T he term emergence is used to describe the appearance of new properties that arise when a system exceeds a certain level of size or complexity, properties that are absent from the constituents of the system. It is a concept often summed up by the phrase that “the whole is greater than the sum of its parts,” and it is a key notion in the burgeoning field of complexity science. Life is often cited as a classic example of an emergent (...) phenomenon: no atoms of my body are living, yet I am living (see, for example, Morowitz [1]). Biological organisms depend on the processes of their constituent parts, yet they nevertheless exhibit a degree of autonomy from their parts (see, for example, Kauffman [2]). How can this be? These seem to be contradictory properties. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

The notion of a physiological individuals has been developed and applied in the philosophy of biology to understand symbiosis, an understanding of which is key to theorising about the major transition in evolution from multi-organismality to multi-cellularity. The paper begins by asking what such symbiotic individuals can help to reveal about a possible transition in the evolution of cognition. Such a transition marks the movement from cooperating individual biological cognizers to a functionally integrated cognizing unit. Somewhere along the way, (...) did such cognizing units simultaneously have cognizers as parts? Expanding upon the multiscale integration view of the Free Energy Principle, this paper develops an account of reciprocal integration, demonstrating how some coupled biological cognizing systems, when certain constraints are met, can result in a cognizing unit that is in ways greater than the sum of its cognizing parts. Symbiosis between V. Fischeri bacteria and the bobtail squid is used to provide an illustration this account. A novel manner of conceptualizing biological cognizers as gradient is then suggested. Lastly it is argued that the reason why the notion of ontologically nested cognizers may be unintuitive stems from the fact that our folk-psychology notion of what a cognizer is has been deeply influenced by our folk-biological manner of understanding biological individuals as units of reproduction. (shrink)

Drift is to evolution as inertia is to Newtonian mechanics. Both are the "natural" or default states of the systems to which they apply. Both are governed by zero-force laws. The zero-force law in biology is stated here for the first time.

The Danish healthcare system must meet the need for easy and equal access to healthcare for every citizen. However, investigations have shown unfair prioritization of cancer patients and unfair prioritization of resources for expensive medicines over care. What is needed are principles for proper prioritization. This article investigates whether American ethicists Tom Beauchamp and James Childress’s principle of justice may be helpful as a conceptual framework for reflections on prioritization of expensive biological therapies in the Danish healthcare system. (...) We present an empirical study exploring the principles for prioritizing new expensive biological therapies. This study includes qualitative interviews with key Danish stakeholders experienced in antibody therapy and prioritizing resources for expensive medicines. Beauchamp and Childress’s model only covers government-funded primary and acute healthcare. Based on the interviews, this study indicates that to be helpful in a Danish context this model should include equal access for citizens to government-funded primary and acute healthcare, costly medicine, and other scarce treatments. We conclude that slightly modified, Beauchamp and Childress’s principle of justice might be useful as a conceptual framework for reflections on the prioritization of expensive biological therapies in the Danish healthcare system. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Müller's target article aims to summarize approaches to the question of how language elements (phonemes, morphemes, etc.) and rules are laid down in the brain. However, it suffers from being too vague about basic assumptions and empirical predictions of neurobiological models, and the empirical evidence available to test the models is not appropriately evaluated. (1) In a neuroscientific model of language, different cortical localizations of words can only be based on biological principles. These need to be made explicit. (...) (2) Evidence for and against word class differences could be evaluated more rigorously. (3) All (and only) humans are able to learn languages with complex syntactic structures; it is, therefore, not appropriate to deny innateness and universality of syntactic principles. The real question appears to be the following: Which neurobiological principles are the linguistic principles based on? (shrink)

