Since the 1990s, the science of memetics has existed outside of any discipline and freely available to all. It has remained clandestine, having failed to become established as a “normal” science, but its vitality has been unabated by the resistance of critics. Today, the accelerated reinvention of the world and its dense global networks have opened up new opportunities for the science of memetics to prove its worth to an intellectual community in dire need of interdisciplinary exchanges.

A simple molecular system is described consisting of the reciprocal linkage between an autocatalytic cycle and a self-assembling encapsulation process where the molecular constituents for the capsule are products of the autocatalysis. In a molecular environment sufficiently rich in the substrates, capsule growth will also occur with high predictability. Growth to closure will be most probable in the vicinity of the most prolific autocatalysis and will thus tend to spontaneously enclose supportive catalysts within the capsule interior. If subsequently disrupted in (...) the presence of new substrates, the released components will initiate production of additional catalytic and capsule components that will spontaneously re-assemble into one or more autocell replicas, thereby reconstituting and sometimes reproducing the original. In a diverse molecular environment, cycles of disruption and enclosure will cause auto-cells to incidentally encapsulate other molecules as well as reactive substrates. To the extent that any captured molecule can be incorporated into the autocatalytic process by virtue of structural degeneracy of the catalytic binding sites, the altered autocell will incorporate the new type of component into subsequent replications. Such altered autocells will be progenitors of “lineages” with variant characteristics that will differentially propagate with respect to the availability of commonly required substrates. Autocells are susceptible to a limited form of evolution, capable of leading to more efficient, more environmentally fitted, and more complex forms. This provides a simple demonstration of the plausibility of open-ended reproduction and evolvability without self-replicating template molecules or maintenance of persistent nonequilibrium chemistry. This model identifies an intermediate domain between prebiotic and biotic systems and bridges the gap from nonequilibrium thermodynamics to life. (shrink)

James Brown’s ‘I’m Real’ (1988) contains numerous lyrics regaled from James Brown’s earlier hits (including ‘Make it Funky’ (1971)) and also James Brown vocal samples from ‘Get Up (I Feel Like Being a) Sex Machine’ (1970) and ‘Get on the Good Foot’ (1972). But why sample James Brown’s voice when the man himself was in the studio recording a vocal? What purpose could it serve, especially when he was already replicating moments from previous hits? This article investigates that chronologic duality. (...) The central questions I pose here focus on what the choice to sample himself reveals about Brown’s status as a Soul legend, and whether the contemporaneous James could sincerely live up to the mythic status he establishes lyrically. Via a detailed investigation of the song ‘I’m Real’, I will probe Brown’s playful employment of his own past. His gambit, I will argue, may be read simultaneously as testament to his own glory, and as a signifier that the excesses of egotistic auto-projection were always more distant than they first appeared to be. (shrink)

You can survive after death in various kinds of artifacts. You can survive in diaries, photographs, sound recordings, and movies. But these artifacts record only superficial features of yourself. We are already close to the construction of programs that partially and approximately replicate entire human lives (by storing their memories and duplicating their personalities). A digital ghost is an artificially intelligent program that knows all about your life. It is an animated auto-biography. It replicates your patterns of belief and (...) desire. You can survive after death in a digital ghost. We discuss a series of digital ghosts over the next 50 years. As time goes by and technology advances, they are progressively more perfect replicas of the lives of their original authors. (shrink)

Engineered microbes are of great potential utility in biotechnology and basic research. In principle, a cell can be built from scratch by assembling small molecule sets with auto‐catalytic properties. Alternatively, DNA can be isolated or directly synthesized and molded into a synthetic genome using existing genomic blueprints and molecular biology tools. Activating such a synthetic genome will yield a synthetic cell. Here we examine obstacles associated with this latter approach using a model system whereby a donor genome from H. (...) influenzae is fragmented, and the pieces are then modified and reassembled stepwise in an E. coli host cell. There are obstacles associated with this strategy related to DNA transfer, DNA replication, cross‐talk in gene regulation and compatibility of gene products between donor and host. Encouragingly, analysis of gene expression indicates widespread transcription of H. influenzae genes in E. coli, and analysis of gap locations in H. influenzae and other microbial genome assemblies reveals few genes routinely incompatible with E. coli. In conclusion, rebuilding and booting a genome remains a feasible and pragmatic approach to creating a synthetic microbial cell. BioEssays 29:580–590, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Replicability and reproducibility of computational models has been somewhat understudied by “the replication movement.” In this paper, we draw on methodological studies into the replicability of psychological experiments and on the mechanistic account of explanation to analyze the functions of model replications and model reproductions in computational neuroscience. We contend that model replicability, or independent researchers' ability to obtain the same output using original code and data, and model reproducibility, or independent researchers' ability to recreate a model without original code, (...) serve different functions and fail for different reasons. This means that measures designed to improve model replicability may not enhance (and, in some cases, may actually damage) model reproducibility. We claim that although both are undesirable, low model reproducibility poses more of a threat to long-term scientific progress than low model replicability. In our opinion, low model reproducibility stems mostly from authors' omitting to provide crucial information in scientific papers and we stress that sharing all computer code and data is not a solution. Reports of computational studies should remain selective and include all and only relevant bits of code. (shrink)

