BET proteins such as Brd3 and Brd4 are chromatin‐associated factors, which control gene expression programs that promote inflammation and cancer. The Nrf2 transcription factor is a master regulator of genes that protect the organism against xenobiotic attack and oxidative stress. Nrf2 has demonstrated anti‐inflammatory activity and can support cancer cell malignancy. This review describes the discovery, mechanism and biomedical implications of the regulatory interplay between Nrf2 and BET proteins. Both Nrf2 and BET proteins are established drug targets. Small molecules that (...) either activate or suppress these proteins are currently tested in clinical trials. The crosstalk between Nrf2 and BET proteins may have important, and until now overlooked, implications for the therapeutic effects of these drugs. Based on the information covered in this review, it should be possible to design combinatorial treatment strategies for cancer and inflammatory diseases, which may improve the efficacy of targeting a Nrf2 or BET proteins individually. (shrink)

Servant leadership has been theorized as a model where the moral virtue of humility co-exists with action-driven behavior. This article provides an empirical study that tests how these two apparently paradoxical aspects of servant leadership interact in generating follower engagement, while considering the hierarchical power of the leader as a contingency variable. Through a three-way moderation model, a study was conducted based on a sample of 232 people working in a diverse range of companies. The first finding is that humble (...) leaders showed the highest impact on follower engagement regardless of their hierarchical position. Less humble leaders in lower hierarchical positions seem to be able to compensate for that through a strong action-oriented leadership style. Most notably for leaders in high hierarchical positions, the moral virtue of humility seems to strengthen the impact of their action-oriented leadership the most. These findings provide empirical support and a better understanding of the interplay between the moral virtue of humility and the action-oriented behaviors of servant leadership. (shrink)

v. 1. International perspectives on business ethics -- v. 2. New theoretical directions -- v. 3. Behavioral business ethics -- v. 4. Managing business ethics.

_Origins of Chinese Political Philosophy_. explores the composition, language, thought, and early history of the _Shangshu_ (Classic of Documents), showing its texts as dynamic cultural products that expressed and shaped the political and intellectual discourses of different times and communities.

John R. Searle is one of the world's leading philosophers. During his long and outstanding career, he has made groundbreaking and lasting contributions to the philosophy of language, to the philosophy of mind, as well as to the nature, structure, and functioning of social reality. This volume documents the 13th Münster Lectures on Philosophy with John R. Searle. It includes not only 11 critical papers on Searle's philosophy and Searle's replies to the papers, but also an original article by John (...) R. Searle on his overall philosophical enterprise entitled "The Basic Reality and the Human Reality". -/- "I think Münster is probably unique among contemporary universities in its ability to produce such a high level of philosophical production from their philosophy students." - John R. Searle. (shrink)

_Origins of Chinese Political Philosophy_. explores the composition, language, thought, and early history of the _Shangshu_ (Classic of Documents), showing its texts as dynamic cultural products that expressed and shaped the political and intellectual discourses of different times and communities.

The related fields of fractal image encoding and fractal image analysis have blossomed in recent years. This book, originating from a NATO Advanced Study Institute held in 1995, presents work by leading researchers. It is developing the subjects at an introductory level, but it also has some recent and exciting results in both fields. The book contains a thorough discussion of fractal image compression and decompression, including both continuous and discrete formulations, vector space and hierarchical methods, and algorithmic optimizations. The (...) book also discusses multifractal approaches to image analysis, segmentation, and recognition, including medical applications. (shrink)

Name der Zeitschrift: Cognitive Linguistics Jahrgang: 26 Heft: 2 Seiten: 289-330.

In this comprehensive interview with Charles Taylor, the focus is put on the conceptual level. Taylor reflects on the relationship between history, narrativity and social critique, between social imaginaries and social change, and between his own thought and that of Cambridge School history of ideas, Nietzschean genealogy, Frankfurt School critical theory, and agonistic approaches to the political. This interview not only captures the tremendous breadth and range of Taylor’s theoretical interests, it also vindicates his contention that the common thread of (...) his oeuvre is the attempt to work out a non-reductive, non-mechanistic, non-atomistic philosophical anthropology. Still, it offers new insights into Taylor's most recent thinking and his intellectual engagement with the challenges of our time. (shrink)

The debate in the Federal Republic of Germany on the estimation of the social compatibility of the consequences of technology as a criterion for the evaluation of technical systems has been going on since the mid seventies. The approach presented discusses the normative structurally transcending perspective of the viability and developmental capacity of society. The question of desirable social development as opposed to the technically possible is raised. A criteria system for evaluating social compatibility of new information and communication technologies (...) including AI is focused on and may serve as a consensus building forum for public technology policy discussion. (shrink)

The extensive, profound and influential oeuvre of Charles Taylor has inspired generations of thinkers. But how can we explore such a body of work? As we try to show in this Special Issue: by understanding him literally and making use of his notion of moral maps – or, differently put, by ‘mapping’ Charles Taylor. As he is far too modest a person to reveal to us his own moral atlas, we have decided to seize the occasion of his 85th birthday (...) to ask several of his renowned colleagues, students and interlocutors to contribute to the reconstruction of such a map. This introduction develops three ‘mountain ridges’ in this cartography – a philosophical anthropology in spatial terms, the indispensable motif of dialogue, and the role of political life –, around which the following 24 illuminating appraisals are grouped. (shrink)

