Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress‐induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type (...) critical to pregnancy in humans, the decidual stromal cell, evolved from a cellular stress reaction. It is hypothesized that the stress reaction in these cells was elicited ancestrally via inflammation caused by embryo attachment. The present study proposes that SIEI is a distinct form of plasticity‐based evolutionary change leading to the origin of novel structures rather than adaptive transformation of pre‐existing characters. (shrink)

Our society is in the middle of the AI revolution. We discuss several applications of AI, in particular medical causality, where deep-learning neural networks screen through big data bases, extracting associations between a patient’s condition and possible causes. While beneficial in medicine, several questionable AI trading strategies have emerged in finance. Though advantages in many aspects of our lives, serious threats of AI exist. We suggest several regulatory measures to reduce these threats. We further discuss whether ‘full AI robots’ should (...) be programmed with a virtual consciousness and conscience. While this would reduce AI threats via motivational control, other threats such as the desire for AI—human socioeconomic equality could prove detrimental. (shrink)

" Because characters and the conception of characters are central to all studies of evolution, and because evolution is the central organizing principle of biology, this book will appeal to a wide cross-section of biologists.

Es soll ein Beitrag zur epistemischen Charakterisierung von Computersimulationen als jenseits von Experiment und Theorie geleistet werden. Es wird argumentiert, dass die in der Simulationstechnik eingesetzten Verfahren nicht numerische Lösungen liefern, sondern deren Dynamik mittels generativer Mechanismen imitieren. Die Computersimulationen in der Klimatologie werden als systematisches wie historisches Fallbeispiel behandelt. Erst "Simulationsexperimente" gestatten es, mittels Modellen eine Dynamik zu imitieren, ohne deren Grundgleichungen zu "lösen". /// Computer simulations will be characterized in epistemic respect as a method between experiment and theory. (...) It will be argued that simulations do not provide numerical solutions, rather they use generative mechanisms to imitate a dynamics. Climate science will be considered as a case both systematically and historically. Only simulation experiments allow to build models that imitate a dynamics without solving the relevant equations. (shrink)

Historische Praxeologie richtet ihren Blick auf vergangenen Alltag. Ihr Interesse gilt dem historischen Menschen in seinem alltäglichen Tun und Sprechen, das sie in Praktiken verortet. Der Band stellt den historisch-praxeologischen Forschungsansatz programmatisch als neuen Zugriff auf die Kulturgeschichte vergangenen Handelns vor. Praktiken sind erkennbare Muster im vergangenen Alltag. Sie zeichnen sich durch Routinen und Dynamiken, zeitgenössische Logik und Bedeutungszuschreibungen sowie das Mitwirken von Dingen aus. Als Zusammenhänge menschlichen Handelns sind sie bis heute lesbar. Der historisch-praxeologische Ansatz versteht sich als eine (...) Weiterführung von Alltags- und Mikrogeschichte sowie Selbstzeugnisforschung. Mit Beiträgen von M. Böth, J. Breittruck, J. Esch, A. Mariss, J. Cáceres Mardones, T. Neu, A. Raapke, B. Reicherdt und D. Sittler sowie einem runden Tisch mit N. Buschmann, D. Freist, M. Füssel, F. Hillebrandt und A. Landwehr. (shrink)

Both the capability and the recognition approach are influential and substantial theories in social philosophy. In this contribution, we outline their main assumptions in their assessment of poverty. The two approaches are set in relation to each other, focusing mainly on (a) their moral evaluation of poverty, (b) issues of justification of their central normative claims, and (c) the role that is attributed to subjective experiences, feelings and emotions in these theories. This comparison reveals that in spite of significant differences, (...) both lead to the claim that poverty can never be adequately assessed without putting it into the context of a comprehensive ethical theory about the nature and function of societies. Drawing on this result, we conclude that the critical function of social philosophy plays an irreducible role in the study and understanding of poverty. (shrink)

The book focuses on the modern understanding of human life-forms as constructs that followed an evolutionary history. The author thus finds science confronted with two questions: firstly, how the transgression of the virtual threshold between natural and cultural history was possible, secondly, how the socio-cultural constructs were able to develop in the course of history the way they did. The discussion concentrates on the problem of determining a processual logic in the development of societal structures as well as in the (...) development of cognition. The focus of attention is the historico-genetic reconstruction of cognition. The book was originally published in German as Historisch-genetische Theorie der Kultur (Weilerswist 2000: Velbrück). (shrink)

The significance and development of Mannheim's sociology Ancient data such as the Code of Hammurabi, the Old Testament, the Confucian Classics, ...

