This paper explores the ethics of introducing genome-editing technologies as a new reproductive option. In particular, it focuses on whether genome editing can be considered a morally valuable alternative to preimplantation genetic diagnosis. Two arguments against the use of genome editing in reproduction are analysed, namely safety concerns and germline modification. These arguments are then contrasted with arguments in favour of genome editing, in particular with the argument of the child’s welfare and the argument of parental reproductive autonomy. In addition (...) to these two arguments, genome editing could be considered as a worthy alternative to PGD as it may not be subjected to some of the moral critiques moved against this technology. Even if these arguments offer sound reasons in favour of introducing genome editing as a new reproductive option, I conclude that these benefits should be balanced against other considerations. More specifically, I maintain that concerns regarding the equality of access to assisted reproduction and the allocation of scarce resources should be addressed prior to the adoption of genome editing as a new reproductive option. (shrink)

BackgroundThis article explores the reasons in favour of revising and extending the current 14-day statutory limit to maintaining human embryos in culture. This limit is enshrined in law in over a dozen countries, including the United Kingdom. In two recently published studies, scientists have shown that embryos can be sustained in vitro for about 13 days after fertilisation. Positive reactions to these results have gone hand in hand with calls for revising the 14-day rule, which only allows embryo research until (...) the 14th day after fertilisation.Main textThe article explores the most prominent arguments in favour of and against the extension of the 14-day limit for conducting research on human embryos. It situates these arguments within the history of the 14-day limit. I start by discussing the history of the 14-day limit in the United Kingdom and the reasons behind the decision to opt for a compromise between competing moral views. I then analyse the arguments that those who are generally in favour of embryo research put forward in support of extending the 14-day rule, namely the argument of the beneficence of research and the argument of technical feasibility. I then show how these two arguments played a role in the recent approval of two novel techniques for the replacement of faulty mitochondrial DNA in the United Kingdom. Despite the popularity and widespread use of these arguments, I argue that they are ultimately problematic and should not be straightforwardly accepted. I end by making a case for respecting value pluralism in the context of embryo research, and I present two reasons in favour of respecting value pluralism: the argument of public trust and the argument of democracy.ConclusionI argue that 14-day limit for embryo research is not a valuable tool despite being a solution of compromise, but rather because of it. The importance of respecting value pluralism needs to be considered in any evaluation concerning a potential change to the 14-day rule. (shrink)

Frauds and misconduct have been common in the history of science. Recent events connected to the COVID-19 pandemic have highlighted how the risks and consequences of this are no longer acceptable. Two papers, addressing the treatment of COVID-19, have been published in two of the most prestigious medical journals; the authors declared to have analysed electronic health records from a private corporation, which apparently collected data of tens of thousands of patients, coming from hundreds of hospitals. Both papers have been (...) retracted a few weeks later. When such events happen, the confidence of the population in scientific research is likely to be weakened. This paper highlights how the current system endangers the reliability of scientific research, and the very foundations of the trust system on which modern healthcare is based. Having shed light on the dangers of a system without appropriate monitoring, the proposed analysis suggests to strengthen the existing journal policies and improve the research process using new technologies supporting control activities by public authorities. Among these solutions, we mention the promising aspects of the blockchain technology which seems a promising solution to avoid the repetition of the mistakes linked to the recent and past history of research. (shrink)

The benefits of full ectogenesis, that is, the gestation of human fetuses outside the maternal womb, for women ground many contemporary authors’ arguments on the ethical desirability of this practice. In this paper, I present and assess two sets of arguments advanced in favour of ectogenesis: arguments stressing ectogenesis’ equality-promoting potential and arguments stressing its freedom-promoting potential. I argue that although successfully grounding a positive case for ectogenesis, these arguments have limitations in terms of their reach and scope. Concerning their (...) limited reach, I contend that ectogenesis will likely benefit a small subset of women and, arguably, not the group who most need to achieve equality and freedom. Concerning their limited scope, I contend that these defences do not pay sufficient attention to the context in which ectogenesis would be developed and that, as a result, they risk leaving the status quo unchanged. After providing examples of these limitations, I move to my proposal concerning the role of ectogenesis in promoting women’s equality and freedom. This proposal builds on Silvia Federici’s, Mariarosa Dalla Costa’s and Selma James’ readings of the international feminist campaign ‘Wages for Housework’. It maintains that the political perspective and provocation that ectogenesis can advance should be considered and defended. (shrink)

