Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.We explore (...) what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking. (shrink)

There is currently an explosion of interest in grounding. In this article we provide an overview of the debate so far. We begin by introducing the concept of grounding, before discussing several kinds of scepticism about the topic. We then identify a range of central questions in the theory of grounding and discuss competing answers to them that have emerged in the debate. We close by raising some questions that have been relatively neglected but which warrant further attention.

Normative realists tend to consider evolutionary debunking arguments as posing epistemological challenges to their view. By understanding Sharon Street’s ‘Darwinian dilemma’ argument in this way, they have overlooked and left unanswered her unique scientific challenge to normative realism. This paper counters Street’s scientific challenge and shows that normative realism is compatible with an evolutionary view of human evaluative judgment. After presenting several problems that her adaptive link account of evaluative judgments faces, I outline and defend an evolutionary byproduct perspective on (...) evaluative judgment. I then argue that a consideration of levels of analysis in biological–behavioral explanation suggests that the realist who adopts the byproduct perspective I outline is not at a prima facie disadvantage to the normative anti-realist on grounds of parsimony. This perspective, I suggest, can enable normative realists to answer evolutionary challenges to their view. (shrink)

I argue that plausible claims in the logic of partial grounding, when combined with a plausible analysis of that concept, entail the falsity of plausible grounding claims. As our account of the concept of partial grounding and its logic should be consistent with plausible grounding claims, this is problematic. The argument hinges on the idea that some facts about what grounds what are grounded in others, which is an idea the paper aims to motivate.

Philosophical discussions of the morality of suicide have tended to focus on its justifiability from an agent’s point of view rather than on the justifiability of attempts by others to intervene so as to prevent it. This paper addresses questions of suicide intervention within a broadly Kantian perspective. In such a perspective, a chief task is to determine the motives underlying most suicidal behaviour. Kant wrongly characterizes this motive as one of self-love or the pursuit of happiness. Psychiatric and scientific (...) evidence suggests that suicide is instead motivated by a nihilistic disenchantment with the possibility of happiness which, at its apex, results in the loss of the individual’s conception of her practical identity. Because of this, methods of intervention that appeal to agents’ happiness, while morally benign, will prove ineffective in forestalling suicide. At the same time, more aggressive methods violate the Kantian concern for autonomy. This apparent dilemma can be resolved by seeing suicide intervention as an action undertaken in non-ideal circumstances, where otherwise unjustified manipulation, coercion, or paternalism are morally permitted. (shrink)

Recently, Kroedel and Schulz have argued that the exclusion problem—which states that certain forms of non-reductive physicalism about the mental are committed to systematic and objectionable causal overdetermination—can be solved by appealing to grounding. Specifically, they defend a principle that links the causal relations of grounded mental events to those of grounding physical events, arguing that this renders mental–physical causal overdetermination unproblematic. Here, we contest Kroedel and Schulz’s result. We argue that their causal-grounding principle is undermotivated, if not outright false. (...) In particular, we contend that the principle has plausible counterexamples, resulting from the fact that some mental states are not fully grounded by goings on ‘in our heads’ but also require external factors to be included in their full grounds. We draw the sceptical conclusion that it remains unclear whether non-reductive physicalists can plausibly respond to the exclusion argument by appealing to considerations of grounding. (shrink)

We highlight connections between accessible categories and abstract elementary classes , and provide a dictionary for translating properties and results between the two contexts. We also illustrate a few applications of purely category-theoretic methods to the study of AECs, with model-theoretically novel results. In particular, the category-theoretic approach yields two surprising consequences: a structure theorem for categorical AECs, and a partial stability spectrum for weakly tame AECs.

Legal statutes prohibiting felons from voting result in nearly 4 million Americans, disproportionately African-American and male, being unable to vote. These felony disenfranchisement (FD) statutes have a long history and apparently enjoy broad public support. Here I argue that despite the popularity and extensive history of these laws, denying felons the right to vote is an unjust form of punishment in a democratic state. FD serves none of the recognized purposes of punishment and may even exacerbate crime. My strategy is (...) not to argue for this conclusion directly. Rather, I consider seven arguments for the moral legitimacy of FD, each of which will be found lacking. My emphasis falls not on the legal or constitutional questions associated with FD, but with its moral justification within a broadly liberal political framework. These arguments draw upon a variety of philosophical outlooks; three justify FD by appealing to justice or desert, three others justify FD based on its allegedly beneficial social consequences, and a final argument is a hybrid of both sorts of considerations. Not only do all these arguments fail, but eliminating FD could have salutary effects on our present climate of political discourse. -/- . (shrink)

