Phillip John Meadows - 2020 - Canadian Journal of Philosophy 50 (2):238-250.
    This paper identifies three claims that feature prominently in recent discussions concerning the experience of silence: that experiences of silence are the most “negative” of perceptions, that we do not hear silences because those silences cause our experiences of silence, and that to hear silence is to hear a temporal region devoid of sound. The principal proponents of this approach are Phillips and Soteriou, and here I present a series of objections to common elements of their attempts to place these (...)
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  25. Perlocutionary Silencing: A Linguistic Harm That Prevents Discursive Influence.David C. Spewak Jr - 2023 - Hypatia 38 (1):86-104.
    Various philosophers discuss perlocutionary silencing, but none defend an account of perlocutionary silencing. This gap may exist because perlocutionary success depends on extralinguistic effects, whereas silencing interrupts speech, leaving theorists to rely on extemporary accounts when they discuss perlocutionary silencing. Consequently, scholars assume perlocutionary silencing occurs but neglect to explain how perlocutionary silencing harms speakers as speakers. In relation to that shortcoming, I defend a novel account of perlocutionary silencing. I argue that speakers (...)
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  26. Silencing speech.Ishani Maitra - 2009 - Canadian Journal of Philosophy 39 (2):pp. 309-338.
    Pornography deserves special protections, it is often said, because it qualifies as speech. Therefore, no matter what we think of its content, we must afford it the protections that we extend to most speech, but don’t extend to other actions.1 In response, Jennifer Hornsby and Rae Langton have argued that the case is not so simple: one of the harms of pornography, they claim, is that it silences women’s speech, thereby preventing women from deriving from speech the very benefits that (...)
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  27.  30
    Unintelligible Silence.Katherine E. Entigar - 2020 - Outlines. Critical Practice Studies 21 (1):06-18.
    What is silence? Is it a loss, an omission? Is it a stopping of the mouth, of the voice? An empty place where no meaning has come forward…or perhaps at times quite the opposite, an absence-as-presence Deleuze, 1990; Derrida, 1976)? Might silence evoke much more about what we assume is our monological, unitary reality, indexing possibilities yet unseen? This paper outlines the ways in which silence is typically understood according to scholarly orthodoxy: as omission in human communication or a (...) of minoritized individuals or communities by those in power. It then moves to critique the preeminence of whitestream Western-centric academic authority, which self-perpetuates via the exclusion of outsider ways of doing, being and knowing such as those brought forward by silence, constituting a loss of meaning and knowledge from the social imaginary. This paper suggests that the pursuit of an articulate unknowing regarding silence as a creative, disruptive force beyond the control of rationality is a means of engaging with radical possibilities for a different, juster world. It proposes a socio-diologic politics of the real that welcomes silence as an unsettling of our current thinking about what is and will be possible, as well as who does and does not matter. It concludes by illustrating the ingenious force of silence in examples of subversive art that expose the hegemonizing, rational version of reality sold by academics and powerholders, bringing forward into the imagination what prospects for change, justice, and social transformation yet await. (shrink)
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  28.  24
    Workplace silence behavior and its consequences on nurses: A new Egyptian validation scale of nursing motives.Nagah Abd El-Fattah Mohamed Aly, Safaa M. El-Shanawany & Maha Ghanem - 2022 - Clinical Ethics 17 (1):71-82.
    BackgroundWorkplace silence behavior is a social collective phenomenon. It refers to nurses choosing to withhold their ideas, opinions and concerns about critical issues in their workplace. Workpla...
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  29.  18
    Listening from Silence: Inner Composure and Engagement.Leonard J. Waks - 2008 - Paideusis: Journal of the Canadian Philosophy of Education Society 17 (2):65-74.
    The Indian-America philosopher Sri Chinmoy Ghose has distinguished between outer silence, inner silence, and innermost silence. In this paper I explore these distinctions and their educational relevance. My main conclusions are that (a) a deep inner silence, undistracted by questions or other thoughts, is at the root of one paradigm kind of good listening in education, and (b) what Chinmoy refers to as “innermost silence” is the moral virtue of receptivity to others that sustains inner silence, even under challenging conditions, (...)
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  30.  84
    On Silencing, Authority, and the Act of Refusal.Laura Caponetto - 2017 - Rivista di Estetica 64:35-52.
    The notion of ‘illocutionary silencing’ has been given a key role in defining the harms of pornography by several feminist philosophers. Though the literature on silencing focuses almost exclusively on the speech act of sexual refusal, oddly enough, it lacks a thorough analysis of that very act. My first aim is to fill this theoretical gap. I claim that refusals are “second-turn illocutions”: they cannot be accomplished in absence of a previous interrogative (or open) call by the hearer. (...)
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  31.  18
    The Silenced and Unsought Beneficiary: Investigating Epistemic Injustice in the Fiduciary.Helen Mussell - forthcoming - Business Ethics Quarterly:1-23.
