This book explores Nietzsche's philosophical naturalism in its historical context, showing that his position is best understood against the background of encounters between neo-Kantianism and the life sciences in the nineteenth century. Analyzing most of Nietzsche's writings from the late 1860s onwards, Christian J. Emden reconstructs Nietzsche's naturalism and argues for a new understanding of his account of nature and normativity. Emden proposes historical reasons why Nietzsche came to adopt the position he did; his genealogy of values and his account (...) of a will to power are as much influenced by Kantian thought as they are by nineteenth-century debates on teleology, biological functions, and theories of evolution. This rich and wide-ranging study will be of interest to scholars and students of Nietzsche, the history of modern philosophy, intellectual history, and history of science. (shrink)

In the climate ethics debate, scholars largely agree that individuals should promote institutions that ensure the reduction of greenhouse gas emissions. This paper aims to establish that there are individual duties beyond compliance with and promotion of institutions. Duties of individuals to reduce their emissions are often objected to by arguing that an individual’s emissions do not make a morally relevant difference. We challenge this argument from inconsequentialism in two ways. We first show why the argument also seems to undermine (...) the case for duties to promote institutions that the arguments’ proponents endorse. Second, we argue that individuals ought to cut emissions if they exceed their fair share of emissions entitlements and, by emitting, contribute to climate-related harm. In response to inconsequentialism, we specify the notion of ‘contribution’ via the so-called NESS theory, according to which an act is causally relevant for and contributes to an outcome if it is a Necessary Element of a Set of conditions that is Sufficient for the outcome. After refuting two objections to our approach, we conclude by discussing how to deal with possible conflicts between duties to promote institutions and to reduce one’s emissions. (shrink)

The Bloomsbury Companion to Ethics offers the definitive guide to this key area of contemporary philosophy. Covering all the fundamental questions asked by meta-ethics and normative ethical theory, thirteen specially commissioned chapters from an international team of experts explore the central ideas, terms and case studies in the field, and new directions in ethics as a whole. Now available in paperback, the Companion to Ethics covers issues such as moral methodology, moral realism, ethical expressivism, constructivism and the error theory, morality (...) and practical reason, moral psychology, morality and religion, consequentialism, Kantian ethics, virtue ethics, feminist ethics, moral particularism, experimental ethics, and biology, evolution and ethics. Featuring a series of indispensable research tools, including key technical terms, a historical chronology, a detailed list of internet resources for research in ethics, and a thorough list of recommended works for further study, this is the essential resource for anyone studying, researching and writing in contemporary philosophical ethics. (shrink)

Focusing primarily on papers and books discussing the evolutionary and systematic interpretation of the Cambrian animal fossils from the Burgess Shale fauna, this paper explores the role of epistemic values in the context of a discipline striving to establish scientific authority within a larger domain of epistemic problems and issues . The focal point of this analysis is the repeated claims by paleontologists that the study of fossils gives their discipline a unique ‘historical dimension’ that makes it possible for them (...) to unravel important aspects of evolution invisible to scientists who study the extant biosphere. The first part of the paper explores the shifting of emphasis in the writings of paleontologists between two strategies that employ opposing views on the classical positivist and physicalist ideal of science. The second part analyzes paleontologists’ claims of privileged access to life’s historical dimension in a situation where a theoretical upheaval occurring independent of the epistemical problem at hand completely shifts the standards for evaluating the legitimacy of various knowledge claims. Though the various strategies employed in defending the privileged historical perspective of paleontology have been disparate and, to an extent contradictory, each impinges on the acceptance of a specific epistemic ideal or set of values and success or failure of each depends on the compatibility of this ideal with the surrounding community of scientists. (shrink)

A provocative exploration of how computers are reshaping ideas about what it means to be human profiles the annual Turing Test to assess a computer's capacity for thought while analyzing related philosophical, biological and moral issues.

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 384-396, September 2022.

The anti-tuberculosis BCG vaccine was conceived and developed between 1905 and 1921 at Pasteur Institutes in France. Between 1921 and A. Calmette’s death in 1933, the vaccine went through a first period of national and international production and distribution for its use in humans. In France these activities were exclusively carried out by Calmette and his collaborators at the Pasteur Institute in Paris. Initially improvised production in a small room in the cellar gave way in 1931 to the construction of (...) the spacious and magnificent ‘New laboratories for research on tuberculosis and the preparation of the BCG’ within the premises of the Pasteur Institute. Presentation and image-building of the vaccine in France insisted on the fact that the BCG was not a commercial specialty but distributed free of charge. The technical monopoly of its production nevertheless lay with the Paris Pasteur Institute and standardization of scientific proof of safety, efficacy and stability was dominated by that Institute in France. In contrast, the international production and distribution of the vaccine was entrusted and transferred, free of charge, to trustworthy laboratories outside France. Multiplication of producers and users led to an increased need for standardization. For this process the analysis distinguishes between the standardization of scientific proof concerning safety, efficacy and stability of the vaccine and standardization of its medical uses. Whereas standardization was rather successful in the inter-war period in France, the international efforts remained rather unsuccessful. Only after world war II under Scandinavian leadership and in the context of mass vaccination programs supported by the WHO and UNICEF was the international standardization effectively implemented and succeeded at least to some extend. (shrink)

