Background Next Generation Sequencing (NGS) is expected to help find the elusive, causative genetic defects associated with Bipolar Disorder (BD). This article identifies the importance of NGS and further analyses the social and ethical implications of this approach when used in research projects studying BD, as well as other psychiatric ailments, with a view to ensuring the protection of research participants. Methods We performed a systematic review of studies through PubMed, followed by a manual search through the titles and abstracts (...) of original articles, including the reviews, commentaries and letters published in the last five years and dealing with the ethical and social issues raised by NGS technologies and genomics studies of mental disorders, especially BD. A total of 217 studies contributed to identify the themes discussed herein. Results The amount of information generated by NGS renders individuals suffering from BD particularly vulnerable, and increases the need for educational support throughout the consent process, and, subsequently, of genetic counselling, when communicating individual research results and incidental findings to them. Our results highlight the importance and difficulty of respecting participants’ autonomy while avoiding any therapeutic misconception. We also analysed the need for specific regulations on the use and communication of incidental findings, as well as the increasing influence of NGS in health care. Conclusions Shared efforts on the part of researchers and their institutions, Research Ethics Boards as well as participants’ representatives are needed to delineate a tailored consent process so as to better protect research participants. However, health care professionals involved in BD care and treatment need to first determine the scientific validity and clinical utility of NGS-generated findings, and thereafter their prevention and treatment significance. (shrink)

The case study presented by Winch and Sinnott (2011) shows not only how difficult it is for clinicians and researchers to identify conflicts of interest (COI), but also how damaging it can be when there are unin- formed and uncoordinated policy responses by senior administrators.

Launched in 2007, the American Medical Students Association PharmFree Scorecard is an annual ranking of conflict of interest policies at American medical centres; it focuses on COIs that may occur when medical education seems likely to be influenced by university-industry relationships, especially those with the pharmaceutical and medical device industries. The PharmFree Scorecard has proven influential in stimulating changes in policy regarding the management of COI at American medical institutions, thus it provides a useful jumping off point for reflection on (...) how and why medical education institutions in other countries – and for our purposes, Canada – should pay more attention to the appropriate identification and management of COI. The PharmFree Scorecard methodology examines a diversity of factors and interests that could influence medical education; as such, it is an interesting approach to analysing the COI policies of medical schools. To test its utility or applicability outside the US, we decided to apply the PharmFree Scorecard to the COI policies of the 16 Canadian universities hosting medical schools. Overall, Canadian institutions rank very poorly, especially in ensuring that education and training tools are provided to staff, students and faculty members to enable the identification and management of COI. However, differences between the US and Canadian medical education contexts, e.g., with regards to the governance and funding of universities, limit to some extent the direct applicability of the AMSA ranking. Canadian medical schools – and their host universities – nonetheless have much to learn from insights provided by the AMSA PharmFree Scorecard ranking, although they can and should go further in developing their own COI policies and procedures. (shrink)

Research on research ethics—regarding both the governance and practice of the ethical review of human subjects research—has a tumultuous history in North America and Europe. Much of the academic literature focuses on issues to do with regulating the conduct and quality of ethics review of research protocols by ethics committees (research ethics boards (REBs) in Canada and institutional review boards (IRBs) in the United States). In addition, some of the literature attends to issues particular to the review of qualitative research, (...) and still other literature addresses the challenges posed by and the need for research on REBs/IRBs. It is this third group of literature within which our article is situated. (shrink)

