BackgroundAn increasing number of studies utilize intracranial electrophysiology in human subjects to advance basic neuroscience knowledge. However, the use of neurosurgical patients as human research subjects raises important ethical considerations, particularly regarding informed consent and undue influence, as well as subjects’ motivations for participation. Yet a thorough empirical examination of these issues in a participant population has been lacking. The present study therefore aimed to empirically investigate ethical concerns regarding informed consent and voluntariness in Parkinson’s disease patients undergoing deep brain (...) stimulator (DBS) placement who participated in an intraoperative neuroscience study.MethodsTwo semi-structured 30-minute interviews were conducted preoperatively and postoperatively via telephone. Interviews assessed participants’ motivations for participation in the parent intraoperative study, recall of information presented during the informed consent process, and participants’ postoperative reflections on the research study.ResultsTwenty-two participants (mean age = 60.9) completed preoperative interviews at a mean of 7.8 days following informed consent and a mean of 5.2 days prior to DBS surgery. Twenty participants completed postoperative interviews at a mean of 5 weeks following surgery. All participants cited altruism or advancing medical science as “very important” or “important” in their decision to participate in the study. Only 22.7% (n = 5) correctly recalled one of the two risks of the study. Correct recall of other aspects of the informed consent was poor (36.4% for study purpose; 50.0% for study protocol; 36.4% for study benefits). All correctly understood that the study would not confer a direct therapeutic benefit to them.ConclusionEven though research coordinators were properly trained and the informed consent was administered according to protocol, participants demonstrated poor retention of study information. While intraoperative studies that aim to advance neuroscience knowledge represent a unique opportunity to gain fundamental scientific knowledge, improved standards for the informed consent process can help facilitate their ethical implementation. (shrink)

One issue in the debate about faith concerns the stance a religious person is committed to take on “God exists.” I argue that this stance is best understood as an assumption that God exists for the purpose of pursuing a good relationship with God. The notion of an “assumption for practical purpose” is distinguished from notions such as “belief” and “hope.” This stance is contrasted with others found in discussions of faith, and its ramifications for the problem of whether it (...) is rational to have faith are discussed. (shrink)

This paper discusses Maharal’s conception of the human being and its four major aspects, namely body, soul, intellect, and tselem (image or form). I suggest that some of his apparently inconsistent remarks concerning the human body may be reconciled by distinguishing two different senses of badness or evil. Secondly, I show that Maharal embraces what might be termed “moderate rationalism.” Thirdly, I elucidate his conception of the tselem by discussing parallel ideas in Kabbalistic literature.

In lieu of an abstract, here is a brief excerpt of the content:Drinking Rules! Byron and BaudelaireJoshua Wilner (bio)This essay 1 takes up two nineteenth-century texts on the theme of intoxication in which the poetic word can no longer, if it ever could, stably figure itself as the metaphoric other of the drug, that is, as a legitimate means of imaginative transport, and in which the writer’s enthrallment by the transporting substance of words shows us its addictive and, one might (...) say, prosaic face.The first of these pieces is a pair of stanzas from Canto II of Byron’s Don Juan, the other, Baudelaire’s brief prose poem “Enivrez-vous,” pieces that Jean Pommier [341] and, following Pommier, Robert Kopp [314–15] have suggested may be connected, though neither reader enters into much more detail than to note that both bits of writing, in Kopp’s words, “chant[e] l’ivresse.” Now the praise of drunkenness is of course a poetic commonplace, and the mere fact of its appearance in these two bits of text argues about as intimate a bond of kinship as that involved in pointing out that you and I are both Noah’s children. But there are, I would argue, compelling reasons for looking at these pieces in relation to one another and to which I believe Pommier was responding.That Byron mattered to Baudelaire is attested to by a number of references scattered throughout the latter’s work and letters, references which, while faulting Byron for garrulousness, praise him for having the thing that makes poets: “une diabolique personnalité” [OC 2: 232]. Perhaps the most interesting of these references occurs in a well-known letter that Baudelaire wrote to his mother in July 1857, shortly after Les fleurs du mal had been published and while the storm of controversy that was to culminate in the prosecution and expurgation of the collection for obscenity was rapidly gathering:On me refuse tout, l’esprit d’invention et même la connaissance de la langue française. Je me moque de tous ces imbéciles, et je sais que ce volume, avec ses qualités et ses défauts, fera son chemin dans la mémoire du public lettré, à côté des meilleurs poésies de V. Hugo, de Th. Gautier et même de Byron.[CP 1: 411][They deny me everything, the spirit of invention and even knowledge of the French language. I could care less about all these imbeciles, and I know that this volume, with its qualities and its faults, will make its way in the memory of the [End Page 34] lettered public, along with the best poetry of V. Hugo, of Th. Gautier, and even of Byron.]The pride of place Baudelaire reserves for Byron in this list was somewhat dated even in its time 2 and odd in other ways, especially given the more qualified expressions of admiration we meet elsewhere in his writings. But it becomes more understandable if one considers that for Baudelaire’s mother, who was of Byron’s generation and had early ties to England 3 (in fact, she apparently taught Charles English during his childhood [E. Crépet 30], making it, strangely enough, part of his “mother tongue”), Byron’s would have been the emblematic case of a writer for whom a reputation for depravity was overtaken by poetic honor, perhaps at the cost of his death in a noble cause.Apart from this evidence of a felt affinity, there are specific formal grounds for associating the two pieces. Since they are fairly brief, allow me first of all to cite them both. Here are the stanzas from Canto II of Don Juan: 179 Man, being reasonable, must get drunk; The best of life is but intoxication: Glory, the grape, love, gold, in these are sunk The hopes of all men, and of every nation; Without their sap, how branchless were the trunk Of life’s strange tree, so fruitful on occasion! But to return, - Get very drunk; and when You wake with head-ache, you shall see what then. 180 Ring for your valet - bid him quickly bring Some hock and soda-water, then you’ll know A pleasure worthy Xerxes the... (shrink)