There can be little doubt that the “will to power” remains one of Nietzsche’s most controversial philosophical concepts. Leaving aside its colorful and controversial political history in the first half of the twentieth century, the will to power poses considerable problems for any serious reconstruction of Nietzsche’s project. This is particularly the case for analytic reconstructions, which view Nietzsche’s philosophical naturalism largely through the lens of metaethical concerns that are themselves grounded in a psychological reading of will, affect, value, or (...) ressentiment.1 The will to power, though, defies interpretations that are schooled in contemporary philosophy of mind, or cognitive psychology. Even.. (shrink)

The destruction of animality that takes place in Heidegger’s Fundamental Concepts of Metaphysics goes as far as to destroy the very idea of an animal life as distinct from plant life. “Life”, as Heidegger says in Being and Time, is “a specific mode of being”, that is to say, as the 1929-30 lecture course will show, that it is “the mode of being of animals and plants”. Conceived as a mere organism that does “nothing more than to live”, the animal (...) find itself deprived of world, living in a vegetative state, in a kind of stupor (Benommenheit). The method of the ontology of life – announced in Being and Time as a “privative interpretation” – will reveal itself as a biological reduction: the strategy is to find functional equivalences for all that, in animals, resemble in any way what we find in humans. The life of animals is not a life, but biological processes. The traditional faculties associated with animal life – movement, perception and irrational desire (i.e. impulsion) – will be held as properly human, letting the animals a form of life deprived of signification, of possibility, of world. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 12.3 (2005) 199-203 [Access article in PDF] Lived Time and to Live Time Christian Kupke Keywords time, dimensional time, temporality, dialectics, subjectivity In this paper, I argue that a phenomenological description of temporality is a description of what it is to "live" time, that is, to live time in its three-dimensional aspects: past, future, and present. And it is suggested that this dimensional time can (...) be analyzed on two different levels: on a microstructural level that is part of the subject–object relationship (cognitive–intentional time), and on a macrostructural level that is part of the subject–subject relationship (intersubjective time). In a close reading of Martin Wyllie's paper "Lived Time and Psychopathology" (2005) some implications and consequences of these suggestions are discussed. Conceptual Problems: Personal and Intersubjective Time One of Martin Wyllie's main theses is that to accurately describe suffering one may have to use a conceptual framework of a bipartite structure that includes the embodied temporal subject on the one hand and the temporal world on the other. It is this what the author calls a "dialectical relationship" between the time of the individual person called "personal time" and the time of the world called "world time" or "intersubjective time" (Wyllie 2005, 173).But then Martin Wyllie also deals with another model, another conceptual framework that follows a different logic and that—in contrast to the dualistic model—is usually associated with dialectics: the tripartite structure of past, future, and present. "Now in lived time", Wyllie claims, "is a unity of the past, present, and future, and is more than simply a succession because the immediate 'no-more', 'present', and 'yet-to-come' are ordinarily never sharply separated" (Wyllie 2005, 174).I want first to discuss the conceptual problems that come along with Martin Wyllie's use of these models. It seems to me that the author is dealing with the complexity of the relationship between these models by means of a double strategy: to conceptualize world time as intersubjective time (a), and to focus the analysis on the external, dualistic model of personal and intersubjective time (b).(a) "World time" may be differentiated at least into three categories: physical and cosmological time; natural and biological time; and social or sociocultural time. But the question is: how are these (quasi-) objective time matrices realized (and perhaps even "constituted") by the individual subject? To answer this question it is, also in my view, a good strategy for a psychopathology of time to concentrate on intersubjective [End Page 199] time, for, as Martin Wyllie states, there is indeed no doubt that "the embodied human subject is always already in an intersubjective world" (Wyllie 2005, 177).But what I think might be a severe problem with this focal point of the analysis is the tendency to identify the world exclusively with an intersubjective world. That the embodied human subject is always already in an intersubjective world does not mean that the subject's whole world is nothing more than an intersubjective world. Those temporal processes that are, for instance, necessary to "read"—in an intersubjective world—Martin Wyllie's text and to "write" a comment on it (as I do now) are part of at least a double temporal structure.First, reading and writing are formal processes of an integration of cognitive and intentional activities that are the transcendental basis of any intelligible discussion of semantic questions, namely, to recognize signs, retentionally and protentionally, as integral parts of higher temporal units to enable the subject to understand what is read or written. Without such retentional and protentional acts, as they were generally described by Husserl, any text would be a mere accumulation of signs without any formal or logical order.But, second, reading and writing are also informal processes of an integration of those intersubjective activities that result in an intelligible discussion of semantic questions. Here it is necessary to remember what was read or written, by Martin Wyllie, myself, and others (an intersubjective remembrance that is essential for the... (shrink)