Droit et complexité. Le rapprochement de ces deux mots pourrait passer pour incongru. L'idéal du droit ne tend-il pas, en effet, à la rigueur et à la clarté garantes de certitudes et d'efficacité? Cet ouvrage, tiré des travaux du colloque tenu à Brest en mars 2006 a pris un parti inverse en faisant le choix, d'une certaine façon pascalien, de dialoguer avec l'incertitude dans des échanges très ouverts qui ont confirmé l'ampleur du changement de perspectives sur le droit. Un changement (...) que traduit bien le vocabulaire : régulation, pluralisation des ordres normatifs, dissémination dans des réseaux, internormativité, droit de coordination, procéduralisation, ajustement, négociation, expérimentation, flexibilité d'un droit devenu " droit souple ", voire " droit soluble "... Le système semble s'être converti à la modestie en perdant non de sa massivité comme l'a récemment souligné le Conseil d'Etat, mais en perdant de sa monumentalité pyramidale intimidante au profit d'un plasma de normes de plus en plus imbriquées dans des rapports de complémentarité, de négociation, de synergie déployés dans la dimension horizontale. La frontière entre les différentes catégories de normes persiste certes, mais elle se brouille, vire au " flou ". Si bien que là où prévalaient des distinctions nettes et des normes chimiquement pures, stables, s'imposent désormais des alliages, des rapports d'interdépendance analogues aux fils de trame d'un tissu. Edgar Morin aime à rappeler que le mot complexe signifie " tisser ensemble " et il définit la complexité comme " un tissu [...] de constituants hétérogènes inséparablement associés ". (shrink)

This article focuses on defective conditionals ? namely indicative conditionals whose antecedents are false and whose truth-values therefore cannot be determined. The problem is to decide which formal connective can adequately represent this usage. Classical logic renders defective conditionals true whereas traditional mathematics dismisses them as irrelevant. This difference in treatment entails that, at the propositional level, classical logic validates some sentences that are intuitively false in plane geometry. With two proofs, I show that the same flaw is shared by (...) a family of trivalent logics. I go on to examine the strict conditional and its derivatives. This family is the only one to avoid the faulty inference but it does so without addressing the status of the truth-value assigned to defective conditionals. (shrink)

The culmination of three decades of studying and treating survivors of adult onset trauma, _Wounded by Reality_ is the first systematic attempt to differentiate adult onset trauma from childhood trauma, with which it is frequently confused. When catastrophic events overtake adult lives, they often scar the psyche in ways that psychodynamically oriented clinicians struggle to understand. For Ghislaine Boulanger, the enormous challenge of working with these patients is unsurprising. Survivors of major catastrophe, whether a natural disaster, a life-threatening assault, (...) a serious accident, or an act of terrorism, experience a near-fatal disruption of fundamental aspects of self experience. The sense of agency, of affectivity, of bodily integrity, the capacity for self-reflection, the sense of time, and the ability to relate to others - all are called into question. (shrink)

After presenting the rules of Eleatic antilogic, i.e., dialectic, I argue that Zeno was a practitioner, and, on the basis of key passages from Plato’s Parmenides (127e-128e and 135d-136c), that his paradoxes of divisibility and movement were notreductio ad absurdum, but simple derivation of impossibilities (adunaton) meant to ridicule Parmenides’ adversaries. Thus, Zeno did not try to prove that there is no motion, but simply derived this consequence from premises held by his opponents. I argue further that these paradoxes were (...) devised, in accordance with Eleatic antilogic, following a scheme that included hypotheses and their contradictories, within which the subject is to be treated both “in relation to itself,” and “in relation to other things”. (shrink)

I call anti-resemblism the thesis that independently of any contextual specification there is no determinate fact of the matter about the comparative overall similarity of things. Anti-resemblism plays crucial roles in the philosophy of David Lewis. For instance, Lewis has argued that his counterpart theory is anti-essentialist on the grounds that counterpart relations are relations of comparative overall similarity and that anti-resemblism is true. After Lewis committed himself to a form of realism about natural properties he maintained that anti-resemblism is (...) true about the relations of overall similarity that enter his counterpart theory and his analysis of counterfactuals. However, in this article I argue that Lewis’s account of degrees of naturalness for properties combined with his modal realism entails that anti-resemblism is false. The Lewisian must amend Lewis’s system if she aims to benefit from the alleged virtues of anti-resemblism. I consider two ways of amending it, neither of which is a free lunch. (shrink)

