Results for 'nonsense‐mediated decay'

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  1.  3
    Nonsense‐mediated decay: paving the road for genome diversification.Francisco Sánchez-Sánchez & Sibylle Mittnacht - 2008 - Bioessays 30 (10):926-928.
    The expression of protein‐encoding genes is a complex process culminating in the production of mature mRNA and its translation by the ribosomes. The production of a mature mRNA involves an intricate series of processing steps. The majority of eukaryotic protein‐encoding genes contain intron sequences that disrupt the protein‐encoding frame, and hence have to be removed from immature mRNA prior to translation into protein. The mechanism involved in the selection of correct splice sites is incompletely understood. A considerable body of evidence (...)
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  2.  3
    Nonsense‐mediated RNA decay: A molecular system micromanaging individual gene activities and suppressing genomic noise.Claudio R. Alonso - 2005 - Bioessays 27 (5):463-466.
    Nonsense‐mediated RNA decay (NMD) is an evolutionary conserved system of RNA surveillance that detects and degrades RNA transcripts containing nonsense mutations. Given that these mutations arise at a relatively low frequency, are there any as yet unknown substrates of NMD in a wild‐type cell? With this question in mind, Mendell et al.1 have used a microarray assay to identify those human genes under NMD regulation. Their results show that, in human cells, NMD regulates hundreds of physiologic transcripts and (...)
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  3.  9
    Nonsense‐mediated RNA decay – a switch and dial for regulating gene expression.Jenna E. Smith & Kristian E. Baker - 2015 - Bioessays 37 (6):612-623.
    Nonsense‐mediated RNA decay (NMD) represents an established quality control checkpoint for gene expression that protects cells from consequences of gene mutations and errors during RNA biogenesis that lead to premature termination during translation. Characterization of NMD‐sensitive transcriptomes has revealed, however, that NMD targets not only aberrant transcripts but also a broad array of mRNA isoforms expressed from many endogenous genes. NMD is thus emerging as a master regulator that drives both fine and coarse adjustments in steady‐state RNA levels (...)
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  4.  9
    Unusual SMG suspects recruit degradation enzymes in nonsense‐mediated mRNA decay.Agathe Gilbert & Cosmin Saveanu - 2022 - Bioessays 44 (5):2100296.
    Degradation of eukaryotic RNAs that contain premature termination codons (PTC) during nonsense‐mediated mRNA decay (NMD) is initiated by RNA decapping or endonucleolytic cleavage driven by conserved factors. Models for NMD mechanisms, including recognition of PTCs or the timing and role of protein phosphorylation for RNA degradation are challenged by new results. For example, the depletion of the SMG5/7 heterodimer, thought to activate RNA degradation by decapping, leads to a phenotype showing a defect of endonucleolytic activity of NMD complexes. (...)
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  5.  5
    Exaptive origins of regulated mRNA decay in eukaryotes.Fursham M. Hamid & Eugene V. Makeyev - 2016 - Bioessays 38 (9):830-838.
    Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense‐mediated decay (NMD) and motif‐specific transcript destabilization by CCCH‐type zinc finger RNA‐binding proteins, originated as a part of cellular defense against RNA pathogens. These branches of the mRNA turnover pathway might have been used by primeval eukaryotes alongside RNA interference to distinguish their own messages from (...)
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  6.  4
    RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.Terra-Dawn M. Plank & Miles F. Wilkinson - 2018 - Bioessays 40 (1):1700170.
    The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro-muscle transcription factor: MYOD. UPF1 achieves this through its RING-like domain, which confers ubiquitin E3 ligase activity. Feng et al. provide evidence that the ability of UPF1 to destabilize MYOD represses myogenesis. In the future, it will be important (...)
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  7.  9
    RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.Terra-Dawn M. Plank & Miles F. Wilkinson - 2018 - Bioessays 40 (1):1700170.
    The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro-muscle transcription factor: MYOD. UPF1 achieves this through its RING-like domain, which confers ubiquitin E3 ligase activity. Feng et al. provide evidence that the ability of UPF1 to destabilize MYOD represses myogenesis. In the future, it will be important (...)
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  8.  8
    Intron retention in mRNA: No longer nonsense.Justin J.-L. Wong, Amy Y. M. Au, William Ritchie & John E. J. Rasko - 2016 - Bioessays 38 (1):41-49.
