For the lack of forty-nine drachmas Socrates was unable to attend the costly epideixis of Prodicus from which he would have learnt the truth about correct use of words. From Prodicus' ὥραι Socrates could also have learnt the concepts and characteristic words associated with arete and kakia: these compete in that work for the allegiance of Heracles, parading their respective characteristics. Thanks to Professor Arthur Adkins we have had for the past decade a book which not only confronts arete and (...) kakia, but also analyses the meaning and usage of many Greek words for the evaluation of action from Homer to Aristotle. The importance of this book is generally acknowledged but it has not received the detailed discussion it deserves. Professor Adkins finds the social structure of ancient Greece inimical to the development of an adequate concept of moral responsibility. He shows, in a most interesting manner, how Greek values changed as the needs of society changed. (shrink)

This essay argues that Stoicism is the ancient philosophy most relevant to modern politics and civic education. Its relevance is due not to the advocacy of any specific political system or public policy but to its theory that the human good depends primarily on rationality and excellence of character rather than on material prosperity and productivity. According to Stoicism, all human beings are related to one another in virtue of our communal nature as rational animals. Reflection on the norms of (...) human nature persuaded the Stoics that we all share a common interest in living just and mutually beneficial lives. This principle, though it favors an equitable distribution of goods and services, makes rationality and integrity, rather than material prosperity, the essential values of community and the measure of normative citizenship and lawmaking. Our goal as Stoic citizens is to practice the art of what is always possible or in our power—doing our best to live mutually beneficial and well-reasoned lives—while recognizing that the external success we are naturally inclined to aim at may be frustrated because we live in a world we can never fully control. (shrink)

This book is a collection of fourteen essays on the themes of selfhood and rationality in ancient Greek philosophy. The discussion ranges over seven centuries of innovative thought, starting with Heraclitus’ injunction to listen to the cosmic logos, and concluding with Plotinus’ criticism of those who make embodiment essential to human identity. For the Greek philosophers the notion of a rational self was bound up with questions about divinity and happiness called eudaimonia, meaning a god-favoured life or a life of (...) likeness to the divine. While these questions are remote from current thought, Long also situates the book’s themes in modern discussions of the self and the self’s normative relation to other people and the world at large. Ideas and behaviour attributed to Socrates and developed by Plato are at the book’s centre. They are preceded by essays that explore general facets of the soul’s rationality. Later chapters bring in salient contributions made by Aristotle and Stoic philosophers. All but one of these pieces has been previously published in periodicals or conference volumes, but the author has revised and updated everything. The book is written in a style that makes it accessible to many kinds of reader, not only professors and graduate students but also anyone interested in the history of our identity as rational animals. (shrink)

These lines, presented as they appear in the O.C.T., are among the most difficult and hotly disputed that Juvenal wrote. The poet defends his decision not to attack contemporary politicians directly: ‘expose a Tigellinus’, he says, ‘and you know what the consequences will be’. It has long been recognized that the consequences related are probably inspired by those suffered by the Christians in A.D. 64 during the reign of Nero, and so vividly described by Tacitus.

Temporal binding via 40-Hz synchronization of neuronal discharges in sensory cortices has been hypothesized to be a necessary condition for the rapid selection of perceptually relevant information for further processing in working memory. Binocular rivalry experiments have shown that late stage visual processing associated with the recognition of a stimulus object is highly correlated with discharge rates in inferotemporal cortex. The hippocampus is the primary recipient of inferotemporal outputs and is known to be the substrate for the consolidation of working (...) memories to long-term, episodic memories. The prefrontal cortex, on the other hand, is widely thought to mediate working memory processes, per se. This article reviews accumulated evidence for the role of a subcortical matrix in linking frontal and hippocampal systems to select and ''stream'' conscious episodes across time (hundreds of milliseconds to several seconds). ''Streaming'' is hypothesized to be mediated by the selective gating of reentrant flows of information between these cortical systems and the subcortical matrix. The physiological mechanism proposed for this temporally extended form of binding is synchronous oscillations in the slower EEG spectrum (< 8 Hz). (shrink)