According to Clifford Geertz, the purpose of anthropology is not to explain culture but to explicate it. That should cause us to rethink our relationship with machine learning. It is, we contend, perfectly possible that machine learning algorithms, which are unable to explain, and could even be unexplainable themselves, can still be of critical use in a process of explication. Thus, we report on an experiment with anthropological AI. From a dataset of 175K Facebook comments, we trained a neural network (...) to predict the emoji reaction associated with a comment and asked a group of human players to compete against the machine. We show that a) the machine can reach the same accuracy as the players, b) it fails in roughly the same ways as the players, and c) easily predictable emoji reactions tend to reflect unambiguous situations where interpretation is easy. We therefore repurpose the failures of the neural network to point us to deeper and more ambiguous situations where interpretation is hard and explication becomes both necessary and interesting. We use this experiment as a point of departure for discussing how experiences from anthropology, and in particular the tension between formalist ethnoscience and interpretive thick description, might contribute to debates about explainable AI. (shrink)

Prominent ethical and policy issues such as affirmative action and female enrollment in science and engineering revolve around the idea that diversity is good. However, a precise definition is seldom provided. I show that diversity may be construed as a factual description, a craving for symmetry, an intrinsic good, an instrumental good, a symptom, or a side effect. These acceptions differ vastly in their nature and properties. Some are deeply mistaken and some others cannot lead to concrete policies. It is (...) thus necessary to clarify what one means by ‘diversity.’ It may be a neutral description of a given state; but this is insufficient to act. The idea that there should be the same representation in a specific context as in the overall population is both puzzling and arbitrary. Diversity as intrinsic good is a mere opinion, which cannot be concretely applied; moreover, the most commonly invoked forms of diversity are not intrinsically good. On the other hand, diversity as instrumental good can be evaluated empirically and can give rise to policies, but these may be very weak. Finally, symptoms and side effects are not actually about diversity. I consider the example of female enrollment in science and engineering, interpreting the various arguments found in the literature in light of this polysemy. (shrink)

Cet article s’intéresse au marché de l’édition scientifique et à son évolution dans le cadre de l’Internet et du développement du libre accès. Il s’attache à montrer la diversité de ce marché en fonction des champs scientifiques, notamment par le type d’éditeurs impliqués, les lectorats concernés, les économies associées. Il met en exergue le nécessaire discernement de ces marchés face aux critiques générales de dysfonctionnement soulignées. Il pointe certains effets contrastés du numérique conduisant à certaines reconfigurations paradoxales. Enfin, la vision (...) prospective sur le devenir de ce marché insiste sur la pluralité des modalités de progression vers le libre accès, le poids de la dimension politique et celui des processus d’évaluation de la recherche. La voie d’un partenariat public-privé est privilégiée au regard de certaines valeurs centrales : indépendance, qualité, accessibilité et pérennité des publications scientifiques.This article investigates the scientific publishing market and how it is being transformed by the Internet and the development of open-access services. We illustrate the diversity of the market in terms of scientific fields, and especially in the types of publishers and readerships concerned, and of the associated economics. In view of the sweeping criticisms of dysfunctional practices illustrated in the article, we alert readers as to the need for discernment among these markets. The article points to a number of contrasting effects of digital publishing that are leading to various paradoxical reconfigurations. Finally, this forward-looking study of the publishing market’s future emphasises the multiple forms of the onward march towards open access and the influence exerted by the political dimension and the research evaluation process. Public-private partnerships are the preferred option to cater for the central values of independence, quality, accessibility and the enduring nature of scientific publications. (shrink)