Despite the ubiquity of bees in Dickinson’s work, most interpreters denigrate her nature poems. But following several recent scholars, I identify Nietzschean/Dionysian overtones in the bee poems and suggest the figure of bees/hive/queen illuminates as feminist key to her corpus. First, (a) the bee’s sting represents martyred death; (b) its gold, immortality; (c) its tongue, the “lesbian phallus”; (d) its wings, poetic power; (e) its buzz, poetic melody, and (f) its organism, a joyful Dionysian Susan (her sister-in-law and love (...) interest) to Emily’s flower. Second, the hive represents her individual poems (with slants/dashes as stingers, wings as hymn meter, honey as rhymes, variant words as exiled bees, and accompanying flowers their Darwinian coevolution with bees), constituting her writing persona as a multi-voiced self-swarm, as organized in the apiary of her letters and fascicles. And third, the queen represents her Western cultural and religious inheritance wherein bees are symbols of the soul, reincarnation, poetic-philosophical vocation, and a Nietzschean, trans-Dionysian naturalist ontology—symbolized by apiarian Artemis. (shrink)

American psychologist and pragmatist philosopher James (1842- 1910) is generally considered too individualistic to have had any interest in politics, but Miller argues that political concerns were in fact central to his intellectual work. He finds in James a theorist of action, explores the complexities of his theory, and related his thought to Miller's own experience as a political activist and scholar. Annotation copyrighted by Book News, Inc., Portland, OR.

_ Source: _Volume 23, Issue 2, pp 161 - 195 The Greek tradition of political philosophy, with its prominent focus on the forms of government, should be distinguished from the discourse typical of many rabbinic sources, with its concern for collective goals. This discourse commonly deploys broad, mid-level goals to mediate between abstract theology and practical law. Among these goals, yishuv medinah focuses on the economic and social development of a region or district, articulating the character of local needs. This (...) is compared to related goals—the settling of the world and the ordering of the world —and contrasted with Aristotle’s approach, which in many ways typifies the Greek tradition. (shrink)

Plato's 'Republic' constructs an ideal city composed of three parts, parallel to the soul's reason, appetites, and fighting spirit. But confusion and controversy have long surrounded this three-way division and especially the prominent role it assigns to angry and competitive spirit. In Plato's Three-fold City and Soul, Joshua I. Weinstein argues that, for Plato, determination and fortitude are not just expressions of our passionate or emotional natures, but also play an essential role in the rational agency of persons and (...) polities. In the Republic's account, human life requires spirited courage as much as reasoned thought and nutritious food. The discussion ranges over Plato's explication of the logical and metaphysical foundations of justice and injustice, the failures of incomplete and dysfunctional cities, and the productive synergy of our tendencies and capacities that becomes fully evident only in the justice of a self-sufficient political community. (shrink)

