Fibroblast growth factor receptors (FGFRs) have been implicated in many developmental and regenerative events, including axial organisation, mesodermal patterning, keratinocyte organisation and brain development. The consensus view that this reflects a role for one or other of the nine known members of the fibroblast growth factor family in these processes has recently been challenged by the suggestion that FGFRs might be directly activated by a much wider range of ligands, including heparan sulphate proteoglycans and neural cell adhesion molecules. In addition, (...) two novel soluble ligands for FGFRs have been identified using yeast two‐hybrid technology. Overall, the new findings suggest that in terms of ligand binding the FGFRs might be an even more promiscuous family of receptor tyrosine kinases than was already appreciated. (shrink)

First Published in 1993. Routledge is an imprint of Taylor & Francis, an informa company.

Although very young children have unprecedented access to touchscreen devices, there is limited research on how successfully they operate these devices for play and learning. For infants and toddlers, whose cognitive, fine motor, and executive functions are immature, several basic questions are significant: Can they operate a tablet purposefully to achieve a goal? Can they acquire operating skills and learn new information from commercially available apps? Do individual differences in executive functioning predict success in using and learning from the apps? (...) Accordingly, 31 2-year-olds were compared with 29 3-year-olds using two commercially available apps with different task and skill requirements: a shape matching app performed across 3 days, and a storybook app with performance compared to that on a matched paper storybook. Children also completed the Minnesota Executive Functioning Scale. An adult provided minimal scaffolding throughout. The results showed: toddlers could provide simple goal-directed touch gestures and the manual interactions needed to operate the tablet after controlling for prior experience with shape matching, toddlers’ increased success and efficiency, made fewer errors, decreased completion times, and required less scaffolding across trials, they recognized more story content from the e-book and were less distracted than from the paper book, executive functioning contributed unique variance to the outcome measures on both apps, and 3-year-olds outperformed 2-year-olds on all measures. The results are discussed in terms of the potential of interactive devices to support toddlers’ learning. (shrink)

Volume 20, Issue 5, June 2020, Page 72-74.

Researchers have documented negative physical and emotional consequences for both family caregivers of persons with cancer as well as caregivers of persons with a neurologic disorder. However, there is a unique subset of caregivers who must provide care for someone who may suffer from both a short, terminal trajectory of disease, as well as neurological and neuropsychiatric sequelae — the caregiver of a person with a primary malignant brain tumor. The purpose of this article was to describe a conceptual framework (...) for providing care for a person with a primary malignant brain tumor. The demands of this particular care situation are described, as well as potential resources available to the caregiver to meet those demands. Finally, the stress response that results from the balance between care demands and caregiver resources is illustrated. Development of a conceptual framework for this caregiving population is the first step in assisting nurses to identify factors that place caregivers of persons with a primary malignant brain tumor at risk for negative consequences, and to design interventions to improve caregiver health. (shrink)

During much of U.S. history, Black women had higher employment rates than white women. But by the late twentieth century, women in more privileged racial/ethnic, national origin, and education groups were more likely to work for pay. The authors compare the employment of white women to Blacks and three groups of Latinas—Mexicans, Cubans, and Puerto Ricans—and explain racial/ethnic group differences. White women work for pay more weeks per year than Latinas or Black women, although the gaps are small for all (...) groups but Mexicans. In all groups, education encourages and children reduce employment. Having a husband does not reduce employment, and husbands’ earnings have little effect. The higher fertility of Mexicans and the large number of recent immigrants among Mexican women reduce their employment relative to that of white women. The higher education of white women explains large shares of the employment gap with each group of women of color because, in today’s labor market, education strongly predicts employment. (shrink)

Packed with ideas designed to help children learn to sing, this booklet offers criteria for selecting songs, strategies to bring out the best in children's voices, and suggestions for games, ideas, and resources.

Feminists have long been aware of the pathology and the dangers of what are now termed “adaptive preferences.” Adaptive preferences are preferences formed in unconscious response to oppression. Thinkers from each wave of feminism continue to confront the problem of women's internalization of their own oppression, that is, the problem of women forming their preferences within the confining and deforming space that patriarchy provides. All preferences are, in fact, formed in response to a limited set of options, but not all (...) preferences are unconscious, pathological responses to oppression. Feminist theory therefore requires a method for distinguishing all preferences from adaptive or deformed preferences. Social contract theory provides such a tool. Social contract theory models autonomous preference-acquisition and retention at both the external level of causation and the internal level of justification. In doing so, social contract theory exposes preferences that do not meet those standards, acting as both a conceptual test that identifies adaptive preferences and as a practical tool for personal and social clarification. A social contract approach helps persons and societies to identify and to confront preferences rooted in unconscious response to oppression. (shrink)

The American Journal of Bioethics, Volume 12, Issue 10, Page 18-20, October 2012.