    Until recently, retention of introns in mature mRNAs has been regarded as a consequence of mis‐splicing. Intron‐retaining transcripts are thought to be non‐functional because they are readily degraded by nonsense‐mediated decay. However, recent advances in next‐generation sequencing technologies have enabled the detection of numerous transcripts that retain introns. As we review herein, intron‐retaining mRNAs play an essential conserved role in normal physiology and an emergent role in diverse diseases. Intron retention should no longer be overlooked as a key (...)
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  9.  5
    Introns in UTRs: Why we should stop ignoring them.Alicia A. Bicknell, Can Cenik, Hon N. Chua, Frederick P. Roth & Melissa J. Moore - 2012 - Bioessays 34 (12):1025-1034.
    Although introns in 5′‐ and 3′‐untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3′‐UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense‐mediated decay (NMD). Nonetheless, recent findings indicate that 5′‐ and 3′‐UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.
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  10.  9
    The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression.Ying Ge & Bo T. Porse - 2014 - Bioessays 36 (3):236-243.
    The explosion in sequencing technologies has provided us with an instrument to describe mammalian transcriptomes at unprecedented depths. This has revealed that alternative splicing is used extensively not only to generate protein diversity, but also as a means to regulate gene expression post‐transcriptionally. Intron retention (IR) is overwhelmingly perceived as an aberrant splicing event with little or no functional consequence. However, recent work has now shown that IR is used to regulate a specific differentiation event within the haematopoietic system by (...)
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  11.  2
    Repressing the neuron within.Will Fairbrother & Diane Lipscombe - 2008 - Bioessays 30 (1):1-4.
    A myriad of coordinated signals control cellular differentiation. Reprogramming the cell's proteome drives global changes in cell morphology and function that define cell phenotype. A switch in alternative splicing of many pre‐mRNAs encoding neuronal‐specific proteins accompanies neuronal differentiation. Three groups recently showed that the global splicing repressor, polypyrimidine track‐binding protein (PTB), regulates this switch.1-3 Although a subset of neuronal genes are turned on in both non‐neuronal and neuronal cells, restricted expression of PTB in non‐neuronal cells diverts their mRNAs to (...) decay and prevents protein expression. When the PTB brake is released, the cell splices like a neuron. BioEssays 30:1–4, 2008. © 2007 Wiley Periodicals, Inc. (shrink)
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  12.  3
    Multifunctional regulatory proteins that control gene expression in both the nucleus and the cytoplasm.Miles F. Wilkinson & Ann-Bin Shyu - 2001 - Bioessays 23 (9):775-787.
    The multistep pathway of eukaryotic gene expression involves a series of highly regulated events in the nucleus and cytoplasm. In the nucleus, genes are transcribed into pre‐messenger RNAs which undergo a series of nuclear processing steps. Mature mRNAs are then transported to the cytoplasm, where they are translated into protein and degraded at a rate dictated by transcript‐ and cell‐type‐specific cues. Until recently, these individual nuclear and cytoplasmic events were thought to be primarily regulated by different RNA‐ and DNA‐binding proteins (...)
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  13. Meillassoux’s Virtual Future.Graham Harman - 2011 - Continent 1 (2):78-91.
    continent. 1.2 (2011): 78-91. This article consists of three parts. First, I will review the major themes of Quentin Meillassoux’s After Finitude . Since some of my readers will have read this book and others not, I will try to strike a balance between clear summary and fresh critique. Second, I discuss an unpublished book by Meillassoux unfamiliar to all readers of this article, except those scant few that may have gone digging in the microfilm archives of the École normale (...)
     
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  14.  5
    The Decay of the Aura and Social Transformation through the Mediatization of Sport: Benjamin's theory of technological reproducibility through the lens of Simmel's theory of perceptionスポーツのメディア化によるアウラの凋落と社会変容:ジンメルの知覚論から見たベンヤミンの複製芸術論.Futoshi Kamasaki - 2020 - Journal of the Philosophy of Sport and Physical Education 42 (1):19-32.
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  15.  7
    Nonsense: cultural mediations on the beyond.Kuang-Ming Wu - 2012 - New York: Nova Science Publishers.
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  16.  2
    The Other Face of an Editor: ADAR1 Functions in Editing-Independent Ways.Konstantin Licht & Michael F. Jantsch - 2017 - Bioessays 39 (11):1700129.