In this paper, I contend that Brandom’s interpretive oversights leave his inferentialist program vulnerable to Hegelian critique. My target is Brandom’s notion of “conceptual realism,” or the thesis that the structure of mind-independent reality mimics the structure of thought. I show, first, that the conceptual realism at the heart of Brandom’s empiricism finds root in his interpretation of Hegel. I then argue that conceptual realism is incompatible with Hegel’s thought, since the Jena Phenomenology, understood as a “way of despair,” includes (...) a critique of the philosophical framework upon which conceptual realism relies. Finally, I offer the Hegelian critique of Brandom that results from these textual infidelities. (shrink)

In the Euthydemus, Socrates is presented as an eager student of seemingly trivial arts, earning derision both for desiring to master the peculiar art of Euthydemus and Dionysodorus and for studying the harp in his old age. I explain Socrates’ interest in these apparently trivial arts by way of a novel reading of the first protreptic argument, suggesting that the wisdom Socrates praises is complex in nature, securing the happiness of its possessor only insofar as it is composed of both (...) ordinary productive knowledge and ethically productive knowledge. This reading of the first protreptic makes sense of the otherwise perplexing second protreptic, explaining why Socrates is so keen to identify an art which makes what it uses. Wisdom acts as a reliable source of benefit only insofar as it is a complex composed of multiple different arts and types of knowledge. These arts, however, can only be acquired one at a time – if no single art is capable of combining the powers of both ordinary productive knowledge and ethically productive knowledge in the way that wisdom as a whole does, then the pursuit of wisdom will fail to offer reliable benefit despite the reliably beneficial nature of its possession. Thus, it is appropriate for the Euthydemus to conclude with Socrates telling Crito to take courage and pursue philosophy despite the seemingly harmful effects that its pursuit has had on others. Euthydemus and Dionysodorus represent the danger facing the aspiring philosopher, the possibility of being ruined by independent possession of the particular kind of ordinary productive knowledge on which philosophical activity depends – verbal mastery, the grasp of subtle conceptual distinctions needed both to argumentatively reveal reality and to argumentatively obscure it, to reliably equivocate and to reliably avoid equivocation. (shrink)

Legal inference is fundamental for building and verifying hypotheses in police investigations. In this study, we build a Natural Language Inference dataset in Korean for the legal domain, focusing on criminal court verdicts. We developed an adversarial hypothesis collection tool that can challenge the annotators and give us a deep understanding of the data, and a hypothesis network construction tool with visualized graphs to show a use case scenario of the developed model. The data is augmented using a combination of (...) Easy Data Augmentation approaches and round-trip translation, as crowd-sourcing might not be an option for datasets with sensible data. We extensively discuss challenges we have encountered, such as the annotator’s limited domain knowledge, issues in the data augmentation process, problems with handling long contexts and suggest possible solutions to the issues. Our work shows that creating legal inference datasets with limited resources is feasible and proposes further research in this area. (shrink)

This article offers a series of critical theorizations on the biopolitical dimensions of methicillin-resistant Staphylococcus aureus (MRSA), with specific attention to what has recently been referred to in the United States as the ‘MRSA Epidemic’. In particular, we reflect on the proliferation of biomedical discourses around the ‘spread’, and the pathogenic potentialities, of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). We turn to the work of Roberto Esposito and Jean-Luc Nancy to better make sense of how, during this immunological crisis, the individualized (...) fleshy and fluid body is articulated to dimensions of community and corporeal proximity; the body is thus conceived in popular biopolitical framings as a site of transmission, inoculation, and isolation – as a living ecological and pathological vessel. We give emphasis to the spatial relations of flesh, namely in how biomedical ‘experts’ have sought to (bio-)technologize spaces of heightened communal bodily contact (such as playgrounds or gymnasia). (shrink)

This book proposes that parties on both sides of this debate might shift their attention in a different direction, by focusing on the question of whether it is ...