The key assumption behind evolutionary epistemology is that animals are active learners or ‘knowers’. In the present study, I updated the concept of natural learning, developed by Henry Plotkin and John Odling-Smee, by expanding it from the animal-only territory to the biosphere-as-a-whole territory. In the new interpretation of natural learning the concept of biological information, guided by Peter Corning’s concept of “control information”, becomes the ‘glue’ holding the organism–environment interactions together. The control information guides biological systems, from bacteria (...) to ecosystems, in the process of natural learning executed by the universal algorithm. This algorithm, summarized by the acronym IGPT (information-gain-process-translate) incorporates natural cognitive methods including sensing/perception, memory, communication, and decision-making. Finally, the biosphere becomes the distributed network of communicative interactions between biological systems termed the interactome. The concept of interactome is based on Gregory Bateson’s natural epistemology known as the “ecology of mind”. Mimicking Bateson’s approach, the interactome may also be designated “physiology of mind”—the principle behind regulating the biosphere homeostasis. (shrink)

The French molecular biologist François Jacob outlined a theory of evolution as tinkering. From a methodological point of view, his approach can be seen as a biologic specification of the relation between laws, describing coherently the dynamics of a system, and contingent boundary conditions on this dynamics. From a semiotic perspective, tinkering is a pragmatic concept well-known from the information-theoretic anthropology of Claude Lévi-Strauss. In idealized contrast to an engineer, the tinkerer has to accept the concrete restrictions on his material (...) resources as only gradually changeable constraints on his projects. Jacobian biopragmatics examines evolution as a biologic analogue to human tinkering devoid of any projecting subjectivity. To validate this analogy, four basic principles concerning main formal aspects of evolutionary objects, agents, histories, and consistency criteria are proposed. (shrink)

Due to the variation, contingency and complexity of living systems, biology is often taken to be a science without fundamental theories, laws or general principles. I revisit this question in light of the quest for design principles in systems biology and show that different views can be reconciled if we distinguish between different types of generality. The philosophical literature has primarily focused on generality of specific models or explanations, or on the heuristic role of abstraction. This paper takes (...) a different approach in emphasizing a theory-constituting role of general principles. Design principles signify general dependency-relations between structures and functions, given a set of formally defined constraints. I contend that design principles increase our understanding of living systems by relating specific models to general types. The categorization of types is based on a delineation of the scope of biological possibilities, which serves to identify and define the generic features of classes of systems. To characterize the basis for general principles through generic abstraction and reasoning about possibility spaces, I coin the term constraint-based generality. I show that constraint-based generality is distinct from other types of generality in biology, and argue that general principles play a unifying role that does not entail theory reduction. (shrink)

The living world is an exciting and inexhaustible source of high performance solutions to the multitude of biological problems, which were attained as a result of a natural selection, during the millions and millions years evolution of life on Earth. This work presents and comments some examples of high performances of living beings, in the light of the universal principle governing the realm of living matter: Optimal Design Principle. At the same time, the transfer of these optimal solutions, from (...) living matter to the technologies, is also discussed. This transfer is offering new and fertile perspectives to future technologies, which must be more efficient, cheaper and in perfect harmony with the biosphere. (shrink)

The modern practice of biological research required the formation of a new ethics of biology, which became a synthesis of observation and experiment. The article considers the ethical aspects of modern biology from the point of view of criticism of the anthropocentric approach. A position has been put forward on the lifetime of a modern biological group as the main criterion for its place and role in the evolution of living things. The consequence of this is the need (...) to form an attitude towards biodiversity as a one-time and equal coexistence of diverse groups of representatives of wildlife. A conceptual connection is proposed between the new ethics of biology and the classical ethical construction – the "golden rule" of ethics, and the ethics of naturalistic biology, which is inextricably linked with it, coming from the ethics of science of Goethe and Meyen. The proposed ethical concept of biology includes several elements, called "principles" by the author, which together cover all aspects of the ethics of biological research. These are the principles: 1. Biological diversity as the basis of biological "equality". 2. "Watch no touch" – look, do not touch – the ethics of "virtual experiment". 3. "Ethical means accurate" – adherence to ethically "pure" approaches to an object as a condition for obtaining accurate information about a living object. (shrink)

