The random nature of immunoglobulin gene segment rearrangement inevitably leads to the generation of self‐reactive B cells. Avoidance of destructive autoimmune reactions is necessary in order to maintain physiological homeostasis. However, current central and peripheral tolerance concepts fail to explain the massive number of autoantibody‐borne autoimmune diseases. Moreover, recent studies have shown that in physiological mouse models autoreactive B cells were neither clonally deleted nor kept in an anergic state, but were instead able to mount autoantibody responses. We propose that (...) activation of autoreactive B cells is induced by polyvalent autoantigen complexes that can occur under physiological conditions. Repeated encounter of autoantigen complexes leads to the production of affinity‐matured autoreactive IgM that protects its respective self‐targets from degradation. We refer to this novel mechanism as adaptive tolerance. This article discusses the discovery of adaptive tolerance and the unexpected role of high affinity IgM autoantibodies. (shrink)

This article identifies problems with regard to providing criteria that regulate the matching of logical formulae and natural language. We then take on to solve these problems by defining a necessary and sufficient criterion of adequate formalization. On the basis of this criterion we argue that logic should not be seen as an ars iudicandi capable of evaluating the validity or invalidity of informal arguments, but as an ars explicandi that renders transparent the formal structure of informal reasoning.

Introduction Most of the papers gathered here were contributions to a series of joint meetings of the Department of Social Administration and Social Work ...

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews 137 The Meanings of Landscape: Essays on Place, Space, Environment and Justice BY KENNETH R. OLWIG London: Routledge, 2019 REVIEWED BY TIMM SCHÖNFELDER Landscape is more than spatial scenery that meets the eye: it is an anthropogenic artefact, an intellectual construct, a mirror of culture; it even has its own language.1 This broadness is reflected in the compilation of nine authoritative essays by the geographer and (...) professor of landscape architecture Kenneth R. Olwig that were published during the past quarter of a century and are now molded into a more coherent whole. In this regard, the present volume can be considered the pinnacle of Olwig’s intellectual oeuvre. In a fervent foreword, the anthropologist Tim Ingold sets the tone when he urges the reader to shed the contemporary notion of what he terms “topophobia”—­ a lack of bond betweenpeopleandplaces—­andtoreinstatephilologyasacentralfield of interest after it was “relegated by techno-­ science to the margins of scholarship” (xv). To achieve this, the essays deal with an eclectic set of themes ranging from Ptolemy’s notion of “choros” as something similar to today’s understanding of landscape, to the humanistic geographer Yi-­Fu Tuan’s concept of “topophilia,” which is hailed as a guiding ideal for much of Olwig’s work. The articles are bound together by an introduction that quickly transcendsthegeometricallimitationsoflandscape,ontologicallyquestioning whether these can be representative of the world itself at all (3). The first chapter thus delves right into the etymologies of “landscape” and its historical implications in the Nordic countries and England with detours through Italy and the German lands. In a cursory, highly associative manner Olwig fathoms the respective cultural implications. Central is the idea that the concept of landscape is more than the mere scenicrepresentationofspaceitcametobeknownasinRenaissance art and culture.2 Rather, the Nordic variants of the word, like the Swedish landskap, are used to denote natural regions with their own polity that were then gradually subjected to a monarchic state, not least through the surveying and mapping of their territory (see also chapter two). ENVIRONMENT, SPACE, PLACE / VOLUME 13 / ISSUE 2 / 2021 138 At times, Olwig’s philological musings appear rather stretched, as when he associates the German word Grundgesetz (the “basic/­ fundamental law” of 1949, which until today serves as Germany’s constitution ) with a biopolitical dimension of “ground” as in “soil” (41).3 In cases like this, his use of literature is selective. This culminates in a problematic assessment of Nazi ideology as being motivated by a specific understanding of landscape. Statements like “there can be no doubt that the modern German conception of Landschaft was implicated in the promotion of blood-­ and-­ soil fascist ideology” (42) neglect important literature on the topic.4 Such generalizations are owed to the author’s sweeping tour de force approach. The reviewer would have preferred more guidance through the theoretical thickets by way of a clear, chronologically ordered argument. This is not helped by the occasional seeming inconsistency, as in the claim that the U.S. “inherited the British scenic idea of landscape” as a former colony while also being “very much the inheritor of German romantic ideas concerning the relation of culture to nature as expressed in the physical landscape” (45), which, in turn, showed parallels to “fascist landscapes” in the “attempt to cleanse geography of its environmentalist taint by making it a science of space” (42). This truly is a lot of ground to cover for one essay. The ensuing chapters, however, try to disentangle this inspired jumble. The second article, “Landscape, Place, and the State of Progress,” identifies a switch since the Renaissance from the idea of circuitous development to linear progress towards utopia. For Olwig, there is a “darker, Faustian side” to it that he identifies as the “dialectic of modernity,” which “opposes cosmic dreams of a utopian future to the topian exigencies of present and past”: to advance, the path had to be cleared of traditional elements (52). This materialized in courteous theatre as well as in Shakespeare’s popular plays, and in the new architecture of parks where landscape was symbolic for cultural and social progress (64). “Choros, place, and the spatialization of landscape” traces important theoretical threads within geography... (shrink)

