Advances in genetic and genomic research have introduced challenges in obtaining informed consent for research in low and middle-income settings. However, there are only few studies that have explored challenges in obtaining informed consent in genetic and genomic research in Africa and none in South Africa. To start filling this gap, we conducted an empirical study to investigate the efficacy of informed consent procedures for an H3Africa genomic study on Rheumatic Heart Disease at the University of Cape Town in South (...) Africa. The main aim of the study was to understand ethical challenges in obtaining informed consent in the RHDGen study. We used a qualitative study methodology involving in-depth interviews and participant observations. Our study participants were RHDGen cases, healthy controls and research staff involved in the recruitment of RHDGen cases and controls. In total, we conducted 32 in-depth interviews with RHDGen cases and controls, 2 in-depth interviews with research staff and 57 direct observations of the consent procedures of RHDGen cases and controls. The interviews were conducted in English, audio-recorded and transcribed verbatim. Data were analyzed using thematic content analysis. The study was conducted in 3 sites within Cape Town, South Africa. Most healthy controls joined the RHDGen study in order to be screened for rheumatic heart disease. A majority of RHDGen cases decided to join the RHDGen study because of therapeutic misconception. The ethical challenges that impacted on obtaining informed consent in the RHDGen study were complex. In this study, the main challenges were diagnostic misconception among RHDGen controls and therapeutic misconception among RHDGen cases. (shrink)

The debate on the European Union's democratic deficit usually operates within a national-democratic framework of analysis. This article argues for a change in methodology. It follows the thesis that the EU is a ‘demoicracy’– a polity of multiple demoi– and has to be evaluated as such. Core principles of demoicracy are developed and the EU is assessed accordingly. Such an evaluation is not only more adequate, but also provides original insights: it is found that, whereas the constitutional development of the (...) EU has approached demoicratic standards in general, major deficits remain at the national level. (shrink)

Engelhardt is correct in thinking that potentiality implies continuity. The central purpose of the Aristotelian notion of potency is to explain continuity, both in becoming and in generation-corruption. If one denies continuity in change, he will have little use for potentiality, at least little use for the Aristotelian types. And there are types that should not be conflated: one to account for continuity in becoming and generation, another to account for continuity of a being going from not acting to acting. (...) The first type, where something happens to a being, is called passive potency; the second type, where a being itself actively does something, is predictably called active potency. (shrink)

Les nouveaux et nombreux défis de la constellation " postnationale " rendent plus actuelle que jamais une ancienne idée philosophique : le cosmopolitisme. Dans ses variantes modernes, celui-ci pose l'autonomie de l'individu humain comme norme fondamentale de toute construction politique. Le cosmopolitisme représente donc une alternative aussi bien au nationalisme qu'à la théorie normative d'un monde multipolaire de confrontations entre empires. L'ouvrage montre que le cosmopolitisme peut être considéré comme une conséquence des principes de la philosophie politique moderne. Définissant les (...) bases normatives de l'Etat-nation démocratique, elle comprend ce dernier comme une réalisation temporaire des principes cosmopolitiques et la nation comme une entité politique qui doit, graduellement, être intégrée dans une construction intergouvernementale et cosmopolitique. L'étude s'achève sur un aperçu du cosmopolitisme dans la philosophie politique actuelle. L'auteur propose un cosmopolitisme processuel qui défende une intégration graduelle, progressive et pragmatique vers la sécularisation du droit et de l'autonomie de l'individu par l'interconnexion d'institutions nationales, intergouvernementales et supranationales. La cité des peuples n'est donc pas l'anticipation normative d'un Etat mondial, mais la volonté d'un processus d'intégration différenciée entre les peuples démocratiquement constitués. (shrink)

This article argues that obligatory, simultaneous, and simple Treaty ratification by referenda is the next step in the consolidation of the political core of European citizenship. In the first part, general remarks about the special nature of EU citizenship highlight the relevance of referenda on EU Treaties for EU citizenship. In the second part, the normative and empirical case in favour of direct democracy is put forward. It is followed by the assessment of direct democracy in European integration as we (...) have known it so far. The practice is irreversible and gaining in momentum. But it is in need of substantial reform due to procedural dysfunctions and discriminatory consequences for the citizens. Section V relates this result to a legal analysis of EU citizenship. The suppression of the discriminatory consequences of the Treaty ratification procedure is necessary from a legal point of view, but it cannot be expected from the 'judicial incrementalism' that has characterised the development of EU citizenship regarding free movement and residence. In section VI, the conclusions of the previous sections are drawn into the final proposal of obligatory, simultaneous and simple Treaty reform by referenda in all Member States. At the end, five counter-arguments to the proposal are discussed. (shrink)