The candid student of scientific method will recognize that biology is not entirely a physical science, while acknowledging that it owes its present state of development largely or mainly to physical conceptions and methods. It is clear that the constant features of vital organization and activity presuppose the physical constancies as basis. Nevertheless the living organism has proved in many ways refractory to a purely physical analysis. This is not merely because the higher organisms have their psychical side and that (...) psychological method differs from physical method; conceivably a properly unified science might apply equally to the physical and the psychical sides of nature. Nor is it entirely because vital behaviour is more individualized and less predictable than physical behaviour. It is rather that certain fundamental features of natural process, largely neglected by physics, are just those which are of chief importance in those flux-like entities which are living organisms. The traditional methods of physics, which analyze nature into combinations of invariant elements and processes, are ill-adapted to deal with the fluid, asymmetrical and largely indeterminate features of process as displayed so conspicuously in living organisms. This, put briefly, is the contention of L. L. Whyte, physicist and author of the recent remarkable book on the relations between physics and biology. In the present paper I propose first to consider especially those sections of the book which bear more particularly on the fundamental problems of biology; this part is paraphrase and commentary rather than summary, although never departing far from the subject of unitary principle as defined by Whyte. Later I shall consider some philosophical implications which seem important. For the details of Whyte's exposition the reader should refer to his book, which is notably clear, concise and critical in style and treatment, as well as comprehensive and fully realistic in its point of view. (shrink)

This chapter describes the origin of the principle of biological relativity and its development since 2012. It was first formulated by distinguishing between the causal properties of initial and boundary conditions, regarded as a formal cause, compared to the dynamics of the differential functions themselves, regarded as an efficient cause. The concept of organisational level, and of boundaries between levels and environmental factors are also central to the principle. Work on the properties of boundaries reveals two important features: the (...) nature of causation differs significantly between different levels of organisation, and the top-down and bottom-up forms must act simultaneously. These developments of the principle are used to clarify the reasons why bottom-up causation alone is inadequate in multi-level biology. (shrink)

The CRISPR-Cas systems of bacterial and archaeal adaptive immunity have become a household name among biologists and even the general public thanks to the unprecedented success of the new generation of genome editing tools utilizing Cas proteins. However, the fundamental biological features of CRISPR-Cas are of no lesser interest and have major impacts on our understanding of the evolution of antivirus defense, host-parasite coevolution, self versus non-self discrimination and mechanisms of adaptation. CRISPR-Cas systems present the best known case in (...) point for Lamarckian evolution, i.e. generation of heritable, adaptive genomic changes in response to encounters with external factors, in this case, foreign nucleic acids. CRISPR-Cas systems employ multiple mechanisms of self versus non-self discrimination but, as is the case with immune systems in general, are nevertheless costly because autoimmunity cannot be eliminated completely. In addition to the autoimmunity, the fitness cost of CRISPR-Cas systems appears to be determined by their inhibitory effect on horizontal gene transfer, curtailing evolutionary innovation. Hence the dynamic evolution of CRISPR-Cas loci that are frequently lost and acquired by archaea and bacteria. Another fundamental biological feature of CRISPR-Cas is its intimate connection with programmed cell death and dormancy induction in microbes. In this and, possibly, other immune systems, active immune response appears to be coupled to a different form of defense, namely, “altruistic” shutdown of cellular functions resulting in protection of neighboring cells. Finally, analysis of the evolutionary connections of Cas proteins reveals multiple contributions of mobile genetic elements to the origin of various components of CRISPR-Cas systems, furthermore, different biological systems that function by genome manipulation appear to have evolved convergently from unrelated MGE. The shared features of adaptive defense systems and MGE, namely the ability to recognize and cleave unique sites in genomes, make them ideal candidates for genome editing and engineering tools. (shrink)

This book proposes the foundation of the relational approach to biology, rejecting the deterministic and reductionist approach of molecular biology. Although biology has made enormous progress in the last seventy years, onto genesis is still conceived as a “revelation” of information (DNA). Recovering the geometric tradition, relational biology conceives scientific and epistemological tools (cause, probability, space etc.) of science in a new way. If probabilistic biology and organicism still proposes a biology based on physics, with a fundamental invariant, relational biology (...) is based on variation: its fundamental invariant is variation, one of the most important elements of life. This is an indispensable book for academics who consider biology from a new theoretical approach, in particular for those working in the domains of cancer, ontogenesis and evolution. (shrink)