If there are facts about what grounds what, are there any grounding relations between them? This paper suggests so, arguing that transitivity and amalgamation principles in the logic of grounding yield facts of grounding that are grounded by others. I develop and defend this view and note that combining it with extant accounts of iterated grounding commits us to seemingly problematic instances of ground-theoretic overdetermination. Taking the superinternality thesis as a case study, I discuss how defenders of this thesis should (...) respond. It emerges that our discussion puts pressure on superinternalists to make an interesting qualification to their view: to only regard as a fundamental metaphysical law a version of the superinternality thesis that is restricted to minimal and immediate grounding. (shrink)

Evolutionary reliabilism is the view that natural selection likely favoured reliable cognitive faculties in humans. While ER enjoys some plausibility, Stephen Stich and Alvin Plantinga have presented well-known challenges to the view. Their arguments rely on a common premiss; namely, that natural selection is indifferent to truth. This article shows that this premiss is both imprecise and too weak to support their conclusions and, therefore, that their challenges to ER fail.

Beginning at the end of the nineteenth century, systematic scientific abstracting played a crucial role in reconfiguring the sciences on an international scale. For mathematicians, the 1931 launch of the Zentralblatt für Mathematik and 1940 launch of Mathematical Reviews marked and intensified a fundamental transformation, not just to the geographic scale of professional mathematics but to the very nature of mathematicians’ research and theories. It was not an accident that mathematical abstracting in this period coincided with an embrace across mathematical (...) research fields of a distinctive form of symbolic and conceptual abstraction. This essay examines the historical, institutional, embodied, and conceptual bases of mathematical abstracting and abstraction in the mid-twentieth century, placing them in historical context within the first half of the twentieth century and then examining their consequences and legacies for the second half of the twentieth century and beyond. Focused on scale, media, and the relationship between mathematical knowledge and its forms of articulation, my analysis connects the changing social structure of modern mathematical research communities to their changing domains of investigation and resources for representation and collective understanding. (shrink)

We introduce a family of rank functions and related notions of total transcendence for Galois types in abstract elementary classes. We focus, in particular, on abstract elementary classes satisfying the condition known as tameness, where the connections between stability and total transcendence are most evident. As a byproduct, we obtain a partial upward stability transfer result for tame abstract elementary classes stable in a cardinal $\lambda$ satisfying $\lambda^{\aleph_{0}}\gt \lambda$, a substantial generalization of a result of Baldwin, Kueker, and VanDieren.

Pseudonymous mathematician Nicolas Bourbaki and his lesser-known counterpart E.S. Pondiczery, devised respectively in France and in Princeton in the mid-1930s, together index a pivotal moment in the history of modern mathematics, marked by international infrastructures and institutions that depended on mathematicians’ willingness to play along with mediated personifications. By pushing these norms and practices of personification to their farcical limits, Bourbaki’s and Pondiczery’s impersonators underscored the consensual social foundations of legitimate participation in a scientific community and the symmetric fictional character (...) of both fraud and integrity in scientific authorship. To understand authorial identity and legitimacy, individual authors’ conduct and practices matter less than the collective interpersonal relations of authorial assertion and authentication that take place within disciplinary institutions. (shrink)

Research into the work of UK estate agents reveals a love‐hate attitude on the part of the public and profound ethical ambivalences. Dr Clarke is a member of the Department of Sociology, Social Policy and Social Work Studies, The University of Liverpool, POB 147, Liverpool L69 3BX. This article draws on his study Slippery Customers: Estate Agents, The Public and Regulation, Blackstone Press 1994, co‐authored with D. Smith and M. McConville.

Christine Korsgaard has argued recently that the thesis that reasons are "essentially public" undermines the distinction between agent-neutral and agent-relative reasons, thus refuting egoism by rejecting its commitment to the universal availability of agent-relative reasons. I conclude that Korsgaard's invocation of the essential publicity of reasons trades on ambiguities concerning the "sharing" of reasons and so does not refute egoism and does not ground moral normativity. Her account of the publicity of reasons shows that solipsism is incoherent, but the egoist (...) need not be a solipsist, nor is she an incompetent user of moral language or the language of reasons. (shrink)

We conducted focus groups with 47 potential jurors who were presented with diferent scenarios in a hypothetical malpractice case involving failure to order a PSA test. Better documentation that a patient made an informed decision to decline a PSA test appeared to provide more medical-legal protection for physicians, especially with the use of a decision aid.

