The nuclear pore complex (NPC) is emerging as a center for recruitment of a class of “difficult to repair” lesions such as double‐strand breaks without a repair template and eroded telomeres in telomerase‐deficient cells. In addition to such pathological situations, a recent study by Su and colleagues shows that also physiological threats to genome integrity such as DNA secondary structure‐forming triplet repeat sequences relocalize to the NPC during DNA replication. Mutants that fail to reposition the triplet repeat locus to the (...) NPC cause repeat instability. Here, we review the types of DNA lesions that relocalize to the NPC, the putative mechanisms of relocalization, and the types of recombinational repair that are stimulated by the NPC, and present a model for NPC‐facilitated repair. (shrink)

I hope to demonstrate the value of a close reading Williams’s ‘Internal and External Reasons’, and to provide a theory of error regarding the substantial body of work which seeks to, in various ways, defang the essay. I do this by providing some historical context for the paper, and sketching where, historically, internalism and certain sorts of moral realism became separated. It will likely not surprise the reader when I suggest that the modern scientific worldview has an important place in (...) the discussion of the notion of external reasons. As mind, motivation, and perception have become less opaque to us, certain avenues for explaining our reasons have come closer to relying on hypotheses which may turn out to be falsifiable, and have thus been abandoned. What may come as more of a surprise is my suggestion that modern egalitarianism is an important factor as well. I suggest that impersonal reason has been used as an (implausible, but perhaps well-intentioned) alternative to the practice of some inflicting their reasons on others. (shrink)

Esta reseña invita a la lectura del ensayo de Dorte Katrin Jansen, dramaturga e investigadora teatral, quien presenta una cartografía de las dramaturgas mexicanas de mediados del siglo pasado hasta su fecha de publicación en 2018. Toma como punto de partida el trabajo de Elena Garro, Luisa Josefina Hernández y Sabina Berman para continuar con los procesos de más de ciento cincuenta dramaturgas. El esfuerzo de la autora por distinguir a las creadoras de acuerdo con su lugar de enunciación, así (...) como, la diferenciación entre escritura de las mujeres, femenina y feminista son tan solo algunos de los aportes que subrayo como relevantes en esta reseña. Con este trabajo la autora obtuvo el Premio Internacional de Ensayo Teatral. (shrink)

Much of cognitive science is committed to the modular approach to the study of cognition. The core of this approach consists of a pair of assumptions - the anatomical and the functional modularity assumptions - which motivate two kinds of inference: the anatomical and the functional modularity inferences. The legitimacy of both of these inferences has been strongly challenged, a situation that has had surprisingly little impact on most theorizing in the field. Following the introduction of an important, yet rarely (...) made, distinction between two functional concepts - the distinction between cognitive working and cognitive role - this paper analyses these kinds of inference, and refocuses the attention on new aspects of their main limitations. It is argued that both the anatomical and functional modularity inferences can, and do, operate in three distinct modes in contemporary cognitive science, and that seeing this is essential to understanding both the power and the limitations of these methodological tools. (shrink)

Introduction Il s’agit d’étudier, dans ce volume, dans quelle mesure le nom propre s’intègre à une classe de mots, celle des noms, et ce, tant par ce qu’il est, que par les limites qui le contienne, le cas échéant. La réflexion sera fondée sur les langues française et anglaise, deux langues suffisamment proches pour pouvoir soutenir une comparaison tout en présentant des particularités susceptibles de faire apparaître des traits remarquables. Dans ces langues, en quoi le nom propre est-il un...

Despite the multidisciplinary dimension of the kinds of research conducted under the umbrella of synthetic biology, the US-based founders of this new research area adopted a disciplinary profile to shape its institutional identity. In so doing they took inspiration from two already established fields with very different disciplinary patterns. The analogy with synthetic chemistry suggested by the term ‘synthetic biology’ is not the only model. Information technology is clearly another source of inspiration. The purpose of the paper, with its focus (...) on the US context, is to emphasize the diversity of views and agendas coexisting under the disciplinary label synthetic biology, as the two models analysed are only presented as two extreme postures in the community. The paper discusses the question: in which directions the two models shape this emerging field? Do they chart two divergent futures for synthetic biology? (shrink)