In this paper, we argue that lesbian couples who wish to have children who are genetically related to both of them should be allowed access to mitochondrial replacement techniques. First, we provide a brief explanation of mitochondrial diseases and MRTs. We then present the reasons why MRTs are not, by nature, therapeutic. The upshot of the view that MRTs are non-therapeutic techniques is that their therapeutic potential cannot be invoked for restricting their use only to those cases where a mitochondrial (...) DNA disease could be ‘cured’. We then argue that a positive case for MRTs is justified by an appeal to reproductive freedom, and that the criteria to access these techniques should hence be extended to include lesbian couples who wish to share genetic parenthood. Finally, we consider a potential objection to our argument: that the desire to have genetically related kin is not a morally sufficient reason to allow lesbian couples to access MRTs. (shrink)

In this paper I would like to propose the notion of “affective artifact”, building on an analogy with theories of cognitive artifacts and referring to the development of a situated affective science. Affective artifacts are tentatively defined as objects that have the capacity to alter the affective condition of an agent, and that in some cases play an important role in defining that agent’s self. The notion of affective artifacts will be presented by means of examples supported by empirical findings, (...) by discussing a tentative definition and classification, and by considering several related but differing notions. Within the framework of situated affectivity, the notion of affective artifacts will represent a further step in the enterprise of understanding how the environment helps us scaffold our affective processes. I will conclude that affective artifacts play a key role in the philosophy of cognitive science, the philosophy of technology and in the debate about the self. (shrink)

In today’s pluralistic society, clinical ethics consultation cannot count on a pre-given set of rules and principles to be applied to a specific situation, because such an approach would deny the existence of different and divergent backgrounds by imposing a dogmatic and transcultural morality. Clinical ethics support needs to overcome this lack of foundations and conjugate the respect for the difference at stake with the necessity to find shared and workable solutions for ethical issues encountered in clinical practice. We argue (...) that a pragmatist approach to CES, based on the philosophical theories of William James, John Dewey, and Charles Sanders Peirce, can help to achieve the goal of reaching practical solutions for moral problems in the context of today’s clinical environment, characterized by ethical pluralism. In this article, we outline a pragmatist theoretical framework for CES. Furthermore, we will show that moral case deliberation, making use of the dilemma method, can be regarded an example of a pragmatist approach to CES. (shrink)

Eugenics is often referred to in debates on the ethics of reproductive technologies and practices, in relation to the creation of moral boundaries between acceptable and unacceptable technologies, and acceptable and unacceptable uses of these technologies. Historians have argued that twentieth century eugenics cannot be reduced to a uniform set of practices, and that no simple lessons can be drawn from this complex history. Some authors stress the similarities between past eugenics and present reproductive technologies and practices (what I define (...) throughout the paper as ‘the continuity view’) in order to condemn the latter. Others focus on the differences between past and present practices (what I define throughout the paper as ‘the discontinuity view’) in order to defend contemporary reproductive technologies. In this paper, I explore the meanings of the word ‘eugenics’ and the relationship between its past and present uses in terms of contemporary debates on reproductive technologies and practices. I argue that moral disagreement about present technologies originate in divergent views of condemnable and justifiable features of the past. (shrink)

