L’article examine le sens de la systématisation de la philosophie transcendantale que Schelling présente en 1800 comme accomplie par l’art, « organon et document » de la philosophie. A partir d’une reconstitution du problème et de la dynamique propres au Système de l’idéalisme transcendantal, puis de la fonction systématique de la philosophie de l’art, on soutient que l’achèvement que l’art est censé accomplir prend en fait plutôt – en lien direct avec l’ambiguïté du principe du Système – la figure d’une (...) mise en suspens, d’une indécision fondamentale entre deux voies, ultérieurement empruntées l’une par la philosophie de l’identité, l’autre par la dernière philosophie.This article examines the significance of the systematization of transcendental philosophy which Schelling claims in 1800 to be fulfilled by art, « the organon and document » of philosophy. After reconstructing the problem and the process peculiar to the System of transcendental Idealism, as well as the systematic function of the philosophy of art, we maintain that the supposed completion of philosophy by art is in fact fundamentally unresolved, suspended between two distinct approaches which will later be taken up in the philosophy of identity and in the late philosophy. (shrink)

Connaissant bien le rôle essentiel pris par le symbolisme, comme présence objective de l’Idée, dans les métaphysiques de l’art postkantiennes (Schelling, Hegel), V. Basch en fait cependant la clef de sa propre esthétique sentimentaliste, subjectiviste et anti-métaphysique. Le déplacement de sens du symbolisme, qui s’effectue chez Basch principalement à partir de son étude de Kant, de Fr. Th. Vischer et de la psychologie physiologique allemande (G. Th. Fechner, W. Wundt), est analysé dans l’article comme le passage d’une incarnation qui est (...) présentation de l’Idée dans le phénomène, à une prise de chair de mes propres sentiments et émotions à même l’objet de l’expérience esthétique. (shrink)

À la croisée des recherches sur l’espace humain et du développement récent des études sur les émotions, l’étude philosophique, esthétique, sociologique, ethnographique, architecturale et urbaine des atmosphères décrit et analyse la manière dont se nouent, dans l’expérience vécue, les propriétés des espaces et des objets, le contexte de la perception sensible, et l’état affectif du sujet sur ses deux versants, l’intime et le partagé. Atmosphère (de même que l’anglais atmosphere ou l’allemand A...

Schelling’s philosophy of art between 1801 and 1807 can be defined as metaphysics of art. The object of that metaphysics is to deploy the absolute as the being of art and of the arts. Schelling has been criticized on the basis that this metaphysics of art represses the infinite diversity of existing works of art, while overlooking concrete aesthetic experience. Based on Schelling’s definition of the “philosophical construction” of art as an inseparably speculative and historical construction, the aim of this (...) paper is to challenge such assertions. It will show that “historical construction” has to be understood in a twofold manner: first, as a transcendental history of the absolute’s artistic individuation and second, as a cultural history of both the ancient and modern worlds of art. Working within this twofold setting the paper argues that Schelling’s systematic approach, while exhibiting a unifying force, still remains open to the otherness of the real. (shrink)

L’article analyse le sens que prend l’architecture dans la philosophie de Schelling vers 1802/05. On montre comment ce dernier subvertit la thèse de l’architecture-art comme imitation de la simple construction, pour finalement définir l’art architectural par sa capacité à présenter, dans l’inorganique, des allégories de l’organique. On illustre pour finir concrètement différents niveaux de compréhension de cette caractérisation, d’une part avec des exemples tirés de Schelling, d’autre part avec des édifices architecturaux récents relevant à divers titres de la bioinspiration.

Institutional ethics consultation services for biomedical scientists have begun to proliferate, especially for clinical researchers. We discuss several models of ethics consultation and describe a team-based approach used at Stanford University in the context of these models. As research ethics consultation services expand, there are many unresolved questions that need to be addressed, including what the scope, composition, and purpose of such services should be, whether core competencies for consultants can and should be defined, and how conflicts of interest should (...) be mitigated. We make preliminary recommendations for the structure and process of research ethics consultation, based on our initial experiences in a pilot program. (shrink)

Big data and artificial intelligence (“AI”) promise to transform virtually all aspects of biomedical research and health care (Matheny et al. 2019), through facilitation of drug development, diagno...