An important task in mathematical sciences is to make quantitative predictions, which is often done via the solution of differential equations. In this paper, we investigate why, to perform this task, scientists sometimes choose to use numerical methods instead of analytical solutions. Via several examples, we argue that the choice for numerical methods can be explained by the fact that, while making quantitative predictions seems at first glance to be facilitated by analytical solutions, this is actually often much easier with (...) numerical methods. Thus we challenge the widely presumed superiority of analytical solutions over numerical methods. (shrink)

Recent studies have shown that self‐explanation is an effective metacognitive strategy, but how can it be leveraged to improve students' learning in actual classrooms? How do instructional treatments that emphasizes self‐explanation affect students' learning, as compared to other instructional treatments? We investigated whether self‐explanation can be scaffolded effectively in a classroom environment using a Cognitive Tutor, which is intelligent instructional software that supports guided learning by doing. In two classroom experiments, we found that students who explained their steps during problem‐solving (...) practice with a Cognitive Tutor learned with greater understanding compared to students who did not explain steps. The explainers better explained their solutions steps and were more successful on transfer problems. We interpret these results as follows: By engaging in explanation, students acquired better‐integrated visual and verbal declarative knowledge and acquired less shallow procedural knowledge. The research demonstrates that the benefits of self‐explanation can be achieved in a relatively simple computer‐based approach that scales well for classroom use. (shrink)

Uffink and Valente claim that there is no time-asymmetric ingredient that, added to the Hamiltonian equations of motion, allows to obtain the Boltzmann equation within the Lanford’s derivation. This paper is a discussion and a reply to that analysis. More specifically, I focus on two mathematical tools used in this derivation, viz. the Boltzmann–Grad limit and the incoming configurations. Although none of them are time-asymmetric ingredients, by themselves, I claim that the use of incoming configurations, as taken within the B–G (...) limit, is such a time-asymmetric ingredient. Accordingly, this leads to reconsider a kind of Stoßzahlansatz within Lanford’s derivation. (shrink)

Direct brain intervention based mental capacity restoration techniques-for instance, psycho-active drugs-are sometimes used in criminal cases to promote the aims of justice. For instance, they might be used to restore a person's competence to stand trial in order to assess the degree of their responsibility for what they did, or to restore their competence for punishment so that we can hold them responsible for it. Some also suggest that such interventions might be used for therapy or reform in criminal legal (...) contexts-i.e. to make non-responsible and irresponsible people more responsible. However, I argue that such interventions may at least sometimes fail to promote these responsibility-related legal aims. This is because responsibility hinges on other factors than just what mental capacities a person has-in particular, it also hinges on such things as authenticity, personal identity, and mental capacity ownership-and some ways of restoring mental capacity may adversely affect these other factors. Put one way, my claim is that what might suffice for the restoration of competence need not necessarily suffice for the restoration of responsibility, or, put another way, that although responsibility indeed tracks mental capacity it may not always track restored mental capacities. (shrink)

In this paper, I present a discrete solution for the paradox of Achilles and the tortoise. I argue that Achilles overtakes the tortoise after a finite number of steps of Zeno’s argument if time is represented as discrete. I then answer two objections that could be made against this solution. First, I argue that the discrete solution is not an ad hoc solution. It is embedded in a discrete formulation of classical mechanics. Second, I show that the discrete solution cannot (...) be falsified experimentally. (shrink)

How do people make sense of their experiences? How do they understand possibility? How do they limit possibility? These questions are central to all the human sciences. Here, Vincent Crapanzano offers a powerfully creative new way to think about human experience: the notion of imaginative horizons. For Crapanzano, imaginative horizons are the blurry boundaries that separate the here and now from what lies beyond, in time and space. These horizons, he argues, deeply influence both how we experience our lives (...) and how we interpret those experiences, and here sets himself the task of exploring the roles that creativity and imagination play in our experience of the world. (shrink)

This paper studies some model-theoretic properties of special groups of finite type. Special groups are a first-order axiomatization of the algebraic theory of quadratic forms, introduced by Dickmann and Miraglia, which is essentially equivalent to abstract Witt rings. More precisely, we consider elementary equivalence, saturation, elementary embeddings, quantifier elimination, stability and Morley rank.