After almost 30 years of publications, Journal of Business Ethics (JBE) has achieved the position of main marketplace for business ethics discussion and knowledge generation. Given the large amount of knowledge produced, an assessment of the state of the art could benefit both the constructive development of the discipline and the further growth of the journal itself. As the evolution of a discipline is set to be reflected in the evolution of its leading journal, we attempt to characterize changes in (...) the intellectual structure of business ethics through a bibliometric analysis of articles published in JBE . Specifically, we conduct a knowledge-stock analysis to assess the evolution, major trends, and current state of the journal. Additionally, we use citation and co-citation analysis to provide an accurate description of the content and the advancement of research in business ethics. Through the results of our analysis, we are able to: (1) pinpoint the characteristics of the growing stock of knowledge published by JBE over the years; (2) identify the most influential works on business ethics research; and (3) detect the formation and evolution of schools of thought in business ethics. (shrink)

According to neo-Russellianism, in a sentence such as John believes that Mont Blanc is 4000 m high, any other proper name co-referring with Mont Blanc can be substituted for it without any change in the proposition expressed. Prima facie, our practice of translation shows that this cannot be correct. We will then show that neo-Russellians have a way out of this problem, which consists in holding that actual translations are not a matter of semantics, but also make an attempt at (...) preserving some pragmatic features of the sentences to be translated. We then turn to translations that only preserve the semantic characteristics of the sentences and we argue that, although these translations are unable to show that neo-Russellianism is incorrect, they still show that it relies on some theses that seem to have no justification, apart from saving neo-Russellianism itself. (shrink)

Traditionally, ‘that’-clauses occurring in attitude attributions are taken to denote the objects of the attitudes. Prior raised a famous problem: even if Frege fears that the Begriffsschrift leads to a paradox, it is unlikely that he fears a proposition, a sentence or what have you as the alleged object denoted by the ‘that’-clause. The usual way out is to say that ‘that’-clauses do not contribute the objects of the attitudes but their contents. I will show that, if we accept this (...) answer, either we’d better stop working on attitude attributions or we’d better work harder on them. (shrink)

How should we regulate genome editing in the face of persistent substantive disagreement about the moral status of this technology and its applications? In this paper, we aim to contribute to resolving this question. We first present two diametrically opposed possible approaches to the regulation of genome editing. A first approach, which we refer to as “elitist,” is inspired by Joshua Greene’s work in moral psychology. It aims to derive at an abstract theoretical level what preferences people would have if (...) they were committed to implementing public policies regulating genome editing in a context of ethical pluralism. The second approach, which we refer to as the democratic approach, defended by Francoise Baylis and Sheila Jasanoff et al., emphasizes the importance of including the public’s expressed attitudes in the regulation of genome editing. After pointing out a serious shortcoming with each of these approaches, we propose our own favored approach—the “enlightened democracy” approach—which attempts to combine the strengths of the elitist and democratic approaches while avoiding their weaknesses. (shrink)

Susanne Langer is mainly known as the American philosopher who, starting from her famous Philosophy in a New Key, worked in aesthetics and famously saw art as the product of the human mind’s most important, distinctive and remarkable ability, i.e., the ability to symbolise. But Langer’s later consideration of the connection between art and symbol is propagated by an early interest in the logic of symbols themselves. This rather neglected early part of Langer’s thought and her early interests and lines (...) of reasoning, which she somehow abandoned later on to dedicate herself exclusively to the study of art, are the topic of this paper. (shrink)

We introduce the notion of infinitary preorder and use it to obtain a predicative presentation of sup-lattices by generators and relations. The method is uniform in that it extends in a modular way to obtain a presentation of quantales, as “sup-lattices on monoids”, by using the notion of pretopology.Our presentation is then applied to frames, the link with Johnstone’s presentation of frames is spelled out, and his theorem on freely generated frames becomes a special case of our results on quantales.The (...) main motivation of this paper is to contribute to the development of formal topology. That is why all our definitions and proofs can be expressed within an intuitionistic and predicative foundation, like constructive type theory. (shrink)

