Spreds form a new protein family with an N‐terminal Enabled/VASP homology 1 domain (EVH1), a central c‐Kit binding domain (KBD) and a C‐terminal Sprouty‐related domain (SPR). They are able to inhibit the Ras–ERK signalling pathway after various mitogenic stimulations. In mice, Spred proteins are identified as regulators of bone morphogenesis, hematopoietic processes, allergen‐induced airway eosinophilia and hyperresponsiveness. They inhibit cell motility and metastasis and have a high potential as tumor markers and suppressors of carcinogenesis. Moreover, in vertebrates, XtSpreds help together (...) with XtSprouty proteins to coordinate gastrulation and mesoderm specification. Here, we give an overview of this new field and summarize the domain functions, binding partners, expression patterns and the cellular localizations, regulations and functions of Spred proteins and try to give perspectives for future scientific directions. BioEssays 29:897–907, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

BackgroundSeveral studies identified low subjective feelings of power in women with anorexia nervosa. However, little is known about implicit power motives and the discrepancy between explicit feelings of power and implicit power motives in AN.AimThe study investigated the discrepancy between explicit feelings of power and implicit power motives and its relationship to anxiety in patients with AN.MethodFifty-three outpatients and inpatients with AN and 48 participants without AN were compared regarding subjective feelings of power and anxiety. Explicit power [investigated with the (...) Personal Sense of Power Scale and a visual analog scale ], implicit power motives [investigated with the Multi-Motive Grid ] and trait anxiety [measured with the State-Trait Anxiety Inventory ], were assessed.ResultsExplicit feelings of power were lower in patients with AN compared to non-AN participants. No differences in implicit power motives were found when comparing the groups against each other. However, looking at the groups separately, women with AN had similar levels of implicit fear of losing power and hope for power, whereas woman without AN had significantly lower fear of losing power than hope for power. Focusing on discrepancies between powerful feelings and power motives, results were mixed, depending on the subscale of the MMG. Lastly, discrepancies between implicit power motives and explicit feelings of power were positively correlated with trait anxiety in AN patients.ConclusionThese findings underline that individuals with AN display significantly lower explicit feelings of power, however, they show similar implicit power motives compared to individuals without AN. The discrepancy between explicit feelings of power and implicit power motives is related to anxiety in AN and may represent a vulnerability factor to illness maintenance. (shrink)

Beiträge zu einer Fachtagung der Universität Ulm 1990, auf der erstmalig israelische und deutsche Psychiater und Juristen über Psychiatrie und Justiz während der nationalsozialistischen Herschaft referierten. Die israelischen Referenten berichten über Entstehung, Manifestation und Behandlung der psychischen Leiden bei den Überlebenden und bei den Tätern der Vernichtungsmaschinerie: u. a. von der nationalsozialistischen Psychiatrie am Beispiel Grafeneck und der Situation in Grafeneck 50 Jahre danach.

The notion of societal boundaries aims to enhance the debate on planetary boundaries. The focus is on capitalist societies as a heuristic for discussing the expansionary dynamics, power relations, and lock-ins of modern societies that impel highly unsustainable societal relations with nature. While formulating societal boundaries implies a controversial process – based on normative judgments, ethical concerns, and socio-political struggles – it has the potential to offer guidelines for a just, social-ecological transformation.

Morality and economic rationality: integrative economic ethics as the rational ethics of economic activity; Part II. Reflections on the Foundations of Economic ...

Ulrich Beck's best selling Risk Society established risk on the sociological agenda. It brought together a wide range of issues centering on environmental, health and personal risk, provided a rallying ground for researchers and activists in a variety of social movements and acted as a reference point for state and local policies in risk management. The Risk Society and Beyond charts the progress of Beck's ideas and traces their evolution. It demonstrates why the issues raised by Beck reverberate widely (...) throughout social theory and covers the new risks that Beck did not foresee, associated with the emergence of new technologies, genetic and cybernetic. The book is unique because it offers both an introduction to the main arguments in Risk Society and develops a range of critical discussions of aspects of this and other works of Beck. (shrink)

This radical, profoundly scholarly book explores the purposes and nature of proof in a range of historical settings. It overturns the view that the first mathematical proofs were in Greek geometry and rested on the logical insights of Aristotle by showing how much of that view is an artefact of nineteenth-century historical scholarship. It documents the existence of proofs in ancient mathematical writings about numbers and shows that practitioners of mathematics in Mesopotamian, Chinese and Indian cultures knew how to prove (...) the correctness of algorithms, which are much more prominent outside the limited range of surviving classical Greek texts that historians have taken as the paradigm of ancient mathematics. It opens the way to providing the first comprehensive, textually based history of proof. (shrink)

How does science create knowledge? Epistemic cultures, shaped by affinity, necessity, and historical coincidence, determine how we know what we know. In this book, Karin Knorr Cetina compares two of the most important and intriguing epistemic cultures of our day, those in high energy physics and molecular biology. The first ethnographic study to systematically compare two different scientific laboratory cultures, this book sharpens our focus on epistemic cultures as the basis of the knowledge society.