"Public engagement in science" is one of the buzzwords that, since 2000, has been used in nanotechnology programs. To what extent does public engagement disrupt the traditional relations between science and the public? This paper briefly contrasts the traditional model of science communication - the diffusionist model - that prevailed in the twentieth century and the new model - the participatory model - that tends to prevail nowadays. Then it will try to disentangle the assumptions underlying the public dialogue initiated (...) about nanotechnology, and conclude that nanotechnology actually develops a managerial model of society. (shrink)

This is a discussion of the reaction to the recent research article publication in the journal Protein & Cell by a group of scientists at Sun Yat-sen University using the CRISPR/Cas9 technique on editing non-viable human zygotes. Many commentators condemned the Chinese scientists for overstepping ethical boundaries long accepted in Western countries and accused China of having lax regulations on genomic research in general. We argue that not only did this research follow strict ethical standards and fully comply with current (...) regulations, but China also has a well-developed regulatory framework governing such research comparable to many developed countries. We see the reactions among Western commentators as a misunderstanding of the current situation and an expression of a lack of willingness to acknowledge China as an equal partner in the international debate about proper limits to the development of new biotechnologies. (shrink)

V članku so proučene odločitve Meddržavnega sodišča v Haagu, kjer je imela Srbija položaj stranke v postopku, in sicer je nastopala tako v vlogi tožeče kakor tožene stranke. V obravnavanih zadevah je bila pravdna sposobnost Srbije večkrat izpodbijana, odgovori Sodišča pa so sprožili številne polemike. Avtor se s strnjeno predstavitvijo sodb loti razčlembe sodniškega razlogovanja in tako poskuša razumeti, kako je Sodišče za obdobje med letoma 1992 in 2000 lahko prišlo do nasprotujočih si rešitev glede vprašanja dostopa Srbije do Sodišča. (...) Članek je nastal v okviru konference Centra za raziskave temeljnih pravic in razvoj prava in je bil predstavljen 27. maja 2010 na Univerzi v Caen-u. Avtor se zahvaljuje Marie Rota za njene nasvete. (shrink)

L'article analyse la compréhension biranienne de la volonté chez Descartes. Pour Biran, Descartes aurait confondu le désir et la volonté, c'est-à-dire la passivité et l'activité. L'article examine au préalable la lecture biranienne des conceptions condilla-cienne et malebranchienne de la volonté. L'occasionnalisme est critiqué par Biran au motif qu'il en viendrait à méconnaître l'évidence de sentiment qui est celle de notre pouvoir sur le corps. Quant au doute cartésien, Biran soutient qu'il ne peut être véritablement soutenu compte tenu de notre incarnation. (...) Il souligne par ailleurs que la conception cartésienne du choix nous éloigne d'une véritable saisie de la volonté, en raison de la passité de l'intellect cartésien. Pour Biran, l'infinité de la volonté n'est en réalité que celle d'une aspiration sans limite déterminée. (shrink)

Abstract.We use a model theoretic approach to investigate properties of local-global principles for positive primitive formulas in spaces of orderings, such as the existence of bounds and the axiomatizability of local-global principles. As a consequence we obtain various classes of special groups satisfying local-global principles for all positive primitive formulas, and we show that local-global principles are preserved by some natural constructions in special groups.

Chemistry deserves more philosophical attention not so much to do justice to a long-neglected science or to enhance its cultural prestige, but to undermine a number of taken-for-granted assumptions about scientific rationality and more importantly to diversify our metaphysical views of nature and reality. In brief, this paper does not make the case for a philosophy of chemistry. It rather urges philosophers of science to listen to chemists and discuss what they learn from them. Because over the course of many (...) centuries chemists have developed a special access to nature and a special way of investigating and dealing with material substances, they have confronted a number of epistemological and ontological issues that are worth discussing. Following critical remarks about the disciplinary partition of philosophy, a historical section presents the contributions to philosophy of a few French twentieth-century chemists-turned philosophers to emphasize how they have challenged the dominant philosophical categories. The final section develops one of the lessons that philosophers can learn from chemists: to pay attention to things, to their materiality and activity in order to develop new ontological perspectives. (shrink)

How do people make sense of their experiences? How do they understand possibility? How do they limit possibility? These questions are central to all the human sciences. Here, Vincent Crapanzano offers a powerfully creative new way to think about human experience: the notion of imaginative horizons. For Crapanzano, imaginative horizons are the blurry boundaries that separate the here and now from what lies beyond, in time and space. These horizons, he argues, deeply influence both how we experience our lives (...) and how we interpret those experiences, and here sets himself the task of exploring the roles that creativity and imagination play in our experience of the world. (shrink)