This book offers a comparative study of the management of legal pluralism. The authors describe and analyse the way state and non-state legal systems acknowledge legal pluralism - defined as the coexistence of a state and non-state legal systems in the same space in respect of the same subject matter for the same population - and determine its consequences for their own purposes. The book sheds light on the management processes deployed by legal systems in Africa, Canada, Central Europe and (...) the South Pacific, the multitudinous factors circumscribing the action of systems and individuals with respect to legal pluralism, and the effects of management strategies and processes on systems as well as on individuals. The book offers fresh practical and analytical insight on applied legal pluralism, a fast-growing field of scholarship and professional practice. Drawing from a wealth of original empirical data collected in several countries by a multilingual and multidisciplinary team, it provides a thorough account of the intricate patterns of state and non-state practices with respect to legal pluralism. As the book's non-prescriptive approach helps to uncover and evaluate several biases or assumptions on the part of policy makers, scholars and development agencies regarding the nature and the consequences of legal pluralism, it will appeal to a wide range of scholars and practitioners in law, development studies, political science and social sciences. (shrink)

La tolérance, telle que l'entend l'édit de Nantes, est un pis-aller. Les partis catholiques et réformés s'accordent sur l'idée que la tolérance est provisoire, car la restauration de l'unité religieuse doit demeurer la visée. Mais les réformés, minoritaires, sont en position défensive. Beaucoup parmi eux pensent que la tolérance ne tiendra que s'ils continuent de se faire craindre des catholiques. D'où la promotion, par Agrippa d'Aubigné, de l'esprit de résistance. Mais les forces armées protestantes sont réduites en 1629. En fonction (...) de ce nouveau contexte, Moyse Amyraut, tout en professant un parfait loyalisme à l'égard du monarque catholique, sera amené à formuler les linéaments d'une nouvelle théorie de la tolérance, selon laquelle la tolérance n'est plus une grâce temporaire, mais un droit. (shrink)

A number of philosophers have recently found it congenial to talk in terms of grounding. Grounding discourse features grounding sentences that are answers to questions about what grounds what. The goal of this article is to explore and defend a counterpart-theoretic interpretation of grounding discourse. We are familiar with David Lewis's applications of the method of counterpart theory to de re modal discourse. Counterpart-theoretic interpretations of de re modal idioms and grounding sentences share similar motivations, mechanisms, and applications. I shall (...) explain my motivations and describe two applications of a counterpart theory for grounding discourse. But, in this article, my main focus is on counterpart-theoretic mechanisms. (shrink)

There is now an awakening to and recognition of the emotionally complex lives of some non-human animals. While their forms of consciousness may vary, some are indeed conscious and deserve political consideration. What that political consideration ought to be is the central topic of this article. First, I argue that interspecies justice must be understood in terms of the relationships that foster individual flourishing of all concerned. The obstacles to such flourishing are the five faces of oppression famously identified by (...) Iris Marion Young: exploitation, marginalization, powerlessness, cultural imperialism, and violence. By extending Young’s concept of the social group to intra- and interspecies groups, we become more attuned to differences between and among species. Theorizing the existence of interspecies groups brings forward new avenues to explore oppression and simultaneously theorize its opposite – interspecies justice. Second, I argue that a positive theory of interspecies flourishing can be developed on the basis of Marx’s materialist philosophy and reclamation of species-being. Though Marx uses humanist language throughout the Economic and Philosophic Manuscripts of 1844, attention to his methodological commitments reveals that some non-human animals can no longer be excluded from the capability of flourishing and species-being. Some non-human animals are conscious, act purposefully, and labor creatively and must be included in our circle of moral and political concern. (shrink)

This article has two goals: a historical and a speculative one. The historical goal is to offer a coherent account of Spinoza’s view on mereological composition. The speculative goal is to show that Spinoza’s substance monism is distinct from versions of monism that are currently defended in metaphysics and that it deserves the attention of contemporary metaphysicians. Regarding the second goal, two versions of monism are currently defended and discussed in contemporary metaphysics: existence monism according to which there actually exists (...) exactly one concrete entity; and priority monism that is famously defended by Jonathan Schaffer and according to which there exists exactly one fundamental concrete being, the cosmos, and several derivative concrete beings that are the parts of the cosmos. In this article, I argue that substance monism is neither an existence nor a priority monism because, while Spinoza’s monist is committed to the existence of a unique fundamental individual—the substance—and to the existence of several derivative individuals—the bodies or modes of extension—, Spinoza denies that the substance is mereologically complex. Regarding the first goal, the paper solves several interpretative puzzles by arguing that Spinoza distinguishes between three kinds of composition and that his talk of composition between the substance and its modes is by his own light not to be interpreted as literally true. (shrink)

