This paper describes an experimental platform for approximate knowledge databases called the Approximate Knowledge Database, based on a semantics inspired by rough sets. The implementation is based upon the use of a standard SQL database to store logical facts, augmented with several query interface layers implemented in JAVA through which extensional, intensional and local closed world nonmonotonic queries in the form of crisp or approximate logical formulas can be evaluated tractably. A graphical database design user interface is also provided which (...) simplifies the design of databases, the entering of data and the construction of queries. The theory and semantics for AKDBs is presented in addition to application examples and details concerning the database implementation. (shrink)

Neural cell adhesion molecules of the immunoglobulin superfamily are important components of the network of guidance cues and receptors that govern axon growth and guidance during development. For neural cell adhesion molecule L1, the combined application of human genetics, knockout mouse technology, and cell biology is providing fundamental insight into the role of L1 in mediating neuronal differentiation. Disease-causing mutations as well as mouse models of L1 disruption can now be used to examine the relevance of L1 binding specificities and (...) signal transduction pathways that have been observed in vitro. BioEssays 20:668–675, 1998.© 1998 John Wiley & Sons Inc. (shrink)

Fibroblast growth factor receptors (FGFRs) have been implicated in many developmental and regenerative events, including axial organisation, mesodermal patterning, keratinocyte organisation and brain development. The consensus view that this reflects a role for one or other of the nine known members of the fibroblast growth factor family in these processes has recently been challenged by the suggestion that FGFRs might be directly activated by a much wider range of ligands, including heparan sulphate proteoglycans and neural cell adhesion molecules. In addition, (...) two novel soluble ligands for FGFRs have been identified using yeast two‐hybrid technology. Overall, the new findings suggest that in terms of ligand binding the FGFRs might be an even more promiscuous family of receptor tyrosine kinases than was already appreciated. (shrink)

Hastings Center Report, Volume 52, Issue 5, Page 32-42, September–October 2022.