This volume deals with the connection between thinking-and-speaking and our form of life. All contributions engage with Wittgenstein’s approach to this topic. As a whole, the volume takes a stance against both biological and ethnological interpretations of the notion "form of life" and seeks to promote a broadly logico-linguistic understanding instead. The structure of this book is threefold. Part one focuses on lines of thinking that lead from Wittgenstein’s earlier thought to the concept of form of life in his later (...) work. Contributions to part two examine the concrete philosophical function of this notion as well as the ways in which it differs from cognate concepts. Contributions to part three put Wittgenstein’s notion of form of life in perspective by relating it to phenomenology, ordinary language philosophy and problems in contemporary analytic philosophy. (shrink)

ArgumentUsing the example of the anti-tuberculosis vaccine BCG during the 1920s and 1930s, this article asks how a labile laboratory-modified bacteria was transformed into a genuine standard vaccine packaged and commercialized as a pharmaceutical product. At the center of the analysis lies the notion of standardization inquiring why and how a local laboratory process with standard operating procedures reached its limits and was transformed when the product faced international distribution. Moving from Paul Ehrlich's initial technological notion ofWertbestimmungreferring to a practice (...) physiologically testing the effects of ill-defined antitoxins, the concept of standardization is extended to pharmaceutical and economical meanings implying quality control for biological therapeutic agents produced by a variety of industrial entrepreneurs. Following the request for product uniformity, two ways to maintain levels of compatibility and commonality are depicted opposing SOPs and end-product control. Furthermore, standardization is understood as a spiral, never ending process where progressive transformation of the vaccine in its production and medical uses periodically recreated the necessity of standardization. Developments analyzed are thus understood as a stabilization process aligning laboratory settings, products, and practices with medical theories and practices through technical, bureaucratic, and organizational systems. A paradox of the analysis is that standardization as a historical phenomenon and moment in the history of drug development was initially linked to a problem of under-determination of what was to be standardized and to a knowledge gap before it could become a central concept for quality control. (shrink)

Can the Stoic conception of what is within our power be adapted to fit our scientifically informed view of nature in general and of human nature in particular? This paper argues that it can, but not without a revision of the Stoic’s classical dichotomy of power principle, namely that some things are up to us, while others are beyond our control. Given the extent to which the Stoic way of life flows from a certain conception of what is real, a (...) revision of the latter is bound to affect the former. The central argument is that for the modern Stoic, follow the facts means that nothing is entirely under our control just as nothing is entirely beyond it. Rather, things are more or less within my power, depending on the range of possibilities that living in accordance with a constantly evolving conception of nature affords. (shrink)

The general aim of this paper is to propose a reductionist strategy to higher-level property types. Starting from a common ground in the philosophy of science, I shall elaborate on possible realizer differences of higher-level property types. Because of the realizer types' causal heterogeneity, an introduction of functional sub-types of higher-level properties will be suggested. Each higher-level functional sub-type corresponds to one realizer type. This means that there is the theoretical possibility to reach some kind of type-identity and this opens (...) up the way for theory reduction in a more complete manner. This kind of type-identity will go beyond the common ground of the identity of tokens and their reductive explanation. In the second part of the paper, this reductionist strategy will be applied to a specific debate in the philosophy of biology — the reductionist approach to classical genetics from a molecular point of view. (shrink)

The fact that Ludwik Fleck drew his inspiration from medicine has been largely overlooked, with the exception of a few scholars. Although Fleck considered his ideas applicable to all sciences, he always insisted on the specificity of medicine. To illustrate the usefulness of Fleck’s concepts for the history of medicine, three main ideas developed by Fleck are applied to the historical study of diabetes mellitus : first, that different and often divergent pictures of disease coexist within a given culture; second, (...) that scientific ideas circulate between ‘esoteric’ and ‘exoteric’ circles; and third, that scientific concepts are often incommensurable. The author also suggests that Fleck’s epistemology, like other scholars’, is loaded with ethical and political consequences. However, the link between an ‘open’ epistemology and political or ethical questions is more explicit in Georges Canguilhem’s pioneering work on the normal and the pathological . Indeed, Canguilhem and Fleck’s conceptions of disease have much in common, so that we can use Canguilhem’s work to bring out the hidden ethical and political issues in Fleck’s work. (shrink)

The prediction defended in this paper is that over the next fifty years we will see a return of the ancient tradition of “universal history”; but this will be a new form of universal history that is global in its practice and scientific in its spirit and methods. Until the end of the nineteenth century, universal history of some kind seems to have been present in most historiographical traditions. Then it vanished as historians became disillusioned with the search for grand (...) historical narratives and began to focus instead on getting the details right through document-based research. Today, however, there are many signs of a return to universal history. This has been made possible, at least in part, by the detailed empirical research undertaken in the last century in many different fields, and also by the creation of new methods of absolute dating that do not rely on the presence of written documents. The last part of the paper explores some of the possible consequences for historical scholarship of a return to a new, scientific form of universal history. These may include a closer integration of historical scholarship with the more historically oriented of the sciences, including cosmology, geology, and biology. Finally, the paper raises the possibility that universal history may eventually be taught in high schools, where it will provide a powerful new way of integrating knowledge from the humanities and the sciences. (shrink)