This volume captures the individuality, the national and personal identity, the cultural exchange, and the self-consciousness that have long been sensed as peculiarly potent in the Hellenistic world. The fields of history, literature, art, philosophy, and religion are each presented using the format of two essays followed by a response. Conveying the direction and focus of Hellenistic learning, eighteen leading scholars discuss issues of liberty versus domination, appropriation versus accommodation, the increasing diversity of citizen roles and the dress and (...) gesture appropriate to them, and the accompanying religious and philosophical ferment. The result is an arresting view of the incredible and unprecedented diversity of the Hellenistic world. (shrink)

A discussion on antiquity with Anthony A. Long, one of the most distinguished scholars in the field of ancient philosophy, would be engaging in any case. All the more so, since his two recently published works, Greek Models of Mind and Self and How to be Free: An Ancient Guide to the Stoic Life, provide the opportunity to revisit key issues of ancient philosophy. The former is a lively and challenging work that starts with the Homeric notions of (...) selfhood, and leads the reader all the way through classical and Hellenistic philosophical psychology; the latter is a profound analysis of the Stoic ethics that focuses in particular on its foundation and principles, followed by Long’s re-worked translation of Epictetus’ Encheiridion and carefully selected parts of his Discourses. Anthony Long kindly accepted the invitation to discuss several issues that are in the core of scholarly concern, sharing interpretations and thoughts that originate from his long acquaintance with the ancient literary tradition. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Professor Ogilvie, co-editor of Classical Quarterly since the summer of 1976, died suddenly at St Andrews on 7 November 1981. He was forty-nine. His untimely death is a grievous blow to his family, his colleagues at St Andrews, and an unusually wide circle of pupils past and present, friends from many walks of life, and classical scholars. At a remarkably young age Robert Ogilvie achieved distinction as a Latinist and Roman historian, a humane man of letters, a don, and a (...) schoolmaster. He was a brilliant lecturer, an educationalist passionately convinced of the good in Greek and Roman life and literature. The demands which others made on him were heavy, and he demanded much of himself. (shrink)

The potential for biased responses that occur when researchers interact with their study participants has long been of interest to both academicians and practitioners. Given the sensitive nature of the field, researcher interaction biases are of particular concern for business ethics researchers regardless of their preference for survey, experimental, or qualitative methodology. Whereas some ethics researchers may inadvertently bias data by misrecording or misinterpreting responses, other biases may occur when study participants' responses are systematically influenced by the mere introduction (...) of researchers into the participants' environment. Although substantial empirical research has been conducted on the general topic of researcher interaction biases, none has focused specifically on business ethics research. In order to remedy this lack of empirical substantiation in the field, we review the related literature on researcher interaction biases, present an empirical example of how such biases can influence research results in an experiment assessing reactions to insurance fraud, and discuss the implications for business ethics research. (shrink)

This study adds to a small but growing literature that situates sleep within gendered work— family responsibilities. We conducted interviews with 25 heterosexual dual-earner working-class couples with children, most of whom had one partner who worked at night. A few men suffered disrupted sleep because of their commitment to being a coparent to their children, but for most their provider status gave them rights to longer and more continuous sleep. By contrast, as they were the primary caregiver during sentient hours, (...) women’s sleep was curtailed and interrupted by responding to the needs of family members at night and at the beginning of each day, and this was true for women who worked nights as well as days. Furthermore, in struggling to meet their daily employment and familial obligations while tired and sleepy, women further stressed their bodies in ways that can cause cumulative sleep debt. This article demonstrates that sleep deficits are another manifestation of gender inequality, with important implications for long-term health and well-being. (shrink)

