Max Weber famously wrote that world images determine the tracks along which societies move. This article examines the relation between world images and the so-called tracks of society, which in this metaphor resemble the current concept of institution. This concept is now associated with the ‘new institutionalisms’ in social science and has no connection to the civilizational level of analysis that Weber used. This article reexamines Weber’s usage of the terms and employs the terms to analyze differences in the principles (...) of legitimacy between those emerging in the West and those in China, differences that Weber himself did not recognize. (shrink)

In the mid-nineteenth century, Karl Marx issued several critiques of political economy writings stressing the exclusive duality of states and the national economies. He argued that capitalism had characteristic features quite apart from those shaped by the idiosyncrasies of national economies. In the first part of this article, we critique the contemporary state-centered explanations for the industrialization of East Asia on same grounds. We claim that most political economists misinterpret or entirely ignore the significance of export-led industrialization, which is a (...) characteristic feature of East Asian capitalism. In the second part of the article, we demonstrate the importance of the retail revolution in the US and Europe on Asian industrialization. In particular, we show that the development of the sequential ordering system that is an inherent feature of Western-based contract manufacturing differentially shaped the industrial organization of East Asian economies. The resulting path-dependent trajectories of development, in turn, encouraged government policy-makers to ‘buy into’ trends of global capitalism in different ways. The trajectories also led business people to privilege and adapt some social institutions and cultural patterns over other ones. (shrink)

This chapter examines Russell’s appreciation of the relevance of psychology for the theory of knowledge, especially in connection with the problem of the external world, and the background for this appreciation in British philosophy of the eighteenth and nineteenth centuries. Russell wrote in 1914 that “the epistemological order of deduction includes both logical and psychological considerations.” Indeed, the notion of what is “psychologically derivative” played a crucial role in his epistemological analysis from this time. His epistemological discussions engage psychological factors (...) in the perception of external objects that had been closely examined in the nineteenth century, among other places in J. S. Mill’s response to William Hamilton’s conception of knowledge of the external world. These considerations came to Russell in various ways, including his contact with British Empiricism (Mill, with Berkeley, Hume, and Reid as background), his engagement with Austrian philosophy, his close acquaintance with the philosophy and psychology of William James, and his exposure to contemporary British writings concerning the problem of the external world. The latter writings provide a crucial context within which natural scientific psychology came to be seen as distinct from epistemology and yet as relevant to its concerns. (shrink)

1. Introduction : humanity's urge to understand -- 2. Elements of scientific thinking : skepticism, careful reasoning, and exhaustive evaluation are all vital. Science Is universal -- Maintaining a critical attitude. Reasonable skepticism -- Respect for the truth -- Reasoning. Deduction -- Induction -- Paradigm shifts -- Evaluating scientific hypotheses. Ockham's razor -- Quantitative evaluation -- Verification by others -- Statistics : correlation and causation -- Statistics : the indeterminacy of the small -- Careful definition -- Science at the frontier. (...) When good theories become ugly -- Stuff that just does not fit -- 3. Christopher Columbus and the discovery of the "Indies" : it can be disastrous to stubbornly refuse to recognize that you have falsified your own hypothesis -- 4. Antoine Lavoisier and Joseph Priestley both test the befuddling phlogiston theory : junking a confusing hypothesis may be necessary to clear the way for new and productive science -- 5. Michael Faraday discovers electromagnetic induction but fails to unify electromagnetism and gravitation : it is usually productive to simplify and consolidate your hypotheses -- 6. Wilhelm Röntgen intended to study cathode rays but ended up discovering X-rays : listen carefully when Mother Nature whispers in your ear : she may be leading you to a Nobel Prize -- 7. Max Planck, the first superhero of quantum theory, saves the universe from the ultraviolet catastrophe : assemble two flawed hypotheses about a key phenomenon into a model that fits experiment exactly and people will listen to you even if you must revolutionize physics -- 8. Albert Einstein attacks the problem "Are atoms real?" from every angle : solving a centuries-old riddle in seven different ways can finally resolve it -- 9. Niels Bohr models the hydrogen atom as a quantized system with compelling exactness, but his later career proves that collaboration and developing new talent can become more significant than the groundbreaking research of any individual -- 10. Conclusions, status of science, and lessons for our time. Conclusions from our biographies -- What thought processes lead to innovation? -- Is the scientist an outsider? -- The status of the modern scientific enterprise -- Lessons for our time -- Can the scientific method be applied to public policy? -- Why so little interest in science? -- Knowledge is never complete. (shrink)

Rutherford and Lindell (2011) review an extensive literature on lateralization of emotion. As they note, an important issue surrounding this question is the nature of emotion, which bears on what, precisely, is lateralized. The present comments are intended to broaden the context of the review, by considering lateralization from the standpoint of a bivariate model of evaluative processes and a neuroevolutionary perspective.