Two welcome extensions of evolutionary thinking have come to prominence over the last thirty years: the so-called ’extended evolutionary synthesis’ (EES) and debate about biological kinds and individuals. These two agendas have, however, remained orthogonal to one another. The EES has mostly restricted itself to widening the explanations of adaptation offered by the preceding ’modern evolutionary synthesis’ by including additional mechanisms of inheritance and variation; while discussion of biological kinds has turned toward philosophical questions of essential vs. contingent properties of (...) life forms and realist vs. epistemological approaches to categorization and classification. Here we attempt to broaden the explanatory scope of evolutionary theory by linking these two agendas. We expand on the mechanistic orientation of the EES, using new understandings of networked systems of components in order to engage the distinct intellectual challenge of the origination of “historical kinds”. With this phrase we designate a subset of natural kinds that acquires, through evolutionary processes, a quasi-independent lineage-history. Such kinds emerge in both biology and culture, and we enlarge the limited number of historical kinds that have thus far been recognized in evolutionary biology in a series of paradigmatic exemplars, from genes and cell types to rituals and music. For each exemplar we discern specific mechanisms by which it arose and persists; comparing these, we suggest a general unity in the ways in which diverse historical kinds originate. (shrink)

mit Beitr. v. Günter C. Behrmann. hrsg. v. Günter Saße. ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- Z 65.262-1447.

Research on the effectiveness of case studies in teaching engineering ethics in higher education is underdeveloped. To add to our knowledge, we have systematically compared the outcomes of two case approaches to an undergraduate course on the ethics of technology: a detached approach using real-life cases and a challenge-based learning approach with students and stakeholders acting as co-creators. We first developed a practical typology of case-study approaches and subsequently tested an evaluation method to assess the students’ learning experiences and outcomes (...) and staff interpretations and operationalizations, seeking to answer three questions: Do students in the CBL approach report higher basic needs, motivation and competence development compared to their peers in the detached approach? What is the relationship between student-perceived co-creation and their basic needs, motivation and competence development? And what are the implications of CBL/CC for engineering-ethics teaching and learning? Our mixed methods analysis favored CBL as it best supported teaching and research goals while satisfying the students’ basic needs and promoting intrinsic motivation and communication competences. Competence progress in other areas did not differ between approaches, and motivation in terms of identified regulation was lower for CBL, with staff perceiving a higher workload. We propose that our case typology model is useful and that as a method to engage students as co-creators, CBL certainly merits further development and evaluation, as does our effectiveness analysis for engineering ethics instruction in general and for case-study approaches in particular. (shrink)

Written in 1839 and chosen as the winning entry in a competition held by the Royal Norwegian Society of Sciences, Schopenhauer's Prize Essay on the Freedom of the Will marked the beginning of its author's public recognition and is widely regarded as one of the most brilliant and elegant treatments of free will and determinism. Schopenhauer distinguishes the freedom of acting from the freedom of willing, affirming the former while denying the latter. He portrays human action as thoroughly determined but (...) also argues that the freedom which cannot be established in the sphere of human action is preserved at the level of our innermost being as individuated will, whose reality transcends all dependency on outside factors. This volume offers the text in a previously unpublished translation by Eric F. J. Payne, the leading twentieth-century translator of Schopenhauer into English, together with a historical and philosophical introduction by Günter Zöller. (shrink)

Etude de la conception des grands penseurs, de Saint Simon à Mannheim en ce qui concerne la sociologie de la connaissance.

Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position‐effect variegation (PEV) therefore, gene inactivation results from a change in chromatin structure. PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components. Consequently, many genes have been identified which, when mutated, act (...) as dominant modifiers (suppressors or enhancers) of PEV. Data available already demonstrate that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin components, and hence to fundamental aspects of chromosome structure and function. (shrink)

This book is open access under a CC BY 4.0 license. We must find new and innovative ways of conceptualizing transboundary energy issues, of embedding concerns of ethics or justice into energy policy, and of operationalizing response to them. This book stems from the emergent gap; the need for comparative approaches to energy justice, and for those that consider ethical traditions that go beyond the classical Western approach. This edited volume unites the fields of energy justice and comparative philosophy to (...) provide an overarching global perspective and approach to applying energy ethics. We contribute to this purpose in four sections: setting the scene, practice, applying theory to practice, and theoretical approaches. Through the chapters featured in the volume, we position the book as one that contributes to energy justice scholarship across borders of nations, borders of ways of thinking and borders of disciplines. The outcome will be of interest to undergraduate and graduate students studying energy justice, ethics and environment, as well as energy scholars, policy makers, and energy analysts. (shrink)

Gadamer’s hermeneutics is no discipline or simply a foundation of the Humanities, but addresses the fundamental problem of phenomenology: how things show themselves and can be attained. It does so, however, not in Husserl’s terminology but in its “ontological turn”. In elaborating on the ontology of language, Gadamer equates the accessibility of things and their Being, a move eminent in the “speculative character of language” discussed in the third part of Truth and Method. For Gadamer as well as for Heidegger, (...) ontology is possible only as phenomenology. How things show themselves, however, cannot be understood in relation to an absolute consciousness or understanding Dasein, but, following Plato, from the “evidence of the beautiful” in an hermeneutics of the artwork. Gadamer’s phenomenology thus describes the accessibility of things as the coming to pass of their truth and presence, much as the later Heidegger does in relation to physis and openness. Hermeneutical reflection of the fundamental problem of phenomenology also reveals the displacement in the continuity of coming to pass as the “space between words” opened in the manifold of interpretations. (shrink)