In recent years two groups of taxonomists have attempted to influence the general goals and methods of biological classification. The first group, which emerged in the late 1950’s, has been called variously neo-Adansonian, numerical, computer and phenetic taxonomy. The founders of this school, Robert R. Sokal and P.H.A. Sneath, termed their unified approach to systematics “neo-Adansonian” because of the affinities which they saw between their views and those of the 18th century botanist, Michel Adanson (1727-1806). Today little mention is (...) made of Adanson. His ideas turned out not to be as prescient as Sokal and Sneath had at first thought. Besides, he had served his purpose as a patron saint ([79], p. 23). Sokal and Sneath also termed their approach “numerical” because they believed that taxonomists should make greater use of available mathematical techniques. Not only should taxonomic characters be coded quantitatively but also estimates of affinity should be made on the basis of explicitly stated clustering procedures. (shrink)

This volume draws together Allan Gotthelf's pioneering work on Aristotle's biology. He examines Aristotle's natural teleology, the axiomatic structure of biological explanation, and the reliance on scientifically organized data in the three great works with which Aristotle laid the foundations of biological science.

The term “synthetic biology” is a popular label of an emerging biotechnological field with strong claims to robustness, modularity, and controlled construction, finally enabling the creation of new organisms. Although the research community is heterogeneous, it advocates a common denominator that seems to define this field: the principles of rational engineering. However, it still remains unclear to what extent rational engineering—rather than “tinkering” or the usage of random based or non-rational processes—actually constitutes the basis for the techniques of synthetic (...) biology. In this article, we present the results of a quantitative bibliometric analysis of the realized extent of rational engineering in synthetic biology. In our analysis, we examine three issues: (1) We evaluate whether work at three levels of synthetic biology (parts, devices, and systems) is consistent with the principles of rational engineering. (2) We estimate the extent of rational engineering in synthetic biology laboratory practice by an evaluation of publications in synthetic biology. (3) We examine the methodological specialization in rational engineering of authors in synthetic biology. Our analysis demonstrates that rational engineering is prevalent in about half of the articles related to synthetic biology. Interestingly, in recent years the relative number of respective publications has decreased. Despite its prominent role among the claims of synthetic biology, rational engineering has not yet entirely replaced biotechnological methods based on “tinkering” and non-rational principles. (shrink)

Unlike inert objects, organisms and their cells have the ability to initiate activity by themselves and thus change their properties or states even in the absence of an external cause. This crucial difference led us to search for principles suitable for the study organisms. We propose that cells follow the default state of proliferation with variation and motility, a principle of biological inertia. This means that in the presence of sufficient nutrients, cells will express their default state. We (...) also propose a principle of variation that addresses two central features of organisms, variation and historicity. To address interdependence between parts, we use a third principle, the principle of organization, more specifically, the notion of the closure of constraints. Within this theoretical framework, constraints are specific theoretical entities defined by their relative stability with respect to the processes they constrain. Constraints are mutually dependent in an organized system and act on the default state.Here we discuss the application and articulation of these principles for mathematical modeling of morphogenesis in a specific case, that of mammary ductal morphogenesis, with an emphasis on the default state. Our model has both a biological component, the cells, and a physical component, the matrix that contains collagen fibers. Cells are agents that move and proliferate unless constrained; they exert mechanical forces that act (i) on collagen fibers and (ii) on other cells. As fibers are organized, they constrain the cells’ ability to move and to proliferate. This model exhibits a circularity that can be interpreted in terms of the closure of constraints. Implementing our mathematical model shows that constraints to the default state are sufficient to explain the formation of mammary epithelial structures. Finally, the success of this modeling effort suggests a stepwise approach whereby additional constraints imposed by the tissue and the organism can be examined in silico and rigorously tested by in vitro and in vivo experiments, in accordance with the organicist perspective we embrace. (shrink)