Current debates about the replication crisis in psychology take it for granted that direct replication is valuable and focus their attention on questionable research practices in regard to statistical analyses. This paper takes a broader look at the notion of replication as such. It is argued that all experimentation/replication involves individuation judgments and that research in experimental psychology frequently turns on probing the adequacy of such judgments. In this vein, I highlight the ubiquity of conceptual and material questions in research, (...) and I argue that replication is not as central to psychological research as it is sometimes taken to be. (shrink)

Replications are often taken to play both epistemic and demarcating roles in science: they provide evidence about the reliability of fields’ methods and, by extension, about which fields “count” as scientific. I argue that, in a field characterized by a high degree of theoretical openness and uncertainty, like comparative cognition, replications do not sit well in these roles. Like other experiments conducted under conditions of uncertainty, replications are often equivocal and open to interpretation. As a result, they are poorly placed (...) to deliver clear judgments about the reliability of comparative cognition’s methods or its scientific bona fides. I suggest that this should encourage us to take a broader view of both the nature of scientific progress and the role of replication in comparative cognition. (shrink)

The history and theoretical role of the concept of a ``replicator''is discussed, starting with Dawkins' and Hull's classic treatmentsand working forward. I argue that the replicator concept is still auseful one for evolutionary theory, but it should be revised insome ways. The most important revision is the recognition that notall processes of evolution by natural selection require thatsomething play the role of a replicator.

Idipsum est une locution qu'Augustin utilise pour désigner Dieu. Elle signifie littéralement "cela même". Ce minimalisme sémantique ne laisse pas de la rendre mystérieuse. Faut-il y voir un emprunt à certains textes bibliques qui déjà en font usage? Dans ce cas, idipsum, tel un nom propre vide de toute signification, se bornerait à indiquer Dieu en tant qu'il échappe à toute définition rationnelle. Ou bien faut-il rattacher idipsum à la tradition platonicienne qui recourt à des locutions grecques similaires pour désigner (...) la réalité intelligible qui est " elle-même en elle-même "? Idipsum serait alors la trace d'un héritage philosophique conduisant Augustin à une définition métaphysique de Dieu comme Etre absolu. Cependant, cette alternative entre origine biblique et tradition platonicienne néglige la diversité des usages philosophiques des locutions formées sur auto puis ipsum: elles expriment d'abord l'identité et le fait d'être soi, puis la réflexivité, au croisement des champs dialectique, pratique et ontologique. Cet ouvrage explore la façon dont ces aspects de l'identité se sont construits, du autos grec à l'idipsum latin, à travers des études portant sur Homère, Platon, Aristote, le stoïcisme, le néoplatonisme grec puis latin, Augustin. (shrink)

The Developmental Systems approach to evolution is defended against the alternative extended replicator approach of Sterelny, Smith and Dickison (1996). A precise definition is provided of the spatial and temporal boundaries of the life-cycle that DST claims is the unit of evolution. Pacé Sterelny et al., the extended replicator theory is not a bulwark against excessive holism. Everything which DST claims is replicated in evolution can be shown to be an extended replicator on Sterelny et al.s definition. Reasons are given (...) for scepticism about the heuristic value claimed for the extended replicator concept. For every competitive, individualistic insight the replicator theorist has a cooperative, systematic blindspot. (shrink)

According to a once influential view of selection, it consists of repeated cycles of replication and interaction. It has been argued that this view is wrong: replication is not necessary for evolution by natural selection. I analyze the nine most influential arguments for this claim and defend the replication–interaction conception of selection against these objections. In order to do so, however, the replication–interaction conception of selection needs to be modified significantly. My proposal is that replication is not the copying of (...) an entity, the replicator, but the copying of a property. Thus, we can have a replication process without there being a replicator that is being copied. (shrink)

We argue that the epistemic functions of replication in science are best understood by their role in assessing kinds of experimental error. Direct replications serve to assess the reliability of an experiment through its precision: the presence and degree of random error. Conceptual replications serve to assess the validity of an experiment through its accuracy: the presence and degree of systematic errors. To illustrate the aptness of this view, we examine the Hubble constant controversy in astronomy, showing how astronomers have (...) responded to the concordances and discordances in their results by carrying out the different kinds of replication that we identify, with the aim of establishing a precise, accurate value for the Hubble constant. We contrast our view with Machery’s “re-sampling” account of replicability, which maintains that replications only assess reliability. (shrink)

This paper explores auto-photography as a form of research practice in the area of identity and self-esteem research. It allows researchers to capture and articulate the ways identity guides human action and thought. It involves the generation and examination of the static images that participants themselves believe best represent them. Auto-photography is an important tool for building bridges with marginalized groups in the research process, since it offers researchers a way to let participants speak for themselves. Furthermore, by (...) using this method researchers can avoid exclusive reliance on survey questionnaires and other such research instruments that may be culturally biased. I present two research projects using auto-photography: one involving adolescent Latina girls and one involving Indian women. Based on the experience of these projects, I discuss auto-photography's importance in identity and self-esteem research. Finally, I discuss some of the benefits and challenges of working with this method. (shrink)

This paper provides an introduction and overview of Michel Henry's work, with particular emphasis on his understanding of auto-affectivity. It concludes by pointing to some objections or questions sympathetic phenomenologists may have for his work.