“De-extinction” projects propose to re-create or “resurrect” extinct species. Perhaps the most common justification offered for these projects is that humans have an obligation to make restitution to species we have eradicated. There are three versions of this argument for de-extinction—one individualistic, one concerned with species, and one that emphasizes ecological restoration—and all three fail to provide a compelling case for species revival. A general critique of de-extinction can be sketched that highlights how it can both facilitate inattentiveness to biological (...) and ecological boundaries and foster a managerial mentality toward the natural world. (shrink)

Using the Burgess Shale controversies as a case-study, this paper argues that controversies within different domains may interact as to create a situation of "complicated intricacies," where the practicing scientist has to navigate through a context of multiple thought collectives. To some extent each of these collectives has its own dynamic complete with fairly negotiated standards for investigation and explanation, theoretical background assumptions and certain peculiarities of practice. But the intellectual development in one of these collectives may "spill over" having (...) far reaching consequences for the treatment of apparently independent epistemic problems that are subject of investigation in other thought collectives. For the practicing scientist it is necessary to take this complex web of interactions into account in order to be able to navigate in such a situation. So far most studies of academic science have had a tendency to treat the practicing scientist as members of a single (enclosed) thought collective that stands intellectually isolated from other similar entities unless the discipline was in a state of crisis of paradigmatic proportions. The richness and complexity of Burgess Shale debate shows that this encapsulated kind of analysis is not enough. (shrink)

While in medicine, comparison of the data supplied by a clinical syndrome with the data supplied by the biological system is used to arrive at the most accurate diagnosis, the same cannot be said of financial economics: the accumulation of statistical results that contradict the Brownian hypothesis used in risk modelling, combined with serious empirical problems in the practical implementation of the Black-Scholes-Merton model, the benchmark theory of mathematical finance founded on the Brownian hypothesis, has failed to change the Brownian (...) representation, which has endured for more than fifty years despite the extent of its invalidation by experience. Without any statistical foundations, one mathematical representation has become the established approach, acting in the minds of practitioners as a “prenotion” in the sense the word is used by Durkheim, i.e. a “schematic, summary representation” which has produced a kind of spontaneous epistemology. The question arises of the persistence of this mathematical representation, which has been the basis for every financial risk modelling approach: how can its long life be explained? How was this spontaneous epistemology formed, and why did it prove to be so persistent? To address this question and offer an answer, I will test the various dynamics of scientific knowledge used with reference to financial modelling. All these dynamics are specific ways of describing the relationship between knowledge of a phenomenon and the phenomenon itself. Observing that it is impossible for the positivist approach to solve the financial puzzle, I turn to the three principal postpositivist dynamics, developed by Kuhn, Lakatos and Quine. I shall try to make to speak these representations of science for financial research, in order to reflect on the dominance of the Brownian representation in finance. We shall see that none of the epistemologies examined can explain why the Brownian representation continues to be used in mathematical finance research. I shall then propose an alternative hypothesis, concerning a significant pervading mental model that has irrigated both academics and practitioners in the financial sector: the “principle of continuity” introduced into economics by Marshall in. I consider that this principle of continuity has become a “persistent idea” in the form of a viral approach to representations, and I give this persistent idea the metaphorical name of the “Brownian virus”. Then, to explain the spread of this Brownian virus through the financial sector, the contamination of financial practices by this mental representation founded on the principle of continuity, I introduce the concept of the “financial Logos”, a discourse that structures practices and organisations, calculations, prudential regulations and accounting standards, leading to a general financialisation of society from the 1980s onwards. (shrink)

Humans routinely make many decisions collectively, whether they choose a restaurant with friends, elect political leaders or decide actions to tackle international problems, such as climate change, that affect the future of the whole planet. We might be less aware of it, but group decisions are just as important to social animals as they are for us. Animal groups have to collectively decide about communal movements, activities, nesting sites and enterprises, such as cooperative breeding or hunting, that crucially affect their (...) survival and reproduction. While human group decisions have been studied for millennia, the study of animal group decisions is relatively young, but is now expanding rapidly. It emerges that group decisions in animals pose many similar questions to those in humans. The purpose of the present issue is to integrate and combine approaches in the social and natural sciences in an area in which theoretical challenges and research questions are often similar, and to introduce each discipline to the other’s key ideas, findings and successful methods. In order to make such an introduction as effective as possible, here, we briefly review conceptual similarities and differences between the sciences, and provide a guide to the present issue. (shrink)

The New Caledonian crow may be the only non-primate species exhibiting cumulative technological culture. Its foraging tools show clear signs of diversification and progressive refinement, and it seems likely that at least some tool-related information is passed across generations via social learning. Here, we explain how these remarkable birds can help us uncover the basic biological processes driving technological progress.