    This article uses philosopher Miranda Fricker’s work on epistemic injustice to shed light on the legal concept of the fiduciary, alongside demonstrating the wider contribution Fricker’s work can make to business ethics. Fiduciary, from the Latin fīdūcia, meaning “trust,” plays a fundamental role in all financial and business organisations: it acts as a moral safeguard of the relationship between trustee and beneficiary. The article focuses on the ethics of the fiduciary, but from a unique historical perspective, referring back to the (...)
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  32. Silencing Desires?Attila Tanyi - 2013 - Philosophia 41 (3):887-903.
    In an overlooked section of his influential book What We Owe to Each Other Thomas Scanlon advances an argument against the desire-model of practical reasoning. In Scanlon’s view the model gives a distorted picture of the structure of our practical thinking. His idea is that there is an alternative to the “weighing behavior” of reasons, a particular way in which reasons can relate to each other. This phenomenon, which the paper calls “silencing”, is not something that the desire-model can (...)
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  33. Appreciative Silencing in Communicative Exchange.Abraham Tobi - forthcoming - Episteme:1-15.
    Instances of epistemic injustice elicit resistance, anger, despair, frustration or cognate emotional responses from their victims. This sort of response to the epistemic injustices that accompanied historical systems of oppression such as colonialism, for example, is normal. However, if their victims have internalised these oppressive situations, we could get the counterintuitive response of appreciation. In this paper, I argue for the phenomenon of appreciative silencing to make sense of instances like this. This is a form of epistemic silencing (...)
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  34.  73
    Silence: A Politics.Kennan Ferguson - 2003 - Contemporary Political Theory 2 (1):49-65.
    This article investigates the unfamiliar political implications of silence. Generally regarded as simply a lack of speech imposed upon the powerless, silence is thereby positioned as inimical to politics. In a normatively constituted lingual politics, silence's role can never be more than that of absence. The subsequent understanding that silence can operate as resistance to domination has opened original and ground-breaking treatments of its role in political practice. However, the argument here moves beyond this simple dualism, examining how silence does (...)
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  35. Illocutionary silencing.Alexander Bird - 2002 - Pacific Philosophical Quarterly 83 (1):1–15.
    Rae Langton and Jennifer Hornsby have argued that pornography might create a climate whereby a woman’s ability to refuse sex is literally silenced or removed. Their central argument is that a failure of ‘uptake’ of the woman’s intention means that the illocutionary speech act of refusal has not taken place. In this paper, I challenge the claims from the Austinian philosophy of language which feature in this argument. I argue that uptake is not in general required for illocution, nor is (...)
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  36. Illocution, silencing and the act of refusal.Mari Mikkola - 2011 - Pacific Philosophical Quarterly 92 (3):415-437.
    Rae Langton and Jennifer Hornsby argue that there may be a free-speech argument against pornography, if pornographic speech has the power to illocutionarily silence women: women's locution ‘No!’ that aims to refuse unwanted sex may misfire because pornography creates communicative conditions where the locution does not count as a refusal. Central to this is the view that women's speech lacks uptake, which is necessary for illocutionary acts like that of refusal. Alexander Bird has critiqued this view by arguing that uptake (...)
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  37.  8
    Le silence et le droit: recherches sur une métaphore.Elodie Bordes - 2018 - [Québec, Québec]: Presses de l'Université Laval.
    "Le droit est traditionnellement appréhendé comme un phénomène inhérent au langage. Est-il possible, dès lors, pour ce droit, qui est enserré dans les rets du langage, de « dire le silence »? « Le silence du droit » ou « le silence dans le droit » témoignent ainsi d'une parole différée ou d'une voix impossible. Cette problématique a été appréhendée, dans cette étude, sur une base métaphorique. Comme toute métaphore, celle-ci rend compte d'une relation de substitution : la relation d'absence (...)
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  38.  7
    20 Silence / Beat.Paul D. Miller - 2016 - In Joel Burges & Amy Elias (eds.), Time: A Vocabulary of the Present. New York University Press. pp. 337-344.
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  39. Sincerity Silencing.Mary Kate Mcgowan - 2014 - Hypatia 29 (2):458-473.
    Catharine MacKinnon claims that pornography silences women in a way that violates the right to free speech. This claim is, of course, controversial, but if it is correct, then the very free speech reasons for protecting pornography appear also to afford reason to restrict it. For this reason, it has gained considerable attention. The philosophical literature thus far focuses on a type of silencing identified and analyzed by Jennifer Hornsby and Rae Langton (H&L). This article identifies, analyzes, and argues (...)
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  40. Silence as a Christian Experience and Practice.Stephen R. Munzer - 2020 - Studia Monastica 62:253-274.