The replicability of experiment is routinely offered as the gold standard of evidence. I argue that it is not supported by a universal principle of replicability in inductive logic. A failure of replication may not impugn a credible experimental result; and a successful replication can fail to vindicate an incredible experimental result. Rather, employing a material approach to inductive inference, the evidential import of successful replication of an experiment is determined by the prevailing background facts. Commonly, these background facts do (...) support successful replication as a good evidential guide and this has fostered the illusion of a deeper, exceptionless principle. (shrink)

The replication crisis is perceived by many as one of the most significant threats to the reliability of research. Though reporting of the crisis has emphasized social science, all signs indicate that it extends to many other fields. This paper investigates the possibility that the crisis and related challenges to conducting research also extend to philosophy. According to one possibility, philosophy inherits a crisis similar to the one in science because philosophers rely on unreplicated or unreplicable findings from science when (...) conducting philosophical research. According to another possibility, the crisis likely extends to philosophy because philosophers engage in similar research practices and face similar structural issues when conducting research that have been implicated by the crisis in science. Proposals for improving philosophical research are offered in light of these possibilities. (shrink)

In the last years, a series of automated self-representational social media sites have emerged that shed light on the information ethics associated with participation in Web 2.0. Sites like Zoominfo.com, Pipl.com, 123People.com and Yasni.com not only continually mine and aggregate personal information and biographic data from the web and beyond to automatically represent the lives of people, but they also engage algorithmic networking logics to represent connections between them; capturing not only who people are, but whom they are connected to. (...) Indeed, these processes of 'auto-biography' are 'secret' ones that for the most part escape the user's attention. This article explores how these sites of auto-biography reveal the complexities of the political economy of Web 2.0, as well as implicate an ethics of exposure concerning how these processes at once participate in the erosion of privacy, and at the same time, in the reinforcement of commodification and surveillance regimes. (shrink)

Se propone una lectura de la interpretación que Heidegger hace del problema de la auto-afección en la primera Crítica kantiana. Si el tiempo y el yo pienso se unifican es gracias a la idea del tiempo como auto-afección pura que permite captar el movimiento de formación del sí-mismo sin subordinarlo a un enlace extratemporal. Intentaremos mostrar que esta comprensión considera el tiempo como un movimiento autorreferencial que no obstante hace necesario un retiro y una demora de sí para (...) liberar lo que viene. Para hacer posible un encuentro con otro, dicha estructura autoafectiva debe darse el tiempo que impide la clausura autárquica de sí mismo. (shrink)

Replication of the main chromosome in the halophilic archaeon Haloferax volcanii was recently reported to continue despite deletion of all active replication origins. Equally surprising, the deletion strain grew faster than the parent strain. It was proposed that origin‐less H. volcanii duplicate their chromosomes via recombination‐dependent replication. Here, we recall our present knowledge of this mode of chromosome replication in different organisms. We consider the likelihood that it accounts for the viability of H. volcanii deleted for its main specific replication (...) origins, as well as possible alternative interpretations of the results. The selective advantages of having defined chromosome replication origins are discussed from a functional and evolutionary perspective. (shrink)

Popper’s (1983, 2002) philosophy of science has enjoyed something of a renaissance in the wake of the replication crisis, offering a philosophical basis for the ensuing science reform movement. However, adherence to Popper’s approach may also be at least partly responsible for the sense of “crisis” that has developed following multiple unexpected replication failures. In this article, I contrast Popper’s approach with Lakatos’ (1978) approach and a related approach called naïve methodological falsificationism (NMF; Lakatos, 1978). The Popperian approach is powerful (...) because it is based on logical refutation, but its theories are noncausal and, therefore, lacking in scientific value. In contrast, the Lakatosian approach considers causal theories, but it concedes that these theories are not logically refutable. Finally, the NMF approach subjects Lakatosian causal theories to Popperian logical refutations. However, its approach of temporarily accepting a ceteris paribus clause during theory testing may be viewed as scientifically inappropriate, epistemically inconsistent, and “completely redundant” (Lakatos, 1978, p. 40). I conclude that the replication “crisis” makes the most sense in the context of the Popperian and NMF approaches because it is only in these two approaches that replication failures represent logical refutations of theories. In contrast, replication failures are less problematic in the Lakatosian approach because they do not logically refute theories. Indeed, in the Lakatosian approach, replication failures can be legitimately ignored or used to motivate theory development. (shrink)

Nowadays, almost everyone seems to agree that science is facing an epistemological crisis – namely the replicability crisis – and that we need to take action. But as to precisely what to do or how...

Greening Auto Jobs: A Critical Analysis of the Green Job Solution provides a major contribution to the growing and important field of environmental sociology and labor studies by providing a theoretical and practical understanding of how the broader political-economic relations of society affect the relationship between labor and the environment.