This paper investigates Aquinas’s thought on the vis cogitativa, in order to determine whether Aquinas’s use of the inner sense of the vis cogitative is an embarrassment (as Dorothea Frede recently suggested), or whether it is rather an important element in Aquinas’s philosophy of mind that calls for serious study (as John Haldane argued several years ago in an ACPA plenary address). An examination of Aquinas’s theory of inner sense (as found in the Commentary on Aristotle’s De Anima) reveals that, (...) for Aquinas, the vis cogitativa has two cognitive functions: (1) to be aware of an individual as an individual, and (2) to recognize an individual as a member of a kind. If Aquinas’ philosophy of mind did not include some account of the vis cogitativa, then it would not be able to accommodate what for Aquinas is a principal ontological category (namely, primary substance). (shrink)

This paper investigates Aquinas’s thought on the vis cogitativa, in order to determine whether Aquinas’s use of the inner sense of the vis cogitative is an embarrassment , or whether it is rather an important element in Aquinas’s philosophy of mind that calls for serious study . An examination of Aquinas’s theory of inner sense reveals that, for Aquinas, the vis cogitativa has two cognitive functions: to be aware of an individual as an individual, and to recognize an individual as (...) a member of a kind. If Aquinas’ philosophy of mind did not include some account of the vis cogitativa, then it would not be able to accommodate what for Aquinas is a principal ontological category. (shrink)

Book reviewed in this article: Long Term Care: Principles, Programs and Policies. By Rosalie A. Kane and Robert L. Kane. Long Term Health Care: providing a Spectrum of Services to the Aged. By Philip W. Brickner, Anthony J. Lechich, Roberta Lipsman, and Linda K. scharer.

Book reviewed in this article: Long Term Care: Principles, Programs and Policies. By Rosalie A. Kane and Robert L. Kane. Long Term Health Care: providing a Spectrum of Services to the Aged. By Philip W. Brickner, Anthony J. Lechich, Roberta Lipsman, and Linda K. scharer.

Most recent discussions of reasons in art criticism focus on reasons that justify beliefs about the value of artworks. Reviving a long-neglected suggestion from Paul Ziff, I argue that we should focus instead on art-critical reasons that justify actions—namely, particular ways of engaging with artworks. I argue that a focus on practical rather than theoretical reasons yields an understanding of criticism that better fits with our intuitions about the value of reading art criticism, and which makes room for a (...) nuanced distinction between criticism that aims at universality and criticism that is resolutely personal. (shrink)

In his famous 1950 paper where he presents what became the benchmark for success in artificial intelligence, Turing notes that "at the end of the century the use of words and general educated opinion will have altered so much that one will be able to speak of machines thinking without expecting to be contradicted" (Turing 1950, 442). Kurzweil (1990) suggests that Turing's prediction was correct, even if no machine has yet to pass the Turing Test. In the wake of the (...) computer revolution, research in artificial intelligence and cognitive science has pushed in the direction of interpreting "thinking" as some sort of computational process. On this understanding, thinking is something computers (in principle) and humans (in practice) can both do. It is difficult to say precisely when in history the meaning of the term "thinking" headed in this direction. Signs are already present in the mechanistic and mathematical tendencies of the early Modern period, and maybe even glimmers are apparent in the ancient Greeks themselves. But over the long haul, we somehow now consider "thinking" as separate from the categories of "thoughtfulness" (in the general sense of wondering about things), "insight" and "wisdom." Intelligent machines are all around us, and the world is populated with smart cars, smart phones and even smart (robotic) appliances. But, though my cell phone might be smart, I do not take that to mean that it is thoughtful, insightful or wise. So, what has become of these latter categories? They seem to be bygones left behind by scientific and computational conceptions of thinking and knowledge that no longer have much use for them. In 2000, Allen, Varner and Zinser addressed the possibility of a Moral Turing Test (MTT) to judge the success of an automated moral agent (AMA), a theme that is repeated in Wallach and Allen (2009).. (shrink)