Examines how the modern city is portrayed in art and literature, discusses modernism, futurism, and expressionism, and looks at the work of Rilke, Eliot, Pound, Joyce, and Brecht.

Any account of “what is special about the human brain” (Passingham 2008) must specify the neural basis of our unique ability to produce speech and delineate how these remarkable motor capabilities could have emerged in our hominin ancestors. Clinical data suggest that the basal ganglia provide a platform for the integration of primate-general mechanisms of acoustic communication with the faculty of articulate speech in humans. Furthermore, neurobiological and paleoanthropological data point at a two-stage model of the phylogenetic evolution of this (...) crucial prerequisite of spoken language: (i) monosynaptic refinement of the projections of motor cortex to the brainstem nuclei that steer laryngeal muscles, presumably, as part of a “phylogenetic trend” associated with increasing brain size during hominin evolution; (ii) subsequent vocal-laryngeal elaboration of cortico-basal ganglia circuitries, driven by human-specificFOXP2mutations.;>This concept implies vocal continuity of spoken language evolution at the motor level, elucidating the deep entrenchment of articulate speech into a “nonverbal matrix” (Ingold 1994), which is not accounted for by gestural-origin theories. Moreover, it provides a solution to the question for the adaptive value of the “first word” (Bickerton 2009) since even the earliest and most simple verbal utterances must have increased the versatility of vocal displays afforded by the preceding elaboration of monosynaptic corticobulbar tracts, giving rise to enhanced social cooperation and prestige. At the ontogenetic level, the proposed model assumes age-dependent interactions between the basal ganglia and their cortical targets, similar to vocal learning in some songbirds. In this view, the emergence of articulate speech builds on the “renaissance” of an ancient organizational principle and, hence, may represent an example of “evolutionary tinkering” (Jacob 1977). (shrink)

Most accounts of cognitive scaffolding focus on ways that external structure can support or augment an agent’s cognitive capacities. We call cases where the interests of the user are served benign scaffolding and argue for the possibility and reality of hostile scaffolding. This is scaffolding which depends on the same capacities of an agent to make cognitive use of external structure as in benign cases, but that undermines or exploits the user while serving the interests of another agent. We develop (...) criteria for scaffolding being hostile and show by reference to examples including the design features of electronic gambling machines and casino management systems that hostile scaffolding exists and can be highly effective. In cases where the scaffolding is deep and permits the offloading of significant cognitive work, hostile scaffolding exploitatively manipulates cognitive processing itself. Given the extent of human reliance on scaffolding this is an important and neglected vulnerability. [This is an updated version of the paper, added in February 2023.]. (shrink)

Conscious existence is the product of a neural brain mechanism, which is largely identical with Immanuel Kant's Oneness Function, a service performed by 200 million neurons in the prefrontal lobe, & makes possible our interior cosmos, the record of our interconnected, or general, experience. Essential for us humans is the well-being of our interior cosmos, or Saint Teresa of Avila's interior castle, in all interactions with each other \& the greater environment. Any disorders of our cosmos are liable to make (...) us fall ill, setting our existence on a path of psychosomatic etiology of a large class of mysterious undiagnosed diseases. (shrink)