In lieu of an abstract, here is a brief excerpt of the content:Artificial Minds and the Dilemma of Personal IdentityChristian Coseru (bio)Artificial You: AI and the Future of Your Mind. By Susan Schneider. Princeton: Princeton University Press, 2019.I. IntroductionAll diurnal organisms are stirred to action by light, but as entomologists have long known, for nocturnal insects the pull of its radiance can also spell doom. The image of a moth drawn to flame is suggestive of the sort of self-destructive behavior (...) that poets have long used to maximum rhetorical effect: "Thus had the candle singed the moth" proclaims Portia in the Merchant of Venice, pitying the fate that befell Arragon. The deceptive lure of artificial lights, however, is no longer mere fodder for the poetic imagination. Ecologists are warning us that species accustomed to navigating by moon or starlight, from beetles to seals and sea turtles, are getting confused, or worse.1 And medical science is beginning to establish a link between night-time light exposure and various sleep and metabolic disorders.2 Yet our Promethean ingenuity is a sight to behold: fueled by illumination tropes as metaphors for awareness and understanding, our mastery of light and of the electromagnetic wave spectrum has brought forth technologies, from CT scans and electromicrography to myoelectric sensors and solid-state lighting, that inspire utopian visions of genetically engineered and neurally enhanced post-humans alongside dystopian fantasies of runaway cyborgs. Among these technologies, AI stands out as the shiny new object commanding our attention.The future envisioned as a result of these technological advancements now includes the prospect of artificial minds, minds that, if they were to come anywhere close to resembling ours, let alone to surpassing human intelligence, would pose serious existential and ethical challenges for humanity. Or so the story goes, if Susan Schneider's compelling foray into AI research is any indication. Indeed, Artificial You: AI and the Future of Your Mind (Schneider 2019) offers a philosophically savvy investigation of the debates that animate much of the contemporary fascination with the prospect of machine intelligence, which by some of the more optimistic [End Page 281] measures could be achieved within the lifetime of most millennials.3 As books aimed at a general audience pondering the promises and perils of superintelligent AI go, Artificial You succeeds precisely where most others falter: it brings conceptual clarity to often vague and nebulous claims by techno optimists about the impending emergence of consciousness from computational complexity, while at the same time offering a sober reminder that the technology underlying, say, artificial neural networks is far more advanced than most AI skeptics realize.I will not address Schneider's survey of the state of the art in AI research, which is succinct, informative, and for the most part illustrative of the transhumanist ethos she appears to embrace. Instead, I will focus on the problem of personal identity and the seemingly insurmountable challenges it raises for the prospect of radical human enhancement and synthetic consciousness. Specifically, I will argue that conceptions of personal identity rooted in psychological continuity akin to those proposed by Parfit and the Buddha may not provide the sort of grounding that many transhumanists chasing the dream of life extension think that they do if they rest upon ontologies that assume an incompatibility between identity and change. I will also suggest that process ontologies that take change to be primary, such as those that align with contemporary systems biology, offer a better way out of the personal identity dilemma. But the solution in this case, which regards biological organisms as processes rather than things, may constrain the possibility of biologically inspired superintelligent aliens (BISAs), which Schneider (following Bostrom 2014) posits as possibly the most common form of (extraterrestrial) superintelligence in the universe.II. Enhancement Beyond RecognitionPerhaps the central leitmotif of transhumanism is the idea of enhancement by means of current technologies such as genetic engineering and information technology as well as future ones such as nanotechnology and artificial intelligence. The range of enhancement options includes the extension of the human lifespan, the elimination of disease, and most importantly the augmentation of human intellectual, physical, and affective capacities (Bostrom 2003b). Further down the line, enhancement may move beyond merely augmenting existing... (shrink)

Recent years have seen a gradual convergence of seemingly distant research fields over a single goal: understanding and replicating biological intelligence in artifacts. This work presents a general overview on the origin, the state-of-the-art, scientific challenges and the future of Biologically Inspired Cognitive Architecture (BICA) research. Our perspective decomposes the field into the four principal semantic components associated with the BICA challenge that together call for an integration of efforts of researchers across disciplines. Areas and directions of study where new (...) integrated efforts will be primarily needed are summarized. (shrink)

The job of veterinarians is often described as morally challenging. This online survey (n = 123) investigated how farm veterinarians in Germany perceive these challenges. Most participants described their job in accordance with the literature: as a profession that regularly has to deal with morally difficult decisions. The majority assumed that their moral challenges were greater than the ones of small animal practitioners. The results indicate that the typical moral challenges are (a) situations in which the farm veterinarians are convinced (...) to know what is morally right, however, specific external obstacles prevent them from implementing their convictions. Therefore, the central moral problem from the veterinarians’ point of view can be described with the following words: “I would like to, but I can’t.” Other ideal types of moral challenges like (b) open ethical questions, (c) ethical dilemmas or (d) “duty vs. inclination” conflicts play a less prominent role. With regard to dealing with these challenges, the study shows that farm veterinarians are looking for exchange, for example with colleagues. Most participants see the current social debate about livestock farming as something that stresses them, arguing that their university’s curriculum did not adequately prepare them to participate in these controversies. (shrink)