continent. 1.3 (2011): 208-212. … intervals of destructuring paradoxically carry the momentum for the ongoing process by which thought and perception are brought into relation toward transformative action. —Brian Massumi, Parables for the Virtual: Movement, Affect, Sensation 1 Facing a blank canvas or blank page is a moment of pure potential, one that can be enervating or paralyzing. It causes a pause, a hesitation, in anticipation of the moment of inception—even of one that never comes. The implication is that the (...) blank is yours in that moment, and it calls on you to act on it, to think into it, to create on it. Each blank canvas gives you time, of an undefined length, to transform that canvas’ inherent potential into a work. This two-dimensional plane of potential can be projected into a space, which the body can then occupy. When you “destructure” a space in the same way, prepare it to be a blank, much as you build a canvas, you allow your entire body to enter the space of potential, and you rest in anticipation of work, like the hand poised above the page. Artists have found that the deliberate creation of that space of potential through sealing the space and painting it white, thereby erasing details and distractions, can be such a transformative experience as to help define their whole practice. The cessation of distraction, the absence of indicator that a “blanked” workspace provides allows for a new presence of mind, it gives them the room, literally, to move into their work, and from there to move their work into the world. The workspace for the artist, the studio, is often perceived as a lab-like condensation of the gallery or museum, the traditional and idealized white cube. Similarly, with the blank page, a concrete relation between space and time comes forward as the intentional simplification of the architecture changes behavior and perception within the space. The work of “blanking” the studio space is a meditative reduction, an erasure, and in a way, an attempt at drawing away from the world beyond the studio - the sealed space is meant to recede from reality, to become abstracted by its willed lack of details and distractions. Within that space the time for a new beginning is made more present, more attainable, and the focus it fosters becomes another tool to aid creation. At the formative moment of his artistic practice, Tom Friedman used the blank of his studio, saturated in white, sealed off from the world, to fight velocity. He describes how he projected his vision of the end goal, the museum - a place he believes to be defined by slow contemplation - onto his own studio experience. He then sat and reflected on common objects, one by one, framed by the blank box he had created. The domestic objects he brought into the space to study foreshadow his mature works, where often the quotidian object has a single additional element – his intense labor. Friedman makes discrete objects through absurdly intense and focused labor, epitomized, perhaps by his 1,000 hours of Staring , made from 1992-97: Tom Friedman. 1000 Hours of Staring (1992-1997) His labor, to use his own words, is his way to “bring all of who you are to the experience.” Friedman shares his labor, allows the slow, deliberate pace of his work born in the studio to penetrate the museum. Nothing seems effortless, or a gesture, the labor is apparent, displayed, and tangible. He gives us the labor, the personal investment in the physical that saved art for him, that divorced the work from the language he cites as a factor of alienation. When we see his work we do not see words, we see acts, we see objects. He has forced the studio as workspace into the exhibition space, as he stuffs hundreds of more hours of labor into his shows with each new piece, filling the space with material and labor, material and labor – his involvement, his investment, is his gift to us as the viewers, as he introduces the laborious and contemplative pace he feels belongs to the museum. He saves us also from the alienation of language, which first drove him into the sealed studio and away from the discourse of his school. He presents us with his real, the object which stands in stark contrast to the white slate of the studio, the sealed white box he started from, where his individual, self-contained objects begin and end, completed through the intensity of isolation, first of the individual artist, and then of the material he chooses to slowly, slowly, slowly work: Tom Friedman. Untitled (1992) In his in-depth analysis of galleries as a blank white cube, Brian O’Doherty emphasizes the religious connotations implied in the strict laws of the exhibition space and the valuation, aesthetics and elements of control he feels it imposes upon the work. Like Friedman, he recognizes the power of the restricted space – indicating the “perceptual fields of force” – that act on any object introduced into it. Going beyond Friedman’s assessment of the space as highly utilitarian for focusing his perception, O’Doherty emphasizes the rejection of the physical body of the artist or observer, saying that the cube allows for only observation - eyes and mind. He later parallels the picture frame as a psychological container for the artist with the room as the same for the observer. In both cases, this is an emphasis on the alienating nature of the relationship – just as the artist is kept out of the frame by the picture, in the gallery the art forces the body of the spectator out, calling for a self-referential purity. Patrick Ireland. White Cube (1998) O’Doherty makes a point of saying that the installation shot of the gallery without figures is “one of the icons of our visual culture.” In recent years, however, installation shots have begun to include figures, in some cases they are essential to understanding the scale and even the nature of the work, specifically with work that captures the experience of the space and the way that it varies from a white cube. The work of Olafur Eliasson is a case in point, as the Danish artist uses elements of scientific and natural phenomena to alter perception within the controlled gallery environment, tweaking and redirecting O’Doherty’s “perceptual fields of force” to make points about the act of seeing, or seeing yourself seeing, to quote the artist. This indicates a shift in the role of the artwork, not to exclude the body and stand discretely and self-sufficiently, but to include it, to manipulate it and to make the observer aware of the nature of that manipulation and the work’s ability to manipulate. Olafur Eliasson. 360º room for all colours (2002) So though in O’Doherty’s analysis, the intense blankness of the gallery pushed the observer out in favor of the artwork’s isolation, artists can replicate this inhumane sterility in their own workspace to focus their work on the influence of the gallery right from inception. This can be interpreted as an almost opposite understanding of the purpose of sealing and whitewashing the workspace as stated by Friedman. He sought a refuge from the critical language of the art school, and a space that, like the museum, gave him a protracted sense of time, and, he felt, welcomed him in, “to bring all of who you are,” as opposed to O’Doherty’s feeling that the museum was asking you, at least in body, to leave, and allow the work to take on its own life. Friedman does not seem to imply the tension with the cube and critical stance that O’Doherty prioritizes. Where Friedman finds a refuge, O’Doherty defines an opponent. In a third position, Robert Irwin describes his sealed studio space as “the world.” Though he made the same effort as Friedman to seal out all influences and distractions, he implies that he is in dialogue with the world through his own concentration and perception. This is reminiscent of the nature of the monad, as interpreted by Deleuze, a unity that envelops a multiplicity, a sealed container that contains the universe. He went through the same ritual described by Friedman, sealing up the space, painting it white, and then forcing himself to remain inside, staring at his own work, training his concentration relentlessly. But he found that the room became the distraction: …he became aware that a thin crack along the wall a few yards away from the canvas likewise exerted its presence; that when he plastered that crack over and repainted the wall, the canvas itself presented an entirely new aspect.2 The context was in a relentless dialogue with the work, and trying to neutralize that dialogue, to mute the conversation between space and object, became part of his ritual as he “fixed” his space each day in the hope of total concentration on the work. Ultimately, Irwin shaped the trajectory of his art by relinquishing the studio, establishing a post-studio practice, where the work is conceived and created out in the world, in dialogue with the world and reflective of the conditions it finds surrounding it. The white cube failed to ever achieve neutrality, his heightened concentration prevented him from ever neutralizing the space, so, instead of continuing to try to maintain the charade of a perfect blank, he acknowledged the unstoppable voice of place and turned all his efforts onto the object and the world, as a constant dialogue. Some artists push their studio space far from purity, domesticating it like a lair or a living room, and others destroy it, fill it with chaos or detritus, blacken or clutter it so as never to be starting from a blank, and thereby try to avoid the anxiety of facing that void. Similarly artists may never prepare a white canvas, a clean page, a marble block, or other form that is intentionally lacking, in order to try to escape the dialogue with emptiness. But Irwin, like O’Doherty, found an opponent in the white cube, and he learned not to fight it, rather he ended the conflict by making it an ally, an interlocutor, a collaborator. We can vainly strive to start from nothing, to find the lull, the clearing, and to always consider what we do in balance with the empty set. Somehow that intangible cloud of hazy nothingness, that softness of a lapse continually offers a place to bounce off of, to react to, to wrestle with, to rest with, in tension, or a place to begin. Robert Irwin. Excursus: Homage to the Square3 (1998) NOTES 1 Massumi. Parables for the Virtual: Movement, Affect, Sensation. p271. 2 MOMA, NY. Eliasson, 360 ? Room for All Colours . Installation. 2002. (shrink)