The question of what living is for—of what one should care about and why—is the most important question a person can ask. Yet under the influence of the modern research ideal, our colleges and universities have expelled this question from their classrooms, judging it unfit for organized study. In this eloquent and carefully considered book, Tony Kronman explores why this has happened and calls for the restoration of life’s most important question to an honored place in higher education. The author (...) contrasts an earlier era in American education, when the question of the meaning of life was at the center of instruction, with our own times, when this question has been largely abandoned by college and university teachers. In particular, teachers of the humanities, who once felt a special responsibility to guide their students in exploring the question of what living is for, have lost confidence in their authority to do so. And they have lost sight of the question itself in the blinding fog of political correctness that has dominated their disciplines for the past forty years. Yet Kronman sees a readiness for change--a longing among teachers as well as students to engage questions of ultimate meaning. He urges a revival of the humanities’ lost tradition of studying the meaning of life through the careful but critical reading of great works of literary and philosophical imagination. And he offers here the charter document of that revival. (shrink)

SummaryMuch excitement surrounded the proposal that a family of endo‐lysosomal channels, the two‐pore channels (TPCs) were the long sought after targets of the Ca2+‐mobilising messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, the role of TPCs in NAADP signalling may be more complex than originally envisaged. First, NAADP may not bind directly to TPCs but via an accessory protein. Second, two papers recently challenged the notion that TPCs are NAADP‐regulated Ca2+ channels by suggesting that they are highly selective Na+ (...) channels regulated by the lipid phosphatidylinositol 3,5‐bisphosphate and by ATP. This paper aims critically to evaluate the evidence for TPCs as NAADP targets and to discuss how the new findings fit in with what we know about endo‐lysosomal Ca2+ stores. (shrink)

Written by a team of distinguished scholars, this is an authoritative and comprehensive history of Western philosophy from its earliest beginnings to the present day. Illustrated with over 150 color and black-and-white pictures, chosen to illuminate and complement the text, this lively and readable work is an ideal introduction to philosophy for anyone interested in the history of ideas. From Plato's Republic and St. Augustine's Confessions through Marx's Capital and Sartre's Being and Nothingness, the extraordinary philosophical dialogue between great Western (...) minds has flourished unabated through the ages. Dazzling in its genius and breadth, the long line of European and American intellectual discourse tells a remarkable story--a quest for truth and wisdom that continues to shape our most basic ideas about human nature and the world around us. That quest is brilliantly brought to life in The Oxford History of Western Philosophy. With spectacular illustrations--including sixteen pages of full-color plates--this splendidly written volume takes the reader on a magnificient chronological tour through the revolutions of thought that have forged the Western philosophical tradition from ancient times to the present. Throughout, the six contributors--an internationally renowned team of philosophers including Roger Scruton, Anthony Quinton, and Anthony Kenny--bring the astonishingly diverse, wide-ranging landscape of intellectual history into sharp focus, emphasizing how notions seen today as part of an inevitable march of ideas were in their own time often considered radical, if not revolutionary. Thus we are treated, for example, to lively accounts of how Plato's "theory of forms" and Aristotle's pioneering exercises in logic broke with the past to irrevocably alter the course of Western thought. The authors also reveal the relationships between landmark thinkers, and the ways they drew on their intellectual heritage. They show, for instance, how St. Augustine and Aquinas, though advancing the cause of Christian doctrine, picked up where their pagan Greek forebears had left off. We witness how, during the Renaissance, the profound empiricist ideas underlying Descarte's famous utterance--"I think, therefore I exist"--lived in a tense but complementary relationship with Locke's rationalist theories. Moving into the eighteenth and nineteenth centuries, the book explores how Hume greatly influenced Kant's conception of the "transcendental aesthetic," and how Hegel drew upon the lesser known (but groundbreaking) work of Fichte and Schelling. The authors bring the story up to our own time, vividly recounting the existential trend from Nietzsche ("God is dead") to Sartre, along with other increasingly fractious schools of thought. Along the way, we not only encounter the vast intellectual riches of the Western mind, but we also meet the personalities behind the great thoughts, from the saintly Hume (described by Adam Smith as having "come as near to perfection as anybody could") to the ill-mannered outcast Fichte. And the hundreds of maps and striking illustrations (including full-color reproductions of art ranging from medieval manuscripts to the works of Raphael, Ingres, and Magritte) form an integral part of the book, revealing the interweaving of art and ideas through the ages, as artists have striven to give visual immediacy to philosophical concepts. The Oxford History of Western Philosophy is the most authoritative single-volume account ever written for the general reader. Engagingly written and astonishingly far-reaching, it provides the consummate introduction to the intellectual bedrock upon which Western civilization is built. (shrink)