We chart how neuroscience and philosophy have together advanced our understanding of moral judgment with implications for when it goes well or poorly. The field initially focused on brain areas associated with reason versus emotion in the moral evaluations of sacrificial dilemmas. But new threads of research have studied a wider range of moral evaluations and how they relate to models of brain development and learning. By weaving these threads together, we are developing a better understanding of the neurobiology of (...) moral judgment in adulthood and to some extent in childhood and adolescence. Combined with rigorous evidence from psychology and careful philosophical analysis, neuroscientific evidence can even help shed light on the extent of moral knowledge and on ways to promote healthy moral development. (shrink)

Philosopher, rabbi, religious historian, Gnostic: who was Jacob Taubes and what is at stake in his works? To begin answering this question, it is useful to consider his writings in conjunction with those of Carl Schmitt, with whom he shared an interest in the theological background of modern politics. Although Taubes made the acquaintance of such thinkers as Gershom Scholem, T. W. Adorno, Herbert Marcuse, and Jacques Derrida, this complex history with Schmitt has been the best known and most notorious (...) of his relationships. Though never blind to the legal theorist's political past, Taubes acknowledged his intellectual debt to Schmitt…. (shrink)

Background: Flow states are considered a positive, subjective experience during an optimal balance between skills and task demands. Previously, experimentally induced flow experiences have relied solely on adaptive tasks. Objective: To investigate whether cathodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) area and anodal tDCS over the right parietal cortex area during video game play will promote an increased experience of flow states. Methods: Two studies had participants play Tetris or first-person shooter (FPS) video games (...) while receiving either real tDCS or sham stimulation. Tetris recruited nineteen untrained players who infrequently played video games while the ten FPS participants played FPS frequently. Flow experience was assessed before and after stimulation. Results: Compared to sham stimulation, real stimulation increased flow experience for both untrained Tetris and trained FPS players. No ceiling effects were noticed between trained and untrained groups. Conclusion: Cathodal and anodal tDCS over the left DLPFC and right parietal areas respectively may encourage flow experiences in complex real-life motor tasks that occur during sports, games and everyday life. (shrink)

Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates (...) and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress. (shrink)

The concept of the receptive field, first articulated by Hartline, is central to visual neuroscience. The receptive field of a neuron encompasses the spatial and temporal properties of stimuli that activate the neuron, and, as Hubel and Wiesel conceived of it, a neuron’s receptive field is static. This makes it possible to build models of neural circuits and to build up more complex receptive fields out of simpler ones. Recent work in visual neurophysiology is providing evidence that the classical receptive (...) field is an inaccurate picture. The receptive field seems to be a dynamic feature of the neuron. In particular, the receptive field of neurons in V1 seems to be dependent on the properties of the stimulus. In this paper, we review the history of the concept of the receptive field and the problematic data. We then consider a number of possible theoretical responses to these data. (shrink)

There are several important arguments in metaethics that rely on explanatory considerations. Gilbert Harman has presented a challenge to the existence of moral facts that depends on the claim that the best explanation of our moral beliefs does not involve moral facts. The Reliability Challenge against moral realism depends on the claim that moral realism is incompatible with there being a satisfying explanation of our reliability about moral truths. The purpose of this chapter is to examine these and related arguments. (...) In particular, this chapter will discuss four kinds of arguments – Harman’s Challenge, evolutionary debunking arguments, irrelevant influence arguments, and the Reliability Challenge – understood as arguments against moral realism. The main goals of this chapter are (i) to articulate the strongest version of these arguments; (ii) to present and assess the central epistemological principles underlying these arguments; and (iii) to determine what a realist would have to do to adequately respond to these arguments. (shrink)

Trust is commonly defined as a metaphysically-hybrid notion involving an attitude and an action. The action component of trust is defined as a special form of reliance in which the trustor has: (1) heightened expectations of their trustee; and (2) a disposition to justifiably feel betrayed if their trust is broken. The first aim of this paper is to reject the view that trust is a form of reliance. -/- The second aim of this paper is to develop and defend (...) a non-reliance-based variation of Katherine Hawley’s commitment trust account. Roughly, on my variant account, if X trusts Y to ϕ, then X has a belief with the following counterfactual as its content: ‘if I were to rely on Y to keep a commitment to ϕ, then I believe that Y would keep that commitment to ϕ.’ I defend this account against the objection that non-reliance accounts cannot explain the intuition that trust involves heightened expectations, and that it elicits justified betrayal when broken. I also respond to the argument that such accounts can’t provide adequate explanations of therapeutic trust, which is taken to be a counterexample of belief trust insofar as it describes instances where trustors trust trustees despite not believing that they are trustworthy. (shrink)