Although previous studies have found that video games induce stress, studies have not typically measured all salient indicators of stress responses including stress appraisals, cardiovascular indicators, and emotion outcomes. The current study used the Biopsychosocial Model of Challenge and Threat (Blascovich & Tomaka, 1996) to determine if video games induce a cardiovascular stress response by comparing the effects of threat and challenge appraisals across two types of video games that have shown different cardiovascular outcomes. Participants received challenge or threat appraisal (...) instructions, and played a fighting game (Mortal Kombat) or a puzzle game (Tetris). Study outcomes were heart rate variability, systolic and diastolic blood pressure, and positive and negative emotion ratings measured before, during and after gameplay. Results indicated that threat appraisal instructions increased negative emotion ratings and decreased heart rate variability, but not blood pressure, which is an essential marker for cardiovascular stress responses. Increased blood pressure and decreased heart rate variability was associated with fighting game players when compared with the puzzle game players, indicating a cardiovascular stress response; however, fighting game players also reported higher positive emotion ratings. Based on the study findings, video games do not induce stress responses like mental stressors used in previous research, demonstrating that the interactive player experience in video gaming may have more complex effects on stress outcomes. Future research should comprehensively measure biopsychosocial stress indicators and multiple emotional states over time to fully examine the relationship between video games and stress. (shrink)

The prevention, treatment and management of disease are closely linked to how the causes of a particular disease are explained. For multi-factorial conditions, the causal explanations are inevitably complex and competing models may exist to explain the same condition. Selecting one particular causal explanation over another will carry practical and ethical consequences that are acutely relevant for health policy. In this paper our focus is two-fold; the different models of causal explanation that are put forward within current scientific literature for (...) the high and rising prevalence of the common complex conditions of coronary artery disease and type 2 diabetes mellitus ; and how these explanations are taken up within national health policy guidelines. We examine the causal explanations for these two conditions through a systematic database search of current scientific literature. By identifying different causal explanations we propose a three-tier taxonomy of the most prominent models of explanations: evolutionary, lifecourse, and lifestyle and environment. We elaborate this taxonomy with a micro-level thematic analysis to illustrate how some explanations are semantically and rhetorically foregrounded over others. We then investigate the uptake of the scientific causal explanations in health policy documents with regard to the prevention and management recommendations of current National Service Frameworks for CAD and T2D. Our findings indicate a lack of congruence between the complexity and frequent overlap of causal explanations evident in the scientific literature and the predominant focus on lifestyle recommendations found in the mainstream health policy documents. (shrink)

Landscapes are public environments in which different communities and individuals dwell and which matter to them in ways which are not always consistent. As such they are open to strong conflicts about what the future of landscapes ought to be and who has an entitlement to involvement in a decision about that future. How should such conflicts be resolved? One influential approach is that embodied in the practice of cost-benefit analysis: the strength of preferences for different landscapes is measured by (...) individuals' willingness to pay and the potential Pareto improvement efficiency criterion is employed as a rule of choice. This paper contends that this approach is flawed. It examines an economic valuation study of landscapes in the Yorkshire Dales. Drawing on interviews with farmers in the Dales and on in-depth discussion groups with respondents to other economic valuation studies, it argues that landscape conflicts involve issues of identity that cannot be captured in terms of preference satisfaction and conflicts of perceived rights which could not in principle be resolved by cost-benefit analysis. (shrink)

Debates between Anglo-American and Continental feminist theorists of the body appear to have been largely settled as we move into the new millennium. The result has been that a particular Anglo-American perspective (represented by Butler) has gained authoritative ascendency over the continental perspective (represented by Irigaray and Braidotti). This paper draws upon these theorist’s main works as well as a series of interviews and a reading of Freud to raise some key questions about the often unacknowledged complexities of the interplays (...) between patriarchalism and phallocentrism present in a great deal of contemporary international feminist theorizations of the body. This has implications for the types of feminist subjects that can emerge and the political direction of international feministtheorizations of the body into the future. (shrink)