Western thought’s worldview of the concept of man has influenced much of the theoretical basis of science. Without realizing it, the Western interpretation of the human concept still raises debates just like the concept of the economic man. The West’s failure to understand the concept of the economic man had an impact on economic problems in the neoclassical era. This study aims to analyze the worldview analogy of Western thinking about human nature from various figures and relate it to the (...) context of economic problems in a neoclassical era. This study uses a conceptual approach. Western interpretations of human nature tend to be based on the nature of animals such as rational animals, zoon politicon, and homo sapiens. Meanwhile, in an economic aspect, humans are considered selfish, materialistic, self-interested, greedy, and always want to gain power. The worldview of various Western figures in interpreting human economics leads to the rationality of materialism. It can be said that the Western worldview fails in understanding the human concept. Failure to understand this concept raises complex economic problems in the neoclassical era such as scarcity, climate crisis, poverty, and welfare. Because human nature is uncontrollably exploiting nature through production activities to increase wealth is a main factor. (shrink)

Replication protein A (RPA) is the main eukaryotic single‐stranded DNA (ssDNA) binding protein, having essential roles in all DNA metabolic reactions involving ssDNA. RPA binds ssDNA with high affinity, thereby preventing the formation of secondary structures and protecting ssDNA from the action of nucleases, and directly interacts with other DNA processing proteins. Here, we discuss recent results supporting the idea that one function of RPA is to prevent annealing between short repeats that can lead to chromosome rearrangements by microhomology‐mediated end (...) joining or the formation of hairpin structures that are substrates for structure‐selective nucleases. We suggest that replication fork catastrophe caused by depletion of RPA could result from cleavage of secondary structures by nucleases, and that failure to cleave hairpin structures formed at DNA ends could lead to gene amplification. These studies highlight the important role RPA plays in maintaining genome integrity. (shrink)

Recent studies based on next‐generation DNA sequencing have revealed that the female inactive X chromosome is replicated in a rapid, unorganized manner, and undergoes increased rates of mutation. These observations link the organization of DNA replication timing to gene regulation on one hand, and to the generation of mutations on the other hand. More generally, the exceptional biology of the inactive X chromosome highlights general principles of genome replication. Cells may control replication timing by a combination of intrinsic replication origin (...) properties, local chromatin states and global levels of replication factors, leading to a functional separation between the activity of genes and their mutation. (shrink)

El prefijo “auto” en autoorganización y autopoiesis se refiere a la existencia de una identidad o agencialidad implicada en el orden, organización o producción de un sistema que se corresponde con el sistema mismo, en contraste con el diseño o la influencia de carácter externo. La autoorganización (AO) estudia la manera en la que los procesos de un sistema alcanzan de forma espontánea un orden u organización complejo, bien como una estructura o patrón emergente, bien como algún tipo de (...) finalidad o identidad autoconstruida. En este trabajo nos ocupamos del concepto de AO en el contexto de la problemática sobre la naturaleza la vida y de los organismos vivientes. Este concepto se elabora en diferentes tradiciones científicas y filosóficas, a partir de su origen en la filosofía kantiana. La cibernética trata de emular la organización de los seres vivos y su teleología mediante la construcción de máquinas; desarrolla una perspectiva centrada en la regulación y en la causalidad mutua entre componentes del sistema. Estos trabajos, a veces complementados con la teoría de sistemas y la teoría de la información, son fundamentales para el desarrollo de la ciencia del siglo XX, especialmente las ciencias computacionales y la biología. Una segunda corriente surge desde la termodinámica de los procesos irreversibles alejados del equilibrio a partir, entre otros, de los trabajos de la escuela de Bruselas, en la que la AO se explora como la formación espontánea de estructuras de orden disipativo. Una tercera tradición, tal vez la más profundamente kantiana, se desarrolla en el contexto de la biología del desarrollo e integra a las dos mencionadas previamente, pues combina aspectos de las dos previas en el desarrollo ontogenético. Podemos decir que cada una de estas concepciones de la AO se relaciona con modelos paradigmáticos diferentes. La noción de autopoiesis (AP), por su parte, fue propuesta en los años 70 por los biólogos chilenos Humberto Maturana y Francisco Varela para explicar la organización individual de los seres vivos como un proceso dinámico que genera una identidad desde las operaciones del sistema (Maturana y Varela 1973). Puede decirse que hereda y reorganiza ideas de la tradición de la AO, especialmente la kantiana y la cibernética, para proponer una teoría biológica alternativa. El enfoque autopoiético concibe el fenómeno de la vida y a los seres vivos de forma muy diferente a la teoría de la evolución o la biología molecular que constituían las líneas de investigación predominantes en la biología de su tiempo. La teoría subraya como propiedad básica de un sistema viviente su autoconstitución dinámica como unidad dotada de identidad a partir de interacciones entre sus componentes. Sin embargo, aquellas propiedades de la vida consideradas primordiales en el enfoque darwiniano, como la reproducción o la evolución, se ven como secundarias, pues requieren de la existencia previa de sistemas autopoiéticos. El objetivo de esta voz es examinar diferentes aspectos que configuran las tradiciones autoorganizativa y autopoiética, en especial las tensiones conceptuales internas que permiten comprender los desafíos a los que se enfrentan ambas en el marco de la filosofía y la teoría de la biología, así como la forma en que sus posiciones e intuiciones contrastan con otras perspectivas en biología. (shrink)