    The RNA editing enzyme ADAR1 seemingly has more functions besides RNA editing. Mouse models lacking ADAR1 and sensors of foreign RNA show that RNA editing by ADAR1 plays a crucial role in the innate immune response. Still, RNA editing alone cannot explain all observed phenotypes. Thus, additional roles for ADAR1 must exist. Binding of ADAR1 to RNA is independent of its RNA editing function. Thus, ADAR1 may compete with other RNA-binding proteins. A very recent manuscript elaborates on this and reports (...)
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  17.  3
    The semantic mediation of evaluative meaning.Francis J. Di Vesta & Donald O. Stover - 1962 - Journal of Experimental Psychology 64 (5):467.
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  18.  2
    A large Hilbert space QRPA and RQRPA calculation of neutrinoless double beta decay.F. Ŝimkovic, J. Schwieger, G. Pantis & Amand Faessler - 1997 - Foundations of Physics 27 (9):1275-1289.
    A large Hilbert space is used for the calculation of the nuclear matrix elements governing the light neutrino mass mediated mode of neutrinoless double beta decay (Ovββ-decay) of76Ge,100Mo,116Cd,128Te, and136Xe within the proton-neutron quasiparticle random phase approximation (pn-QRPA) and the renormalized QRPA with proton-neutron pairing (full-RQRPA) methods. We have found that the nuclear matrix elements obtained with the standard pn-QRPA for several nuclear transitions are extremely sensitive to the renormalization of the particle-particle component of the residual interaction of the (...)
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  19.  11
    Implicit and explicit mediation in paired-associate learning.Randall B. Martin & Sanford J. Dean - 1964 - Journal of Experimental Psychology 68 (1):21.
  20.  9
    The Nexus Between Human Resource Management Practices and Service Recovery Performance in Takaful Insurance Industry in Pakistan: The Mediating Role of Employee Commitment.Jie Mao, Saeed Siyal, Munawer Javed Ahmed, Riaz Ahmad, Chunlin Xin & Samina Qasim - 2022 - Frontiers in Psychology 12.
    Service recovery performance is very important for the takaful insurance industry for maintaining and attracting new clients, which in turn serves as a competitive advantage for the survival and continued future of the businesses. If the insurance sector could not maintain SRP, then the competitive advantage of the organizations could be decayed. Therefore, under the theoretical foundation of equity theory and resource-based theory, this research has investigated the link between human resources management practices and SRP directly and indirectly through the (...)
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  21.  5
    Deubiquitinating Enzymes in Model Systems and Therapy: Redundancy and Compensation Have Implications.Sarah Zachariah & Douglas A. Gray - 2019 - Bioessays 41 (11):1900112.
    The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently proposed (...)
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  22. Supporting Solidarity.Claire Moore, Ariadne Nichol & Holly Taylor - 2023 - Voices in Bioethics 9.
    Photo ID 72893750 © Rawpixelimages|Dreamstime.com ABSTRACT Solidarity is a concept increasingly employed in bioethics whose application merits further clarity and explanation. Given how vital cooperation and community-level care are to mitigating communicable disease transmission, we use lessons from the COVID-19 pandemic to reveal how solidarity is a useful descriptive and analytical tool for public health scholars, practitioners, and policymakers. Drawing upon an influential framework of solidarity that highlights how solidarity arises from the ground up, we reveal how structural forces can (...)
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  23.  56
    A Revolutionary New Metaphysics, Based on Consciousness, and a Call to All Philosophers.Lorna Green - manuscript
    June 2022 A Revolutionary New Metaphysics, Based on Consciousness, and a Call to All Philosophers We are in a unique moment of our history unlike any previous moment ever. Virtually all human economies are based on the destruction of the Earth, and we are now at a place in our history where we can foresee if we continue on as we are, our own extinction. As I write, the planet is in deep trouble, heat, fires, great storms, and record flooding, (...)
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  24.  45
    Dissipating the Logogram.Alistair Welchman - 1995 - Parallax 1 (1):67-80.
    Three thoughts of culture: (1) the logogram: high-level software, the ROM BIOS of civilisation, the ‘best that has ever been thought and written’ (Matthew Arnold), secular theology, social phylum, explicitly ideal rampart against philistine disaggregation and the entropy of commodification, desperate and universal cognitive erection in the face of the massive loss of integrity brought about by capital; (2) the decay of the logogram: low-level shoring-up routine, localised resistance mediated through patchy and fragmented attempts at reconstitution, quotidian custom and (...)