The question of what living is for—of what one should care about and why—is the most important question a person can ask. Yet under the influence of the modern research ideal, our colleges and universities have expelled this question from their classrooms, judging it unfit for organized study. In this eloquent and carefully considered book, Tony Kronman explores why this has happened and calls for the restoration of life’s most important question to an honored place in higher education. The author (...) contrasts an earlier era in American education, when the question of the meaning of life was at the center of instruction, with our own times, when this question has been largely abandoned by college and university teachers. In particular, teachers of the humanities, who once felt a special responsibility to guide their students in exploring the question of what living is for, have lost confidence in their authority to do so. And they have lost sight of the question itself in the blinding fog of political correctness that has dominated their disciplines for the past forty years. Yet Kronman sees a readiness for change--a longing among teachers as well as students to engage questions of ultimate meaning. He urges a revival of the humanities’ lost tradition of studying the meaning of life through the careful but critical reading of great works of literary and philosophical imagination. And he offers here the charter document of that revival. (shrink)

Unreal City: a zany cartoon megalopolis where towers are built of cotton candy, facts scatter like pixie dust, and the truth is whatever you feel it to be. And it's no fantasy. It's where we live. We dwell in Unreal City. We believe in un-being. With saber-like wit, poet and professor Anthony Esolen leads readers on a tour through the ruins of their own Western world--through king-size bookstores, manicured college campuses, strobe-lit choir lofts, mechanized farms, divorce courts, drag-queen libraries, (...) and beyond. This hilarious guide to a culture gone mad with sex and self-care minces no words and spares no egos. We the people of Unreal City are no better, and certainly no smarter, than our fathers. But fear not. Sex and the Unreal City insists there's no need to settle down in the ninth circle of unreality. Esolen lights a torch and heads up the well-trod path back to our cleaner, kinder, truer homeland: earth. Along the way, the author sings the songs of masters somehow long forgotten--Shakespeare, Dante, Milton, the evangelists--and asks us to chant along. Readers of essayists like George Weigel, George Rutler, Malcom Muggeridge, and Walker Percy will enjoy this rollicking, intelligent book."--Amazon. (shrink)

The “information age” is often thought in terms of the digital revolution that begins with Turing’s 1937 paper, “On computable numbers, with an application to the Entscheidungsproblem.” However, this can only be partially correct. There are two aspects to Turing’s work: one dealing with questions of computation that leads to computer science and another concerned with building computing machines that leads to computer engineering. Here, we emphasize the latter because it shows us a Turing connected with mechanisms of information flow (...) rather than solely with the mathematical and logical problems of computability for which he is better known. Our reasons for doing so will become clear in what follows. In fact, the 1937 paper just mentioned provides a general schematic for building a computing machine; this mechanical connection puts Turing on an historical continuum with others who discovered mechanisms to cope with information. Of those involved in this quest in the 19th Century, two people in particular, Edison and Bell, had explicit visions of an information age that would follow from their work. Because they were explicitly aware of what they were doing and partly brought it about long before 1937, they deserve substantial credit for the information age they set out to inaugurate. Regarding one purely mechanical and non-electronic technology, Edison noted ten uses for the phonograph, including not only the replication of sound, but also “connection with the telephone, so as to make that instrument an auxiliary in the transmission of permanent and invaluable records, instead of being the recipient of momentary and fleeting communication”. Even though the telephone was only two years old when Edison wrote of a network made up of mechanical hard storage systems and people connected by wire, the network vision was already clearly in his head. (shrink)