Bringing Pierre Bourdieu to Science and Technology Studies Content Type Journal Article Pages 263-273 DOI 10.1007/s11024-011-9174-2 Authors Mathieu Albert, Wilson Centre and Department of Psychiatry, Faculty of Medicine, University of Toronto, 200 Elizabeth Street , Eaton-South 1-581, Toronto, ON M5G 2C4, Canada Daniel Lee Kleinman, Department of Community and Environmental Sociology, University of Wisconsin-Madison, 348 Agricultural Hall 1450 Linden Drive, Madison, WI 53706, USA Journal Minerva Online ISSN 1573-1871 Print ISSN 0026-4695 Journal Volume Volume 49 Journal Issue Volume 49, (...) Number 3. (shrink)

Résumé La collaboration avec une chorégraphe engage une réévaluation du travail de sculpture. Cette interprétation débouche sur des formes nouvelles par l’intermédiaire de sculptures animées qui s’apparentent à des formes de marionnettes.

A Polish space is not always homeomorphic to a computably presented Polish space. In this article, we examine degrees of non-computability of presenting homeomorphic copies of compact Polish spaces. We show that there exists a $\mathbf {0}'$ -computable low $_3$ compact Polish space which is not homeomorphic to a computable one, and that, for any natural number $n\geq 2$, there exists a Polish space $X_n$ such that exactly the high $_{n}$ -degrees are required to present the homeomorphism type of $X_n$. (...) Along the way we investigate the computable aspects of Čech homology groups. We also show that no compact Polish space has a least presentation with respect to Turing reducibility. (shrink)

This article maps a controversy in network science over the last 15 years, dividing the field about the epistemic status of a central notion, scale-freeness. The article accounts for the two main disputes, in 2005 and in 2018, as they unfolded in academic publications and on social media. This article analyzes the conflict, and the reasons why it reignited in 2018, to the surprise of many. It is argued that the concept of complex networks is shared by the distinct subcultures (...) of theorists and experimentalists; and that these subcultures have incompatible approaches to knowledge: nomothetic and idiographic. Following Galison, this article contends that network science is a trading zone where theorists and experimentalists can trade knowledge across the epistemic divide. (shrink)

This article defends the principle of sufficient reason (PSR) from a simple and direct valid argument according to which PSR implies that there is a truth that explains every truth, namely an omni-explainer. Many proponents of PSR may be willing to bite the bullet and maintain that, if PSR is true, then there is an omni-explainer. I object to this strategy by defending the principle that explanation is irreflexive. Then I argue that proponents of PSR can resist the conclusion that (...) there is an omni-explainer by denying that explanation distributes over conjunction. In the final section, I consider a plausible revision of this assumption. I argue there that, given the revised assumption, PSR seems to yield a striking picture of the explanatory structure of the universe. I explain why the resulting model does not appear utterly implausible to me. (shrink)

This chapter explores an objection to explanatory universalism, the doctrine that the principle of sufficient reason is true or everything has an explanation. This objection is a direct argument to the conclusion that the PSR yields the existence of an omni-explainer, i.e. something that explains everything. The objection crucially relies on the assumption that explanation is dissective in its explanandum place, and its conclusion conflicts with the irreflexivity of explanation. So the chapter considers two responses to the mentioned objection. The (...) first response consisting in restricting the irreflexivity of explanation is criticised in connection with topics in the metaphysics of grounding. The second response consisting in denying that explanation is dissective is vindicated. Finally, the chapter argues that a plausible revised version of the principle that explanation is dissective, the PSR, and the irreflexivity of explanation together yield a striking picture of our universe. (shrink)