Screening for prostate cancer with the prostate-specific antigen blood test is controversial, as evidence to date has not demonstrated such screening does more good than harm. While the potential benefit of PSA screening on reducing prostate cancer mortality has not been documented in randomized trials, many risks of PSA screening have been well documented. These risks include a substantially higher risk of a prostate cancer diagnosis over a screenee’s lifetime, false-positive and false-negative test results, possible complications from biopsies done in (...) response to suspicious test results, and substantial risks of side effects from subsequent prostate cancer treatments. Nevertheless, PSA screening is widespread in the United States, and many physicians in a national survey reported supporting routine PSA screening as well as getting PSA tests themselves, despite the lack of evidence. (shrink)

Where does the particular form or configuration of a pattern come from, and how is it propagated from pattern to pattern? Templets and the Explanation of Complex Patterns provides a natural language for analysing such questions. Using it, the organisational forces that underlie the fabrication of any pattern can be divided into two classes. First, there are the 'universal laws' of pattern assembly, the configurational rules and constraints inherent within the fabric of the pattern elements themselves. Second, there are the (...) 'templets' - external, situational constraints imposed on the pattern elements. From the perspective of templeting, simple patterns can be directly contrasted with complex patterns: the former are completely determined by their universal laws, whereas the latter also require extensive templets. Natural patterns range along the entire spectrum from simple to complex, and the most complex of these include both random patterns and many biological patterns. (shrink)

The first part of this paper consists of an exposition of the views expressed by Pierre Duhem in his Aim and Structure of Physical Theory concerning the philosophy and historiography of mathematics. The second part provides a critique of these views, pointing to the conclusion that they are in need of reformulation. In the concluding third part, it is suggested that a number of the most important claims made by Duhem concerning physical theory, e.g., those relating to the Newtonian method, (...) the limited falsifiability of theories, and the restricted role of logic, can be meaningfully applied to mathematics. (shrink)

The definition of precision medicine has continued to evolve, partly in response to criticism of the original concept. However, whatever the definition or current state of the brand, it fundamentally relies on a putatively tight linkage between genotype and complex human traits. If such a linkage is truly robust, then it should be possible to predict the occurrence of complex traits, both good and bad. If such prediction is possible, it should also be feasible to intervene to prevent or preempt (...) disease-related traits. There are of course many potential barriers to this sort of genomic medicine two-step. For example, a number of statistical considerations make generating biomarker (including gene... (shrink)

A recent American Academy of Pediatrics (AAP) clinical report states that it is an acceptable option for pediatric care clinicians to dismiss families who refuse vaccines. This is a clear shift in guidance from the AAP, which previously advised clinicians to “endeavor not to discharge” patients solely because of parental vaccine refusal. While this new policy might be interpreted as encouraging or recommending dismissal of vaccine-refusing families, it instead expresses tolerance for diverse professional approaches. This is unlike the earlier guidance, (...) which promoted a unified response to vaccine refusal. In fact, the resolution (which was presented at the AAP’s Annual Leadership Forum) that led to this clinical report also calls on the AAP “to continue to support pediatricians who continue to provide health care to children of parents who refuse to immunize their children.” However, the shift toward embracing dismissal as an acceptable response to vaccine refusal may erode professional solidarity. Pediatricians are clearly divided on this question; most do not dismiss vaccine-refusing families. By declaring that dismissal is an acceptable option, the AAP has sanctioned a practice that may be unfair to the many clinicians who do not dismiss these families. Clinicians who adopt a policy of dismissal toward families who refuse vaccines might impose burdens on colleagues who remain willing to offer care to those families, and their actions might show insufficient commitment to the efforts of their profession to promote health for all children. (shrink)

Comparing my historical account of the early years of Laurent Schwartz’s theory of distributions with number theorist Michael Harris’s narrative of the early years of Peter Scholze’s perfectoid theory, I develop a perspective on change and temporality in mathematics that emphasizes the relationships between concepts, expectations, and communities of practice. Contemporary mathematics, understood as mathematics imbued with temporality, reflects the dynamic relationship between the people, ideas, pasts, and prospects of mathematical knowledge. Studying these historically may offer critical perspectives on (...) the social and political conditions and implications of mathematical research and the communities that practice it. (shrink)