_In this passionate and searching book, Anthony Kronman offers a third way—beyond atheism and religion—to the God of the modern world__ “An astonishing,... epically ambitious book.... An intellectual adventure story based on the notion that ideas drive history, and that to dedicate yourself to them is to live a bigger, more intense life.”—David Brooks, _New York Times__ We live in an age of disenchantment. The number of self-professed “atheists” continues to grow. Yet many still feel an intense spiritual longing (...) for a connection to what Aristotle called the “eternal and divine.” For those who do, but demand a God that is compatible with their modern ideals, a new theology is required. This is what Anthony Kronman offers here, in a book that leads its readers away from the inscrutable Creator of the Abrahamic religions toward a God whose inexhaustible and everlasting presence is that of the world itself. Kronman defends an ancient conception of God, deepened and transformed by Christian belief—the born-again paganism on which modern science, art, and politics all vitally depend. Brilliantly surveying centuries of Western thought—from Plato to Augustine, Aquinas, and Kant, from Spinoza to Nietzsche, Darwin, and Freud—Kronman recovers and reclaims the God we need today. (shrink)

A long encyclopedia entry, sketching his life, analysing his work.

Monty was just like any other dog. A scruffy and irascible Maltese terrier, he enjoyed barking at pugs and sniffing at trees. But after yet another dramatic confrontation with the local Rottweiler, Anthony McGowan realizes it's high time he and Monty had a chat about what makes him a good or a bad dog. Taking his lead from Monty's canine antics, McGowan takes us on a hilarious and enlightening jaunt through the major debates of philosophy. Will Kant convince Monty (...) to stop stealing cheesecake? How long will they put up with Socrates poking holes in every argument? In this uniquely entertaining take on morality and ethics, the dutiful duo set out to uncover who--if anyone--has the right end of the ethical stick and can tell us how best to live one's life."--GoogleBooks. (shrink)

The philosophy of mind has long been dominated by the view that mental states are identical with, constituted by, or grounded in brain states. Lynne Rudder Baker has been a persistent critic of this view, developing instead a theory grounded in a larger metaphysical outlook called Practical Realism. This volume is the first critical book-length evaluation of her views and criticism; leading philosophers answer her challenges and explore the consequences of Practical Realism, and Baker herself provides thoughtful replies to (...) elaborate her own position. (shrink)

John Caius is no longer a household name, except in a few households in East Anglia. Yet he was in many ways a characteristic and dominating figure of a particular moment in the 1560s and 1570s. For a few years, British courtiers, churchmen and country aristocrats—as well as successful medical men like Caius—shared a particular late humanist culture. They believed in the power and utility of ancient and medieval texts. These common assumptions kept them engaged in the scholarly study of (...) the past long after their formal studies were over, and inspired them to nurse what were sometimes exaggerated hopes for the power of education. Many of them took a special interest in pragmatic political history, which they saw as a guide to public life. Caius was also a historian, like so many other medical men. But as we will see, he practiced a particular kind of history—one normally focused on the history of the church and produced more often by groups than by individuals. (shrink)

The University of Pennsylvania Linguistics Department is home of a long-running project to create syntactically annotated (parsed) corpora of historical English. The project is directed by Anthony Kroch, Professor of Linguistics, and the research associate in charge of corpus annotation is Dr. Beatrice Santorini. The Middle English corpus was constructed by Dr. Ann Taylor, now research associate in charge of corpus annotation at the University of York, England.