Es wird der Nachweis versucht, dass es — ebenso wie in der Physik — auch in der Biologie komplementäre Erkenntnissysteme gibt. Wie Welle und Korpuskel in der Physik, so sind innerhalb der Biologie u.a. Form und Funktion, Innenwelt und Umwelt sowie auch vor allem Vererbung und Anpassung komplementäre Begriffsgefüge. Das wird im einzelnen diskutiert und nachgewiesen.Für die Erkenntnis der Wirklichkeit im Ganzen folgt daraus, dass systematisch aufgebaute Erkenntnisgefüge nur in Teilbereichen des Wirklichen möglich sind — nur in der klassischen Mechanik, (...) der Elektrodynamik, der vergleichenden Anatomie, der Genetik usw. — Das Wirkliche in seiner Gesamthet hingegen besitzt keine systematische sondern nur eine historisch-dialektische Struktur. Metaphysisch bedeutet das, dass das Wesen der Wirklichkeit in schöpferischer Freiheit im Sinne etwaGoethes, aber nicht in sturer Notwendigkeit besteht.Se demuestra que — como en laFisica — tambien en la Biologia existen complementarios sistemas de conocimiento. Como onda y corpúsculo dentro de la Fisica, asi son dentro de la Biologia entre otros forma y función, mundo internoy ambientey en primer lugar también herencia y adaptación principios complementarios. Esto será discutido y demonstrado en sus particularidades.Para el conocimiento de la realidad como totalidad sigue de tales consideraciones la conclusión que conocimientos sistematicamente construidos son posibles solo en esferas particulares de la realidad — como p.e. en la mecánica racional, en la electrodinámica, en la anatomia comparada, en la genética etc. —. Lo real en su totalidad posee al contrario ninguna estructura sistemática sino solo un históricadialectica. Metafisicamente hablado significa esto que la esencia de la realidad consiste en una libertad creativa en el sentido deGoethe, pero de ninguna manera en una necesidad absoluta en el sentido deSpinoza. (shrink)

According to the free energy principle, life is an “inevitable and emergent property of any random dynamical system at non-equilibrium steady state that possesses a Markov blanket” :20130475, 2013). Formulating a principle for the life sciences in terms of concepts from statistical physics, such as random dynamical system, non-equilibrium steady state and ergodicity, places substantial constraints on the theoretical and empirical study of biological systems. Thus far, however, the physics foundations of the free energy principle have received hardly any (...) attention. Here, we start to fill this gap and analyse some of the challenges raised by applications of statistical physics for modelling biological targets. Based on our analysis, we conclude that model-building grounded in the free energy principle exacerbates a trade-off between generality and realism, because of a fundamental mismatch between its physics assumptions and the properties of actual biological targets. (shrink)

With the emergence of systems biology the notion of organizing principles is being highlighted as a key research aim. Researchers attempt to ‘reverse engineer’ the functional organization of biological systems using methodologies from mathematics, engineering and computer science while taking advantage of data produced by new experimental techniques. While systems biology is a relatively new approach, the quest for general principles of biological organization dates back to systems theoretic approaches in early and mid-20th century. The aim (...) of this paper is to draw on this historical background in order to increase the understanding of the motivation behind the systems theoretic approach and to clarify different epistemic aims within systems biology. We pinpoint key aspects of earlier approaches that also underlie the current practice. These are i) the focus on relational and system-level properties, ii) the inherent critique of reductionism and fragmentation of knowledge resulting from overspecialization, and iii) the insight that the ideal of formulating abstract organizing principles is complementary to, rather than conflicting with, the aim of formulating detailed explanations of biological mechanisms. We argue that looking back not only helps us understand the current practice but also points to possible future directions for systems biology. (shrink)

The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that aims to combine the knowledge (...) and methods of biology, engineering, and related disciplines in the design of chemically synthesized DNA to create organisms with novel or enhanced .. (shrink)

The free-energy principle states that all systems that minimize their free energy resist a tendency to physical disintegration. Originally proposed to account for perception, learning, and action, the free-energy principle has been applied to the evolution, development, morphology, anatomy and function of the brain, and has been called a postulate, an unfalsifiable principle, a natural law, and an imperative. While it might afford a theoretical foundation for understanding the relationship between environment, life, and mind, its epistemic status is unclear. Also (...) unclear is how the free-energy principle relates to prominent theoretical approaches to life science phenomena, such as organicism and mechanism. This paper clarifies both issues, and identifies limits and prospects for the free-energy principle as a first principle in the life sciences. (shrink)