Recent advances in neuroscience lead to a wider realm for philosophy to include the science of the Darwinian-evolved computational brain, our inner world producing organ, a non-recursive super- Turing machine combining 100B synapsing-neuron DNA-computers based on the genetic code. The whole system is a logos machine offering a world map for global context, essential for our intentional grasp of opportunities. We start from the observable contrast between the chaotic universe vs. our orderly inner world, the noumenal cosmos. So far, philosophy (...) has been rehearsing our thoughts, our human-internal world, a grand painting of the outer world, how we comprehend subjectively our experience, worked up by the logos machine, but now we seek a wider horizon, how humans understand the world thanks to Darwinian evolution to adapt in response to the metaphysical gap, the chasm between the human animal and its environment, shaping the organism so it can deal with its variable world. This new horizon embraces global context coded in neural structures that support the noumenal cosmos, our inner mental world, for us as denizens of the outer environment. Kant’s inner and outer senses are fundamental ingredients of scientific philosophy. Several sections devoted to Heidegger, his lizard debunked, but his version of the metaphysical gap & his doctrine of the logos praised. Rorty and others of the behaviorist school discussed also. (shrink)

Impressions, energy radiated by phenomena in the momentary environmental scene, enter sensory neurons, creating in afferent nerves a data stream. Following Kant, by our inner sense the mind perceives its own thoughts as it ties together sense data into an internalized scene. The mind, residing in the brain, logically a Language Machine, processes and stores items as coded grammatical entities. Kantian synthetic unity in the linguistic brain is able to deliver our experience of the scene as we appear to see (...) it. Uniquely, the brain records its own history, synthesizing a Movie-in-the-Brain, called the Noumenal Cosmos. Attempting thereby to represent the actual Universe, this makes for a sovereign brain that governs itself. The brain is domicile of an Ego, with its selfhood at stake at all times. Yet, it can know itself only by its actions, in which it appears as an actor in its own movie. Phenomena enter garbled, as confused apparitions, and must be put in good form using top–down feedback control by Ego, so that each movie frame makes rational sense within the overall context of the Noumenal Cosmos. A stack of frames is processed typically in 40 Hz rhythm with 300 ms process time each, for about 12 in the stack at any time. Successive neural centers are processing the stack in the brain assembly line, based on data from increasingly global receptive fields. Ego stitches together the movie frames, but only the top frame is in consciousness for 25 ms. The top frame contains the whole scene where the Ego makes an appearance as the actor that imposes Kantian synthetic unity on the scene, merely an assembly of grammatical texts, in a system-internal coded process language, fitting the scene into the Noumenal Cosmos. But Ego observes Ego only to the extent permitted by the objectivity rule, only what it does and thinks, not its true face. From the Noumenal Cosmos, the Ego receives grammatical messages in the internal sense code. They are integrated into a whole in the reaction of the Ego to the momentary scene. The voluntary nature of Ego’s decisions is explained, based on its ability to code in advance its own actions sequentially in time, as it sees fit with a view to an orderly Noumenal Cosmos, records of code being arranged spatially in neural structures. (shrink)

Phenomenology’s return to lived experience and “to the things themselves” is often contrasted with the synthesized perspective of science and its “view from nowhere.” The extensive use of neuropsychological case reports in Merleau-Ponty’s Phenomenology of Perception, however, suggests that the relationship between phenomenology and science is more complex than a sheer opposition, and a fruitful one for the praxis of medicine. Here, I propose a new reading of how Merleau-Ponty justifies his use of Adhémar Gelb and Kurt Goldstein’s reports on (...) Johann Schneider for his phenomenology of embodied perception. I argue that for Merleau-Ponty these neuropsychological case reports represent a coherent deformation of the intercorporeally expressed existence of Schneider that through speech fall again onto the common ground of perception, thereby allowing Merleau-Ponty to understand, in the equivalent sense delivered by language, Schneider’s total being and fundamental illness. I then discuss what Merleau-Ponty’s method implies for a phenomenological praxis of medicine, and for the role of science in this praxis. (shrink)