BackgroundHIV cure research involving cell and gene therapy has intensified in recent years. There is a growing need to identify ethical standards and safeguards to ensure cell and gene therapy (CGT) HIV cure research remains valued and acceptable to as many stakeholders as possible as it advances on a global scale.MethodsTo elicit preliminary ethical and practical considerations to guide CGT HIV cure research, we implemented a qualitative, in-depth interview study with three key stakeholder groups in the United States: (1) biomedical (...) HIV cure researchers, (2) bioethicists, and (3) community stakeholders. Interviews permitted evaluation of informants’ perspectives on how CGT HIV cure research should ethically occur, and were transcribed verbatim. We applied conventional content analysis focused on inductive reasoning to analyze the rich qualitative data and derive key ethical and practical considerations related to CGT towards an HIV cure.ResultsWe interviewed 13 biomedical researchers, 5 community members, and 1 bioethicist. Informants generated considerations related to: perceived benefits of CGT towards an HIV cure, perceived risks, considerations necessary to ensure an acceptable benefit/risk balance, CGT strategies considered unacceptable, additional ethical considerations, and considerations for first-in-human CGT HIV cure trials. Informants also proposed important safeguards to developing CGT approaches towards an HIV cure, such as the importance of mitigating off-target effects, mitigating risks associated with long-term duration of CGT interventions, and mitigating risks of immune overreactions.ConclusionOur study identified preliminary considerations for CGT-based HIV cure across three key stakeholder groups. Respondents identified an ideal cure strategy as one which would durably control HIV infection, protect the individual from re-acquisition, and eliminate transmission to others. Known and unknown risks should be anticipated and perceived as learning opportunities to preserve and honor the altruism of participants. Preclinical studies should support these considerations and be transparently reviewed by regulatory experts and peers prior to first-in-human studies. To protect the public trust in CGT HIV cure research, ethical and practical considerations should be periodically revisited and updated as the science continues to evolve. Additional ethics studies are required to expand stakeholder participation to include traditionally marginalized groups and clinical care providers. (shrink)

Literature and philosophy have long shared an interest in questions of truth, value, and form. And yet, from ancient times to the present, they have often sharply diverged, both in their approach to these questions and in their relationship to one another. Moreover, the vast differences among individual writers, historical periods, and languages pose challenges for anyone wishing to understand the relationship between them. This Introduction provides a synthetic and original guide to this vast terrain. It uncovers the deep (...) interests that literature and philosophy share while offering a lucid account of their differences. It sheds new light on many standing debates and offers students and scholars of literary criticism, literary theory, and philosophy a chance to think freshly about questions that have preoccupied the Western tradition from its very beginnings up until the present. (shrink)

The sexual revolution: an evocative term, but what meaning can be given to it today? How does “sexuality” come into being, and what connections does it have with the changes that have affected personal life more generally? In answering these questions, the author disputes many of the dominant interpretations of the role of sexuality in modern culture. The author suggests that the revolutionary changes in which sexuality has become cauth up are more long-term than generally conceded. He sees them (...) as intrinsic to the development of modern societies as a whole and to the broad characteristics of that development. Sexuality as we know it today is a creation of modernity, a terrain upon which the contradictory tendencies of modern social life play themselves out in full. Emancipation and oppression, opportunity and risk—these have become a part of a heady mix that irresistably ties our individual lives to global outcomes and the transformation of intimacy. We live today in a social order in which, for the first time in histroy, women are becoming equal to men—or at least have lodged a claim to such equality as their right. The author does not attempt to analyze the gender inequalities that persist in the economic or political domains, but instead concentrates on a more hisdden personal area in which women—ordinary women, in the course of their day-to-day lives, quite apart from any political agenda—have pioneered changes of greate, and generalizable, importance. These changes essentially concern an exploration of the potentialities of the “pure relationship,” a relaitonship that presumes sexual and emotional equality, and is explosive in its connotations for pre-existing relations of power. The author analyzes the emergence of what he calls plastic sexuality—sexuality freed from its intrinsic relation to reproduction—in terms of the emotional emancipation implicit in the pure relationship, as well as women’s claim to sexual pleasure. Plastic sexuality is decentered sexuality, freed from both reproduction and subservience to a fixed object. It can be molded as a trait of personality, and thus become bound up with the reflexivity of the self. Premised on plastic sexuality, the pure relationship is not exclusively heterosexual; it is neutral in terms of sexual orientation. The author speculates that the transformaion of intimacy might be a subversive influence on modern institutions as a whole, for a social world in which the dominant ideal was to achieve intinsic rewards from the company of others might be vastly different from that which we know at the present. (shrink)