Autoinhibition is a design principle realized in many molecular mechanisms in biology. After explicating the notion of a design principle and showing that autoinhibition is such a principle, we focus on how researchers discovered instances of autoinhibition, using research establishing the autoinhibition of the molecular motors kinesin and dynein as our case study. Research on kinesin and dynein began in the fashion described in accounts of mechanistic explanation but, once the mechanisms had been discovered, researchers discovered that they exhibited a (...) second phenomenon, autoinhibition. The discovery of autoinhibition not only reverses the pattern in terms of which philosophers have understood mechanism discovery but runs counter to the one phenomenon-one mechanism principle assumed to relate mechanisms and the phenomena they explain. The ubiquity of autoinhibition as a design principle, therefore, necessitates a philosophical understanding of mechanisms that recognizes how they can participate in more than one phenomenon. Since mechanisms with this design are released from autoinhibition only when they are acted on by control mechanisms, we advance a revised account of mechanisms that accommodates attribution of multiple phenomena to the same mechanism and distinguishes them from other processes that control them. (shrink)

The prohibition of commercialisation of the human body and its parts is not applied consistently and suffers from many exceptions in the human biological material (HBM) market. Examples include the possibility of patenting certain HBM-derived products and their commercial marketing or payments for blood donations. Thus, the current practice of marketing HBM-derived products makes the altruistic donor most vulnerable to exploitation while being deprived of benefits. There seem to be two ways to improve this state of affairs. The first (...) is to apply consistently the prohibition of commercialisation of the body and its parts to commercially marketed tissue and cell products as well. This would require limiting the possibility of financial gain associated with the processing, distribution and sale of HBM-based products. Such a solution, however, does not seem to gain wide acceptance or have a chance of implementation in the near future. Therefore, introducing more transparent rules and greater donor empowerment seems more reasonable by exempting HBM from the ban on commercialisation under certain conditions and with clear limitations. (shrink)

This article discusses the problem of the influence of the Leibniz' continuity principle on the concept of structural plan and homology formation in biology. The concept of body plan was established for the justification of the thesis about the structural sameness of the all living objects at the organismal level. However, the continuity hypothes is testing which was made on the comparative anatomical material has showed the impossibility of reducing the animals structure explanation to the single plan. The idea of (...) organic evolution has made it possible to present the continuity of the organic world as a historical consistency. From an evolutionary point of view homology was interpreted as a homogeny. That made it possible to consider the continuity of the organic world on the suborganismal level. This hypothesis was tested on the embryological material. The results, however, showed that the morphological structures, which seemed to be identical according to the first criterion of the Remane homology and occurred epigenetically, are not really gomogenic. This fact does not allow us to recognize the continuity ofthe organic world on the suborganismal level. The key concepts of classical biological disciplines (comparative anatomy, systematics, evolutionism) could be reconciled only on the basis ofthe discrete principle. (shrink)

The evolutionary origin of consciousness has been a growing area of study in recent years. Nevertheless, there is intense debate on whether the existence of phenomenal consciousness without the cerebral cortex is possible. The corticocentrists have an empirical advantage because we are quasi-confident that we humans are conscious and have the well-developed cortex as the site of our consciousness. However, their prejudice can be an anthropic bias similar to the anthropocentric prejudice in pre-Darwinian natural history. In this paper, I propose (...) three basic principles to provide a conceptual basis for evolutionary studies of consciousness: the non-solipsistic principle, the evolution principle, and the anthropic principle. These principles collectively help us to avoid solipsism, anthropocentrism, and anthropomorphism to some degree, although we cannot be completely free from them. Also, the landscape metaphor associated with the anthropic principle provides an image of how different forms of consciousness can be acquired. (shrink)

In this article I analyze a regular pattern in the developmental and evolutionary processes, formed by a gradual shortening of developmental stages. This shortening is the expected result of a selection process, in the biological as well as in the cultural evolutionary process. Biology and culture are in this way unified by a common mechanism. A mathematical analysis further indicates a vital condition for a continued progress of human culture, especially for a continued progressive scientific evolution, implying continued shortening (...) of mental developmental stages by means of enhanced education. (shrink)