In feminist media studies, the growing body of research on media production has indicated that journalism remains divided along gender lines. The purpose of this study is to address the lack of relevant multi-method research on gender inequality in journalism. To assess the structural position of women in the journalistic workforce, the authors conducted a large-scale survey of journalists in Belgium. The survey results were explored in more depth by conducting qualitative interviews with 19 female journalists. The analysis confirms the (...) existence of all traditional barriers that women journalists experience. The added value of this study is that it enumerates several additional difficulties, and offers insight into the strategies that the respondents use to deal with gender-related career obstacles. These strategies were associated with the degree of flexibility in the newsroom for journalists with children, the choice to work part-time or freelance, and the use of new communication technologies. (shrink)

The ArgumentTo highlight speculative trends specific to the mathematical tradition that developed in China, the paper analyzes an excerpt of a third-century commentary on a mathematical classic, which arguably contains a proof. The paper shows that the following three tasks cannot be dissociated one from the other: (1) to discuss how the ancient text should be read; (2) to describe the practice of mathematical proof to which this text bears witness; (3) to bring to light connections between philosophy and mathematics (...) that it demonstrates were established in China. To this end the paper defines its use of the word “proof” and outlines a program for an international history of mathematical proof. It describes the sense in which the text conveys a proof and shows how it simultaneously fulfills algorithmic ends, bringing to light a formal pattern that appears to be fundamental both for mathematics and for other domains of reality. The interest in transformations that mathematical writings demonstrate in China at that time seems to have been influenced by philosophical developments based onThe Book of Changes (Yi-jing), which the excerpt quotes. This quotation within a mathematical context makes it possible to suggest an interpretation for a rather difficult philosophical statement. (shrink)

L'oeuvre de Pic de la Mirandole offre un terrain d'expansion très large à la notion de métamorphose en même temps qu'elle l'investit au profit de la notion de dignité humaine cristallisée autour d'une liberté créatrice qui est tout d'abord libération de la pensée.

Isaac Newton, in popular imagination the Ur-scientist, was an outstanding humanist scholar. His researches on, among others, ancient philosophy, are thorough and appear to be connected to and fit within his larger philosophical and theological agenda. It is therefore relevant to take a closer look at Newton’s intellectual choices, at how and why precisely he would occupy himself with specific text-sources, and how this interest fits into the larger picture of his scientific and intellectual endeavours. In what follows, we shall (...) follow Newton into his study and look over his shoulder while reading compendia and original source-texts in his personal library at Cambridge, meticulously investigating and comparing fragments and commentaries, and carefully keeping track in private notes of how they support his own developing ideas. Indeed, Newton was convinced that precursors to his own insights and discoveries were present already in Antiquity, even before the Greeks, in ancient Egypt, and he puts a lot of time and effort into making the point, especially, and not incidentially, in the period between the first and the second edition of the Principia. A clear understanding of his reading of the classic sources therefore matters to our understanding of its content and gestation process. In what follows we will confine ourselves to the classical legacy, and investigate Newton’s intellectual intercourse with it. (shrink)

Generality is a key value in scientific discourses and practices. Throughout history, it has received a variety of meanings and of uses. This collection of original essays aims to inquire into this diversity. Through case studies taken from the history of mathematics, physics and the life sciences, the book provides evidence of different ways of understanding the general in various contexts. It aims at showing how individuals have valued generality and how they have worked with specific types of "general" entities, (...) procedures, and arguments. (shrink)

In this new book, Ulrich Beck develops his now widely used concepts of second modernity, risk society and reflexive sociology into a radical new sociological ...