Phosphoinositides are inositol‐containing phospholipids whose hydrolysis is a key step in the rapid responses of animal cells to extracellular signals. Whether they play similar roles in plant cells has not been established, and some have suggested alternative roles as direct modulators of specific proteins. Nonetheless, evidence is accumulating that phosphoinositide hydrolysis mediates transduction of some signal in plants. The evidence is strongest for a role in triggering the shedding of flagella by the unicellular alga Chlamydomonas reinhardtii under acid stress. Rapid (...) kinetic analysis indicates that phosphoinositide hydrolysis occures within half a second and could trigger the rapid loss of flagella. Plant responses to pathogens and osmotic stress, as well as the regulation of turgor changes which underlie stomatal opening and closing and the movement of leaves and flower parts, may also be mediated by phosphoinositide hydrolysis. The evidence thus indicates that at least one reason plants have phosphoinositides is to mediate transduction of environmental signals. (shrink)

Some have argued that because factually meaningful assertions must be falsifiable, putative theistic assertions such as “God loves us” are not meaningful because they are not falsifiable. It is further suggested that every attempt to make a factually significant theistic assertion founders on the same shoal of falsifiability.

The precise relationship between the autonomic nervous system and emotion has been a topic of intense debate and research throughout the history of modern psychology. The present article considers some of the more influential theoretical frameworks that continue to drive contemporary research on the relationship between emotion and physiological processes. In particular, we highlight the multiple routes through which somatovisceral afference influences emotion and how this relates to the topic of emotion-specific patterns of autonomic nervous system activity.

Pietraszewski asserts that social psychological research on groups is too vague, tautological, and dependent on intuitions to be theoretically useful. We disagree. Pietraszewski's contribution is thought-provoking but also incomplete and guilty of many of the faults he attributes to others. Instead of rototilling the existing knowledge landscape, we urge for more integration of new and old ideas.

THE TWO-FOLD PURPOSE OF THIS DISCUSSION IS: (1) TO CRITICIZE THE FIRST THREE OF HUME�S REASONS FOR REJECTING AS UNRELIABLE THE HISTORICAL RECORDS OF MIRACLES; (2) TO DRAW A DISTINCTION BETWEEN DESCRIPTION AND EXPLANATION WHICH CHALLENGES THE "A PRIORI" JUDGEMENT THAT AUTHENTIC MIRACLE REPORTS CANNOT FORM A RELIABLE PART OF HISTORY. HUME FAILED TO REALIZE THAT THE NATURALISTIC EXPLAINABILITY OF AN EVENT SAID TO BE A MIRACLE IS NOT LOGICALLY IMPLIED BY ITS ACCURATE DESCRIPTION.

Microtubules are organized into diverse cellular structures in multicellular organisms. How is such diversity generated? Although highly conserved overall, variable regions within α‐ and β‐tubulins show divergence from other α‐ and β‐tubulins in the same species, but show conservation among different species. Such conservation raises the question of whether diversity in tubulin structure mediates diversity in microtubule organization. Recent studies probing the function of β‐tubulin isotypes in axonemes of insects(1) suggest that tubulin structure, through interactions with extrinsic proteins, can direct (...) the architecture and supramolecular organization of microtubules. (shrink)

Behrendt & Young's (B&Y's) theory offers a potentially important perspective on the neurobiology of schizophrenia, but it remains incomplete. In addition to bottom-up contributions, such as those associated with disturbances in sensory constraints on cognitive processes, a comprehensive model requires the integration of the consequences of abnormal top-down modulation of input processing for the evolution of “underconstrained” perceptions. Dysfunctional cholinergic modulation of input functions represents a necessary mechanism for the generation of false perceptions.