O presente artigo tem como objetivo evidenciar as contribuições da História Oral como um importante caminho metodológico para os estudos das culturas escolares. Para tanto, o texto inicia discutindo as mudanças ocorridas no campo da História, que deram voz aos sujeitos do cotidiano. Em seguida o conceito de culturas escolares é entrelaçado à História Oral, sendo abordada como uma das possibilidades para recuperar os registros do passado através da subjetividade dos sujeitos de hoje. O artigo é concluído através de uma (...) reflexão sobre as contribuições desta abordagem metodológica para a História da Educação e os estudos das culturas escolares, bem como sinalizando a importância de os agentes da escola perceberem-se como protagonistas da história, questionando certezas, dualidades, a fim de colaborar na compreensão da sua construção sociocultural, bem como dos espaços em que atuam. (shrink)

The response to feeding needs in advanced dementia patients is a subject of ethical inquiry. Advanced dementia is the debilitating result of a range of neurodegenerative diseases. As this terminal illness progresses, patients develop mild to severe dysphagia that can make swallowing difficult. Of the two available options, artificial tube feeding or oral hand feeding, an estimated one-third of these patients will receive artificial tube feeding. However, observational studies have failed to validate the clinical benefits of tube feeding. Ethics of (...) care, the feminist philosophical perspective, and Ubuntu philosophy offer arguments for the choice of oral hand-feeding as a preferrable first option by caregivers as far as possible. These moral theories acknowledge that human beings can be dependent for long periods, mostly early and later years of life. Both views reflect an approach that draws people into a system of interdependent caring relationships. They encourage hand feeding as a way of exhibiting solidarity and respecting human dignity even at the end of life. (shrink)

Outlines of Metaphysic - dictated portions of the lectures of Hermann Lotze is an unchanged, high-quality reprint of the original edition of 1884. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to (...) the preservation of literature which has become rare and historical knowledge for the future. (shrink)

One of the central logical ideas in Wittgenstein’sTractatus logico-philosophicusis the elimination of the identity sign in favor of the so-called “exclusive interpretation” of names and quantifiers requiring different names to refer to different objects and (roughly) different variables to take different values. In this paper, we examine a recent development of these ideas in papers by Kai Wehmeier. We diagnose two main problems of Wehmeier’s account, the first concerning the treatment of individual constants, the second concerning so-called “pseudo-propositions” (Scheinsätze) of (...) classical logic such as$a=a$or$a=b \wedge b=c \rightarrow a=c$. We argue that overcoming these problems requires two fairly drastic departures from Wehmeier’s account: (1) Not every formula of classical first-order logic will be translatable into asingleformula of Wittgenstein’s exclusive notation. Instead, there will often be a multiplicity of possible translations, revealing the original “inclusive” formulas to beambiguous. (2) Certain formulas of first-order logic such as$a=a$will not be translatable into Wittgenstein’s notation at all, being thereby revealed as nonsensical pseudo-propositions which should be excluded from a “correct” conceptual notation. We provide translation procedures from inclusive quantifier-free logic into the exclusive notation that take these modifications into account and define a notion of logical equivalence suitable for assessing these translations. (shrink)