In bacteria, PriA protein, a conserved DEXH‐type DNA helicase, plays a central role in replication restart at stalled replication forks. Its unique DNA‐binding property allows it to recognize and stabilize stalled forks and the structures derived from them. Cells must cope with fork stalls caused by various replication stresses to complete replication of the entire genome. Failure of the stalled fork stabilization process and eventual restart could lead to various forms of genomic instability. The low viability of priA null cells (...) indicates a frequent occurrence of fork stall during normal growth that needs to be properly processed. PriA specifically recognizes the 3′‐terminus of the nascent leading strand or the invading strand in a displacement (D)‐loop by the three‐prime terminus binding pocket (TT‐pocket) present in its unique DNA binding domain. Elucidation of the structural basis for recognition of arrested forks by PriA should provide useful insight into how stalled forks are recognized in eukaryotes. (shrink)

Basado en argumentos previos, propongo una [auto] etnografía civil, públicamente responsable, que aborde las temáticas centrales de self, raza, género, clase, sociedad y democracia. Comienzo con la pedagogía de la esperanza y la imaginación sociológica y etnográfica. Paso entonces al etnógrafo y los estudios culturales, revisando varios modelos de etnografía crítica. A continuación, examino la pedagogía performativa crítica, la política y la teoría racial crítica, concluyendo con una breve discusión sobre la práctica de una política cultural performativa.

Cette contribution témoigne de l’importance de la réception de la phénoménologie de langue française en Amérique Latine. En revisitant la thèse de la duplicité de l’apparaître – apparaître de la vie comme affect et comme force, apparaître du monde comme sens et distance –, Roberto J. Walton s’attache au concept fondamental de la phénoménologie de la vie, en mettant en avant des modalités dans lesquelles l’auto-affection opère sans hétéro-affection d’une manière avérée. Il précise d’emblée que cette auto-affection sans (...) hétéro-affection est définie par deux aspects : un premier « aspect de base » – ou rapport de fondation – en vertu duquel l’auto-affection est la condition de possibilité de toute intentionnalité ou ek-stase ; et un deuxième aspect « d’intensification ou d’excédence » qui renvoie à la phénoménologie de l’événement, en ceci que l’auto-affection y apparaît dans une sorte de plus-value, c’est-à-dire dans la condition de l’acte comme accroissement créateur. (shrink)

A published simulation model Riolo et al. 2001 ) was replicated in two independent implementations so that the results as well as the conceptual design align. This double replication allowed the original to be analysed and critiqued with confidence. In this case, the replication revealed some weaknesses in the original model, which otherwise might not have come to light. This shows that unreplicated simulation models and their results can not be trusted - as with other kinds of experiment, simulations need (...) to be independently replicated. (shrink)

This essay starts with the possibility of situating Derrida’s aporetic ethics in the domain of normative ethics and argues that Derrida’s reflection on ethics is enrooted in the specific way he conceives the phenomenological notion of auto-affection. In the second section, I analyze, in the early work, auto-affection with signs and show its centrality in Derrida’s first encounter with Levinas’s philosophy. Derrida refuses to substitute the hetero-affective relation to the Other for auto-affection as the source of universal (...) law and normativity. He does not sacrifice universality and tackles the problem of autonomous ethical decision-making even though he welcomes through affectivity the signification of the singular other, which is irreducible to conceptual, emotive, and normative self-relation. This background helps us understand the rootedness of ethical aporias in a reflection on auto-affection. (shrink)

Scholars are increasingly concerned about social biases in facial analysis systems, particularly with regard to the tangible consequences of misidentification of marginalized groups. However, few have examined how automated facial analysis technologies intersect with the historical genealogy of racialized gender—the gender binary and its classification as a highly racialized tool of colonial power and control. In this paper, we introduce the concept of auto-essentialization: the use of automated technologies to re-inscribe the essential notions of difference that were established under (...) colonial rule. We consider how the face has emerged as a legitimate site of gender classification, despite being historically tied to projects of racial domination. We examine the history of gendering the face and body, from colonial projects aimed at disciplining bodies which do not fit within the European gender binary, to sexology's role in normalizing that binary, to physiognomic practices that ascribed notions of inferiority to non-European groups and women. We argue that the contemporary auto-essentialization of gender via the face is both racialized and trans-exclusive: it asserts a fixed gender binary and it elevates the white face as the ultimate model of gender difference. We demonstrate that imperialist ideologies are reflected in modern automated facial analysis tools in computer vision through two case studies: commercial gender classification and the security of both small-scale and large-scale spaces. Thus, we posit a rethinking of ethical attention to these systems: not as immature and novel, but as mature instantiations of much older technologies. (shrink)

The idea of replication is based on the premise that there are permanent laws to be replicated and verified, and the scientific method is adequate for doing so. Scientific truth, however, is not absolute but relative to time and context, and the method used. Time and context are inextricably interwoven, in that time creates different contexts and contexts (e.g., Christmas Day vs. New Year’s Day) create different experiences of time, rendering psychological phenomena inherently variable. This means that internal and external (...) conditions fluctuate and are different in a replication study vs. the original. Thus, a replication experiment is just another empirical investigation that has no special status in the establishment of scientific truth. It is not the final arbiter of whether or not something exists. In their pursuit of homogeneous external conditions, replications have ignored the homogeneity of internal conditions. There is not a single replication reported in the literature that would have shown participants’ feelings and thoughts—both conscious and nonconscious—to be identical to those of the original participants. Experimental instructions can create varying ratios of conscious over nonconscious processing from one study to another. Ironically, every replication is a failure at the fundamentals of human psychology. While patterns can be discovered, they are not permanent or unchangeable laws of human behavior to be proven by the pinpoint statistical verification through replication. As scientific knowledge in physics is temporary and incomplete, should it be any surprise that science can only provide “temporary winners” for psychological knowledge of human behavior? (shrink)