In this review essay of Michelle Montague’s The Given we focus on the central thesis in the book: the awareness of awareness thesis. On that thesis, a state of awareness constitutively involves an awareness of itself. In Section 2, we discuss what the awareness of awareness thesis amounts to, how it contrasts with the transparency of experience, and how it might be motivated. In Section 3, we discuss one of Montague’s two theoretical arguments for the awareness of awareness thesis. A (...) view that accepts the awareness of awareness thesis, Montague argues, is to be preferred over competing views because it outperforms them in accounting for the property attributions one makes in perceptual experience. We suggest that it is not clear that this argument for the awareness of awareness thesis is successful. Finally, in Section 4 we consider the relation between Montague’s view of color experience and what she calls Strawson’s datum, arguing that Montague may not be able to explain this datum as straightforwardly as she supposes. This, we suggest, threatens Montague’s second theoretical argument for the awareness of awareness thesis. (shrink)

J. Benjamin Hurlbut’s book Experiments in Democracy: Human Embryo Research and the Politics of Bioethics is an historiographical analysis of the American debate over embryo research. It covers more than four decades of this debate and uses key actors, bodies, and events as empirical evidence for its analysis. At a first glance, it might seem like a book that tells a story, but Experiments in Democracy is much more than that. Hurlbut uses the chapters of this narrative as case studies (...) through which to examine practices of deliberative democracy and the role played by scientists and ethicists in the deliberative processes concerning embryo research and the governance thereof. (shrink)

ABSTRACTAccording to Zalabardo, Wittgenstein in TLP solves the metaphysical problem of the unity of facts by holding that facts are the only ultimate items of Tractarian ontology. With his intrigui...

The research fieldwork dedicated to trend analysis and foresight/forecast scenarios building, represents an unusual raid in an area where economic and social sciences have invested many efforts. Nevertheless, the semiotic dimension of this subject is not sufficiently thorough; many issues are at stake:We are going to investigate this area of analysis, for its relevance in post-Greimassian studies, for its interface with social sciences, as well as for its relevance for the legitimacy of semiotics in contemporary discussions of innovation and evolution.

Propositional attitude sentences, such as John believes that snow is white, are traditionally taken to express the holding of a relation between a subject and what ‘that’-clauses like ‘that snow is white’ denote, i.e. propositions. On the traditional account, propositions are abstract, mind- and language-independent entities. Recently, some have raised some serious worries for the traditional account and thought that we were mistaken about the kind of entities propositions are. Over the last ten years there has then been a boom (...) of accounts of propositions in terms of mental acts . But Friederike Moltmann has recently suggested that in accounting for attitudes we should forget about mind- and language-independent entities and acts and follow Twardowski in focusing instead on attitudinal objects, which are the products of our mental life. In this paper, I will focus on some semantic problems that any product-based account seems to face. Moreover, I will show that product-based accounts may be also criticised on ontological grounds. My conclusion will be that we lack a reason to think that in accounting for propositional attitudes we should focus on the alleged products of our mental lives. (shrink)

Many take the lesson of the paradoxes to be that we ought to impose some form of logical revision. It is argued here that this kind of move should not be taken lightly.

In this paper, an integrated, cognitive view of different mechanisms, reasons and pathways to norm compliance is presented. After a short introduction, theories of norm compliance are reviewed, and found to group in four main typologies: the rational choice model of norm compliance; theories based on conditional preferences to conformity, theories of thoughtless conformity, and theories of norm internalization. In the third section of the paper, the normative architecture EMIL-A is presented. Previous work discussed the epistemic module of this normative (...) architecture, allowing for the generation of normative beliefs being formed. The fourth and fifth sections present the pragmatic modules of EMIL-A, i.e. norm adoption—leading to normative goals—and norm compliance—leading to their execution. Not only are several alternative reasons for norm adoption shown, but also several pathways to norm compliance are identified. Finally, a summary and ideas for future works conclude the paper. (shrink)