Linear logic, introduced by Girard, is a refinement of classical logic with a natural, intrinsic accounting of resources. This accounting is made possible by removing the ‘structural’ rules of contraction and weakening, adding a modal operator and adding finer versions of the propositional connectives. Linear logic has fundamental logical interest and applications to computer science, particularly to Petri nets, concurrency, storage allocation, garbage collection and the control structure of logic programs. In addition, there is a direct correspondence between polynomial-time computation (...) and proof normalization in a bounded form of linear logic. In this paper we show that unlike most other propositional logics, full propositional linear logic is undecidable. Further, we prove that without the modal storage operator, which indicates unboundedness of resources, the decision problem becomes PSPACE-complete. We also establish membership in NP for the multiplicative fragment, NP-completeness for the multiplicative fragment extended with unrestricted weakening, and undecidability for fragments of noncommutative propositional linear logic. (shrink)

This paper examines the impact of a shift in focus from political praxis to trauma work in the context of a failed democratisation movement. It investigates the various phenomena which emerge when intellectuals, under the traumatic impact of violence and atrocities, place trauma narration at the core of their interventions. Drawing on document analysis, participant observation and semi-structured interviews with twenty nine exiled Syrian intellectuals in Paris and Berlin who had participated in the revolutionary movement of 2011, the paper suggests (...) that an inversion of the normative power structures pertaining to how intellectuals relate to their publics occurs when they adopt, under conditions of extreme violence and trauma, what we call a radically embedded positionality vis-à-vis ‘the people’. This results in the dismantling of previous figurations of the ‘militant intellectual’ along with praxis-focused notions of the ‘responsibility of intellectuals’, ultimately undermining their ideational influence upon domestic publics and weakening their political impact and critical role within a revolutionary movement. (shrink)