In this essay, our goal is to discover science in Martin Heidegger's Introduction to Metaphysics, lecture notes for his 1935 summer semester course, because, after all, his subject is metaphysica generalis, or ontology, and this could be construed as a theory of the human brain. Here, by means of verbatim quotes from his text, we attempt to show that indeed these lectures can be viewed as suggestion for an objective scientific theory of human perception, the human capacity for deciphering phenomena, (...) ie. hermeneutics in its broadest sense. His added notes from the 1953 edition, all of which are comments, not corrections, imply that he never abandoned these thoughts on metaphysics, despite all of his utterances about a need to overcome it, and their popular interpretations to that effect. In his presentation, he further develops the colorful and intuitive style, an hermeneutic language, that he had created in his earlier work Being and Time. Of human existence he speaks in such expressions as being-there -- ``Dasein" -- and being-in-the-world, the latter term no longer explicit in the 1935 lectures. The lectures can be read as a pre-scientific analysis of how man, being-there, perceives his environment, artfully managing to deal with the manifold challenges posed by the phenomenal structures of the universe. Man attentively recognizes and deciphers their pre-linguistic contents and, while trying to make sense of it all, puts into words his awareness. There are numerous passages in Heidegger's work where he in fairly concrete terms provides us with hints for a perceptive science that, as it turns out and is demonstrated below in this essay, can be explained in terms of recent advances in neuroscience. It would be implausible, even unthinkable, unimaginable, for there not to be found essential agreement between on one hand his philosophical insights gained by hermeneutics of Dasein, into how our brain functions to let us know what's happening & on the other hand, scientific discoveries obtained through anatomy, EEG, fMRI, TMS, electrode implants, etc, of brain structures & functions employed in perception of the momentary scene. A nexus between science and philosophy is provided in Heidegger's definitive treatment of the Logos, here interpreted as a structural version of Platonic forms (Burchard, 2014). This allows for neurolinguistic brain functions to serve as meta-context for Heidegger's being-in-the-world. The logical functions of Dasein's anatomical brain are performed by the logos machine, formerly the human soul, using top-down processing based on a global context, the noumenal cosmos which humans maintain internally. Heidegger's 1942/43 winter semester lectures Parmenides extend in unbroken fashion his 1935 work, proving that he never abandoned, as is widely claimed, his metaphysical avenue of thought. (shrink)

The ancient dualism of a sensible and an intelligible world important in Neoplatonic and medieval philosophy, down to Descartes and Kant, would seem to be supplanted today by a scientific view of mind-in-nature. Here, we revive the old dualism in a modified form, and describe mind as a symbolic language, founded in linguistic recursive computation according to the Church-Turing thesis, constituting a world L that serves the human organism as a map of the Universe U. This methodological distinction of L (...) vs. U helps to understand how and why structures of phenomena come to be opposed to their nature in human thought, a central topic in Heideggerian philosophy. U is uncountable according to Georg Cantor’s set theory but Language L, based on the recursive function system, is countable, and anchored in a Gray Area within U of observable phenomena, typically symbols, prelinguistic structures, genetic-historical records of their origins. Symbols, the phenomena most familiar to mathematicians, are capable of being addressed in L-processing. The Gray Area is the human Environment E, where we can live comfortably, that we manipulate to create our niche within hostile U, with L offering overall competence of the species to survive. The human being is seen in the light of his or her linguistic recursively computational mind. Nature U, by contrast, is the unfathomable abyss of being, infinite labyrinth of darkness, impenetrable and hostile to man. The U-man, biological organism, is a stranger in L-man, the mind-controlled rational person, as expounded by Saint Paul. Noumena can now be seen to reside in L, and are not fully supported by phenomena. Kant’s noumenal cause is the mental L-image of only partly phenomenal causation. Mathematics occurs naturally in pre-linguistic phenomena, including natural laws, which give rise to pure mathematical structures in the world of L. Mathematical foundation within philosophy is reversed to where natural mathematics in the Gray Area of pre-linguistic phenomena can be seen to be a prerequisite for intellectual discourse. Lesser, nonverbal versions of L based on images are shared with animals. (shrink)

Georg Cantor's absolute infinity, the paradoxical Burali-Forti class Ω of all ordinals, is a monstrous non-entity for which being called a "class" is an undeserved dignity. This must be the ultimate vexation for mathematical philosophers who hold on to some residual sense of realism in set theory. By careful use of Ω, we can rescue Georg Cantor's 1899 "proof" sketch of the Well-Ordering Theorem––being generous, considering his declining health. We take the contrapositive of Cantor's suggestion and add Zermelo's choice function. (...) This results in a concise and uncomplicated proof of the Well-Ordering Theorem. (shrink)

Newton claims to have proven the heterogeneity of light through his experimentum crucis. However, Olaf Müller has worked out in detail Goethe’s idea that one could likewise prove the heterogeneity of darkness by inverting Newton’s famous experiment. Müller concludes that this invalidates Newton’s claim of proof. Yet this conclusion only holds if the heterogeneity of light and the heterogeneity of darkness is logically incompatible. This paper shows that this is not the case. Instead, in Quine’s terms, we have two logically (...) compatible theories based on mutually irreducible theoretical terms. From a Quinean point of view, this does no harm to the provability of the corresponding statements. (shrink)