Algorithms are used across a wide range of societal sectors such as banking, administration, and healthcare to make predictions that impact on our lives. While the predictions can be incredibly accurate about our present and future behavior, there is an important question about how these algorithms in fact represent human identity. In this paper, we explore this question and argue that machine learning algorithms represent human identity in terms of what we shall call the statistical individual. This statisticalized representation of (...) individuals, we shall argue, differs significantly from our ordinary conception of human identity, which is tightly intertwined with considerations about biological, psychological, and narrative continuity—as witnessed by our most well-established philosophical views on personal identity. Indeed, algorithmic representations of individuals give no special attention to biological, psychological, and narrative continuity and instead rely on predictive properties that significantly exceed and diverge from those that we would ordinarily take to be relevant for questions about how we are. (shrink)

Two essential periods may be identified in the early stages of the history of vitamin D-resistant rickets. The first was the period during which a very well known deficiency disease, rickets, acquired a scientific status: this required the development of unifying principles to confer upon the newly developing science of pathology a doctrine without which it would have been condemned to remain a collection of unrelated facts with very little practical application. One first such unifying principle was provided by the (...) notion of hygiene; while the blanket explanations provided by this notion alone were much too general to enable rickets to achieve scientific status, it did point out the need to look for specific external causes for the disease and to examine the life-style and dietary habits of the patients. The second phase of the conceptualization of the disease was the assumption of a specific cause — that is, using concepts developed in the area of infectious diseases. This was made possible by fundamental similarities between deficiency and infectious diseases, in spite of their apparent differences. Both types of illness have some of the characteristics of what Georges Canguilhem calls the ontological representation of disease as opposed to dysharmonic representations, which primarily concern the endocrine diseases. It is precisely this shift from one to the other manner of perceiving ill health that enabled the identification of the vitamin D-resistant rickets. Conceptualization of the notion of vitamin D resistancy required that the conditions causing the disease be looked for within the organism rather than outside it; this was thus the first time that endocrine concepts were applied to studying the physiology of vitamin D.The history of resistant rickets therefore represents an interesting model for understanding the growth of biomedical knowledge. It allows the development of a number of more general ideas on the question of the relationship between biology and medicine and on the thorny problem of specificity in medical thinking. As far as this topic is concerned it can be seen that there was an ongoing exchange between medical and biological thinking during the initial period up until 1937, and that one could deny any such specificity in medical thinking during this same period. Albright, for example, used human diseases as spontaneously produced models for experimental biology. It was also more feasible for an experimental biologist to administer toxic doses than for a clinician to do so.What, then, if any, is the place of the specificity of medical thinking in this history? The fact that medicine is characterized not only by it ccognitive content78 but also by its final aim, which is to restore health, makes it necessary to take factors other than objective knowledge into consideration. This is particularly evident in two aspects of medicine, therapeutics and nosology, and in approaching the notion of pathological individuality.Therapeutic activity has a largely empirical approach. Many drugs, such as cod-liver oil, were discovered empirically. Treatment often in the past, and still now, has proceeded by trial and error, upon no established theoretical basis. At this level the relationship between biology and medicine is roughly comparable to that between science and technology79 \3- that is, it is impossible to reduce either therapeutics or technical activities to the simple application of basic science. In this sense, the application of vitamin D to vitamin-resistant rickets is quite typical. Further-more, in the case studied here, the therapeutic activity heralds a definite breaking away from the medicatrix naturae of conventional medicine dating back to ancient times, and it embodies a new concept of the organism and of disease: no longer can the diseased organism be thought of as merely having a perturbed equilibrium requiring restoration by means of a natural style of medicine. On the contrary, vitamin D resistance is an obstacle that indicates profound biological dysfunction, to be rectified only by means of an extremely aggressive and therefore dangerous therapy. The therapy thus serves to reveal the severity of the dysfunction, thereby leading inevitably to conceptual innovation. This sheds light on the theoretical innovations of which the therapeutic activity is capable.Therapeutic activity is also influenced by notions of health and illness, normal and pathological states, none of which may be determined entirely objectively. For example, the term healing as used by Albright in the case of resistant rickets that he described may be discussed in this light.Nosology, or the classification of diseases, depends largely on the description of clinical syndromes, which are themselves mainly based on subjective elements (discomfort, disability, or the extent of a patient's suffering). The advent of pathological anatomy at the beginning of the nineteenth century disrupted classification by introducing the concept of localized anatomical lesions81-and, hence, an element of material objectivity \3- into nosology. Radiological examination further complicated matters by enabling the equivalent of an autopsy on living matter. Lastly, biological examination complicated nosology by showing that biological anomalies may exist in human beings without necessarily leading to a pathological condition. Medical thinking can choose to combine all these elements to describe a disease, but can also separate them and retain only a few, or a single one, according to requirements - as did Albright.The notion of biological and pathological individuality is fundamental to the development of medical thinking. Whatever its theoretical origin, medical thinking has since ancient times incorporated the idea that each individual reacts differently to the same treatment and his own specific pathological tendencies. I mentioned earlier that in the history of vitamin D-resistant rickets the notion of rachitic tendency reflected this type of thinking. After 1937, this history progressed by successively separating new individual entities, affecting smaller and smaller groups of individuals in each case. In other words, the need to understand and to define individual illness more closely required the development of new concepts and the construction of new individual categories of disease linking these concepts to older clinical, radiological, and biochemical elements. (shrink)

