Based on genetic and biochemical advances on the molecular mechanism of circadian rhythms, a computational model for the mammalian circadian clock is used to examine the dynamical bases of circadian‐clock‐related physiological disorders in humans. Entrainment by the light–dark cycle with a phase advance or a phase delay is associated with the Familial advanced sleep phase syndrome (FASPS) or the Delayed sleep phase syndrome (DSPS), respectively. Lack of entrainment corresponding to the occurrence of quasiperiodic oscillations with or without phase jump can (...) be associated with the non‐24 h sleep–wake syndrome. In the close vicinity of the entrainment domain, the model uncovers the possibility of infradian oscillations of very long period. Perturbation in the form of chronic jet lag, as used in mice, prevents entrainment of the circadian clock and results in chaotic or quasiperiodic oscillations. It is important to clarify the conditions for entrainment and for its failure because dysfunctions of the circadian clock may lead to physiological disorders, which pertain not only to the sleep–wake cycle but also to mood and cancer. BioEssays 30:590–600, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Thanks to genetic and biochemical advances on the molecular mechanism of circadian rhythms in Drosophila, theoretical models closely related to experimental observations can be considered for the regulatory mechanism of the circadian clock in this organism. Modeling is based on the autoregulatory negative feedback exerted by a complex between PER and TIM proteins on the expression of per and tim genes. The model predicts the occurrence of sustained circadian oscillations in continuous darkness. When incorporating light‐induced TIM degradation, the model accounts (...) for damping of oscillations in constant light, entrainment of the rhythm by light‐dark cycles of varying period or photoperiod, and phase shifting by light pulses. The model further provides a molecular dynamical explanation for the permanent or transient suppression of circadian rhythmicity triggered in a variety of organisms by a critical pulse of light. Finally, the model shows that to produce a robust rhythm the various clock genes must be expressed at the appropriate levels since sustained oscillations only occur in a precise range of parameter values. BioEssays 22:84–93, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

Oscillations in cytosolic Ca2+ occur in a wide variety of cells, either spontaneously or as a result of external stimulation. This process is often accompanied by intracellular Ca2+ waves. A number of theoretical models have been proposed to account for the periodic generation and spatial propagation of Ca2+ signals. These models are reviewed and their predictions compared with experimental observations. Models for Ca2+ oscillations can be distinguished according to whether or not they rely on the concomitant, periodic variation in inositol (...) 1,4,5‐trisphosphate. Such a variation, however, is not required in models based on Ca2+‐induced Ca2+ release. When Ca2+diffusion is incorporated into these models, propagating waves of cytosolic Ca2+ arise, with profiles and rates comparable to those seen in the experiments. (shrink)

The past twenty-five years have seen a major renewal of interest in the topic of a priori knowledge. In the sixteen essays collected here, which span this entire period, philosopher Albert Casullo documents the complex set of issues motivating the renewed interest, identifies the central epistemological questions, and provides the leading ideas of a unified response to them.

As one of the world's most eminent living philosophers, John Perry has covered a remarkable breadth of subjects in his published work, including semantics, indexicality, self-knowledge, personal identity, and consciousness. Looking particularly at the way in which he deals with issues of self, communication, and reality, this volume is organized in seven chapters that highlight a different aspect of Perry's work on the intersection of these subjects. A fundamental work for students and scholars, Identity, Language, and Mind explores questions that (...) are not only essential in understanding Perry's writings, but also contemporary philosophy as a whole. (shrink)

An extraordinary horde of aberrant, deformed, and grotesque beings inhabits the writings collected in the Zhuangzi. Crippled, malformed, hideous, foolish, eccentric, and even outlawed individuals conquer the central place of philosophical narration, traditionally proscribed for them, and create one of the most important and intriguing voices echoing through the text. Yet, for all their undeniably significant presence, scholars of ancient Chinese philosophy have paid surprisingly little attention to the topic of monsters. Structured into three sections and adopting a critical, strictly (...) philosophical standpoint, this paper aims to draw attention to the crucial role played by monsters in the Zhuangzi. The first section underlines the essential characteristics of these monsters and, most particularly, their disruptive dimension together with the challenge they pose to philosophical thinking. The second section offers a detailed review of the recent bibliography on the Zhuangzi with regard to analysis of these aberrant figures. Finally, based on contributions in the work of Jacques Rancière, the third section highlights the political scope embodied by the monstrous beings of the Zhuangzi. (shrink)

Pierce challenges the argument that economic sanctions are always morally preferable to the use of military force. He argues that such sanctions inflict suffering and physical harm on noncombatants and that small-scale military operations are sometimes preferable.

Albert Einstein, among the greatest scientists of all time, was also a man of profound thought and deeply humane feelings. His collected essays offer a fascinating and moving look at one of the twentieth century's leading minds. Covering a fifteen year period from 1934 to 1950, the contents of this book have been drawn from Einstein's articles, addresses, letters and assorted papers. Through his words, you can understand the man and gain his insight on social, religious, and educational issues.