D. Alan Shewmon has advanced a well-documented challenge to the widely accepted total brain death criterion for death of the human being. We show that Shewmon's argument against this criterion is unsound, though he does refute the standard argument for that criterion. We advance a distinct argument for the total brain death criterion and answer likely objections. Since human beings are rational animals – sentient organisms of a specific type – the loss of the radical capacity for sentience involves a (...) substantial change, the passing away of the human organism. In human beings total brain death involves the complete loss of the radical capacity for sentience, and so in human beings total brain death is death. (shrink)

Experimental research by social and cognitive psychologists has established that cooperative groups solve a wide range of problems better than individuals. Cooperative problem solving groups of scientific researchers, auditors, financial analysts, air crash investigators, and forensic art experts are increasingly important in our complex and interdependent society. This comprehensive textbook--the first of its kind in decades--presents important theories and experimental research about group problem solving. The book focuses on tasks that have demonstrably correct solutions within mathematical, logical, scientific, or verbal (...) systems, including algebra problems, analogies, vocabulary, and logical reasoning problems.The book explores basic concepts in group problem solving, social combination models, group memory, group ability and world knowledge tasks, rule induction problems, letters-to-numbers problems, evidence for positive group-to-individual transfer, and social choice theory. The conclusion proposes ten generalizations that are supported by the theory and research on group problem solving. Group Problem Solving is an essential resource for decision-making research in social and cognitive psychology, but also extremely relevant to multidisciplinary and multicultural problem-solving teams in organizational behavior, business administration, management, and behavioral economics. (shrink)

Abstract Of the many ways in which identity is constructed and performed online, few are as strongly ‘anchored’ to existing offline relationships as in online social networks like Facebook and Myspace. These networks utilise profiles that extend our practical, psychological and even corporeal identity in ways that give them considerable phenomenal presence in the lives of spatially distant people. This raises interesting questions about the persistence of identity when these online profiles survive the deaths of the users behind them, via (...) the practice of ‘memorialising’ social network profile pages. I situate these practices within a phenomenology of grief that accounts for the ways in which the dead can persist as moral patients, and show how online survival in this case illuminates an important difference between persons and selves within contemporary philosophy of personal identity. Ultimately, the online persistence of the dead helps bring into view a deep ontological contradiction implicit in our dealings with death: the dead both live on as objects of duty and yet completely cease to exist. Content Type Journal Article Category Special Issue Pages 1-17 DOI 10.1007/s13347-011-0050-7 Authors Patrick Stokes, Philosophy Group, School of Humanities, University of Hertfordshire de Havilland Campus, Hatfield, Hertfordshire AL10 9AB, UK Journal Philosophy & Technology Online ISSN 2210-5441 Print ISSN 2210-5433. (shrink)

Most definitions of radical emergentism characterize it epistemologically. This leads to misunderstandings and makes it hard to assess the doctrine's metaphysical worth. This paper puts forward purely metaphysical characterizations of emergentism and property emergence. It explores the nature of the necessitation relation between base and emergent and argues that emergentism entails a Humean account of causation and related relations. Then it presents arguments against emergentism, both as a wider metaphysic and as an account of consciousness. These maintain that emergentism makes (...) implausible claims about how the world works. The paper also stresses the doctrine's contemporary relevance: most current property dualists endorse views effectively identical to classical emergentism less its historical commitment to novel emergent forces. (shrink)

This introduction provides background information on the emerging field of nanotechnology and its ethical dimensions. After defining nanotechnology and briefly discussing its status as a discipline, about which there exists a meta-controversy, this introduction turns to a discussion of the status of nanoethics and lays out particular issues of concern in the field, both current and emerging.

Cognitive Science, Literature, and the Arts is the first student-friendly introduction to the uses of cognitive science in the study of literature, written specifically for the non-scientist. Patrick Colm Hogan guides the reader through all of the major theories of cognitive science, focusing on those areas that are most important to fostering a new understanding of the production and reception of literature. This accessible volume provides a strong foundation of the basic principles of cognitive science, and allows us to (...) begin to understand how the brain works and makes us feel as we read. (shrink)