It will be shown in this article that an ontological approach for some problems related to the interpretation of Quantum Mechanics (QM) could emerge from a re-evaluation of the main paradox of early Greek thought: the paradox of Being and non-Being, and the solutions presented to it by Plato and Aristotle. More well known are the derivative paradoxes of Zeno: the paradox of motion and the paradox of the One and the Many. They stem from what was perceived by classical (...) philosophy to be the fundamental enigma for thinking about the world: the seemingly contradictory results that followed from the co-incidence of being and non-being in the world of change and motion as we experience it, and the experience of absolute existence here and now. The most clear expression of both stances can be found, again following classical thought, in the thinking of Heraclitus of Ephesus and Parmenides of Elea. The problem put forward by these paradoxes reduces for both Plato and Aristotle to the possibility of the existence of stable objects as a necessary condition for knowledge. Hence the primarily ontological nature of the solutions they proposed: Plato’s Theory of Forms and Aristotle’s metaphysics and logic. Plato’s and Aristotle’s systems are argued here to do on the ontological level essentially the same: to introduce stability in the world by introducing the notion of a separable, stable object, for which a ‘principle of contradiction’ is valid: an object cannot be and not-be at the same place at the same time. So it becomes possible to forbid contradiction on an epistemological level, and thus to guarantee the certainty of knowledge that seemed to be threatened before. After leaving Aristotelian metaphysics, early modern science had to cope with these problems: it did so by introducing “space” as the seat of stability, and “time” as the theater of motion. But the ontological structure present in this solution remained the same. Therefore the fundamental notion ‘separable system’, related to the notions observation and measurement, themselves related to the modern concepts of space and time, appears to be intrinsically problematic, because it is inextricably connected to classical logic on the ontological level. We see therefore the problems dealt with by quantum logic not as merely formal, and the problem of ‘non-locality’ as related to it, indicating the need to re-think the notions system, entity, as well as the implications of the operation ‘measurement’, which is seen here as an application of classical logic (including its ontological consequences) on the material world. (shrink)

The social licence to operate concept is little developed in the academic literature so far. Deployment of the term was made by the United National Guiding Principles on Business and Human Rights and the UN ‘Protect, Respect and Remedy’ Framework, which apply SLO as an argument for responsible business conduct, connecting to social expectations and bridging to public regulation. This UN guidance has had a significant bearing on how public regulators seek to influence business conduct beyond Human Rights to broader (...) Corporate Social Responsibility concerns. Drawing on examples of such public regulatory governance, this article explores and explains developments towards a juridification of CSR entailing efforts by public regulators to reach beyond jurisdictional and territorial limitations of conventional public law to address adverse effects of transnational economic activity. Through analysis of an expansion of law into the normative framing of what constitutes responsible business conduct, we demonstrate a process of juridification entailing a legal framing of social expectations of companies, a proliferation of law into the field of business ethics, and an increased regulation by law of social actors or processes. (shrink)

Human science researchers tend to be targeted for critique on the grounds that their approach is too individualistic to take due cognisance of societal and political influences. What is accordingly advocated is that the phenomenological and so-called romantic theories should be abandoned in favour of analytic or continental theories that have as their main focus the system, the group, the society, and the various influences of the social world on the existential reality of the individual.Without trying to invalidate these social (...) science strategies, this paper attempts to show that it is not necessary to surrender phenomenology in order to understand not only the individual, but also the social world in which individuals live. It is argued that the desired goal of a less individualistic human science’s theoretical basis can still be founded in phenomenology, in that Merleau-Ponty’s philosophy, which has its origin in Husserlian phenomenology, provides us with an adequate ontology for understanding human existence more comprehensively. Merleau-Ponty’s ontological philosophy elucidates the in-between world, that structure of existence where the individual cannot be separated from her/his world context. In his exploration of the reversibility of existence, Merleau-Ponty demonstrates that there is no ontological gulf between the individual and the social world. Instead, the world is ‘in’ the individual as much as the individual is ‘in’ the world. With this phenomenological epistemology, it is argued, it is possible to generate research that is capable “of more than a frozen existence”, as Merleau-Ponty puts it. (shrink)

This book provides an exciting and diverse philosophical exploration of the role of practice and practices in human activity. It contains original essays and critiques of this philosophical and sociological attempt to move beyond current problematic ways of thinking in the humanities and social sciences. It will be useful across many disciplines, including philosophy, sociology, science, cultural theory, history and anthropology.

By assembling authors with a wide range of different disciplinary backgrounds, from philosophy, literature, political science, sociology to medical anthropology ...

"Thinking about thinking", the topic of this section of our volume, leads us into an Escherian web of self-referential interconnections — which nevertheless make sense, at least if we do not shy away at once in the face of paradox, for fear of inconsistency. How do our critical faculties enter the picture? Adding a few conceptual dimensions to the merely linearly causal one may help us to shed light on the issue, and may help us also to understand some of (...) the basic strategies "Western" thought has developed throughout its historical pathway in its conscious dealings with the 'real'. Of course, in a few pages it is impossible to do justice to this complicated subject. But I'll try to give the reader an as clear as possible description of the, in my view, crucial issues, pointing out the ways they resonate into the many fields of interest represented in the intended readership, and leave it to the reader to dig deeper through the given references. (shrink)

The aim of the paper is this: Instead of presenting a provisional and necessarily insufficient characterization of what mathematical physics is, I will ask the reader to take it just as that, what he or she thinks or believes it is, yet to be prepared to revise his opinion in the light of what I am going to tell. Because this is precisely, what I intend to do. I will challenge some of the received or standard views about mathematical physics (...) and replace them by a more sophisticated picture, which takes into account the methodological and philosophical roots of mathematical physics in Göttingen. (shrink)

Investigates the intellectual affinities of Adorno and Nietzsche, culminating in a discussion of their readings of Wagner, who serves as a medium and supplement for their critiques of modern culture.