This paper explores the intimate connection between love and hope. Building on insights from Pamela Sue Anderson’s writings on vulnerable love, it focuses on the often-overlooked insight that love is saturated with risks, including the risk of rejection. Even though love intensifies vulnerabilities, it remains creative, albeit in a dangerous way. Hope addresses the problems love poses by temporizing them, but hope is not without risks and ambiguities itself. The distinction between “hope for” and “hope in” someone, a move which (...) is crucial for a Christian understanding of love and hope, can help to address this insufficiency. (shrink)

Recent investigations with non‐model species and whole‐genome approaches have challenged several paradigms in animal epigenetics. They revealed that epigenetic variation in populations is not the mere consequence of genetic variation, but is a semi‐independent or independent source of phenotypic variation, depending on mode of reproduction. DNA methylation is not positively correlated with genome size and phylogenetic position as earlier believed, but has evolved differently between and within higher taxa. Epigenetic marks are usually not completely erased in the zygote and germ (...) cells as generalized from mouse, but often persist and can be transgenerationally inherited, making them evolutionarily relevant. Gene body methylation and promoter methylation are similar in vertebrates and invertebrates with well methylated genomes but transposon silencing through methylation is variable. The new data also suggest that animals use epigenetic mechanisms to cope with rapid environmental changes and to adapt to new environments. The main benefiters are asexual populations, invaders, sessile taxa and long‐lived species. (shrink)

The paper assesses Martin’s recent logico-phenomenological account of judgment that is cast in the form of an eclectic history of judging, from Hume and Kant through the 19th century to Frege and Heidegger as well as current neuroscience. After a preliminary discussion of the complex unity and temporal modalities of judgment that draws on a reading of Titian’s “Allegory of Prudence”, the remainder of the paper focuses on Martin’s views on Kant’s logic in general and his theory of singular existential (...) judgment in particular. The paper argues against Martin’s key claims of the primacy of formal logic over transcendental logic and of the synthetic nature of judgment in Kant. It also takes issue with each of the four interpretations of singular existential judgment in Kant offered by Martin: existence as logical predicate, as copula, as thesis and as logical subject. (shrink)

Two hundred years after his death, Kant remains one of the most important modern philosophers. The Prolegomena is the ideal introduction to Kant's unique account of the nature human knowledge, according to which we actively shape the world as we know it. This new edition of Kant's own summary of his philosophy is designed specially for students. Guenter Zoeller assumes no prior knowledge of the Prolegomena and provides an extensive and comprehensive introduction which explores Kant's life, the origin and reception (...) of the Prolegomena, the organization of the work, its principal arguments, and its philosophical significance. This edition also includes detailed notes to aid student understanding, as well as a chronology, a glossary and an annotated bibliography. (shrink)

Das Buch spielt mit einem neuen, ganzheitlichen Vorstellungsbild des Menschen, der aus drei Einheiten zusammengesetzt gedacht wird: das analytische Denken residiert in einer computer¿lichen linken Gehirnh¿te, die kreative Intuition sitzt wie ein naturbelassenes neuronales Netzwerk in der rechten. Der Mensch denkt, wohin ihn das dritte System lenkt: Ein hyperschneller Anzeichen-Identifizierer alarmiert etwa bei gef¿lichen Ereignissen die Aufmerksamkeit, unbewusst, ohne Denken. Bis auf ein paar Zeilen mathematischer Erkl¿ng ist dieses Buch fulminante Philosophie. Wichtige Ansichten dieser Welt werden gedreht und bleiben zum (...) Teil auf dem Kopf stehen. Die Lehren von Platon, Aristoteles, Konfuzius, Epikur, Freud & Co. erscheinen als notwendige Philosophien verschiedener Gehirnnutzungsvarianten. Das Buch ist eine scharfsinnig-bissig-humorvolle und sehr pers¿nliche Auseinandersetzung mit dem, was wir "Lebenssinn" nennen. (shrink)

Las depresiones y los estados depresivos varían de una persona a otra. Si se quiere trabajar para mejorar la situación de las víctimas de estos males, sería indicado saber en qué se distinguen los diferentes fenómenos y dónde se encuentra la causa. Pues las depresiones a menudo cumplen una función que suele aparecer camuflada./////Depression and depressive moods are varying from one person to another one. When working to alleviate the situation of the victims of these complaints it is advisable to (...) distinguish between different phenomena and to find the fundamental cause. Because depressions many times have a veiled function for the person in question. (shrink)