_An intimate, philosophic quest for eternity, amidst the disenchantments and disappointments of our time “Anyone who, in our age of disbelief, longs to believe in God will find Mr. Kronman worth reading.”—Andrew Stark, _Wall Street Journal___ “Aims to persuade America’s ‘relentlessly rational’ elites to acknowledge the existence of ‘divinity.’... Kronman’s ambition is to repair ‘the schism between those for whom religion continues to matter and those who view it with amusement or contempt.’”—Tunku Varadarajan, _Wall Street Journal__ Many people of faith (...) believe the meaning of life depends on our connection to an eternal order of some kind. Atheists deride this belief as a childish superstition. In this wise and profound book, Anthony Kronman offers an alternative to these two entrenched positions, arguing that neither addresses the complexities of the human condition. We can never reach God, as religion promises, but cannot give up the longing to do so either. We are condemned by our nature to set goals we can neither abandon nor fulfill, yet paradoxically are able to approach more closely if we try. The human condition is one of inevitable disappointment tempered by moments of joy. Resolutely humanistic and theologically inspired, this moving book offers a rational path to the love of God amidst the disenchantments of our time. (shrink)

__Improvement in Action_, Anthony S. Bryk’s sequel to _Learning to Improve_, illustrates how educators have effectively applied the six core principles of continuous improvement in practice._ The book highlights relevant examples of rigorous, high-quality improvement work in districts, schools, and professional development networks across the country. The organizations featured in the book have addressed, with remarkable results, long-standing inequitable educational outcomes in high school graduation rates, college readiness, and absenteeism. The cases emphasize the measures the educators took and (...) the thinking that motivated their actions. Bryk describes how improvers, working in different contexts and confronting different problems, used select principles, tools, and methods to make improvement come to life. Brief analytic reflections are embedded throughout the narratives, and each chapter concludes with an analysis of a set of larger lessons illuminated by the organization’s story. Taken as a set, these examples offer readers valuable insights about the actual dynamics of doing improvement work. _Improvement in Action_, paired with _Learning to Improve_, provides readers with a comprehensive understanding of the practice, method, and theory of large-scale continuous improvement in education. (shrink)

Regulating war has long been a concern of the international community. From the Hague Conventions to the Geneva Conventions and the multiple treaties and related institutions that have emerged in the twentieth and twenty-first centuries, efforts to mitigate the horrors of war have focused on regulating weapons, defining combatants, and ensuring access to the battlefield for humanitarians. But regulation and legal codes alone cannot be the end point of an engaged ethical response to new weapons developments. This short essay (...) reviews some of the existing ethical works on lethal autonomous weapon systems (LAWS), highlighting how rule- and consequence-based accounts fail to provide adequate guidance for how to deal with them. I propose a virtue-based account, which I link up with an Aristotelian framework, for how the international community might better address these weapons systems. (shrink)

What lessons are there yet to learn from the works of Homer and Hesiod for political life? These ancient texts vividly illustrated an ethic which insisted that one must strive to maintain a consistent character against a chaotic world and one’s own inconstant human nature. This essay, therefore, recovers a long dismissed conception of the world, as well as a notion of virtue that was cultivated to steel one’s self against the tragic turns of radical, ironic chance that are (...) always a possibility in a kosmos sprung from chaos. (shrink)