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  25.  92
    On the nature of the Higgs boson.Damiano Anselmi - 2019 - Mod. Phys. Lett. A 34.
    Several particles are not observed directly, but only through their decay products. We consider the possibility that they might be fakeons, i.e. fake particles, which mediate interactions but are not asymptotic states. A crucial role to determine the true nature of a particle is played by the imaginary parts of the one-loop radiative corrections, which are affected in nontrivial ways by the presence of fakeons in the loop. The knowledge we have today is sufficient to prove that most non (...)
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  26.  7
    Thermodynamic Theory for Simple and Complex Dissipative Structures.Pallavi Rastogi & Shripad P. Mahulikar - 2021 - Foundations of Physics 51 (3):1-19.
    Dissipative structures exist at all scales, systems, and at different levels of complexity. A thermodynamic theory integrating simple and complex DS is introduced, which addresses existence of growing/decaying DS based on their entropy analysis. Two entropy-based dimensionless ratios are introduced, which explain negentropy-debt payment and existence of DS with growth or decay. It is shown that excess negentropy debt payment is needed and beneficial for growing DS; but for decaying DS, it hastens its approach to perish and is counter-productive. (...)
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  27.  8
    What the digital world leaves behind: reiterated analogue traces in Mexican media art.David M. J. Wood - 2021 - AI and Society:1-10.
    How might experimental media art help theorise what falls by the wayside in the digital public sphere? Working in the years immediately following the launch of YouTube in 2005, some media artists centred their creative praxis towards the end of that decade upon rescuing, revalorising, and placing back into digital circulation audiovisual media formats and technologies that appeared aged or obsolete. Although there may be a degree of nostalgia behind such practices, these artworks articulate a cogent critique of the drive (...)
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  28. Gonzo Strategies of Deceit: An Interview with Joaquin Segura.Brett W. Schultz - 2011 - Continent 1 (2):117-124.
    Joaquin Segura. Untitled (fig. 40) . 2007 continent. 1.2 (2011): 117-124. The interview that follows is a dialogue between artist and gallerist with the intent of unearthing the artist’s working strategies for a general public. Joaquin Segura is at once an anomaly in Mexico’s contemporary art scene at the same time as he is one of the most emblematic representatives of a larger shift toward a post-national identity among its youngest generation of artists. If Mexico looks increasingly like a foreclosed (...)
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  29.  6
    The Art of Interpreting Art.Paul Barolsky - 2020 - Arion 28 (1):101-113.
    In lieu of an abstract, here is a brief excerpt of the content:The Art of Interpreting Art PAUL BAROLSKY “The quality of the prose is just as important in nonfiction as in fiction.” —Robert Caro If as Horace famously wrote in the Ars poetica the aim of poetry is to instruct and delight, why shouldn’t the goal of all writing be the same? Why should all readers not enjoy as well as learn from what they read? In the realm of (...)
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  30.  6
    I never promised you a rose garden.… When landscape architecture becomes a laboratory for the Anthropocene.Henriette Steiner - 2023 - History of the Human Sciences 36 (2):178-201.
    In the summer of 2017, wildflower seeds were spread on a large, empty open space close to a motorway flyover just outside Copenhagen, Denmark. This was an effort to use non-mechanical methods to prepare the soil for an ‘urban forest’ to be established on the site, since the flowers’ roots would penetrate the ground and enable the planned new trees to settle. As a result, the site was transformed into a gorgeous meadow, and all summer long Copenhageners were invited to (...)
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  31.  6
    Wittgenstein, Ordinary Language, and Poeticity.David Hommen - 2020 - Kriterion - Journal of Philosophy (AO):313-334.
    The later Wittgenstein famously holds that an understanding which tries to run up against the limits of language bumps itself and results in nothing but plain nonsense. Therefore, the task of philosophy cannot be to create an ‘ideal’ language so as to produce a ‘real’ understanding in the first place; its aim must be to remove particular misunderstandings by clarifying the use of our ordinary language. Accordingly, Wittgenstein opposes both the sublime terms of traditional philosophy and the formal frameworks of (...)
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  32.  6
    Wittgenstein, Ordinary Language, and Poeticity.David Hommen - 2021 - Kriterion – Journal of Philosophy 35 (4):313-334.