In this paper, I articulate an argument for incompatibilism about moral responsibility and determinism. My argument comes in the form of an extended story, modeled loosely on Peter van Inwagen’s “rollback argument” scenario. I thus call it “the replication argument.” As I aim to bring out, though the argument is inspired by so-called “manipulation” and “original design” arguments, the argument is not a version of either such argument—and plausibly has advantages over both. The result, I believe, is a more convincing (...) incompatibilist argument than those we have considered previously. (shrink)

Si l ’ on peut bien affirmer que certains Sceptiques s ’ auto-réfutent, ce n ’ est pas le cas de Sextus Empiricus. En distinguant entre les modèles auto-référentiel et performatif de l ’ auto-réfutation auxquels on confronte les problèmes anciens du Menteur et du renversement ( peritropè ), on peut montrer que Sextus recourt à ce qu ’ il désigne par le mot sumperigraphè, qu ’ il convient de considérer comme un schème topologique verbal (une boucle (...) récursive). Il ressort que Sextus circonscrit la logique dont relève l ’ auto-réfutation, dans un effet réfléchissant et abyssal, rejoignant la grande tradition sceptique du théâtre grec. (shrink)

This article is a response to Ole Martin Skilleås's "Knowledge and Imagination in Fiction and Biography." The first section of the article summarizes the line of the argument in four theses: (1) What is real is more influential than what is made up; (2) there is no metaphysical chasm between autobiographers and us; (3) (auto)biographies are not just empirical; and (4) the moral lesson of a fiction need not be accepted. In the second section each of these theses is (...) criticized. This criticism leads to the conclusion that we should welcome (auto)biographical texts in our moral investigations, but not at the cost of fictional texts. This conclusion is coupled with a proposal to formulate criteria to distinguish texts that matter from those that do not. (shrink)

The reward system of science is the priority rule. The first scientist making a new discovery is rewarded with prestige, while second runners get little or nothing. Michael Strevens, following Philip Kitcher, defends this reward system, arguing that it incentivizes an efficient division of cognitive labor. I argue that this assessment depends on strong implicit assumptions about the replicability of findings. I question these assumptions on the basis of metascientific evidence and argue that the priority rule systematically discourages replication. My (...) analysis leads us to qualify Kitcher and Strevens’s contention that a priority-based reward system is normatively desirable for science. (shrink)

This special issue on what some regard as a crisis of replicability in cognitive science (i.e. the observation that a worryingly large proportion of experimental results across a number of areas cannot be reliably replicated) is informed by three recent developments. -/- First, philosophers of mind and cognitive science rely increasingly on empirical research, mainly in the psychological sciences, to back up their claims. This trend has been noticeable since the 1960s (see Knobe, 2015). This development has allowed philosophers to (...) draw on a wider range of relevant resources, but it also makes them vulnerable to relying on claims that may not survive further scrutiny. If we have reasons to believe that a large proportion of findings in the psychological sciences cannot be reliably replicated, this would be a problem for philosophers who use such findings in their work. Second, philosophers are increasingly designing and carrying out their own experiments to back up claims, or to test claims earlier made from the armchair, for example, on the perceived permissibility of diverting trolleys or on the nature of free will. This growing field of experimental philosophy has diversified the intellectual field in philosophy, but may also be vulnerable to issues of replicability that philosophers did not face before. -/- Third, the recent evidence of apparently widespread non-replicability in the social sciences (and other fields) has forced philosophers of science to grapple with long standing questions from their field from a new perspective. To what extent does replicability matter for theory construction? How do the notions of replicability and scientific progress interact? How can normative insights from philosophy of science be used in order to improve scientific practice? -/- It is with these three developments in mind—the increasing importance of empirically-informed philosophy, of experimental philosophy, and of philosophy of science around replicability—that this special issue has been conceived. (shrink)

The regulation of DNA replication is a fascinating biological problem both from a mechanistic angle—How is replication timing regulated?—and from an evolutionary one—Why is replication timing regulated? Recent work has provided significant insight into the first question. Detailed biochemical understanding of the mechanism and regulation of replication initiation has made possible robust hypotheses for how replication timing is regulated. Moreover, technical progress, including high‐throughput, single‐molecule mapping of replication initiation and single‐cell assays of replication timing, has allowed for direct testing of (...) these hypotheses in mammalian cells. This work has consolidated the conclusion that differential replication timing is a consequence of the varying probability of replication origin initiation. The second question is more difficult to directly address experimentally. Nonetheless, plausible hypotheses can be made and one—that replication timing contributes to the regulation of chromatin structure—has received new experimental support. (shrink)