Der Artikel erläutert mit dem kosmopolitischen Republikanismus einen Aspekt, der in der nationalstaatlich fixierten und meist euroskeptischen Republikanismus-Forschung vernachlässigt worden ist, aber in der frühen Phase der Französischen Revolution eine wichtige Rolle spielte. In der Perspektive des hier vorliegenden Artikels erscheint der revolutionäre Republikanismus zumindest in seinen Anfängen nicht als Inbegriff nationalstaatlich gehegter Demokratie und Autonomie, sondern als kosmopolitische oder zumindest Europa einigende Idee. Das Beispiel von Cloots zeigt, dass der Republikanismus in jener Zeit des Umbruchs und am historischen Ursprung (...) der modernen europäischen Demokratie nicht partikularstaatlich, sondern kosmopolitisch konnotiert war. Heutige Versuche, den Republikanismus kosmopolitisch zu transformieren, wie sie von R. Bellamy und D. Castiglione unternommen werden, können in die Tradition des kosmopolitischen Republikanismus gestellt werden. Der Artikel würdigt sechs systematisch bedeutende Merkmale von Cloots’ Theorie und stellt diese in Beziehung zum kantischen Kosmopolitismus, der sich hauptsächlich durch seinen prozessualen, historisch-hermeneutisch reflektierten Charakter von Cloots’ kosmopolitischem Republikanismus unterscheidet. (shrink)

Globalization stands for systemic integration, mainly economical and technological. It is related to the expansion of the free market economy, trade, and the global integration of systems of communication and information technology. As such, globalization co-exists with strong cultural affirmations of individual and collective difference and with political fragmentation. Cosmopolitanism needs to take into consideration cultural and political conditions of human existence. The cosmopolitan imperative to form a political community beyond the nation state is a process-guiding principle or regulative ideal, (...) not an institutional blueprint. Cosmopolitanism needs to stress the voluntary character of integration among self-governed peoples who are willing to enhance the transnational rights and freedoms of their citizens while accepting institutional constraints. (shrink)

Este artigo examina três figuras típicas do discípulo na filosofia antiga: o socrático (“filho ciumento”), o epicurista (“doente curado, mas psitacista”) e o aristotélico (“hermeneuta insatisfeito”).

This paper explores the development of the chemical table as a tool designed for chemical information visualization. It uses a historical context to investigate the purpose of chemical tables and charts, analyzing them from the perspective of theory of tables, cartography, and design. It suggests reasons why the two-dimensional periodic table remains the de facto standard for chemical information display.

This book offers clinicians a long-awaited comprehensive paradigm for assessing object relations functioning in disturbed younger and older adolescents. It gives a clear sense of how object relations functioning is manifest in different disorders, and illuminates how scores on object relations measures are converted into a therapeutically relevant diagnostic matrix and formulation. Outlining the process of object relations assessment, Kelly presents vividly detailed cases of a range of disorders including anorexia nervosa, borderline states, depressive disorders, and trauma. The cases portray (...) the vicissitudes of object relations functioning and disruption that result in a unique structural developmental composite for a given adolescent. A major concern is demonstrating the utility and validity of two object representation measures--The Mutuality of Autonomy Scale and The Social Cognition Object Relations Scale --that are the main ones employed in the assessment of adolescents. MOA and SCORS scores facilitate a multidimensional understanding of the nuances of an adolescent's object relations functioning, and provide clinicians with organized, theory-based data leading to clear, specific treatment directions and guidelines and appropriate therapeutic programming. The book addresses the following questions: * Is individual psychotherapy indicated--will this adolescent benefit from an insight-oriented approach? * What are the likely directions that transference parameters will take in the treatment? * What types of countertransference reactions are likely to be anticipated in a given patient? * Is medication likely to be helpful in making this adolescent more accessible for treatment? Focusing only on adolescents, covering both the TAT and the Rorschach, and utilizing object relations theory as its major interpretive foundation, the book offers practitioners an alternative to general references based on a more actuarial, nomothetic, and atheoretical interpretive approach. It reflects one school of contemporary thought in projective assessment--one that advocates a more phenomenological, theory-based approach to test application and interpretation. (shrink)

This book offers clinicians a long-awaited comprehensive paradigm for assessing object relations functioning in disturbed younger and older adolescents. It gives a clear sense of how object relations functioning is manifest in different disorders, and illuminates how scores on object relations measures are converted into a therapeutically relevant diagnostic matrix and formulation. Outlining the process of object relations assessment, Kelly presents vividly detailed cases of a range of disorders including anorexia nervosa, borderline states, depressive disorders, and trauma. The cases portray (...) the vicissitudes of object relations functioning and disruption that result in a unique structural developmental composite for a given adolescent. A major concern is demonstrating the utility and validity of two object representation measures--The Mutuality of Autonomy Scale and The Social Cognition Object Relations Scale --that are the main ones employed in the assessment of adolescents. MOA and SCORS scores facilitate a multidimensional understanding of the nuances of an adolescent's object relations functioning, and provide clinicians with organized, theory-based data leading to clear, specific treatment directions and guidelines and appropriate therapeutic programming. The book addresses the following questions: * Is individual psychotherapy indicated--will this adolescent benefit from an insight-oriented approach? * What are the likely directions that transference parameters will take in the treatment? * What types of countertransference reactions are likely to be anticipated in a given patient? * Is medication likely to be helpful in making this adolescent more accessible for treatment? Focusing only on adolescents, covering both the TAT and the Rorschach, and utilizing object relations theory as its major interpretive foundation, the book offers practitioners an alternative to general references based on a more actuarial, nomothetic, and atheoretical interpretive approach. It reflects one school of contemporary thought in projective assessment--one that advocates a more phenomenological, theory-based approach to test application and interpretation. (shrink)

The God who is there -- Escape from reason -- He is there and He is not silent -- Back to freedom and dignity.