Our epistemic access to mathematical objects, like numbers, is mediated through our external representations of them, like numerals. Nevertheless, the role of formal notations and, in particular, of the internal structure of these notations has not received much attention in philosophy of mathematics and cognitive science. While systems of number words and of numerals are often treated alike, I argue that they have crucial structural differences, and that one has to understand how the external representation works in order to form (...) an advanced conception of numbers. The relation between external representations and mathematical cognition will be discussed by drawing on experimental results from cognitive science and mathematics education, and I argue for the constitutive role of external representations for the development of an advanced conception of numbers. (shrink)

In Chapter 8 of The Language Animal, Charles Taylor claims that narratives are unsubstitutable for an appropriate understanding of social life and ‘human affairs’ in general. In order to identify open questions in his argumentation as well as unwanted consequences of his outlook, I proceed in three consecutive steps. I first problematize Taylor’s distinction between laws and stories, then go on to address his intentional blurring of stories and histories, and finally suggest that the concept of genealogy might be a (...) promising candidate for describing Taylor’s approach, concluding that he implicitly forms the equation: narrative equals history equals critique. (shrink)

This paper, based on our forthcoming book (Crane, Matten, & Moon, 2007), examines the effects of globalization on reconfiguring notions of citizenship and the role of corporations in influencing, and being influenced by, this process. Based on an analysis of the literature on global citizenship, we explore the current and potential role for corporations in contributing to global governance systems and processes, both independent of, and in conjunction with, governmental and non-governmental organizations.

Drawing on letters, orations and disputations, this book argues that during the seventeenth century, the Amsterdam Athenaeum, despite the revolutionary debates of the time, and despite the intellectual liberalism characteristic of Amsterdam, remained traditional in its teaching.

Jonathan Wolff is Professor of Philosophy at University College London. He is the author of Robert Nozick (1991), An Introduction to Political Philosophy (1996) and Why Read Marx Today (2002). He is currently working on a number of topics at the intersection of political philosophy and public policy.

There has recently been a wave of attempts to make sense of the role of de se thoughts in linguistic communication. A majority of the attempts assume a Perryan or a Lewisian view of de se thought. Views with these assumptions, I suggest, come in four varieties: uncentering (Egan 2007, Kölbel 2013, Moss 2012), recentering (Heim 2004, Weber 2012), multicentering (Kindermann 2014, Ninan 2010, Torre 2009), and no centering (Kaplan 1989, Perry 1979). I argue first that all four varieties of (...) centering are committed to what I call a shifting operation on the hearer's part. I argue second that, against common assumption, there is no real choice to make between the views. By showing that attempts to establish an advantage for some view over the others fail across the board, I make the case for neutralism regarding the varieties of centering – the claim that coverage of the empirical data is exactly the same for each view, and that the views are broadly equal in simplicity and elegance. (shrink)

The importance of digital technologies for social and economic developments and a growing focus on data collection and privacy concerns have made the Internet a salient and visible issue in global politics. Recent developments have increased the awareness that the current approach of governments and business to the governance of the Internet and the adjacent technological spaces raises a host of ethical issues. The significance and challenges of the digital age have been further accentuated by a string of highly exposed (...) cases of surveillance and a growing concern about issues of privacy and the power of this new industry. This special issue explores what some have referred to as the “Internet-industrial complex”—the intersections between business, states, and other actors in the shaping, development, and governance of the Internet. (shrink)

Die primäre Aufgabe des Artikels ist es, die Eckpfeiler einer methodisch-kulturalistischen Handlungstheorie einzuschlagen. Zunächst soll die kategoriale Unterscheidung von Handeln und Verhalten und die Notwendigkeit einer philosophischen Handlungstheorie motiviert werden. Darüber hinaus liefert der Aufsatz die terminologischen Grundlagen einer entsprechenden Handlungstheorie und es wird aufgezeigt, wie diese in eine Theorie des Sprechhandelns und eine Theorie der Handlungsdeutung erweitert werden kann.

In "Plato's Ghost" Jeremy Gray presented many connections between mathematical practices in the nineteenth century and the rise of mathematical platonism in the context of more general developments, which he refers to as modernism. In this paper, I take up this theme and present a condensed discussion of some arguments put forward in favor of and against the view of mathematical platonism. In particular, I highlight some pressures that arose in the work of Frege, Cantor, and Gödel, which support adopting (...) a platonist position. The aim of this discussion is to provide an historically informed introduction to the philosophical position of mathematical platonism and to point at some of its mathematical and philosophical roots in the nineteenth century. (shrink)

Scheitern wie Gelingen sind ambivalente und zugleich existentielle Erfahrungen des Menschen. Die Sehnsucht, das eigene Leben als gelingend zu erfahren, ist dabei Ausdruck des menschlichen Strebens nach Glück. Das Wagnis einer unwiderruflichen Lebensentscheidung ist dabei der verbindlichste Ausdruck individueller Sinnstiftung für ein gelingendes Leben. Zur Frage, welche Gründe dem Gelingen oder Scheitern eines biografischen Lebensprojektes zugrunde liegen, hat Klaus Demmer wesentliche Überlegungen angestellt, denen in dieser Arbeit nachgegangen wird. Zentral ist dabei die Verhältnisbestimmung von sittlicher Persönlichkeit und Identität. Indem das (...) vorgelegte Konzept aus philosophischer, soziologischer und psychologischer Perspektive befragt wird, zeigt der Autor die Anschlussfähigkeit der moraltheologischen Erwägungen für den gegenwärtigen Diskurs um denBegriff der Identität auf. (shrink)