The aim of this paper is to clarify what kind of normativity characterizes a convention. First, we argue that conventions have normative consequences because they always involve a form of trust and reliance. We contend that it is by reference to a moral principle impinging on these aspects (i.e. the principle of Reliability) that interpersonal obligations and rights originate from conventional regularities. Second, we argue that the system of mutual expectations presupposed by conventions is a source of agreements. Agreements stemming (...) from conventions are “tacit” in the sense that they are implicated by what agents do (or forbear from doing) and without that any communication between them is necessary. To justify this conclusion, we assume that: (1) there is a salient interpretation, in some contexts, of everyone’s silence as confirmatory of the others’ expectations (an epistemic assumption), and (2) the participating agents share a value of not being motivated by hostile attitudes (a motivational assumption). By clarifying the relation between conventions and agreements, the peculiar normativity of conventions is analyzed. (shrink)

Funds and positions in philosophy should be awarded through systems that are reliable, objective, and efficient. One question usually taken to be relevant is how many publications people have in a group of well-respected journals. In the context of significant competition for jobs and funding, however, relying on quantity of publications creates a serious downside: the oft-lamented demand that we publish or perish. This article offers a systematic review of the problems involved in contemporary academic philosophy, and argues that the (...) resulting situation is bad not just for individual philosophers but also for philosophy itself: we are not working as a discipline to as high a standard as we might. The article then suggests some potential solutions, including some more detailed considerations around what seems a particularly promising option: a professional code of conduct for philosophers. (shrink)

A proper understanding of the moral and political significance of migration requires a focus on global inequalities. More specifically, it requires a focus on those global inequalities that affect people’s ability to participate in the production of economic goods and non-economic goods. We call cooperative infrastructures the complex material and immaterial technologies that allow human beings to cooperate in order to generate human goods. By enabling migrants to access high-quality cooperative infrastructures, migration contributes to the diffusion of technical and socio-political (...) innovations. In this way, it positively affects the ability of individuals from poorer countries to participate in the production of human goods, to benefit from such production, and to contribute to human development. Migration can also damage the material and immateri al components of the cooperative infrastructures accessible in both the host and sending countries; these potential downsides of migration should not be ignored, although arguably they can often be neutralized, alleviated, or compensated. (shrink)

This paper addresses the problem of pluralism in democratic societies, by exploiting some insights from the debate about the epistemology of disagreement. First, by focusing on the permissibility of experiments on nonhuman animals for research purposes, we provide an epistemic analysis of deep normative disagreements. We understand that to mean disagreements in which epistemic peers disagree about both the substantive content of an ethical issue and the correct justificatory reasons for their contrary claims. Second, we argue for a compromise solution (...) in which the reasons for reaching it are not prudential but grounded on the recognition of epistemic peerhood. (shrink)

BackgroundClinical ethics support aims to support health care professionals in dealing with ethical issues in clinical practice. Although the prevalence of CES is increasing, it does meet challenges and pressing questions regarding implementation and organization. In this paper we present a specific way of organizing CES, which we have called integrative CES, and argue that this approach meets some of the challenges regarding implementation and organization.MethodsThis integrative approach was developed in an iterative process, combining actual experiences in a case study (...) in which we offered CES to a team that provides transgender health care and reflecting on the theoretical underpinnings of our work stemming from pragmatism, hermeneutics and organizational and educational sciences.ResultsIn this paper we describe five key characteristics of an integrative approach to CES; 1. Positioning CES more within care practices, 2. Involving new perspectives, 3. Creating co-ownership of CES, 4. Paying attention to follow up, and 5. Developing innovative CES activities through an emerging design.ConclusionsIn the discussion we compare this approach to the integrated approach to CES developed in the US and the hub and spokes strategy developed in Canada. Furthermore, we reflect on how an integrative approach to CES can help to handle some of the challenges of current CES. (shrink)