This paper presents the first possible world semantics for concessive conditionals (i.e., even if A, C conditionals) constructed in a compositional way. First, the meaning of if is formalized through a semantics that builds on the proposal given by Stalnaker (1968). A major difference from Stalnaker’s approach is that irrelevant conditionals (i.e., conditionals where the antecedent and the consequent have no connection) are false in this new setting. Second, the meaning of even is analyzed through a formal semantics based on (...) the notion of scale. This analysis overcomes the problems arising in standard approaches, in which even is analyzed with the help of pragmatic presuppositions. Finally, the two particles are combined in order to provide a formal analysis of even if. This theory predicts the major phenomena concerning the behavior of concessive conditionals and without any call to pragmatic explanations. More generally, this approach creates the possibility of a compositional analysis of other conditionals such as if then or only if forms. (shrink)

Un temps de crise grave peut devenir un moment de grande espérance. Nous savons aujourd'hui que la civilisation du logos sous laquelle l'Occident vit depuis près de trois mille ans, dans une dialectique constante entre philosophie et christianisme, arrive à un point à la fois d'accomplissement et d'épuisement. Elle avait d'abord donné sa confiance à des explications englobantes. Celles-ci ont trouvé, dans l'Antiquité, leur forme quasi idéale : le logos avait pris alors un tour mystique et débouchait vers un Au-delà (...) de tout, qui n'a laissé indifférent ni l'islam ni le christianisme. Dans la modernité, il s'était organisé de manière parfaitement immanente ou soigneusement historique. A présent, il continue son chemin, mais devant l'épuisement des idées et des constructions qui lui donnaient corps et sens, il ne conserve que son armature essentiellement mathématique, dépouillée de toute réalité, sinon celle du nombre - ce que, dans notre langage actuel, nous appelons le " virtuel ". Nous pouvons recueillir aujourd'hui l'efficacité de ces pensées et pratiques pénétrées de la dynamique du Tout et du Rien. Mais, au point où nous en sommes actuellement, il y a une vraie menace que le Tout bascule vraiment dans le Rien et que nous allions à la catastrophe éthique, humaine, cosmique. Il a manqué sans doute à cette civilisation le respect du Quelque chose : ni tout, ni rien, mais substance, action, relation. Ici Aristote, dans l'Antiquité, et Thomas d'Aquin, au seuil de la modernité, peuvent venir à notre secours et nous aider à retrouver notre épaisseur d'homme, à ne pas fuir le jeu étrange en nous de la matière pénétrée de ce que nous appelons esprit, qui à la fois lui est immanent et la dépasse, à restituer par là un humanisme et une approche non aliénante du divin. Il y a sans doute là un motif d'espérance. Mais ce grand motif d'espérance réside surtout dans le tournant anthropologique contemporain : nous comprenons aujourd'hui que l'homme n'existe pas en réalité sans son frère qui lui parle. A la lumière de cette conversation essentielle, on doit pouvoir définir un humanisme et une politique ; une perspective s'ouvre aussi pour réinterpréter la religion et particulièrement le christianisme. À l'horizon apparaissent le symbole, la relation, la mort et la résurrection, l'amour. (shrink)

This chapter is concerned with the coextension difficulty for nominalist theories of properties that reject tropes alongside universals. After carefully explaining the coextension difficulty and describing the theories it targets, the chapter describes different solutions to the difficulty. These solutions differ with respect to how much involved they are into a dualist approach to coextension. A dualist approach to a case of coextension consists in agreeing with the realist that the relevant ascriptions of properties are numerically distinct. A monist approach (...) to a case of coextension consists in contending that the relevant ascriptions of properties are identical. In this chapter, I defend a monist approach to cases of coextension that appeals to a counterpart theory for propositions. (shrink)