This paper has a twofold objective. First, it engages with the interrelation of time, space, and matter in Kant, Heidegger, and Derrida and questions whether and how this interrelation effects the possibility of self-relation. In Kant and the Problem of Metaphysics Heidegger suggests that the very structure of subjectivity is constituted by what he calls the ‘pure self-affection’ of time and thus the possibility of self-relation is intimately bound up with the temporalizing of time. In his 1964–65 seminar, Heidegger: the (...) Question of Being and History, Derrida translates this pure affection of time into the more generic term ‘auto-affection,’ which will remain a pivotal reference point for his deconstruction of the metaphysical privileging of time as presence. Derrida shows how the (im)possibility of auto-affection is bound up not only with time but also with space, or rather with the ‘spacing of time’ that he also refers to as ‘the trace.’ Second, the paper moves across the frontiers of philosophy and physics posing anew the question concerning the interrelations of temporality, spatiality, and materiality. With reference to what in general relativity is called ‘the curvature of spacetime,’ the efficacy of materiality in the movement of auto-affection is called into question. (shrink)

Despite its imperative to include all gendered positions under one umbrella, ‘trans’ is continually riven by intramural confrontation over the differences between its masculine and feminine iterations. Whether in political organizing, on social media or in the pages of academic trans theory, it sometimes seems like ‘trans’ is subject to an interminable and gendered custody battle. Dissatisfied with the terms of masc–femme antagonism, this essay uses the gendered interfaces of critique and autotheory to enmesh the work of Jules Gill-Peterson and (...) Paul B. Preciado. Reading into the interdependence of Gill-Peterson’s and Preciado’s texts yields a different theory: trans as an auto-antonym, a word that produces opposite meanings depending on context. Treating trans as auto-antonymic conjures a relational and even erotic escape from the naturalization of gendered antagonism in trans theory, affirming the unexpected bridges, reversals or ‘sex changes’ of specifically trans writing. (shrink)

Partant de l'idée énoncée par le philosophe Charles Taylor, selon laquelle les êtres humains sont « des animaux capables d'auto-interprétation », cet article vise à comprendre le rôle constitutif de l'auto-interprétation dans la connaissance de soi. Une conception satisfaisante de l'auto-interprétation devrait à la fois rendre compte de l'autorité de la connaissance de soi en première personne et satisfaire les exigences du réalisme ordinaire. Si la version constitutiviste de l'auto-interprétation semble incompatible avec de telles exigences, c'est (...) parce qu'elle considère ce pouvoir constituant comme le privilège du sujet de modeler ses états mentaux au gré de sa volonté. Pour autant, il est possible de conserver un rôle constitutif à l'auto-interprétation en évitant toute implication volontariste et en maintenant une certaine indépendance des contenus mentaux du sujet envers lui-même. C'est ce que proposent les philosophes américains Richard Moran et David Finkelstein, le premier, en redéfinissant l'activité d'auto-interprétation en termes de croyance impliquant l'adhésion du sujet à ses attitudes mentales. Considérant le sujet en tant qu'agent responsable de ses attitudes, Moran défend une conception cognitive et engagée de l'interprétation, un point de vue pratique du sujet sur lui-même. La délibération fournit ainsi les raisons d'adopter une croyance, un désir, une émotion,... raisons qui justifient en même temps l'auto-interprétation. Moins attaché à la valeur cognitive de l'auto-interprétation, Finkelstein développe également une conception pratique de la connaissance de soi, fondée sur la fonction expressive des auto-attributions et où l'auto-interprétation a valeur de contexte de cela même qu'elle interprète. (shrink)

El punto de partida de este trabajo es que la idea de autoconservación es constitutiva para la comprensión y el desarrollo histórico de la subjetividad moderna. El análisis kierkegaardiano de la psicología del individuo moderno en La enfermedad mortal retoma y reelabora el tópico de la autoconservación. Anti-Climacus (el pseudónimo kierkegaardiano) sostiene que los seres humanos no están ocupados con el mantenimiento de un yo ya determinado y concluido; sino, más bien, con la constitución misma de ese yo. En su (...) exposición, él considera que la potenciación de la auto-constitución puede conducir a la autodestrucción. Este artículo procura interpretar la desesperación como autodestrucción y ofrecer, desde dicha interpretación, una comprensión consistente de sus dos modalidades principales: no querer ser sí mismo y querer ser sí mismo. Por último, el artículo considera la posibilidad de superación de la desesperación y concluye reflexionando en torno al desarrollo moderno del concepto de autoconservación. (shrink)