Long recognized as one of the main branches of political science, political theory has in recent years burgeoned in many different directions. Close textual analysis of historical texts sits alongside more analytical work on the nature and normative grounds of political values. Continental and post-modern influences jostle with ones from economics, history, sociology, and the law. Feminist concerns with embodiment make us look at old problems in new ways, and challenges of new technologies open whole new vistas for political theory. (...) This Handbook provides comprehensive and critical coverage of the lively and contested field of political theory, and will help set the agenda for the field for years to come. Forty-five chapters by distinguished political theorists look at the state of the field, where it has been in the recent past, and where it is likely to go in future. They examine political theory's edges as well as its core, the globalizing context of the field, and the challenges presented by social, economic, and technological changes."This is a unique and impressive set of analyses about scholarship in political theory. It is comprehensive, as we would expect. Beyond that, it is remarkably creative in the way that Dryzek, Honig and Phillips have organized categories, and it includes much overdue reference to scholarship on non-Western and postcolonial thought."-Iris Marion Young, Late Professor of Political Science at the University of Chicago"This extraordinary series offers 'state of the art' assessments that instruct, engage, and provoke. Both synoptic and directive, the fine essays across these superbly edited volumes reflect the ambitions and diversity of political science. No one who is immersed in the discipline's controversies and possibilities should miss the intellectual stimulation and critical appraisal these works so powerfully provide."-Ira Katznelson, Ruggles Professor of Political Science and History, Columbia UniversityJohn S. Dryzek is Professor of Social and Political Theory at Australian National University.Bonnie Honig is Professor of Political Science at Northwestern University.Anne Phillips is Professor of Gender Theory at the London School of Economics.Introduction, John S Dryzek, Bonnie Honig, and Anne PhilipsI. CONTEMPORARY CURRENTS1. Justice After Rawls, Richard Arneson2. Power After Foucault, Wendy Brown3. Critical Theory Beyond Habermas, William E Scheuerman4. Feminist Theory and the Canon of Political Thought, Linda Zerilli5. After the Linguistic Turn: Poststructuralist and Liberal Pragmatist Political Theory, Paul Patton6. The Pluralist Imagination, David SchlosbergII. THE LEGACY OF THE PAST7. Theory in History: Problems of Context and Narrative, J G A Pocock8. The Political Theory of Classical Greece, Jill Frank9. Republican Visions, Eric Nelson10. Modernity and its Critics, Jane Bennett11. The History of Political Thought, as Disciplinary Genre, James FarrIII. POLITICAL THEORY IN THE WORLD12. The Challenge of European Union, Richarad Bellamy13. East Asia and the West: The Impact of Confucianism on Anglo-American Political Thought, Daniel A Bell14. In the Beginning all the World was America: American Exceptionalism in New Contexts, Ronald J Schmidt Jr15. Changing Interpretations of Modern and Contemporary Islamic Political Theory, Roxanne L EubenIV. STATE AND PEOPLE16. Constitutionalism and the Rule of Law, Shannon Stimson17. Emergency Powers, John Ferejohn and Pasquale Pasquino18. The People, Margaret Canovan19. Civil Society and State, Simone Chambers and Jeffrey Kopstein20. Democracy and the State, Mark E Warren21. Democracy and Citize. (shrink)

O presente artigo consiste no registro de memórias de um diretor e de uma diretora que atuaram em escolas públicas de M inas Gerais, e na análise de suas narrativas. O objetivo foi captar suas representações sobre as práticas administrativas e pedagógicas rememoradas dos anos de exercício profissional. Com a metodologia da história oral, nossa investigação buscou construir uma interpretação a respeito de atitudes, posturas e práticas enraizadas nos rituais da escola contemporânea. Pudemos observar que no período estudado havia uma (...) política extremamente centralizada, cujas diretrizes eram difundidas pelos órgãos centrais da administração burocrática. O trabalho de gestão das unidades escolares era pautado, principalmente, pelo controle do cumprimento das normas estabelecidas pela política pública de educação. (shrink)

Abstract:Vulnerability is an important criterion to assess the ethical justification of the inclusion of participants in research trials. Currently, vulnerability is often understood as an attribute inherent to a participant by nature of a diagnosed condition. Accordingly, a common ethical concern relates to the participant’s decisionmaking capacity and ability to provide free and informed consent. We propose an expanded view of vulnerability that moves beyond a focus on consent and the intrinsic attributes of participants. We offer specific suggestions for how (...) relational aspects and the dynamic features of vulnerability could be more fully captured in current discussions and research practices. (shrink)