Evaluative processes have their roots in early evolutionary history, as survival is dependent on an organism’s ability to identify and respond appropriately to positive, rewarding or otherwise salubrious stimuli as well as to negative, noxious, or injurious stimuli. Consequently, evaluative processes are ubiquitous in the animal kingdom and are represented at multiple levels of the nervous system, including the lowest levels of the neuraxis. While evolution has sculpted higher level evaluative systems into complex and sophisticated information-processing networks, they do not (...) come to replace, but rather to interact with more primitive lower level representations. Indeed, there are basic features of the underlying neuroarchitectural plan for evaluative processes that are common across levels of organization—including that of evaluative bivalence. (shrink)

Los autores abordan el desafío de integrar la medicina convencional, la medicina psicosomática, y la medicina alternativa, necesario, según señalan, no sólo por razones clínicas y económicas, sino por el desafío de crear una teoría comprehensiva que integre la riqueza de datos aparentemente disparatados y teorías de la salud y la enfermedad en un todo organizado. Se trata de llegar a una medicina integrada. En este trabajo los autores identifican ocho visiones fundacionales sobre la naturaleza, cada una de las cuales (...) genera hipótesis diferentes acerca de la naturaleza y de la medicina, y han conducido a tres diferentes conceptos de medicina. El artículo aborda cómo el conocimiento de tales hipótesis puede alcanzar el objetivo de integrar la medicina. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. We reject arbitrary distinctions that deny adequate protections to other animals who share with protected humans relevantly similar vulnerabilities to harms and relevantly similar interests in avoiding such harms. We strongly urge this Court, in keeping with the best philosophical standards of rational judgment and ethical standards of justice, to recognize that, as a nonhuman person, Happy should be (...) released from her current confinement and transferred to an appropriate elephant sanctuary, pursuant to habeas corpus. (shrink)

In December 2013, the Nonhuman Rights Project (NhRP) filed a petition for a common law writ of habeas corpus in the New York State Supreme Court on behalf of Tommy, a chimpanzee living alone in a cage in a shed in rural New York (Barlow, 2017). Under animal welfare laws, Tommy’s owners, the Laverys, were doing nothing illegal by keeping him in those conditions. Nonetheless, the NhRP argued that given the cognitive, social, and emotional capacities of chimpanzees, Tommy’s confinement constituted (...) a profound wrong that demanded remedy by the courts. Soon thereafter, the NhRP filed habeas corpus petitions on behalf of Kiko, another chimpanzee housed alone in Niagara Falls, and Hercules and Leo, two chimpanzees held in research facilities at Stony Brook University. Thus began the legal struggle to move these chimpanzees from captivity to a sanctuary, an effort that has led the NhRP to argue in multiple courts before multiple judges. The central point of contention has been whether Tommy, Kiko, Hercules, and Leo have legal rights. To date, no judge has been willing to issue a writ of habeas corpus on their behalf. Such a ruling would mean that these chimpanzees have rights that confinement might violate. Instead, the judges have argued that chimpanzees cannot be bearers of legal rights because they are not, and cannot be persons. In this book we argue that chimpanzees are persons because they are autonomous. (shrink)

Subjects and Simulations presents essays focused on suffering and sublimity, representation and subjectivity, and the relation of truth and appearance through engagement with the legacies of Jean Baudrillard and Philippe Lacoue-Labarthe.

Intended for logicians and mathematicians, this text is based on Dr. Hamilton's lectures to third and fourth year undergraduates in mathematics at the ...

In recent years, with both the development of next‐generation sequencing approaches and the Supreme Court decision invalidating gene patents, declining costs have contributed to the emergence of a new model of hereditary cancer genetic testing. Multigene panel testing (or multiplex testing) involves using next‐generation sequencing technology to determine the sequence of multiple cancer‐susceptibility genes. In addition to high‐penetrance cancer‐susceptibility genes, multigene panels frequently include genes that are less robustly associated with cancer predisposition. Scientific understanding about associations between many specific moderate‐penetrance (...) gene variants and cancer risks is incomplete. The emergence of multigene panel tests has created unique challenges that may have meaningful psychosocial implications. Contrasted with the serial testing process, wherein patients consider the personal and clinical implications of each evaluated gene, with multigene panel testing, patients provide broad consent to whichever genes are included in a particular panel and then, after the test, receive in‐depth genetic counseling to clarify the distinct implications of their specific results. Consequently, patients undergoing multigene panel testing may have a less nuanced understanding of the test and its implications, and they may have fewer opportunities to self‐select against the receipt of particular types of genetic‐risk information. Evidence is conflicting regarding the emotional effects of this testing. (shrink)