Hegel's philosophy of biology is one of the strongest chapters of Hegel'sPhilosophy of Nature. It can be argued that Hegel's understanding of organicity underscores the explanatory power of ‘dialectical thinking’, as Hegel himself claims. Hegel's interpretation of organicity is based upon the logical development of categories in his chapter on Objectivity of his Logic. If we compare Hegel's treatment of teleology in the Logic with his interpretation of organicity in his Philosophy of Nature, a mismatch can be found. In (...) the Logic, Hegel introduces the notion of life (Leben) after the chapter on Objectivity, i.e. after elaborating on external teleology. In his Philosophy of Nature, the notion of the inner purposiveness of organicity belongs to the externality of nature. This article compares Hegel's treatment of teleology in his Logic and his Philosophy of Nature, reconstructs possible explanations for mismatches and offers a possible solution to the question whether the notion of life should be regarded as the last part of the chapter on teleology or the first part of the chapter on the Idea. (shrink)

The Continuum Companion to Ethics offers a definitive guide to a key area of contemporary philosophy. The book covers all the fundamental questions asked by meta-ethics and normative ethical theory - areas that have continued to attract interest historically as well as topics that have emerged more recently as active areas of research. Fourteen specially commissioned essays from an international team of experts reveal where important work continues to be done in the field and, most valuably, the exciting new directions (...) the field is taking. The Companion explores issues pertaining to moral methodology, moral realism, ethical expressivism, constructivism and the error theory, morality and practical reason, moral psychology, morality and religion, consequentialism, Kantian ethics, virtue ethics, feminist ethics, moral particularism, experimental ethics, and biology, evolution, and ethics. Featuring a series of indispensable research tools, including important technical terms in ethics, a historical chronology, an extensive overview of contemporary meta-ethics and normative ethical theory, a detailed list of internet resources for research in ethics, and a thorough list of recommended works for further study, this is the essential reference tool for anyone working in contemporary philosophical ethics. (shrink)

"Die Hypothese eines neuen Erdzeitalters, des »Anthropozän«, wird seit ihrer Postulierung durch den Chemiker und Nobelpreisträger Paul Crutzen im Jahr 2000 intensiv diskutiert. Der Beginn des Anthropozän wird zumeist um 1800 datiert und in einen Zusammenhang mit der Industrialisierung gestellt. Seither, so die These, ist die Menschheit zu einer quasi geologischen Kraft und sind menschliche Infrastrukturen zum wichtigsten Einflussfaktor auf die biologischen, geologischen und atmosphärischen Prozesse auf der Erde geworden. Christian Schwägerl und Reinhold Leinfelder führen in ihrem Beitrag Argumente und (...) Beispiele für die langfristigen Veränderungen und für die »Reorganisation des gesamten Erdsystems« an, welche die These vom Anthropozän und der »menschgemachten« Erde stützen. In ihrem Beitrag widersprechen sie dem vorschnellen Eindruck, es handle sich bei der Idee einer neuen geologischen Erdepoche nur um einen neuen Sammelbegriff für all das, was als Umweltproblem gilt. Vielmehr betonen die Autoren auch das Potential des Menschen und seiner Technologien zur positiven Gestaltung seines Lebensraums und zur Transformation der Erde. Sie verstehen das Anthropozän nicht nur als rein physische Zustandsbeschreibung, sondern auch als gesellschaftliche Herausforderung und als Forschungsauftrag. Niels Werber setzt in seinem Beitrag an der Frage der notorischen Epochenbildung um 1800 an und kritisiert, dass der Anthropozän-Diskurs sich allein auf die vermeintliche Evidenz naturwissenschaftlicher, vor allem geologischer Daten und Zahlen verlassen würde und ausgerechnet für die Plausibilisierung des Zeitalters des Menschen Kenntnisse über den Menschen, seine Sozialordnung und Kultur offenbar nicht nötig seien. Stattdessen fordert Werber im Anschluss an Niklas Luhmann dazu auf, die Anthropozän-Hypothese als einen Beitrag zur »Selbstbeschreibung der Gesellschaft«, das heißt zur Beschreibung der Einfügung des Menschen und seiner Gesellschaft in die Welt zu verstehen. The hypothesis of a new geological era, the »Anthropocene«, is discussed intensively since its presentation by the chemist and Nobel Prize winner Paul Crutzen in 2000. The beginning of the Anthropocene is usually dated to 1800 and put into the context of the industrialization. Since then, according to Crutzen, mankind has become a quasi-geological force and human infrastructures have developed into a primary influence on the biological, geological and atmospheric processes on Earth. In their contribution, Christian Schwägerl and Reinhold Leinfelder present examples of the long-term changes and arguments for the »reorganization of the entire Earth system«, supporting the thesis of the Anthropocene and the »man-made« Earth. In their article they contradict the premature impression that the Anthropocene is nothing but a new umbrella term for everything that is considered an environmental problem. Rather, the authors emphasize the potential of man and his technologies for the positive design of his habitat and the transformation of the earth. They understand the Anthropocene not only as a description of a purely physical state, but also as a social and scientific challenge. Niels Werber puts in his contribution the notorious epoch threshold 1800 in question. Furthermore, he criticizes that the discourse of the Anthropocene relies solely on the supposed evidence of science, especially of geological data and figures, and thus neglects in its effort to describe a »geological age of mankind« precisely the emerging knowledge of man, social order and culture. Instead, Werber understands the »Anthropocene« as a contribution to the »self-description of society,« i.e. to a possible integration of mankind and society into the world.". (shrink)