: A familiar criticism of bioethics charges it with being more conceptual than practical—having little application to the "real world." In order to answer its critics and keep its feet on the ground, bioethics must utilize the social sciences more effectively. Empirical research can provide the bridge between conceiving a moral vision of a better world, and actually enacting it.

The use of racial categories in biomedicine has had a long history in the United States. However, social hierarchy and discrimination, justified by purported scientific differences, has also plagued the history of racial categories. Because “race” has some correlation with biological and genetic characteristics, there has been a call not to “throw the baby out with the bathwater” by eliminating race as a research or clinical category. I argue that race is too undefined and fluid to be useful as a (...) proxy for biology or genetics. (shrink)

A peculiar feature of Hutcheson’s system is his claim that there exist no original pains in the imagination, and hence no real displeasures concerning form or beauty. This position, when set against a clear emphasis upon the pains of the moral sense in apprehending evil, seems to render tenuous his frequent analogies between the experiences of beauty and goodness. In light of this apparent discrepancy in Hutcheson’s argument, the repeated use of the term “moral beauty” presents interpretive difficulties, particularly on (...) the matter of whether, and in what way, goodness is itself a species of beauty. These problems can be surmounted by way of close attention to Hutcheson’s connection and ordering of the various “senses.” On the present interpretation, Hutcheson denies formal displeasure aspart of a broader theological argument concerning the moral function of the imagination. On this view, “moral beauty” is a special type of imaginative pleasure. (shrink)

A familiar criticism of bioethics charges it with being more conceptual than practical—having little application to the “real world.” In order to answer its critics and keep its feet on the ground, bioethics must utilize the social sciences more effectively. Empirical research can provide the bridge between conceiving a moral vision of a better world, and actually enacting it.

Human genetic and genomic research can yield information that may be of clinical relevance to the individuals who participate as subjects of the research. It has been common practice among researchers to notify participants during the informed consent process that no individual results will be disclosed, “incidental” or otherwise. However, as genetic information obtained in research becomes orders of magnitude more voluminous, increasingly accessible online, and more informative, this precedent may no longer be appropriate. There is not yet consensus on (...) the responsibilities of researchers to disclose individual research results to research participants. Empirical research suggests that participants want to know individual research results. On the other hand, the increased resolution and power aforded by new genomic analyses may lead to fndings of statistical, but not necessarily clinical, signifcance. This paper addresses the issues to be considered in deciding whether and how to disclose “incidental” fndings or other fndings of clinical signifcance that arise in the course of human genomic and genetic research. What research results should be ofered, and what should not be ofered? For which research should individual results be ofered to research participants, when should they be ofered, how, and to whom? (shrink)

Human genetic and genomic research can yield information that may be of clinical relevance to the individuals who participate as subjects of the research. However, no consensus exists as yet on the responsibilities of researchers to disclose individual research results to participants in human subjects research. “Genetic and genomic research” on humans varies widely, including association studies, examination of allele frequencies, and studies of natural selection, human migration, and genetic variation. For the purposes of this article, it is defined broadly (...) to include analysis of DNA collected from humans that has implications for human health. This paper addresses both research results of individual research participants that may be an intended product of the research, as well as unanticipated, “incidental” findings. (shrink)

In recent years, English-language scholars have begun to approach the daunting field of Kant's politics by way of its technical core: the deduction of private right. In this interpretive project, t...