Das Buch entwickelt einen neuartigen, physikalistischen Interpretationsansatz zu Wittgensteins Tractatus Logico-Philosophicus. Das traditionelle Urteil, Wittgenstein habe im Tractatus keine klare Vorstellung der Analyse gehabt, wird widerlegt. Auf der Basis der Rekonstruktion der um die Jahrhundertwende etablierten Sinnesdatenanalysen im allgemeinen und der Farbanalysen im besonderen wird nachgewiesen, daß Wittgensteins Tractatus eine physikalische Sinnesdatenanalyse voraussetzt. Auf diesem Hintergrund werden Wittgensteins allgemeine Auffassungen zur Analyse der Welt und Sprache gedeutet, begründet und exemplifiziert. Der Tractatus liefert die philosophische Klärung des mechanistischen Weltbildes von Boltzmann (...) und Hertz. Er stellt die Mittel bereit, um den Sinn der Sätze zu analysieren und die logische Zulässigkeit von Aussagen zu prüfen. Die Anwendung dieser Mittel ist Aufgabe der Philosophie. Daß sie anwendbar sind und wie sie anzuwenden sind, demonstriert dieses Buch. (shrink)

Big data represents a significant challenge for the social sciences. From a philosophy-of-science perspective, it is important to reflect on related theories and processes for developing them. In this paper, we start by examining different views on the role of theories in big data-related social research. Then, we try to show how big data is related to standards for evaluating theories. We also outline how big data affects theory- and data-based research approaches and the process of theory building. Discussions include (...) a summary of lines of reasoning, limitations, and a proposal for future developmental steps. (shrink)

This new edition of Aristotle s De interpretatione provides an improved text compared to the 1949 Oxford edition, based upon an evaluation of the seven earliest surviving medieval manuscripts as well as many translations and commentaries from late antiquity. A text-critical apparatus provides information about the different readings.".

According to some scholars, such as Rodych and Steiner, Wittgenstein objects to Gödel’s undecidability proof of his formula $$G$$, arguing that given a proof of $$G$$, one could relinquish the meta-mathematical interpretation of $$G$$ instead of relinquishing the assumption that Principia Mathematica is correct. Most scholars agree that such an objection, be it Wittgenstein’s or not, rests on an inadequate understanding of Gödel’s proof. In this paper, I argue that there is a possible reading of such an objection that is, (...) in fact, reasonable and related to Gödel’s proof. (shrink)

Es wird anhand von Fallbeispielen aus der Geschichte der Farbenlehre inwissenschaftstheoretische Probleme eingeführt. Das Buch dient als Grundlagefür eine anwendungsbezogene Lehre und als Einführung in folgende ThemenbereicheNewton vs. Goethe; Theorie und Experiment, Colormetrie; Empfindungsmessung;Helmholtz vs. Hering; Theorienevaluation, Psychologische Farbenlehre; Phänomenologie,Farbausschluss; Beweistheorie, Farbdefinitionen; Theorien- und Begriffsbildung.Neben Aufgaben, Texten und Lösungsvorschlägen finden sich eine Bibliographiesowie Einleitungen zu den behandelten Fragen und Lösungsvorschlägen derjeweiligen Themen.

Hermann Karl Usener published his monumental Epicurea in 1887. The volume is a collection of Epicurean texts and citations from a wide range of classical authors including Arrian, Cicero, Diodorus, Euripides, Plato and Seneca. The volume includes critical texts of Epicurus' most important letters: Letter to Menoeceus, Letter to Herodotus and Letter to Pythocles, preserved by the third-century compiler Diogenes Laertius. The letters give important summaries of Epicurus' philosophy. Usener's pioneering work represented the first attempt to deal critically with (...) the manuscript traditions behind Epicurean texts. His reconstructions of the texts included in this volume are based on a thorough understanding of the trajectories of textual transmission. Each text is supported by a detailed critical apparatus, and another apparatus records manuscript glosses and scholia. This work provided for the first time accurate and reliable texts for the critical study of Epicureanism. (shrink)