Site‐specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to alteration of the filament structure, in vitro and in vivo. Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation. Thus, IF phosphorylation appears to be one of the most predominant strategies in coordinating intracellular organization of the IF network.

We investigate the novel problem of what happens in special relativity and in relativistic field theories whenthree-dimensional space is quantized. First we examine the equation for elastic waves on a linear chain, the simplest example of a quantized medium, and propose, on its analogy, a nonlinearp-k relationp=ħk(sinhkl)/kl for light and material waves. Here,kl is a new variable which represents the space-quantization effect on the plane wave of wave numberk=|k|. (Note thatkl=0 givesp=ħk.) This relation makes the light velocity in vacuum dependent (...) onkl. We postulate, however, that the phase and group velocities of each individual light wave are still invariant, and try to generalize special relativity to the case ofkl ≠ 0. This can be simply done if the invariance ofkl is assumed. Our results suggest that “localization” might be a relative concept. One interesting consequence of our proposal is that relativistic field theories become automatically finite. This comes out without violating unitarity or causality. A precise measurement of velocities of high-energy photons or massive particles is desirable for checking our proposal. (shrink)

This book, Emerson, the Philosophy of Obedience, attempts to trace Emerson who sought to integrate Western and Eastern thoughts to found a new philosophy in the new world. An ardent admirer of Plato, he is at the same time an enthusiast of Eastern philosophy. "Memory," for example, is one of his last lecture series, "Natural Method of Mental Philosophy," in which men are all taken as the halves, because men have aftersight, but not aforesight. Memory is, to Emerson, not only (...) to call forth the past knowledge to the present, but also there is something related to the future, because some past things memorized in the mind are changed into "a possession of its law." This is called "a mutation in quality," by which past things in the mind come into "a possession of its law," obeying the law, just as, in Phaedo, "all the apparent equals strive to attain absolute equality." The Platonic method of Analogy works doubtlessly in Emerson. Men obey this law, because "Nature and [Man] are from one source, and that he, when humble and obedient, is nearer to the source." The mind is such a movement, as he finds that "The mind yields sympathetically to the tendencies or laws which stream through things." The idea of "humble and obedient," or humility and obedience, comes originally from the Chaldæan Oracles and the Heetopades, which have a decisive influence on Emerson, through "the light-armed arrive at the summit," and "the flower of the mind." Because of this profound Eastern thought and ideas, he is called "this student of Eastern philosophy.". (shrink)

Classical Marxism is apparently a past topic. But, Marxist methodology is still useful to treat several contemporary problems of science and technology studies (STS). Marx had criticized the capitalist economy of his time and classical economic theory by analyzing the commodity production of the industrial revolution. But, he accepted western science and industrial technology as given factors in the capitalist economy. Though Classical Marxism attributed knowledge to the ideological superstructure of social relationships, it did not treat knowledge production as an (...) economic and social process. Now knowledge, especially scientific and technological knowledge, is an essential feature of the contemporary economy of the developed countries. Now the, critical study of production and distribution of knowledge, the object of STS, is an essential subject of our time. It includes the problems of ever expanding new working class: technical specialists, professionals, software workers, and health-related professionals. They, once independent proud professionals, are now in unstable working conditions. Improved Marxist methodology might make possible such a critical study. (shrink)

The development of a reliable and relatively simple micro‐assay for lipid peroxides in serum or plasma has made it possible to conduct clinical surveys of lipid peroxide levels in man. From many studies made in Japan, those suggesting a relationship between the elevation of lipid peroxide level plasma serum and the occurrence of vascular disorders are discussed here.The data described in this paper show that the elevation of the serum lipid peroxide level over the normal value is a direct cause (...) of the initiation of atherogenesis. Therefore, any factor bringing about the elevation of serum lipid peroxide levels, such as irradiation, would be an indirect cause of atherogenesis. In fact, irradiation is known to provoke this disorder and to elevate serum lipid peroxide levels. (shrink)

This international selection of 34 papers from the Tokyo '99 conference held at the United Nations University gives a valuable state of the art overview of consciousness research.

This international selection of 34 papers from the Tokyo '99 conference held at the United Nations University gives a valuable state of the art overview of consciousness research. Not only the recognized European and American approaches but also the distinguishing approaches from many Japanese researchers are presented. It will provide a world-wide audience with a comprehensive outlook for the remarkable potential contribution in the future scene of consciousness research.The Tokyo '99 declaration to promote scientists' ethical warning against the thoughtless aiming (...) of consciousness research at warfare is also included.(Series B). (shrink)

For brain science, the binary code is embodied in the all or none characteristic of nerve impulses by which one part of the brain communicates with another. ...

The aim of the present paper is to suggest an alternative view to the conventional distinction between ontology and epistemology, thereby reconstituting the relationship between the cognitive self and the real world. More specifically, we will criticize the distinction by shedding light on a peculiar character of the body, which can provide a critical perspective against Cartesian dualism. Furthermore, we will give a sketchy description of the philosophy of touch, and propose the notion of skin-self, or self-manifesting self, as a (...) radical alternative to the modern conception of self. (shrink)

Phenomenology of the body and the third generation of cognitive science, both of which attribute a central role in human cognition to the body rather than to the Cartesian notion of representation, face the criticism that higher-level cognition cannot be fully grasped by those studies. The problem here is how explicit representations, consciousness, and thoughts issue from perception and the body, and how they cooperate in human cognition. In order to address this problem, we propose a research program, a cognitive (...) phenomenology of the body, which is basically motivated by the perspective of Merleau-Ponty. We find a substantial clue in developmental psychological studies on the body and language. (shrink)

This multidisciplinary subject in clinical anthropology was started in April 1996 among 206 students distributed over all Colleges and Schools in the University of Tsukuba with the exception of School of Medical Sciences. After every class students write down their comments on a compulsory attendance slip, and these comments were examined. Female students agreed with the surrogate mothers and homosexuality more than male students. Male students denied childcare by homosexual parents more than female students. Sex selection insemination with the exception (...) for disease prevention was denied by female students significantly more than male students. (shrink)