We introduce a sequent calculus B for a new logic, named basic logic. The aim of basic logic is to find a structure in the space of logics. Classical, intuitionistic, quantum and non-modal linear logics, are all obtained as extensions in a uniform way and in a single framework. We isolate three properties, which characterize B positively: reflection, symmetry and visibility. A logical constant obeys to the principle of reflection if it is characterized semantically by an equation binding it with (...) a metalinguistic link between assertions, and if its syntactic inference rules are obtained by solving that equation. All connectives of basic logic satisfy reflection. To the control of weakening and contraction of linear logic, basic logic adds a strict control of contexts, by requiring that all active formulae in all rules are isolated, that is visible. From visibility, cut-elimination follows. The full, geometric symmetry of basic logic induces known symmetries of its extensions, and adds a symmetry among them, producing the structure of a cube. (shrink)

The new Coronavirus has been declared a global pandemic by the World Health Organization. The sudden outbreak of this new virus and the measure of lockdown adopted to contain the epidemic have profoundly changed the lifestyles of the Italian population, with an impact on people’s quality of life and on their social relationships. In particular, due to forced and prolonged cohabitation, couples may be subject to specific stressors during the epidemic. In addition, living with a chronic health condition may add (...) specific challenges to the ones posed by the epidemic itself. The present cross-sectional study aimed to provide a picture of the challenges as well as the resources for both individual and relational well-being of Italian individuals in a couple relationship, with a specific attention to the comparison between individuals living with and without a chronic disease. Results showed that people with a chronic disease had lower psychological well-being and more fears and worries about the COVID-19. People with a chronic disease perceived fewer resources than healthy people. Moreover, the challenges are shown to be associated with less psychological well-being and high pessimism about the future. Instead individual, relational, and social resources play a protective role during the pandemic for both healthy and chronically ill people. (shrink)

Journal Name: Semiotica Issue: Ahead of print.

We introduce a sequent calculus B for a new logic, named basic logic. The aim of basic logic is to find a structure in the space of logics. Classical, intuitionistic, quantum and non-modal linear logics, are all obtained as extensions in a uniform way and in a single framework. We isolate three properties, which characterize B positively: reflection, symmetry and visibility. A logical constant obeys to the principle of reflection if it is characterized semantically by an equation binding it with (...) a metalinguistic link between assertions, and if its syntactic inference rules are obtained by solving that equation. All connectives of basic logic satisfy reflection. To the control of weakening and contraction of linear logic, basic logic adds a strict control of contexts, by requiring that all active formulae in all rules are isolated, that is visible. From visibility, cut-elimination follows. The full, geometric symmetry of basic logic induces known symmetries of its extensions, and adds a symmetry among them, producing the structure of a cube. (shrink)

The necessity to model the mental ingredients of norm compliance is a controversial issue within the study of norms. So far, the simulation-based study of norm emergence has shown a prevailing tendency to model norm conformity as a thoughtless behavior, emerging from social learning and imitation rather than from specific, norm-related mental representations. In this paper, the opposite stance—namely, a view of norms as hybrid, two-faceted phenomena, including a behavioral/social and an internal/mental side—is taken. Such a view is aimed at (...) accounting for the difference between norms, on one hand, and either behavioral regularities (conventions) on the other. This paper, in particular, is addressed to find out the internal ingredients required for the former distinction, i.e., to model norms as distinct from mere conventions, and defined as behaviors spreading to the extent that and because the corresponding commands and beliefs do spread as well. After a brief presentation of a normative agent architecture, the results of agent-based simulations testing the impact of norm recognition and the role of normative beliefs in the emergence and innovation of social norms are presented and discussed. More specifically, the present work will endeavour to show that a sudden external constraint (e.g. a barrier preventing agents from moving among social settings) facilitates norm innovation: under such a condition, agents provided with a module for telling what a norm is can generate new (social) norms by forming new normative beliefs, irrespective of the most frequent actions. (shrink)