Institutional ethics consultation services for biomedical scientists have begun to proliferate, especially for clinical researchers. We discuss several models of ethics consultation and describe a team-based approach used at Stanford University in the context of these models. As research ethics consultation services expand, there are many unresolved questions that need to be addressed, including what the scope, composition, and purpose of such services should be, whether core competencies for consultants can and should be defined, and how conflicts of interest should (...) be mitigated. We make preliminary recommendations for the structure and process of research ethics consultation, based on our initial experiences in a pilot program. (shrink)

With the growth of precision medicine research on health data and biospecimens, research institutions will need to build and maintain long-term, trusting relationships with patient-participants. While trust is important for all research relationships, the longitudinal nature of precision medicine research raises particular challenges for facilitating trust when the specifics of future studies are unknown. Based on focus groups with racially and ethnically diverse patients, we describe several factors that influence patient trust and potential institutional approaches to building trustworthiness. Drawing on (...) these findings, we suggest several considerations for research institutions seeking to cultivate long-term, trusting relationships with patients: Address the role of history and experience on trust, engage concerns about potential group harm, address cultural values and communication barriers, and integrate patient values and expectations into oversight and governance structures. (shrink)

In the third volume of the History of England, David Hume considers the political ramifications of the Protestant reformation with a “Digression concerning the ecclesiastical state.” He advocates the establishment of a state church, believing it will dampen religious “enthusiasm” in the polity. Unlike later secularization theorists, Hume assumes an intractable basis for religion in the human passions. Tensions in Hume’s “cooptation” strategy are evident from Adam Smith’s famous attack upon it in section five of The Wealth of Nations, and (...) in Hume’s own treatment of seventeenth century independency in the fifth volume of the History. Smith argues that public competition among sects facilitates political moderation. In History V Hume stresses the positive role of enthusiasm in fostering civil liberty. This article traces Hume’s indecision to his “external” mode of moral and historical analysis, arguing that a secular policy on religion cannot proceed fruitfully without engaging the theological particulars of the religions at issue. (shrink)

Physically frail, badly educated girls, brought up to lead useless lives as idle gentlewomen, married to dominant husbands, and relegated to "separate spheres" of life—these phrases have often been used to describe Victorian upper-middle-class women. M. Jeanne Peterson rejects such formulations and the received wisdom they embody in favor of a careful examination of Victorian ladies and their lives. Focusing on a network of urban professional families over three generations, this book examines the scope and quality of gentlewomen's education, their (...) physical lives, their relationship to money, their experience of family illness and death, and their relationships to men (brothers and friends as well as fathers and husbands). Peterson also examines the prominent place of work in the lives of these "leisured" Victorian ladies, both single and married. Far from idle, the mothers, wives, and daughters of Victorian clergymen, doctors, lawyers, university dons, and others were accomplished and productive members of society who made substantial public and private contributions to virtually every sphere of Victorian life. (shrink)

There are deep divides over the use of racial and ethnic categories in biomedical research and its application in both medical and non-medical contexts. On one side of a roughly described dividing line are practitioners who need to use every piece of information at their disposal to solve pressing, realworld problems in real time, such as making clinical diagnoses or identifying perpetrators of crime. On the other side are scientists and policy makers committed to meeting a scientific and social need (...) for accuracy and thus trying to avoid miscategorization.As Jay Cohn describes in this issue, medical practitioners in particular have used racial and ethnic categories to “enhance diagnostic and therapeutic precision.” He argues for retaining this practice. The plea, motivated by genuine concern for patients, is to avoid “throwing the baby out with the bathwater.” However, Cohn and others mischaracterize the nature of the debate. The argument is not about whether differences among populations exist, or even whether differences among “races” exist. (shrink)

Bioethics is reexamining how to implement diversity, equity, inclusion, and justice concerns into scholarship. However, bioethicists should question the categories used to define diversity. The act of categorization is value laden, and classification systems confer power and benefits and generate harms. For example, what conditions count as disabilities? We should consider the equity implications of offering only “male” and “female” options for self‐identification in health records. However, we should also interrogate all ideas about categorization, including how categories are formed, why (...) they are formed, and who decides. Bioethicists cannot comprehend fully what equity and justice mean for underrepresented, underserved, or marginalized people until there is an understanding of how the boundaries of marginalization are created. (shrink)

