This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King’s College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotransplantation into the clinical setting. The symposium was the first of its kind in the UK for 20 years. This paper (...) summarises the content of the expert lectures showcasing the progress which has been made in xenotransplantation including—the history of xenotransplantation, advances in gene edited animals and progress towards clinical xenotransplantation. We then set out the ethical and legal issues still to be resolved. Finally, we report the themes of the roundtable discussion highlighting areas of consensus and controversy. While the detail of the legal discussion was directed towards the UK, the principles and summary reported here are intended to be applicable to any jurisdiction seeking to implement clinical xenotransplantation. (shrink)

By means of an example, shows the possibility of beliefs that are separately rational whilst together inconsistent.

The target article skillfully evaluates data on mental disorders in relation to predictions from evolutionary genetic theories of neutral evolution, balancing selection, and polygenic mutation-selection balance, resulting in a negative outlook for the likelihood of success finding genes for mental disorders. Nevertheless, new conceptualizations, methods, and continued interactions across disciplines provide hope.

Page's proposal to stipulate representations in which individual units correspond to meaningful entities is too unconstrained to support effective theorizing. An approach combining general computational principles with domain-specific assumptions, in which learning is used to discover representations that are effective in solving tasks, provides more insight into why cognitive and neural systems are organized the way they are.

I argue that thought experiments are a form of experimental reasoning similar to real experiments. They require the same ability to participate by following a narrative as real experiments do. Participation depends in turn on using what we already know to visualize, manipulate and understand what is unfamiliar or problematic. I defend the claim that visualization requires embodiment by an example which shows how tacit understanding of the properties of represented objects and relations enables us to work out how such (...) objects might behave in a postulated world. This knowledge is that of embodied agents. That thought experiments require embodied participation is what makes them experiments rather than arguments. Unlike real experiments, from which ordinary perception has been displaced by instrumentation, thought experiments still appeal to relatively unmediated common sense, even when their purpose is to criticize or subvert common sense notions. (shrink)

We (Patterson & Plaut, 2009) argued that cognitive neuropsychology has had a limited impact on cognitive science due to a nearly exclusive reliance on (a) single‐case studies, (b) dissociations in cognitive performance, and (c) shallow, box‐and‐arrow theorizing, and we advocated adopting a case‐series methodology, considering associations as well as dissociations, and employing explicit computational modeling in studying “how the brain does its cognitive business.” In reply, Coltheart (2010) claims that our concern is misplaced because cognitive neuropsychology is concerned only with (...) studying the mind, in terms of its “functional architecture,” without regard to how this is implemented in the brain. In this response, we do not dispute his characterization of cognitive neuropsychology as it has typically been practiced over the last 40 years, but we suggest that our understanding of brain structure and function has advanced to the point where studying the mind without regard to the brain is unwise and perpetuates the field’s isolation. (shrink)

William James is frequently considered one of America's most important philosophers, as well as a foundational thinker for the study of religion. Despite his reputation as the founder of pragmatism, he is rarely considered a serious philosopher or religious thinker. In this new interpretation David Lamberth argues that James's major contribution was to develop a systematic metaphysics of experience integrally related to his developing pluralistic and social religious ideas. Lamberth systematically interprets James's radically empiricist world-view and argues for an (...) early dating for his commitment to the metaphysics of radical empiricism. He offers a close reading of Varieties of Religious Experience; and concludes by connecting James's ideas about experience, pluralism and truth to current debates in philosophy, the philosophy of religion, and theology, suggesting James's functional, experiential metaphysics as a conceptual aid in bridging the social and interpretive with the immediate and concrete while avoiding naive realism. (shrink)

The sciences use a wide range of visual devices, practices, and imaging technologies. This diversity points to an important repertoire of visual methods that scientists use to adapt representations to meet the varied demands that their work places on cognitive processes. This paper identifies key features of the use of visualization in a range of scientific domains and considers the implications of this repertoire for understanding scientists as cognitive agents.

Technology's contribution to economic growth and competitiveness has been the subject of vigorous debate in recent years. This book demonstrates the importance of a historical perspective in understanding the role of technological innovation in the economy. The authors examine key episodes and institutions in the development of the U.S. research system and in the development of the research systems of other industrial economies. They argue that the large potential contributions of economics to the understanding of technology and economic growth have (...) been constrained by the narrow theoretical framework employed within neoclassical economies. A richer framework, they believe, will support a more fruitful dialogue among economists, policymakers, and managers on the organization of public and private institutions for innovation. David Mowery is Associate Professor of Business and Public Policy at the School of Business Administration, University of California, Berkeley. Nathan S. Rosenberg is Fairleigh Dickinson Professor of Economics at Stanford University. He is the author of Inside the Black Box: Technology and Economics. (shrink)