The military is a major driver of technological, world-changing innovations which, like the Internet, often have unpredictable dual uses and widespread civilian impact (?blowback?). Ethical and policy concerns arising from such technologies, therefore, are not limited to military affairs, but can have great implications for society at large as well. This paper will focus on two technology areas making headlines at present: human enhancement technologies and robotics, representing both biological and technological upgrades to the military. The concerns we will raise (...) are about (1) the unintended effects that these technologies could have on society and (2) the possibly self-defeating nature of these military programs in making war itself more, rather than less likely to occur. Given that society also can influence military programs (e.g., through civil protests) it is important for the military to attend to such concerns. (shrink)

The determination of individual moral status is a central factor in the ethical evaluation of controversial practices such as elective abortion, human embryo-destructive research, and the care of the severely disabled and those in persistent vegetative states. A review of recent work on Kant reveals the need for a careful examination of the content of Kant ’s biological and psychological theories and their relation to his views about moral status. Such an examination, in conjunction with Kant ’s practical-metaphysical analysis of (...) the origins of freedom, reveals Kant ’s principled basis for his contention that all human beings possess moral status. (shrink)

ABSTRACT In this article, I reply to criticisms of Dean Stretton of the pro‐life argument from substantial identity. When the criterion for the right to life proposed by most proponents of the pro‐life position is rightly understood – being a person, a distinct substance of a rational nature – this position does not lead to the difficulties Stretton claims it does.

An embedding of the implicational propositional intuitionistic logic into the nonmodal fragment of intuitionistic linear logic is given. The embedding preserves cut-free proofs in a proof system that is a variant of IIL. The embedding is efficient and provides an alternative proof of the PSPACE-hardness of IMALL. It exploits several proof-theoretic properties of intuitionistic implication that analyze the use of resources in IIL proofs.

This book explores how the creations of great authors result from the same operations as our everyday counterfactual and hypothetical imaginations, which cognitive scientists refer to as 'simulations'. Drawing on detailed literary analyses as well as recent research in neuroscience and related fields, Patrick Colm Hogan develops a rigorous theory of the principles governing simulation that goes beyond any existing framework. He examines the functions and mechanisms of narrative imagination, with particular attention to the role of theory of mind, (...) and relates this analysis to narrative universals. In the course of this theoretical discussion, Hogan explores works by Austen, Faulkner, Shakespeare, Racine, Brecht, Kafka and Calvino. He pays particular attention to the principles and parameters defining an author's narrative idiolect, examining the cognitive and emotional continuities that span an individual author's body of work. (shrink)

Cet article présente, contre le physicalisme, un argument métaphysique fondé sur la distinction entre les propriétés intrinsèques et extrinsèques. Il soutient que le physique, comme le physicalisme doit le comprendre, comprend uniquement des propriétés extrinsèques, tandis que la conscience implique au moins certaines propriétés intrinsèques. Il conclut que la conscience a des propriétés non-physiques et que le physicalisme est faux. L’article défend ensuite ses prémisses contre la pensée physicaliste actuelle. Autant que possible, il offre des arguments métaphysiques portant sur les (...) propriétés physiques et conscientes plutôt que des arguments épistémologiques portant sur nos concepts physiques et phénoménaux. (shrink)