    The later Wittgenstein famously holds that an understanding which tries to run up against the limits of language bumps itself and results in nothing but plain nonsense. Therefore, the task of philosophy cannot be to create an ‘ideal’ language so as to produce a ‘real’ understanding for the first time; its aim must be to remove particular misunderstandings by clarifying the use of our ordinary language. Accordingly, Wittgenstein opposes both the sublime terms of traditional philosophy and the formal frameworks of (...)
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  33.  3
    What the digital world leaves behind: reiterated analogue traces in Mexican media art.David M. J. Wood - 2023 - AI and Society 38 (6):2427-2436.
    How might experimental media art help theorise what falls by the wayside in the digital public sphere? Working in the years immediately following the launch of YouTube in 2005, some media artists centred their creative praxis towards the end of that decade upon rescuing, revalorising, and placing back into digital circulation audiovisual media formats and technologies that appeared aged or obsolete. Although there may be a degree of nostalgia behind such practices, these artworks articulate a cogent critique of the drive (...)
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  34. Aesthetics in the 21st Century: Walter Derungs & Oliver Minder.Peter Burleigh - 2012 - Continent 2 (4):237-243.
    Located in Kleinbasel close to the Rhine, the Kaskadenkondensator is a place of mediation and experimental, research-and process-based art production with a focus on performance and performative expression. The gallery, founded in 1994, and located on the third floor of the former Sudhaus Warteck Brewery (hence cascade condenser), seeks to develop interactions between artists, theorists and audiences. Eight, maybe, nine or ten 40 litre bags of potting compost lie strewn about the floor of a high-ceilinged white washed hall. Dumped, split (...)
     
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  35. A New Negentropic Subject: Reviewing Michel Serres' Biogea.A. Staley Groves - 2012 - Continent 2 (2):155-158.
    continent. 2.2 (2012): 155–158 Michel Serres. Biogea . Trans. Randolph Burks. Minneapolis: Univocal Publishing. 2012. 200 pp. | ISBN 9781937561086 | $22.95 Conveying to potential readers the significance of a book puts me at risk of glad handing. It’s not in my interest to laud the undeserving, especially on the pages of this journal. This is not a sales pitch, but rather an affirmation of a necessary work on very troubled terms: human, earth, nature, and the problematic world we made. (...)
     
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  36.  15
    Painting in tongues: Faith-based languages of formalist art.Kevin Z. Moore - 2007 - Journal of Aesthetic Education 41 (4):40-52.
    In lieu of an abstract, here is a brief excerpt of the content:Painting in Tongues:Faith-Based Languages of Formalist ArtKevin Z. Moore (bio)A philosophical problem is created by the incoherence between the earlier state and the later one.—Ian Hacking, Historical OntologyWhatever is happening to evidence-based treatment? When the facts contravene conventional wisdom, go with the anecdotes?—New York Times, "Science Times," February 14, 2006Cephalopods have a visual language that may be considered artful; humans have written and vocalized languages that are sometimes artful; (...)
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  37. Knowledge of the Self.Laird Stevens - 1994 - Dissertation, Concordia University (Canada)
    I contend that a great deal of western philosophical thought is based upon a mistaken assumption, and that is: there is something real that we can know. I argue that, on the contrary, insofar as our experience is of a world that has meaning, this experience is not of the world "as it really is," but of the world as we perceive it through language. The very process of making the world meaningful, or learning about it, is at the same (...)
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  38.  83
    Review of Between Levinas and Heidegger. [REVIEW]Subhasis Chattopadhyay - 2020 - Prabuddha Bharata or Awakened India 125 (6):525-26.
    This is a comprehensive critique of the Heidegger problem and while putting forward a critique of Heidegger; it establishes the sanctity of Levinas. In the process of doing so; the reviewer touches on the problems of not considering Edith Stein in a book of this sort. When I got my tenure in India, one wisecrack on the board of interviewers asked me how Kit Marole influenced Shakespeare. I knew that he was just quoting Wayne C Booth's stuff on Macbeth. John (...)
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  39.  7
    The Disarticulation of Time: the Zeitbewußtsein in Phenomenology of Perception.Keith Whitmoyer - 2015 - Journal of the British Society for Phenomenology 46 (3):213-232.
    In an effort to reassess the status of Phenomenology of Perception and its relation to The Visible and the Invisible, this essay argues that Merleau-Ponty's engagement with Husserl's text and his discussion of the “field of presence” in La temporalité are intended to think through the field in which time makes its appearance as one of passage. Time does not show itself as presence or in the present but manifests itself as Ablauf, as lapse or flow, an écoulement that is (...)