In the following paper I attempt to show how in Locke''s liberalthought the individual is subject to a complex operation involvingliberation and subjugation. In A Letter on Toleration (1685),Locke argues that the individual''s inward beliefs should be freed fromthe coercion of Church and State. To ensure liberty of conscience, theindividual''s soul should be constituted in practice – notstructured by violence but negotiated by rational persuasion. However,as I suggest, the authority of reason is not established without anelement of violence. In his (...) writings on education, Locke maintains thatthe right to care for one''s soul should be enjoyed only after rigorousmoral training. Thus, the individual''s conscience is to be freed fromoutward violence of ecclesiastic and civil powers only after first, inyouth, being subject to the moral discipline of esteem, disgrace, andshame, the inward violence of which discloses limits in Locke''sdiscourse on toleration. (shrink)

The principles of sexual selection were used as an organizing framework for interpreting cross-national patterns of sex differences in mathematical abilities. Cross-national studies suggest that there are no sex differences in biologically primary mathematical abilities, that is, for those mathematical abilities that are found in all cultures as well as in nonhuman primates, and show moderate heritability estimates. Sex differences in several biologically secondary mathematical domains are found throughout the industrialized world. In particular, males consistently outperform females in the solving (...) of mathematical word problems and geometry. Sexual selection and any associated proximate mechanisms influence these sex differences in mathematical performance indirectly. First, sexual selection resulted in greater elaboration in males than in females of the neurocognitive systems that support navigation in three-dimensional space. Knowledge implicit in these systems reflects an understanding of basic Euclidean geometry, and may thus be one source of the male advantage in geometry. Males also use more readily than females these spatial systems in problem-solving situations, which provides them with an advantage in solving word problems and geometry. In addition, sex differences in social styles and interests, which also appear to be related in part to sexual selection, result in sex differences in engagement iii mathematics-related activities, thus further increasing the male advantage in certain mathematical domains. A model that integrates these biological influences with sociocultural influences on the sex differences in mathematical performance is presented in this article. (shrink)

"Dr. Rubin has brought cognitive psychology into a wholly unprecedented dialogue with studies in oral tradition. The result is a truly new perspective on memory and the processes of oral tradition." --John Miles Foley, University of Missouri.

Leading a corporation through a crisis requires rational decision making guided by an ethical approach (Snyder et al., Journal of Business Ethics, 63, 2006, 371). Three such approaches are virtue ethics (Seeger and Ulmer, Journal of Business Ethics, 31, 2001, 369), an ethic of justice, and an ethic of care (Simóla, Journal of Business Ethics, 46, 2003, 351). In this article, I consider the effectiveness of these approaches for leading a corporation after a crisis. The standard I use is drawn (...) from recent studies that examine how people tend to react to corporate unintentional harms. I conclude from these studies that an ethic of care approach is most effective for managing corporate crises when it comes to stakeholder concerns. I conclude the article with strategies for managing a crisis using an ethic of care. (shrink)

In this work David Durst explores the development of modernism in the philosophy, politics, and culture of the first German Republic between 1918 and 1933. Through a reasoned critique of various Weimar intellectual figures such as Ernst Bloch, Martin Heidegger, and Theodor Adorno, Durst offers clarity and insight into the various aesthetic postures of the interwar period. From the cultural vibrancy of the early Weimar period to the eventual decay towards fascism and Nazi rule,Weimar Modernism provides a new and (...) coherent way to examine this important era, which has often been presented in a fragmented manner. (shrink)

Book reviewed in this article: Balancing Act: The New Medical Ethics of Medicine's New Economics. By E. Haavi Morreim.

I offer a critical analysis of a view that has become a dominant aspect of recent thought on the relationship between evolution and morality, and propose an alternative. An ingredient in Michael Ruse's 'error theory' (Ruse 1995) is that belief in moral (prescriptive, universal, and nonsubjective) guidelines arose in humans because such belief results in the performance of adaptive cooperative behaviors. This statement relies on two particular connections: between ostensible and intentional types of altruism, and between intentional altruism and morality. (...) The latter connection is problematic because it makes morality redundant, its role having already been fulfilled by the psychological dispositions that constitute intentional altruism. Both behavioral ecology and moral psychology support this criticism, and neither human behavioral flexibility nor the self-regard / other-regard distinction can provide a defense of the error theory. I conclude that morality did not evolve to curb rampant selfishness; instead, the evolutionarily recent 'universal law' aspect of morality may function to update behavioral strategies which were adaptive in the paleolithic environment of our ancestors (to which our psychological dispositions are best adapted), by means of norms more appropriate to our novel social environment. (shrink)