Le matérialisme que ce livre interroge et construit n'est pas une « philosophie », mais la condition de possibilité et l'outil de la connaissance objective. Historiquement, il se confond, de fait, avec l'élaboration de la science moderne s'affranchissant graduellement des contrats de parole qui l'asservirent longtemps à la métaphysique et à la théologie. Comment cette émancipation s'est-elle effectuée en des temps où une croyance instituée dictait sa loi théologico-politique aux efforts de la connaissance en leur imposant a priori la limite (...) de l'Inconnaissable? Comment d'autre part, face à cet affranchissement toujours inachevé, une métaphysique résiduelle impose-t-elle encore aux artisans de la connaissance objective, sans qu'ils s'en doutent, des cadres, des frontières, des démarches et des représentations? Ce livre montre qu'une analyse savante des complexes de discours dans l'histoire, à travers ce qu'elle explique du passé, peut permettre de comprendre et d'améliorer ce qui constitue proprement aujourd'hui l'acte de connaître. De redéfinir la « conscience ». De sortir des leitmotivs exténués sur le « hasard ». De penser plus authentiquement la singularité émergente du vivant. De s'éloigner d'un modèle strictement nécessitariste du « déterminisme ». De sortir des impasses avérées du réductionnisme. De résoudre les contradictions tacitement acceptées entre matérialisme et morale, ou entre déterminisme et conduites autonomes. D'entrevoir l'origine du symbolisme. De comprendre la nature originellement et fondamentalement politique de la religion. De penser l'articulation évolutive entre « nature » et « civilisation », et un lien cohérent et critique entre sciences de la nature et sciences de la société. D'identifier les comportements discursifs récurrents de ce que l'on nomme l'« idéologie ». Et d'édifier sur de nouvelles bases une histoire naturelle et sociale de la liberté. Revenant sur une part essentielle de son oeuvre, Patrick Tort invite ici à une véritable réforme logique de l'initiative de connaissance, et, simultanément, à instruire la méthode capable d'éclairer les mécanismes qui la favorisent et la combattent dans l'univers infini des discours. (shrink)

McInerney, Patrick Review of: World Christianity encounters world religions: A summa of interfaith dialogue, by Edmund Kee-Fook Chia, pp. 272, US$29.95.

The above passage, from Maternus' first speech, poses a number of rather intricate textual problems. J. F. Gronovius rightly divined that the meaningless vaticiniireferred to a person whose evil power Maternus had broken. Who else but Vatinius, Nero's notorious jester? To read Vatiniifor vaticiniiis intrinsically attractive, and in default of a better alternative has found almost universal approval. The contextual implications of this acclaimed conjecture have not, however, always been appreciated. It is with these that the present paper is concerned. (...) Discussing the conjecture imperante Nerone, and the interpretation of J. Stroux, it will attempt in the final section to relate the Vatinius incident to its original political and ideological context. (shrink)

An influential body of recent work on moral psychology has stressed the interconnections among ethics, narrative, and empathy. Yet as Patrick Colm Hogan argues, this work is so vague in its use of the term 'narrative' as to be almost substanceless, and this vagueness is in large part due to the neglect of literary study. Extending his previous work on universal story structures, Hogan argues that we can transform ill-defined intuitions about narrative and ethics into explicit and systematic accounts (...) of the deep connections between moral attitudes and narratives. These connections are, in turn, inseparable from empathy, a concept that Hogan proceeds to clarify and defend against a number of widely read critiques. In the course of the book, Hogan develops and illustrates his arguments through analyses of global narratives, constructing illuminating ethical interpretations of literary works ranging from Shakespeare to Chinese drama and the Bhagavad Gita. (shrink)

This book presents, for the first time in English, two studies by Salvatore I. Camporeale on the fifteenth-century thinker Lorenzo Valla. Camporeale’s work offers new perspectives on Valla, in terms of both content and method.

During his encounter with Lethaeus Amor in theRemedia amoris, in which he discusses techniques to forget a former lover, Ovid writes the following:quisquis amas, loca sola nocent: loca sola caveto;quo fugis? in populo tutior esse potes.non tibi secretis est opus; auxilio turba futura tibi est.tristis eris, si solus eris, dominaeque relictaeante oculos facies stabit, ut ipsa, tuos.This passage has been discussed in Hardie's treatment of Lethaeus Amor, and, while he directly addresses Ovid's use oflociin this passage as I shall below, (...) his focus is on the rich intertextuality – textual remembrances – within theRemediarather than the use oflociin thears memoriaeproper. Hardie points out numerous intertexts in theRemedia, using the character of Lethaeus Amor to highlight the paradox of a learned reader of love poetry being unable to forget the poetry he has read, despite this specific oblivion being a precondition for curing oneself of love. In this case, theloca solaOvid warns against are ‘topics of solitude’ which ‘conjure up for the experienced reader scenes of erotic despair’, thus calling to mind the lover's own lovelorn state. (shrink)

We present in this article a new logical system inspired from linear logic. This system is designed in order to express causality and dynamism. The cut elimination theorem holds for this logic. Examples of applications are given.