BACKGROUND: There is a need for interdisciplinary research to better understand how pedagogical approaches in primary physical education (PE) can support the linked development of physical, cognitive and affective aspects of physical literacy and physical activity behaviours in young children. The Skill Acquisition Methods fostering Physical Literacy in Early-Physical Education (SAMPLE-PE) study aims to examine the efficacy of two different pedagogies for PE, underpinned by theories of motor learning, to foster physical literacy, especially for children living in disadvantaged areas. METHODS: (...) SAMPLE-PE will be evaluated through a cluster-randomised controlled trial targeting 5-6 year old children from schools located in areas of high deprivation in Merseyside, North-West England. Schools will be randomly allocated to one of three conditions: Linear Pedagogy, Nonlinear Pedagogy or Control. Nonlinear and Linear Pedagogy intervention primary schools will receive a PE curriculum delivered by trained coaches over 15 weeks, while control schools will follow their usual practice. Data will be collected at baseline (T0), immediately post-intervention (T1) and six months after the intervention has finished (T2). Children’s movement competence is the primary outcome in this trial. Secondary outcomes include physical activity, perceived competence, motivation, executive functions, and self-regulation. An extensive process evaluation will also examine implementation factors such as intervention context, reach, dose, fidelity and acceptability. DISCUSSION: The SAMPLE-PE project will enable better understanding surrounding how to operationalise physical literacy through enrichment of PE practices in early PE. The study will provide robust scientific evidence regarding the efficacy of underpinning PE pedagogy with theories of motor learning to promote the development of physical literacy. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Parts one and two of this volume present the theoretical lenses used to study the social contexts of education. These include long-established foundations disciplines such as sociology of education and philosophy of education as well as newer theoretical perspectives such as critical race theory, feminist educational theory, and cultural studies in education. Parts three, four, and five demonstrate how these theoretical lenses are used to examine such phenomena as globalization, media, popular culture, technology, youth culture, and schooling. This groundbreaking volume (...) helps readers understand the history, evolution, and significance of this wide-ranging, often misunderstood, and increasingly important field of study. This book is appropriate as a reference volume not only for scholars in the social foundations of education but also for scholars interested in the cultural contexts of teaching and learning. It is also appropriate as a textbook for graduate-level courses in Social Foundations of Education, School and Society, Educational Policy Studies, Cultural Studies in Education, and Curriculum and Instruction. (shrink)

La violencia de género contra las mujeres está relacionada con la desigualdad de género y se entiende que es la interrupción de cualquier forma de integridad de las mujeres. Puede ser del tipo físico, sexual, psicológico, patrimonial, económica o moral y puede ocurrir tanto en el entorno privado-familiar, como en el trabajo y los espacios públicos. La violencia de género tiene un impacto en la salud y la calidad de vida de las mujeres y puede generalizarse en entornos universitarios, lo (...) que también implica el desarrollo académico de las mujeres. El presente estudio tuvo como objetivo analizar la evidencia sobre la prevalencia de la violencia de género en estudiantes universitarias y sus factores asociados. Esta es una revisión integral de la literatura realizada en las bases de datos LILACS, PubMed, CINAHL, ERIC y ASSIA, en la que 22 artículos cumplieron con los criterios de selección. La evidencia disponible en la literatura ha indicado diferentes formas de violencia de género en mujeres universitarias perpetradas por parejas íntimas y otros agresores. La prevalencia de la violencia de género en las estudiantes universitarias informadas en los estudios varió entre el 1,3% y el 85%, difiriendo según el tipo de violencia. La violencia está asociada a factores sociales y de comportamiento, ya que las estudiantes más jóvenes tuvieron tasas más altas de violencia, así como aquellos de raza/etnia no blanca, aquellos que se identificaron como homosexuales o bisexuales y los que tenían un historial de victimización Anterior. Las pruebas sobre el uso de alcohol y otras drogas por parte de las mujeres y la participación en hermandades sociales diferían según el tipo de violencia. Por lo tanto, se concluye que la prevalencia de la violencia de género en la población de estudiantes universitarias varía según su tipificación, en su mayoría es perpetrada por hombres cercanos a ellas y está asociada con marcadores sociales. (shrink)

For years, both psychologists and the general public have been fascinated with the notion that there are gender differences in cognitive abilities; even now, flashy cover stories exploiting this idea dominate major news magazines, while research focuses on differences in verbal, mathematical, spatial, and scientific abilities across gender. This new volume in the Counterpoints series not only summarizes and addresses the validity of such research, but also questions its ideology and consequences. Why do we search so intently for these differences? (...) And what are the social and cultural implications of this relentless emphasis? Do biological mechanisms, in fact, contribute to the male-female differences in cognition? These are just a few of the questions generated by this controversial topic as it is debated throughout the book. (shrink)

This paper provides a systematic description and analysis of the non-predictive use of the Italian future. Several authors claim that, on this use, the Italian future is an evidential (Squartini 2001, Mari 2010, Eckardt and Beltrama 2019, Frana and Menéndez-Benito 2019 ). Others argue that the non-predictive future does not directly contribute an evidential signal (e.g., Giannakidou and Mari 2018, Farkas and Ippolito 2022 ). We side with the evidential camp. From an empirical standpoint, we present the results of a (...) battery of tests that show that the non-predictive future patterns with evidentials cross-linguistically. From a theoretical standpoint, we put forward an analysis that combines a slightly modified version of the proposal for evidentials in Davis et al. ( 2007 ) with Schlenker’s ( 2007 ) view of expressive content. On this account, the Italian evidential future (i) lowers the quality threshold required to perform a successful speech act (Davis et al. 2007 ) and (ii) triggers an evidential presupposition relativized to the speaker’s beliefs (modeled after Schlenker’s analysis of expressives). Our treatment of the evidential component as an expressive presupposition opens up a new perspective on the study of evidentiality and highlights the need for further detailed empirical studies exploring the extent to which this perspective is applicable cross-linguistically. (shrink)

The article regards children’s literature as a certain cultural tool. This approach enables to reveal various characteristic aspects of the poetics of children’sliterature, while relating them to children’s cognitive and cultural development. Focusing on a book series Paula’s Life by Estonian author Aino Pervik, it can beseen how two different ways of understanding — the initial, so-called mythological type of thinking of preschoolers and the emerging conceptual thinking — arecombined.The article draws mostly on the concepts of cultural psychology and (...) the authors of Tartu–Moscow school of semiotics, who have elaborated the idea thatproper names form one of the central components of mythological consciousness, the latter being comparable to “the language of proper names”. The main attention is drawn on the functioning of names and the topic of naming and categorizing in these texts. (shrink)

The article regards children’s literature as a certain cultural tool. This approach enables to reveal various characteristic aspects of the poetics of children’s literature, while relating them to children’s cognitive and cultural development. Focusing on a book series Paula’s Life by Estonian author Aino Pervik, it can be seen how two different ways of understanding — the initial, so-called mythological type of thinking of preschoolers and the emerging conceptual thinking — are combined. The article draws mostly on the concepts (...) of cultural psychology and the authors of Tartu–Moscow school of semiotics, who have elaborated the idea that proper names form one of the central components of mythological consciousness, the latter being comparable to “the language of proper names”. The main attention is drawn on the functioning of names and the topic of naming and categorizing in these texts. (shrink)

The article regards children’s literature as a certain cultural tool. This approach enables to reveal various characteristic aspects of the poetics of children’sliterature, while relating them to children’s cognitive and cultural development. Focusing on a book series Paula’s Life by Estonian author Aino Pervik, it can beseen how two different ways of understanding — the initial, so-called mythological type of thinking of preschoolers and the emerging conceptual thinking — arecombined.The article draws mostly on the concepts of cultural psychology and (...) the authors of Tartu–Moscow school of semiotics, who have elaborated the idea thatproper names form one of the central components of mythological consciousness, the latter being comparable to “the language of proper names”. The main attention is drawn on the functioning of names and the topic of naming and categorizing in these texts. (shrink)

The article regards children’s literature as a certain cultural tool. This approach enables to reveal various characteristic aspects of the poetics of children’sliterature, while relating them to children’s cognitive and cultural development. Focusing on a book series Paula’s Life by Estonian author Aino Pervik, it can beseen how two different ways of understanding — the initial, so-called mythological type of thinking of preschoolers and the emerging conceptual thinking — arecombined.The article draws mostly on the concepts of cultural psychology and (...) the authors of Tartu–Moscow school of semiotics, who have elaborated the idea thatproper names form one of the central components of mythological consciousness, the latter being comparable to “the language of proper names”. The main attention is drawn on the functioning of names and the topic of naming and categorizing in these texts. (shrink)