How many words—and which ones—are sufficient to define all other words? When dictionaries are analyzed as directed graphs with links from defining words to defined words, they reveal a latent structure. Recursively removing all words that are reachable by definition but that do not define any further words reduces the dictionary to a Kernel of about 10% of its size. This is still not the smallest number of words that can define all the rest. About 75% of the Kernel turns (...) out to be its Core, a “Strongly Connected Subset” of words with a definitional path to and from any pair of its words and no word's definition depending on a word outside the set. But the Core cannot define all the rest of the dictionary. The 25% of the Kernel surrounding the Core consists of small strongly connected subsets of words: the Satellites. The size of the smallest set of words that can define all the rest—the graph's “minimum feedback vertex set” or MinSet—is about 1% of the dictionary, about 15% of the Kernel, and part-Core/part-Satellite. But every dictionary has a huge number of MinSets. The Core words are learned earlier, more frequent, and less concrete than the Satellites, which are in turn learned earlier, more frequent, but more concrete than the rest of the Dictionary. In principle, only one MinSet's words would need to be grounded through the sensorimotor capacity to recognize and categorize their referents. In a dual-code sensorimotor/symbolic model of the mental lexicon, the symbolic code could do all the rest through recombinatory definition. (shrink)

Je propose d’analyser une pratique de la recherche en mathématiques constructives, celle qui consiste à reformuler constructivement les théories physiques. Je discute plus précisément trois aspects de cette pratique. Je montre d’abord que celle-ci a la particularité d’être motivée par des considérations philosophiques et comment la physique est utilisée pour arbitrer un débat de philosophie des mathématiques entre constructivisme et classicisme. Ensuite, j’identifie la méthodologie de la recherche en mathématiques que cette pratique implique et montre qu’il s’agit, selon une terminologie (...) empruntée à Poincaré, d’une méthodologie de « logiciens ». Enfin, je montre que dans cette pratique, les théories physiques ont un rôle heuristique sur le développement des mathématiques constructives. Elles permettent avec succès de stimuler la recherche d’énoncés constructifs et d’orienter la recherche en mathématiques constructives vers de nouveaux domaines. (shrink)

Epistemic logic begins with the recognition that our everyday talk about knowing and believing has some systematic features that we can track and re‡ect upon. Epistemic logicians have studied and extended these glints of systematic structure in fascinating and important ways since the early 1960s. However, for one reason or another, mainstream epistemologists have shown little interest. It is striking to contrast the marginal role of epistemic logic in contemporary epistemology with the centrality of modal logic for metaphysicians. This article (...) is intended to help in correcting this oversight by presenting some important developments in epistemic logic and suggesting ways to understand their applicability to traditional epistemological problems. Obviously, by itself, tweaking the formal apparatus of epistemic logic does not solve traditional epistemological problems. Epistemic logic can help us to navigate through problems in a systematic fashion by unpacking the logic of the problematic concepts, it can also lead us to recognize problems that we had not anticipated. This is basically analogous to the role that modal logic has played in contemporary metaphysics. (shrink)

Epistemic logic is the logic of knowledge and belief. It provides insight into the properties of individual knowers, has provided a means to model complicated scenarios involving groups of knowers and has improved our understanding of the dynamics of inquiry.

James Prescott Joule’s (1818–1889) bicentenary took place in 2018 and commemorated by the IDTC with a Symposium—‘James Joule’s Bicentenary: Scientific and Pedagogical Issues Concerning Energy Conservation’—at the European Society for the History of Science (ESHS & BSHS), 14th–17th September, 2018, in London. This symposium had three main objectives: It aimed specifically to celebrate James Joule’s achievements considering the most recent historiographical works with a particular focus on the principle of conservation of energy; It served the purpose of discussing the scientific (...) and pedagogical issues related to heat, energy and work and how they are presented in textbooks and worked out in classrooms; It also provided discussions on the present situation of teaching and learning science through the use of History of Science, both in K-12 and college level with an emphasis on energy and related concepts. In the following, the Introduction of this Special Issue on Joule is presented. (shrink)