T.M. Scanlon (1998) proposes that promise breaking is wrong because it shows manipulative disregard for the expectations for future behavior created by promising. I argue that this account of promissory obligation is mistaken in it own right, as well as being at odds with Scanlon's contractualism. I begin by placing Scanlon's account of promising within a tradition that treats the creation of expectations in promise recipients as central to promissory obligation. However, a counterexample to Scanlon's account, his case of the (...) "Profligate Pal," will show that this view of promissory obligation, which I call the Expectations View, is incorrect. In its place, I propose an account of promissory obligation I call Promising as Accountability, according to which promising is a way of making oneself accountable to others for a future act. Not only is Promising as Accountability a more defensible approach to promissory obligation, it also better fits with certain general features of Scanlon's contractualism. (shrink)

E. Beltrami in 1868 did not intend to prove the consistency of non-euclidean plane geometry nor the independence of the euclidean parallel postulate. His approach would have been unsuccessful if so intended. J. Hoüel in 1870 described the relevance of Beltrami's work to the issue of the independence of the euclidean parallel postulate. Hoüel's method is different from the independence proofs using reinterpretation of terms deployed by Peano about 1890, chiefly in using a fixed interpretation for non-logical terms. Comparing the (...) work of Beltrami and Hoüel with the treatment of non-euclidean geometry after the development of the axiomatic method in the 1890s indicates an important shift in mathematicians? attitudes towards mathematical theories. (shrink)

Ockham appeared to maintain that God necessarily knows all true propositions, including future contingent propositions, despite the fact that such propositions have determinate truth values. While some commentators believe that Ockham’s attempt to reconcile divine omniscience with the contingency of true future propositions amounts to little more than a simple-minded assertion of Ockham’s Christian faith, I argue that Ockham’s position is more sophisticated than this and rests on attributing to God a dual knowledge property: God not only knows every true (...) proposition, but knows its modal properties as well. Future contingent propositions are determinately true when actualized, not timelessly, and God’s knowledge of their truth values is knowledge of when the truth value of a proposition is actually determined. (shrink)

Evidence from the Apology, Crito, Protagoras, and Gorgias is mustered in defense of the claim that for Socrates, dialectic typifies just punishment: Dialectic benefits the punished by making her more just, since it disabuses her of the false beliefs that stand in the way of her acquiring knowledge of justice. Though painful and disorienting to the interlocutor, having one’s opinions refuted by Socrates—who is wiser than his interlocutors due to his awareness of the vastness of his ignorance—is in fact a (...) benefit. Socrates’ attitude toward his own pending death sentence, his claim that the virtues are unified around wisdom, and his opposition to vengeance or retaliation as a moral motive, all underscore how dialectical engagement is a paradigm instance of just Socratic punishment. (shrink)

Evidence from the Apology, Crito, Protagoras, and Gorgias is mustered in defense of the claim that for Socrates, dialectic typifies just punishment: Dialectic benefits the punished by making her more just, since it disabuses her of the false beliefs that stand in the way of her acquiring knowledge of justice. Though painful and disorienting to the interlocutor, having one’s opinions refuted by Socrates—who is wiser than his interlocutors due to his awareness of the vastness of his ignorance—is in fact a (...) benefit. Socrates’ attitude toward his own pending death sentence, his claim that the virtues are unified around wisdom, and his opposition to vengeance or retaliation as a moral motive, all underscore how dialectical engagement is a paradigm instance of just Socratic punishment. (shrink)

Increasing frauds in insurance and mortgage‐lending illustrate the dilemma for companies between tackling fraud in the public interest and retaining customer confidence and competitive position.

Book Reviewed in this article: Multinationals as Moral Agents George Goyder Meeting Customer Expectations Sheila M. Evers E PLURIBUS UNUM?! Tim Traverse‐Healy The Impacts of Tourism Marion Wheeler.

Most large frauds develop only gradually and incidentally. When things fall apart it is politic to call it anything but fraud. The author is a member of the Department of Sociology, University of Liverpool, POB 147, Liverpool L69 3BX.

Most large frauds develop only gradually and incidentally. When things fall apart it is politic to call it anything but fraud. The author is a member of the Department of Sociology, University of Liverpool, POB 147, Liverpool L69 3BX.

How much real impact on business behaviour is achieved by ethical debate and discussion? The author contends that little ethical change will come about unless it is the subject of regulation and institutions, as instanced in equal opportunities, corporate governance and the quality of financial services. Dr Clarke is a member of the Department of Sociology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX.

How much real impact on business behaviour is achieved by ethical debate and discussion? The author contends that little ethical change will come about unless it is the subject of regulation and institutions, as instanced in equal opportunities, corporate governance and the quality of financial services. Dr Clarke is a member of the Department of Sociology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX.