Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...) be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research. -/- . (shrink)

Written by an ardent spokesman for the Libertarian philosophy, this is an important book for Americans, most of whom have been steeped in the concept that their ...

The conclusion of Chrysalus' famouscanticumcomparing the successful duping of his master Nicobulus to the sack of Troy has often been suspected by critics (Plaut.Bacch.976–7):nunc Priamo nostro si est quis emptor, comptionalem senemuendam ego, uenalem quem habeo, extemplo ubi oppidum expugnauero.Now, if there's any buyer for our Priam, I'll sell as a job lot the old man, whom I have for sale as soon as I've stormed the city.The lines are condemned by Leo, Gaiser, and Jocelyn, but defended by Lefèvre and (...) printed by Lindsay, Barsby, Questa (in his first and third editions, but not his second), and most recently De Melo. In addition to qualms about the inconsistency of casting Nicobulus as Priam here when he was Ilium little over thirty lines earlier – an inconsistency which can surely be attributed to the ebullience of Chrysalus rather than the incompetence of an interpolator – the main objection to these lines is their divergence from the mythological tradition about Priam's fate at the sack of Troy. As Jocelyn puts it, ‘The threatsenem uendam… would have been ludicrous to any audience acquainted with the heroic story.’. (shrink)

Alongside other virtues like honesty, courage, integrity, and generosity, it is widely accepted that we should all strive to be humble people. But what if humility isn’t all it’s cracked up to be? Some philosophers, for example, have argued that humility can reinforce subordination and entrench exploitation. Despite some popular misconceptions, humility isn’t fundamentally about being servile. Humility doesn’t require being a doormat for whoever wants to take advantage of us. Instead, humility helps us avoid being distracted by our own (...) egos, a trait that is valuable for those from all walks of life. (shrink)

Social cognition differs from general cognition in its focus on understanding, perceiving, and interpreting social information. However, we argue that the significance of domain‐general processes for controlling cognition has been historically undervalued in social cognition and social neuroscience research. We suggest much of social cognition can be characterized as specialized feature representations supported by domain‐general cognitive control systems. To test this proposal, we develop a comprehensive working model, based on an interactive activation and competition architecture and applied to the control (...) of action. As such, we label the model “ICON” (interactive activation and competition model for the control of action). We used the ICON model to simulate human performance across various laboratory tasks. Our simulations emphasize that many laboratory‐based social tasks do not require socially specific control systems, such as those that are argued to rely on neural networks associated with theory‐of‐mind. Moreover, our model clarifies that perceived disruptions in social cognition, even in what appears to be disruption to the control of social cognition, can stem from deficits in social representation instead. We advocate for a “default stance” in social cognition, where control is usually general, but representation is specific. This study underscores the importance of integrating social cognition within the broader realm of domain‐general control processing, offering a unified perspective on task processing. (shrink)

What is compassion? I suggest that it is, as Adam Smith and David Hume once argued, a moral sentiment that is subject to a great many constraints and variations but is nonetheless “natural.” I also consider Nietzsche's rather vehement attack on Mitleid and current social psychological literature on empathy.

There seems to be no end to moralizing about the vices, but there is too little appreciation of them as mere human foibles and an essential part of the “human circus.” There are also serious questions about whether some of the so-called deadly sins are sinful at all.

Too often, since the 19th century, sensitivity is dismissed as mere “sentimentality” in philosophy and in literature. It is charged that sentimentality is distorting, self-indulgent, self-deceptive. I argue that all of these charges are misplaced or themselves distorted and betray a suspicion of emotions and the tender sentiments that is unwarranted.

Do we love for reasons? Most romantics would insist not. In fact, we love despite good reasons not to love. I argue that love necessarily involves reasons. I discuss the problem of loving someone for his or her looks and what I call Plato's Problem, loving only the properties of a person. I end by discussing some dubious and perverse reasons for love.

Spirituality is often dismissed as mere sentimentality. It is also often opposed to science and the scientific worldview, as if the one is anathema to the other. I suggest that spirituality has distinct advantages over religion and is not at all opposed to science or scientific thinking.

This book is the first complete survey and critical appraisal of the large body of research that has appeared during approximately the last decade concerning the analysis of knowing. Robert K. Shope pays special attention to the social aspects of knowing and proposes a new formulation of the fundamental structure of the Gettier problem. Originally published in 1983. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton (...) University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

In “Conditions and Analyses of Knowledge”, Robert Shope focuses on the conditions that must be satisfied for a person to have knowledge, specifically knowledge that something is so. Traditionally, knowledge has been analyzed in terms of justified true belief. Shope addresses philosophers’ disagreements concerning the truth and belief conditions. After introducing the justification condition, he presents challenges that have provoked several attempts to replace or to supplement the justification condition for knowledge. Shope presents and assesses several of these, including (...) early causal theories, the nonaccidentality requirement, reliable process and conditional analyses, the reliable‐indicator analysis, the conclusive reasons analysis, defeasibility analyses, analyses in terms of cognitive or intellectual virtues, and proper functionalism as well as his own account of knowledge. (shrink)

In order to appreciate the contributions of Star Noise: Discovering the Radio Universe, a little history will help. At the end of the nineteenth century, astronomy consisted of two branches, `posit...

A bridge between semipopular works for the general reader and technical treatises written for specialists, this excellent work discusses the foundational ideas and background of modern physics. It is not a text on theoretical physics, but a discussion of the methods of physic description and construction of theory. As such, it is especially valuable for the physicist with a background in elementary calculus who is interested in the ideas which give meaning to the data and tools of modern physics.

Galen Strawson (2004) has championed an influential argument against the view that a life is, or ought to be, understood as a kind of story with temporal extension. The weight of his argument rests on his self-report of his experience of life as lacking the form or temporal extension necessary for narrative. And though this argument has been widely accepted, I argue that it ought to have been rejected. On one hand, the hypothetical non-diachronic life Strawson proposes would likely be (...) psychologically fragmented. On the other, it would certainly be morally diminished, for it would necessarily lack the capacity for integrity. (shrink)

The paper offers an analysis of Protagoras’ fr. DK 80 B 1 and rejects the traditional reading of Protagoras as relativist. By considering the ipsissima verba that Protagoras makes use of in his passage, it is argued that alternative interpretations are possible, of which epistemological reism and psychological individualism are proposed. On a more general level, it is discussed to what extent Protagoras’ fragment contains descriptive rather than normative claim.

Current research in affectivity is often dominated by perspectives on the feeling/thinking dichotomy. In the paper first I reconstruct Collingwood’s position on this point as it is presented in his Religion and Philosophy, The Principles of Art, and New Leviathan, and then compare it shortly with Bergson’s view. In total five of Collingwood’s different readings of the feeling/thought relation are brought to light. Finally, I opt for a view that takes feeling and thought to be complementary and inseparable, and I (...) try to explain why and how they are better treated in this way. (shrink)