" Où placez-vous l'esprit? " demandons-nous aux philosophes qui nous parlent du mental. Or il y a deux réponses qui s'offrent à nous dedans, selon les héritiers mentalistes de Descartes, de Locke, de Hume et de Maine de Biran, héritiers parmi lesquels on peut compter les phénoménologues et les cognitivistes ; dehors, selon les philosophes de l'esprit objectif et de l'usage public des signes, comme l'ont soutenu par exemple Peirce et Wittgenstein. Mon propos dans ce livre est double. Il est (...) d'abord de soutenir la thèse de l'extériorité de l'esprit : l'esprit doit être placé dehors, dans les échanges entre les personnes, plutôt que dedans, dans un flux interne de représentations. Il est ensuite d'apprécier la différence entre ces deux réponses du point de vue des sciences morales, ou " sciences de l'esprit ". Cela permet de considérer dans des termes nouveaux la controverse sur les sciences humaines qui n'a pas cessé pendant tout ce siècle : herméneutique contre positivisme, philosophie du sujet contre structuralisme, individualisme méthodologique contre holisme du mental. (shrink)

Skeptics argue that the acquisition of knowledge is impossible given the standing possibility of error. We present the limiting convergence strategy for responding to skepticism and discuss the relationship between conceivable error and an agent’s knowledge in the limit. We argue that the skeptic must demonstrate that agents are operating with a bad method or are in an epistemically cursed world. Such demonstration involves a significant step beyond conceivability and commits the skeptic to potentially convergent inquiry.

Rivers stopped or flowing backward -- Harmony, number, and others --Twentieth-Century measures.

I ARGUE IN THIS PAPER that there are profound and legitimate worries concerning the application of organic and personal criteria to groups. I try to specify the reasons why we object to such ideas, while contending that some of these objections are misguided. Primarily, to refer to a group as a person is not necessarily the same as referring to it as either organic or as an individual. Further, each term--organic, individual, and person--must be carefully unpacked and analyzed. One conclusion (...) of this analysis is that there are important senses in which these concepts both overlap and also diverge. One should not therefore automatically conflate them. Another conclusion is that there are senses of these terms which are perfectly innocuous. Finally, there are clearly ways in which we can sensibly use the notion of personality to apply to groups. The groups in question are usually diverse, and do not have to include the state. In fact, despite the absence of such "group person" usage from mainstream political theory, such language is more of a commonplace in international politics and legal discourse and practice. I attempt, in the final part of the paper, to schematize the various uses of personality. I conclude by suggesting the fruitfulness of one particular sense of juristic personality. (shrink)

Positive Polarity indefinites, such as some in English, are licensed in simplex negative sentences as long as they take wide scope over negation. When it surfaces under a clausemate negation, some can in principle take wide scope either by movement or by some semantic mechanism; e.g., it can take pseudoscope if it is interpreted as a choice function variable. Therefore, there is some uncertainty regarding the way in which PPI indefinites get licensed: can pseudoscope suffice? In this article we show, (...) using novel data from Hindi-Urdu and English, that pseudoscope is not sufficient, and that it is the syntactic position of PPI indefinites at LF, rather than their actual scope, which is relevant for licensing. These facts support a unified view of PPI indefinites as generalized quantifiers, and disfavor analyses where they are, or can be, interpreted as choice function variables. (shrink)

ArgumentThe interwar period in France is characterized by intense activity to disseminate science in society through various media: magazines, conferences, book series, encyclopedias, radio, exhibitions, and museums. In this context, the scientific community developed significant attempts to disseminate science in close alliance with the State. This paper presents three ambitious projects conducted in the 1930s which targeted different audiences and engaged the social sciences along with the natural sciences. The first project was a multimedia enterprise aimed at bridging what would (...) later be named “the two cultures” – natural sciences and humanities – rather than at popularizing scientific results in the society at large. The second project, an encyclopedia namedEncyclopédie françaiseedited by the French historian Lucien Febvre, was meant to shape a cultural view of science for the general public. The third project and the most successful enterprise was thePalais de la découvertedesigned by the physicist Jean Perrin and explicitly aimed at attracting the young public. This paper explores the paradoxes that resulted from these large enterprises. Despite their social ideals, the scientists-popularizers favored an elitist concept of popular science essentially aimed at integrating science into high culture. While they strove to overcome the increased specialization of sciences, their efforts nevertheless accelerated the professionalization of scientific research and the isolation of science in an ivory tower. In their attempts to get closer to the public, they eventually contributed to spreading the cliché of the increasing gap between the scientists and the public. (shrink)

Abstract: Pluralistic ignorance is a nasty informational phenomenon widely studied in social psychology and theoretical economics. It revolves around conditions under which it is "legitimate" for everyone to remain ignorant. In formal epistemology there is enough machinery to model and resolve situations in which pluralistic ignorance may arise. Here is a simple first stab at recovering from pluralistic ignorance by means of knowledge transmissibility.