Feminist Auto/biography as a Means of Empowering Women: A Case Study of Sylvia Plath's The Bell Jar and Janet Frame's Faces in the Water Feminism, as a political, social and cultural movement, pays much attention to the importance of text. Text is the carrier of important thoughts, truths, ideas. It becomes a means of empowering women, a support in their fight for free expression, equality, intellectual emancipation. By "text" one should understand not only official documents, manifestos or articles. The (...) term also refers to a wide range of literary products—poetry, novels, diaries. The language of literature enables female authors to omit obstacles and constraints imposed by the phallogocentric world, a world dominated by masculine propaganda. Through writing, female authors have an opportunity to liberate their creative potential and regain the territory for unlimited expression. In order to produce a truly powerful text, they resort to a variety of writing styles and techniques. Here the notions of a situated knowledge and context sensitivity prove useful. There are three methodologies working within situated knowledge, namely, the politics of location, self-reflexivity and feminist auto/biography. All of them regard text as a fundamental tool to signify one's authority, yet feminist auto/biography, a concept widely discussed by the British theorist Liz Stanley, appears to be the most empowering mode of writing. It challenges the overused genre of auto/biography and reconstructs its role within feminist epistemologies, thus creating a favourable environment for text production. The works by Sylvia Plath and Janet Frame can be analyzed from the point of view of auto/biographical empowerment, even though their auto/biographical potential is mainly instinctive. Nevertheless, they help to comprehend the strength of the auto/biographical.The aim of this article is to "investigate" two novels by these authors, The Bell Jar by Sylvia Plath and Faces in the Water by Janet Frame, and their compatibility with Stanley's concept. The paper attempts to answer several questions. Are these novels actual feminist auto/biographies or rather fictional auto/biographies with feminist undertones? What kind of narrative strategy is used to achieve the effect of authority over the text? Last but not least, what is the function of auto/biographical narration in the case of these two novels? The article also explores the idea of writing as a means of regaining control over one's life. (shrink)

A lot of Indian research is replicative in nature. This is because originality is at a premium here and mediocrity is in great demand. But replication has its merit as well because it helps in corroboration. And that is the bedrock on which many a fancied scientific hypothesis or theory stands, or falls. However, to go from replicative to original research will involve a massive effort to restructure the Indian psyche and an all round effort from numerous quarters. The second (...) part of this paper deals with the essence of scientific temper, which need not have any basic friendship, or animosity, with religion, faith, superstition and other such entities. A true scientist follows two cardinal rules. He is never unwilling to accept the worth of evidence, howsoever damning to the most favourite of his theories. Second, and perhaps more important, for want of evidence, he withholds comment. He says neither yes nor no. Where will Science ultimately lead Man is the third part of this essay. One argument is that the conflict between Man and Science will continue till either of them is exhausted or wiped out. The other believes that it is Science which has to be harnessed for Man and not Man used for Science. And with the numerous checks and balances in place, Science will remain an effective tool for man's progress. The essential value-neutrality of Science will have to be supplemented by the values that man has upheld for centuries as fundamental, and which religious thought and moral philosophy have continuously professed. (shrink)

Derrida always stressed the importance of his engagement with Heidegger and often returned throughout his life to different aspects of Heidegger’s thought. With the recent publication of his 1964-65 course, Heidegger: The Question of Being and History greater insight is now possible into the exact terms of Derrida’s early engagement with Heidegger and the significance he would accord it in the major works of 1967 and beyond. With the reception of this text just beginning, many lines of interpretation are being (...) unfolded. However, one aspect not yet addressed in this early reception which will be crucial for approaching and orienting this work is the theme of auto-affection. The concept of auto-affection is important for assessing Derrida’s Heidegger course for two reasons. Firstly, Derrida understands auto-affection to be Heidegger’s most radical figuration of temporality in the period of Being and Time. Secondly, tracing Derrida’s early focus on auto-affection in Heidegger can provide an important context for understanding the initial development of what would become a prominent theme in Derrida’s own work. My argument in this paper is structured in three sections. In the first, I give a brief introduction to Derrida’s course. I then present the theme of auto-affection in this course and demonstrate its central importance. In conclusion, I show how Derrida’s treatment of this theme in the context of his early Heidegger engagement can be seen to look forward to his employment of auto-affection in Speech and Phenomena. (shrink)

This fascinating study in the sociology of science explores the way scientists conduct, and draw conclusions from, their experiments. The book is organized around three case studies: replication of the TEA-laser, detecting gravitational rotation, and some experiments in the paranormal. "In his superb book, Collins shows why the quest for certainty is disappointed. He shows that standards of replication are, of course, social, and that there is consequently no outside standard, no Archimedean point beyond society from which we can lever (...) the intellects of our fellows. "- -Donald M. McCloskey, Journal of Economic Psychology "Collins is one of the genuine innovators of the sociology of scientific knowledge.... Changing Order is a rich and entertaining book. "- - Isis "The book gives a vivid sense of the contingent nature of research and is generally a good read. "- -Augustine Brannigan, Nature "This provocative book is a review of [Collins's] work, and an attempt to explain how scientists fit experimental results into pictures of the world.... A promising start for new explorations of our image of science, too often presented as infallibly authoritative. "- -Jon Turney, New Scientist. (shrink)

Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in replication, repair, and recombination. Recent studies have shown that RPA binding to ssDNA is highly dynamic and that more than high‐affinity binding is needed for function. Analysis of DNA binding mutants identified forms of RPA with reduced affinity for ssDNA that are fully active, and other mutants with higher affinity that are inactive. Single molecule studies showed that (...) while RPA binds ssDNA with high affinity, the RPA complex can rapidly diffuse along ssDNA and be displaced by other proteins that act on ssDNA. Finally, dynamic DNA binding allows RPA to prevent error‐prone repair of double‐stranded breaks and promote error‐free repair. Together, these findings suggest a new paradigm where RPA acts as a first responder at sites with ssDNA, thereby actively coordinating DNA repair and DNA synthesis. (shrink)