The concept of “humanity” is integral to David Hume's Enquiry Concerning the Principles of Morals, but barely appears in his earlier Treatise. Many consider the later “humanity” theory superior, permitting a more “extensive” sympathy not limited by proximate associations. This paper argues for Hume's consistency on humanity by surveying The History of England. Hume's History discussions lend support to the associative, and thus limited, Treatise conception. Humanity is opposed to religious enthusiasm; its positive effects are local and particular. Moreover, Hume's (...) historiography involves a hesitation on the content of “humane” judgments, which cannot fulfill the cosmopolitan function envisioned by many present-day interpreters. (shrink)

Higher plant shoot meristems are multicellular structures that are the site of postembryonic organogenesis. Analysis of chimeric plants has indicated that cells in different regions of the meristem can interact with each other so that their activities are coordinated during developmental processes. Correlations have not been demonstrated between events at a molecular level and the interactions observed at a phenotypic level in chimeras. Two recent papers(1,2) address this problem by reporting that expression of the floricaula gene in one region of (...) chimeric snapdragon meristems is sufficient to promote the transition from inflorescence to floral development and to induce the expression of the downstream organ identity genes deficiens and plena throughout the meristem. (shrink)

A peculiar feature of Hutcheson’s system is his claim that there exist no original pains in the imagination, and hence no real displeasures concerning form or beauty. This position, when set against a clear emphasis upon the pains of the moral sense in apprehending evil, seems to render tenuous his frequent analogies between the experiences of beauty and goodness. In light of this apparent discrepancy in Hutcheson’s argument, the repeated use of the term “moral beauty” presents interpretive difficulties, particularly on (...) the matter of whether, and in what way, goodness is itself a species of beauty. These problems can be surmounted by way of close attention to Hutcheson’s connection and ordering of the various “senses.” On the present interpretation, Hutcheson denies formal displeasure aspart of a broader theological argument concerning the moral function of the imagination. On this view, “moral beauty” is a special type of imaginative pleasure. (shrink)

"Republicanism" in Kant's political philosophy describes the type of state and the kind of politics demanded by freedom. Thus understood, republicanism expresses the limits of practical reason in politics. ;Kant sets his political thought against Hobbes' empirical description of political individuals, for whom norms arise through imaginative "picturing" of various conditions. For Kant free practical subjects are motivationally independent of sensed objects and possess ability for self-legislation . Kant further maintains that ideas are "regulative", not constitutive, of human understanding, such (...) that correct use of them requires knowledge of their "principles." ;Because autonomy governs internal determinations, it cannot be the principle of republicanism, which as a matter of "right" concerns actions in their external aspect alone. Actions are subject only to moral possibility, or "permission". Kant's "permissive law" can be understood as law only if moral obligation is distinguished from the specification of duty, a distinction drawn by Achenwall, who influenced Kant. Right built on "permission" connects "first taking" and "intelligible possession". This explains two notions permeating Kant's political writings: obedience to state authority as such, and skepticism regarding any identification of existing arrangements with the idea of a perfectly rightful state. ;Thus conceived, right legitimizes various constitutions. The republican idea and its principle of "representation" are civil elaborations of permission's skeptical aspect. State authority represents the "universal united will", and cannot legitimately be resisted. ;This interpretation faces two challenges. One is unreserved cosmopolitanism, the claim that no right is conclusive without global authority. However, this position misinterprets "permission" as a preliminary violation of right, and therefore not as law. Secondly, the state may be seen as "rightfully" constituted for "fairness". This mistakenly attributes to Kant a Hobbesian view of individuals, and employs ideas not according to their principles , but in a direct, "pictorial" manner . ;Kant's "republicanism" is not an institutional arrangement but a principle of governance. The republican idea is the condition of the possibility of gradual, nonrevolutionary progress. Kant's "permission"---through its lack of specification and its deference to existing authority---is the expression of freedom in external contexts and the foundation of properly critical politics. (shrink)