    Silence often plays a significant role in Christian experience and practice. However, the varieties of silence and the effects of silence for good and. bad merit examination. It is important to distinguish between physical, auditory, and metaphorical silence, and bet- ween experiencing silence as "quiet" and experiencing silence as keeping quiet . Silence can be an instrumental good as well as an expressive good, a concomitant good, or a constitutive good. Christian monks, theologians, and other thinkers sometimes identify experiences of (...)
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  41.  14
    Just Silences: The Limits and Possibilities of Modern Law.Marianne Constable - 2007 - Princeton University Press.
    Is the Miranda warning, which lets an accused know of the right to remain silent, more about procedural fairness or about the conventions of speech acts and silences? Do U.S. laws about Native Americans violate the preferred or traditional "silence" of the peoples whose religions and languages they aim to "protect" and "preserve"? In Just Silences, Marianne Constable draws on such examples to explore what is at stake in modern law: a potentially new silence as to justice.Grounding her claims about (...)
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  42.  56
    Beyond Silencing: Virtue, Subjective Construal, and Reasoning Practically.Denise Vigani - 2021 - Australasian Journal of Philosophy 99 (4):748-760.
    ABSTRACT In the contemporary philosophical literature, ideal virtue is often accused of setting a standard more appropriate for saints or gods than for human beings. In this paper, I undermine divinity-infused depictions of the fully virtuous, and argue that ideal virtue is, indeed, human. I focus on the virtuous person’s imperviousness to temptation, and contend that this imperviousness is not as psychologically implausible as it might seem. I argue that it is a virtuous person’s subjective construal of a situation that (...)
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  43. Silencing, Epistemic Injustice, and Epistemic Paternalism.Jonathan Matheson & Valerie Joly Chock - 2020 - In Amiel Bernal & Guy Axtell (eds.), Epistemic Paternalism Reconsidered: Conceptions, Justifications and Implications. Lanham, Md: Rowman & LIttlefield.
    Members of oppressed groups are often silenced. One form of silencing is what Kristie Dotson calls “testimonial smothering”. Testimonial smothering occurs when a speaker limits her testimony in virtue of the reasonable risk of it being misunderstood or misapplied by the audience. Testimonial smothering is thus a form of epistemic paternalism since the speaker is interfering with the audience’s inquiry for their benefit without first consulting them. In this paper, we explore the connections between epistemic injustice and epistemic paternalism (...)
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  44. Silence and the Word: Negative Theology and Incarnation.Oliver Davies & Denys Turner (eds.) - 2002 - Cambridge University Press.
    Negative theology or apophasis - the idea that God is best identified in terms of 'absence', 'otherness', 'difference' - has been influential in modern Christian thought, resonating as it does with secular notions of negation developed in continental philosophy. Apophasis also has a strong intellectual history dating back to the early Church Fathers. Silence and the Word both studies the history of apophasis and examines its relationship with contemporary secular philosophy. Leading Christian thinkers explore in their own way the extent (...)
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  45.  3
    Between Silencing and Ignorance.Joanna Mizielińska - 2010 - Dialogue and Universalism 20 (5-6):77-88.
    The aim of this article is to show contemporary changes in intimate and family life on the example of “families of choice”. In the first part, I present state-of-the-art concepts of families and argue for the urgent need for their re-definition due to the fact that what we call family nowadays differs drastically from what it used to be. I propose to treat those changes as a natural phenomenon and not as a sign of the crisis of the family, as (...)
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  46.  20
    Between Silencing and Ignorance: “Families of Choice” in Poland.Joanna Mizielińska - 2010 - Dialogue and Universalism 20 (5-6):77-88.
    The aim of this article is to show contemporary changes in intimate and family life on the example of “families of choice”. In the first part, I present state-of-the-art concepts of families and argue for the urgent need for their re-definition due to the fact that what we call family nowadays differs drastically from what it used to be. I propose to treat those changes as a natural phenomenon and not as a sign of the crisis of the family, as (...)
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  47.  7
    Silence speaks: from the chalkboard of Baba Hari Dass.Hari Dass - 1977 - Santa Cruz, Calif.: Sri Rama.
    Silence Speaks is a collection of writings of Baba Hari Dass, 1971-1977, consisting of answers to questions from group gatherings, personal interviews, and personal letters to students.
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  48. The silence of the senses.Charles Travis - 2004 - Mind 113 (449):57-94.
    There is a view abroad on which perceptual experience has representational content in this sense: in it something is represented to the perceiver as so. On the view, a perceptual experience has a face value at which it may be taken, or which may be rejected. This paper argues that that view is mistaken: there is nothing in perceptual experience which makes it so that in it anything is represented as so. In that sense, the senses are silent, or, in (...)
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  49. Exploring Silence and Absence in Discourse: Empirical Approaches.[author unknown] - 2018
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  50.  5
    The Silences of Feeling in advance.Naomi Waltham-Smith - forthcoming - Philosophy Today.
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