Classical conceptual distinctions in philosophy of education assume an individualistic subjectivity and hide the learning that can take place in the space between child and adult. Grounded in two examples from experience I develop the argument that adults often put metaphorical sticks in their ears in their educational encounters with children. Hearers’ prejudices cause them to miss out on knowledge offered by the child, but not heard by the adult. This has to do with how adults view education, knowledge, as (...) much as child, and is even more extreme when child is also black. The idea is what Miranda Fricker calls ‘epistemic injustice’ which occurs when someone is wronged specifically in their capacity as a knower. Although her work concerns gender and race, I extrapolate her radical ideas to child. Awareness of the epistemic injustice that is done to children and my proposal for increased epistemic modesty and epistemic equality could help transform pedagogical spaces to include child subjects as educators. A way forward is suggested that involves ‘cracking’ the concept of child and a different non-individualised conception of education. (shrink)

Tracing efforts to control unwanted sound--the noise of industry, city traffic, gramophones and radios, and aircraft--from the late nineteenth to the late twentieth century.

Cultural accounts of scientific ideas and practices have increasingly come to be welcomed as a corrective to previous—and still widely held—theories of scientific knowledge and practices as universal. The editors caution, however, against the temptation to overgeneralize the work of culture, and to lapse into a kind of essentialism that flattens the range and variety of scientific work. The book refers to this tendency as culturalism. The contributors to the volume model a new path where historicized and cultural accounts of (...) scientific practice retain their specificity and complexity without falling into the traps of culturalism. They examine, among other issues, the potential of using notions of culture to study behavior in financial markets; the ideology, organization, and practice of earthquake monitoring and prediction during China's Cultural Revolution; the history of quadratic equations in China; and how studying the "glass ceiling" and employment discrimination became accepted in the social sciences. Demonstrating the need to understand the work of culture as a fluid and dynamic process that directly both shapes and is shaped by scientific practice, Cultures without Culturalism makes an important intervention in science studies. Contributors. Bruno Belhoste, Karine Chemla, Caroline Ehrhardt, Fa-ti Fan,Kenji Ito, Evelyn Fox Keller, Guillaume Lachenal, Donald MacKenzie, Mary S. Morgan, Nancy J. Nersessian, David Rabouin, Hans-Jörg Rheinberger, Claude Rosental, Koen Vermeir. (shrink)

One theme of this special issue is an incitement to reconsider the relationship between pragmatism and critical realism. While their advocates sometimes come into conflict, there are also clearly b...

Jock Young, em “A sociedade excludente: Exclusão social, criminalidade e diferença na modernidade recente” nos convida a examinar as circunstâncias que contribuíram para a transição da modernidade para a modernidade recente, ou seja, a transição que ocorreu no Primeiro Mundo entre os “anos dourados” do pós-guerra e o período de crise a partir do final dos anos 1960. Ao longo do livro, Young busca evidenciar as mudanças dramáticas que ocorreram nos níveis de criminalidade, na natureza do desvio e nas mudanças (...) materiais ocorridas nas esferas de produção e do consumo, estabelecendo um contraste material e cultural na Europa Ocidental e nos Estados Unidos. (shrink)

In den letzten Jahren neu aufgefundene und publizierte Briefe, Gedichte und private Notizen von Marilyn Monroe verändern das Bild ihrer Biographie, ihrer psychischen Entwicklung und ihrer Analysen. Unter Berücksichtigung dieser Informationen kann Marilyn Monroes Analyse bei Ralph Greenson auf der einen Seite als eine intensive Idealisierung und eine tiefe Vertrauensbeziehung zu ihrem Analytiker interpretiert werden. Auf der anderen Seite wird klar, in welchem Ausmaß der Behandlungsprozess Schritt für Schritt entgleiste und zu vielfältigem Agieren aller beteiligten Personen in Marilyn Monroes Umfeld (...) führte. Monroe hatte sich entschieden, Unbeabsichtigt zerstörte Greenson einen Übertragungsprozess, der hoffnungsvoll begonnen hatte. Nach Monroes Tod entwickelte Greenson sein Konzept eines unverzichtbaren Arbeitsbündnisses zwischen Patient und Analytiker, das allen Psychoanalytikern gut bekannt ist. Aus heutiger Sicht stellt sich dieses Arbeitsbündnis als ein abgespaltener Teil eines ichpsychologischen Übertragungsbegriffs dar. (shrink)