Virtue ethics has been dogged by the objection that it lacks the ability to provide adequate action-guidance, that it is agent-centered rather act-centered. Virtue ethics has also been faulted for devolving into moral cultural relativism. Rosalind Hursthouse has presented an action-based, naturalistic theory of virtue ethics intended to defuse these charges. Despite its merits, I argue that Hurthouse’s theory fails to successfully solve the problems associated with action guidance and relativism precisely because her attempt to provide a non-cultural basis for (...) virtue ethics undermines the possibility of using virtue ethics to derive useful action-guidance. The action-guiding power of virtue is derived from culture; seeking to avoid the cultural grounding of virtue merely brings one back to the problem of how virtue ethics can provide action-guidance. (shrink)

I advocate an ad hominem reading of the hedonism that appears in the final argument of the Protagoras. I that attribute hedonism both to the Many and to Protagoras, but my focus is on the latter. I argue that the Protagoras in various ways reflects Plato’s view that the sophist is an inevitable advocate for, and himself implicitly inclined toward, hedonism, and I show that the text aims through that characterization to undermine Protagoras’ status as an educator. One of my (...) objectives in the course of my arguments is to explore connections between the final argument of the Protagoras and the Man-Measure Doctrine as it is developed in the Theaetetus. (shrink)

There is a thinking animal in your chair and you are the only thinking thing in your chair; therefore, you are an animal. So goes the main argument for animalism, the Thinking Animal Argument. But notice that there are many other things that might do our thinking: heads, brains, upper halves, left-hand complements, right-hand complements, and any other object that has our brain as a part. The abundance of candidates for the things that do our thinking is known as the (...) Thinking Parts Problem. Animalists who endorse the Thinking Animal Argument must solve this problem by giving reasons for privileging the animal over its rivals. In order to meet this challenge, some animalists have argued that the best solution is a biological minimalist one. In what follows, I argue that every extant biological minimalist solution to the Thinking Parts Problem fails. (shrink)

A conventional wisdom about the progress of physics holds that successive theories wholly encompass the domains of their predecessors through a process that is often called reduction. While certain influential accounts of inter-theory reduction in physics take reduction to require a single "global" derivation of one theory's laws from those of another, I show that global reductions are not available in all cases where the conventional wisdom requires reduction to hold. However, I argue that a weaker "local" form of reduction, (...) which defines reduction between theories in terms of a more fundamental notion of reduction between models of a single fixed system, is available in such cases and moreover suffices to uphold the conventional wisdom. To illustrate the sort of fixed-system, inter-model reduction that grounds inter-theoretic reduction on this picture, I specialize to a particular class of cases in which both models are dynamical systems. I show that reduction in these cases is underwritten by a mathematical relationship that follows the broad prescriptions of Nagel/Schaffner reduction, and support this claim with several examples. Moreover, I show that this broadly Nagelian analysis of inter-model reduction encompasses several cases that are sometimes cited as instances of the "physicist's" limit-based notion of reduction. (shrink)

This paper defends pro-realism, the view that it is better if moral realism is true rather than any of its rivals. After offering an account of philosophical angst, I make three general arguments. The first targets nihilism: in securing the possibility of moral justification and vindication in objecting to certain harms, moral realism secures something that is non-morally valuable and even essential to the meaning and intelligibility of our lives. The second argument targets antirealism: moral realism secures a desirable independence (...) for moral justification that is qualitatively different from the anti-realistic construal of independence that is only explicable in terms of degrees of distance from our subjective responses and attitudes. Finally, I argue that while the pan-expressivist semantic program of quasi-realism has significant effects on what can be appropriately said in meta-ethical discourse, it provides no comfort to the pro-realist who is already angsty about anti-realism. (shrink)

I argue for the existence of imaginative beliefs: mental states that are imaginative in format and doxastic in attitude. I advance two arguments for this thesis. First, there are imaginings that play the functional roles of belief. Second, there are imaginings that play the epistemic roles of belief. These arguments supply both descriptive and normative grounds for positing imaginative beliefs. I also argue that this view fares better than alternatives that posit distinct imaginative and doxastic states to account for the (...) same phenomena. Along the way, I demonstrate the theoretical significance of imaginative beliefs by showing how they pose a challenge for standard taxonomies of the mind, clarify the sense in which imagination is occurrent and voluntary, explain the justificatory role of the imagination, and point to a deep but underappreciated symmetry between imagistic and non-imagistic thought. (shrink)