St. John of the Cross’ work, The Dark Night of the Soul, and Joseph Symonds’ work, The Case and Cure of a Deserted Soul, offer two compelling treatments on the subject of spiritual dryness. Moreover, these works represent two spiritual traditions which offer distinct but viable perspectives on the Christian life. This paper seeks to answer the following question: What is the degree of similarity between St. John of the Cross’ understanding of the dark night of the soul and Joseph (...) Symonds’ understanding of spiritual desertion? A secondary question is also addressed: What is the value of these resources for pastoral care today? Although notable differences exist between the two, their degree of similarity is significant considering the disconnection between the spiritual traditions that each represent. Moreover, these works are invaluable resources for contemporary pastoral care. (shrink)

Interdisciplinary studies has grown significantly in the last 25 years. The reductionisms of secular modernism and postmodem relativism present an opportunity for an approach to interdisciplinary faith-learning integration that provides a unifying basis for research addressing major challenges. An approach developed at Oxford Graduate School offers promise for interdisciplinary studies comprehensive enough to bridge the three cultures of the natural, social, and humane sciences in the service of bettering the world. The Learning... to Change the World methodology proceeds through seven (...) stages: problem clarification, literature review, faith-learning integration, interdisciplinary research, contextualization, ethical/social leadership, and lifelong learning evaluation. Grounded in a Creation-Fall-Redemption-Consummation metaphysical worldview, it assumes a critical realist epistemology to engage real-world challenges. The process accommodates multiple research methods and aims for a redemptive-ethical transformation of social problems. (shrink)

"Dr. Rubin has brought cognitive psychology into a wholly unprecedented dialogue with studies in oral tradition. The result is a truly new perspective on memory and the processes of oral tradition." --John Miles Foley, University of Missouri.

This book, in language accessible to the general reader, investigates twelve of the most notorious, most interesting, and most instructive episodes involving the interaction between science and Christianity, aiming to tell each story in its historical specificity and local particularity. Among the events treated in When Science and Christianity Meet are the Galileo affair, the seventeenth-century clockwork universe, Noah's ark and flood in the development of natural history, struggles over Darwinian evolution, debates about the origin of the human species, and (...) the Scopes trial. Readers will be introduced to St. Augustine, Roger Bacon, Pope Urban VIII, Isaac Newton, Pierre-Simon de Laplace, Carl Linnaeus, Charles Darwin, T. H. Huxley, Sigmund Freud, and many other participants in the historical drama of science and Christianity. (shrink)

List of contributors; Acknowledgments; Introduction Robert S. Westman and David C. Lindberg; 1. Conceptions of the scientific revolution from Bacon to Butterfield: a preliminary sketch David C. Lindberg; 2. Conceptions of science in the scientific revolution Ernan McMullin; 3. Metaphysics and the new science Gary Hatfield; 4. Proof, portics, and patronage: Copernicus’s preface to De revolutionibus Robert S. Westman; 5. A reappraisal of the role of the universities in the scientific revolution John Gascoigne; 6. Natural magic, hermetism, and (...) occultism in early modern science Brian P. Copenhaver; 7. Natural history and the emblematic world view William B. Ashworth, Jr.; 8. From the secrets of nature to public knowledge William Eamon; 9. Chemistry in the scientific revolution: problems of language and communication Jan V. Golinski; 10. The new philosophy and medicine in seventeenth-century England Harold J. Cook; 11. Science and heterodoxy: an early modern problem reconsidered Michael Hunter; 12. Infinitesimals and transcendent relations: the mathematics of motion in the late seventeenth century Michael S. Mahoney; 13. The case of mechanics: one revolution or many? Alan Gabbey; Index. (shrink)

The organism is one of the fundamental concepts of biology and has been at the center of many discussions about biological individuality, yet what exactly it is can be confusing. The definition that we find generally useful is that an organism is a unit in which all the subunits have evolved to be highly cooperative, with very little conflict. We focus on how often organisms evolve from two or more formerly independent organisms. Two canonical transitions of this type—replicators clustered in (...) cells and endosymbiotic organelles within host cells—demonstrate the reality of this kind of evolutionary transition and suggest conditions that can favor it. These conditions include co-transmission of the partners across generations and rules that strongly regulate and limit conflict, such as a fair meiosis. Recently, much attention has been given to associations of animals with microbes involved in their nutrition. These range from tight endosymbiotic associations like those between aphids and Buchnera bacteria, to the complex communities in animal intestines. Here, starting with a reflection about identity through time, we consider the distinctions between these kinds of animal–bacteria interactions and describe the criteria by which a few can be considered jointly organismal but most cannot. (shrink)

We seek a better understanding of why an inferential semantics devised by Tor Sandqvist yields full classical logic, by providing and analysing a direct proof via a suitable maximality construction.