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  40. Should divorcing parties have a lawyer to represent each of them during mediation?Divorce Mediation, Stephen B. Goldberg, Eric D. Green & Frank Ea Sander - 1984 - In Norman E. Bowie (ed.), Making ethical decisions. New York: McGraw-Hill. pp. 5.
     
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  41. The apparently simple notion of fairness in custody mediation actually is a complex and multi-level issue.Custody Mediation & Donald T. Saposnek - 1984 - In Norman E. Bowie (ed.), Making ethical decisions. New York: McGraw-Hill. pp. 8--9.
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  42. What are guidelines for practice for both court-connected and private mediators?Divorce Mediation & Ann Milne - 1984 - In Norman E. Bowie (ed.), Making ethical decisions. New York: McGraw-Hill. pp. 8--73.
     
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  43. Copyright© 2007 SAGE Publications (Los Angeles, London, New Delhi and Singapore) and David Rasmussen.Possible Levinasian Mediation - 2007 - Philosophy and Social Criticism 33 (7):892-896.
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  44.  7
    Gerald W. Glaser.is Perception Cognitively Mediated - 1991 - In Terence E. Horgan & John L. Tienson (eds.), Connectionism and the Philosophy of Mind. Kluwer Academic Publishers. pp. 437.
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  45.  2
    Abel, Oliver, et al. La juste mémoire: Lectures autour de Paul Ricoeur. Fribourg: Labor et Fides, 2006. 22.00 pb. Almeida, Rogério Miranda de. Nietzsche and Paradox. Translated by Mark S. Roberts. Albany: SUNY Press, 2006. $55.00 Arriaga, Manuel P. The Modernist-Postmodernist Quarrel on Philosophy and Justice: A Possible. [REVIEW]Levinasian Mediation - forthcoming - Philosophy Today.
  46.  12
    Rigid Flesh – Towards the Critique of Technologically Mediated Chiasm.Domonkos Sik - 2024 - Critical Horizons 25 (2):94-110.
    Technology has been at the centre of existentialist (e.g. Heidegger) and sociological (e.g. Marcuse) critique for a long time. The latest versions of criticism rely on the results of “science and technology studies”: they argue that essentialist conceptualisations of technology should be replaced while aiming at “democratizing technology” (e.g. Feenberg). However, even these approaches are characterised by a shortcoming when it comes to providing a normative basis: as contemporary technology intermeshes with the elementary levels of existence (such as perception or (...)
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  47.  20
    The Logic of Nonsense.Sören Halldén - 1949 - Uppsala, Sweden: Upsala Universitets Arsskrift.
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  48.  13
    Robust Lexically Mediated Compensation for Coarticulation: Christmash Time Is Here Again.Sahil Luthra, Giovanni Peraza-Santiago, Keia'na Beeson, David Saltzman, Anne Marie Crinnion & James S. Magnuson - 2021 - Cognitive Science 45 (4):e12962.
    A long-standing question in cognitive science is how high-level knowledge is integrated with sensory input. For example, listeners can leverage lexical knowledge to interpret an ambiguous speech sound, but do such effects reflect direct top-down influences on perception or merely postperceptual biases? A critical test case in the domain of spoken word recognition is lexically mediated compensation for coarticulation (LCfC). Previous LCfC studies have shown that a lexically restored context phoneme (e.g., /s/ in Christma#) can alter the perceived place of (...)
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  49.  7
    Undue Inducement: Nonsense on Stilts?Ezekiel J. Emanuel - 2005 - American Journal of Bioethics 5 (5):9-13.
    1. The opinions expressed are the author's own. They do not reflect any position or policy of the National Institutes of Health, Public Health Service, Department of Health and Human Services, or any of the authors affiliated organizations.
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  50.  98
    Belonging Online: Rituals, Sacred Objects, and Mediated Interations.Lucy Osler - forthcoming - In Luna Dolezal & Danielle Petherbridge (eds.), Phenomenology of Belonging.
    In this chapter, I explore how experiences of social belonging might emerge and be sustained in online communities, drawing from the work on rituals by Randall Collins. I argue that rather than viewing mediated interactions in terms of whether they are suitable substitutes for face-to-face interactions, we should consider mediated encounters in their own right. This allows us to recognize the creative ways that people can create rituals in a mediated setting and thus support and create a sense of belonging (...)
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