In this paper, I argue that, beyond a philosophy of sport, space should be made for a ‘philosophy from sport.’ A philosophy from sport is one that can allow us to see sport as more than instantiating broader social values or possessing an isolated set of unique values. It can, as I believe a philosophy from sport, by paying special attention to the actual practice of sport, bring with it ways of developing, informing, even justifying a set of broader social (...) values. Using as a test case Michael Sandel’s arguments counter markets in What Money Can’t Buy, with a particular focus on his critique of naming rights for stadiums and arenas, I maintain that sport shows how markets can be reformed in order not to suffer the charge that they breed inequality and corruption or indecency. In fact, with sport, I argue it is possible to see exactly how markets can serve equality, decency, and ultimately the pursuit of excellence. Relying, in part, on the work of philosophers of sport from div.. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This paper explores metaphilosophy’s role in pragmatism. It does so particularly in relation to pragmatism’s multiplying and competing forms (e.g. classical pragmatism, neo-pragmatism, analytic pragmatism, third-wave pragmatism, new pragmatism, etc.). Focusing on the most comprehensive treatment of metaphilosophy in pragmatism, that of Scott Aikin and Robert Talisse, I argue their attempt to turn pragmatism into a metaphilosophy is problematic. Using a “metaphilosophical minimalism” to address pragmatism’s tendency toward what they label an inward looking and dogmatic “insularity” and “triumphalism” – a (...) tendency that feeds competition among pragmatists – I charge displays that very tendency (it also leads to a regress). I then pivot to outline what I dub “eclectic pragmatism.” This pragmatism embraces the contemporary zeitgeist of the inclusionary, decentered “more.” It does so by abandoning competition over the singular, right form of pragmatism (and indeed philosophy). It embraces the “more,” but not because it is right (which would be an obvious contradiction). Rather, it embraces the “more” because it is “’satisfying.” Simply put, there is a metaphilosophy at work with eclectic pragmatism. It is a “naturalized metaphilosophy” where the “choice” for pragmatism, especially eclectic pragmatism, is seen to stem from psychological and sociological propensities not the necessity of long exalted “reason.”. (shrink)

A dramatic illustrated tour of the nation's first five Civil War Battlefield Parks takes readers inside the monuments at Gettysburg, Shiloh, Antietam, Vicksburg, and Chickamauga.

0.1 Logic, in particular the modern symbolic logic, is not accused of being deficient in precision and accuracy, but one does sometimes hear that it is unrealistic, that it cannot be applied to reality, that it is utopian.

Samuel Imbo has written a short, concise introduction to some of the major issues addressed over the last century by scholars and activists concerned with African philosophy. The book is divided into five chapters, the first of which surveys answers to the question "What is African philosophy?". Because of a legacy of intellectual denigration that portrays Africans as incapable of abstract thought, this question is often the first raised by those outside the field. This legacy is reinforced by the assumption (...) that philosophy requires a tradition of written communication. Imbo addresses both of these sources of skepticism, delineating three senses of African philosophy: ethnological, universalist, and hermeneutical. (shrink)

This paper explores the continued reliance of the music of the Black Atlantic on oral rather than literate forms, and elaborates the thesis that African music in modern culture exemplifies an alternative to the culture of modern industrial society. A critical reappraisal of the work of Alaine Locke, Paul Gilroy, and John Dewey is used to extend our appreciation of pragmatism from its usual focus on science and technology to a more inclusive focus on art and the social value of (...) music. (shrink)

The complex problems facing developing countries have often been attributed to the tendency of their people to maintain traditional beliefs and practices. Many contemporary philosophers have criticized traditional thought for failing to match the levels of efficiency and effectiveness achieved by modern science. However, other contemporary philosophers have suggested that modern science embodies tendencies that are as likely to exacerbate as relieve the problems of the developing world. I conclude that philosophers must be as wary of modern practices and beliefs (...) as they are of traditional practices and beliefs. Modernity rather than tradition is undoubtably a principal source of Africa's problems. Philosophers discussed include Kwame Gyekye, Robin Horton, Godwin Sogolo, Charles Taylor, Karl Popper, Joseph Rouse, Justen Habermas, and Segun Gbadegesun.. (shrink)

For Charles Mills, the "Racial Contract" is a set of meta-agreements between whites to categorize nonwhites as subpersons of inferior moral and legal status relative to whites. This "contract" gives whites the right to exploit non-whites and deny them opportunities provided to whites. It portrays non-whites as designated to serve whites much as non-humans were designated by God to serve the benefit of humans. Mills argument helps make clear how, for most of the modern era, whites have had as little (...) obligation to recognize the rights of non-whites as they have had to recognize the rights of non-humans. (shrink)

El texto se propone como un estudio del reconocimiento recíproco a través de una revisión de la propuesta elaborada por Axel Honneth en su filosofía, y con el objetivo de señalar sus principales contribuciones tanto para la configuración de la identidad humana como para la práctica de la metodología de la transformación pacífica de los conflictos. Tanto es así que se enfatiza, especialmente y siguiendo a Honneth, cómo el hecho de reconocerse recíprocamente ayudará a las personas a sentirse más confiadas, (...) respetadas y estimadas, siendo éstos tres valores fundamentales para la regulación positiva de los conflictos y para la construcción de culturas para la paz. Además, el reconocimiento recíproco se pondrá en relación en estas páginas con otros medios pacíficos de la transformación de los conflictos. (shrink)