The hypothesis of a new geological era, the »Anthropocene«, is discussed intensively since its presentation by the chemist and Nobel Prize winner Paul Crutzen in 2000. The beginning of the Anthropocene is usually dated to 1800 and put into the context of the industrialization. Since then, according to Crutzen, mankind has become a quasi-geological force and human infrastructures have developed into a primary influence on the biological, geological and atmospheric processes on Earth. In their contribution, Christian Schwägerl and Reinhold Leinfelder (...) present examples of the long-term changes and arguments for the »reorganization of the entire Earth system«, supporting the thesis of the Anthropocene and the »man-made« Earth. In their article they contradict the premature impression that the Anthropocene is nothing but a new umbrella term for everything that is considered an environmental problem. Rather, the authors emphasize the potential of man and his technologies for the positive design of his habitat and the transformation of the earth. They understand the Anthropocene not only as a description of a purely physical state, but also as a social and scientific challenge. Niels Werber puts in his contribution the notorious epoch threshold 1800 in question. Furthermore, he criticizes that the discourse of the Anthropocene relies solely on the supposed evidence of science, especially of geological data and figures, and thus neglects in its effort to describe a »geological age of mankind« precisely the emerging knowledge of man, social order and culture. Instead, Werber understands the »Anthropocene« as a contribution to the »self-description of society,« i.e. to a possible integration of mankind and society into the world. German Die Hypothese eines neuen Erdzeitalters, des »Anthropozän«, wird seit ihrer Postulierung durch den Chemiker und Nobelpreisträger Paul Crutzen im Jahr 2000 intensiv diskutiert. Der Beginn des Anthropozän wird zumeist um 1800 datiert und in einen Zusammenhang mit der Industrialisierung gestellt. Seither, so die These, ist die Menschheit zu einer quasi geologischen Kraft und sind menschliche Infrastrukturen zum wichtigsten Einflussfaktor auf die biologischen, geologischen und atmosphärischen Prozesse auf der Erde geworden. Christian Schwägerl und Reinhold Leinfelder führen in ihrem Beitrag Argumente und Beispiele für die langfristigen Veränderungen und für die »Reorganisation des gesamten Erdsystems« an, welche die These vom Anthropozän und der »menschgemachten« Erde stützen. In ihrem Beitrag widersprechen sie dem vorschnellen Eindruck, es handle sich bei der Idee einer neuen geologischen Erdepoche nur um einen neuen Sammelbegriff für all das, was als Umweltproblem gilt. Vielmehr betonen die Autoren auch das Potential des Menschen und seiner Technologien zur positiven Gestaltung seines Lebensraums und zur Transformation der Erde. Sie verstehen das Anthropozän nicht nur als rein physische Zustandsbeschreibung, sondern auch als gesellschaftliche Herausforderung und als Forschungsauftrag. Niels Werber setzt in seinem Beitrag an der Frage der notorischen Epochenbildung um 1800 an und kritisiert, dass der Anthropozän-Diskurs sich allein auf die vermeintliche Evidenz naturwissenschaftlicher, vor allem geologischer Daten und Zahlen verlassen würde und ausgerechnet für die Plausibilisierung des Zeitalters des Menschen Kenntnisse über den Menschen, seine Sozialordnung und Kultur offenbar nicht nötig seien. Stattdessen fordert Werber im Anschluss an Niklas Luhmann dazu auf, die Anthropozän-Hypothese als einen Beitrag zur »Selbstbeschreibung der Gesellschaft«, das heißt zur Beschreibung der Einfügung des Menschen und seiner Gesellschaft in die Welt zu verstehen. (shrink)

There is a substantial class of collective decision problems whose successful solution requires interdependence among decision makers at the agenda-setting stage and independence at the stage of choice. We define this class of problems and describe and apply a search-and-decision mechanism theoretically modeled in the context of honeybees and identified in earlier empirical work in biology. The honeybees’ mechanism has useful implications for mechanism design in human institutions, including courts, legislatures, executive appointments, research and development in firms, and basic (...) research in the sciences. Our paper offers a fresh perspective on the idea of “biomimicry” in institutional design and raises the possibility of comparative institutional analysis across species. (shrink)

Background The work of Research Ethics Boards (REBs), especially when involving genetics research and biobanks, has become more challenging with the growth of biotechnology and biomedical research. Some REBs have even rejected research projects where the use of a biobank with coded samples was an integral part of the study, the greatest fear being the lack of participant protection and uncontrolled use of biological samples or related genetic data. The risks of discrimination and stigmatization are a recurrent issue. In light (...) of the increasing interest in biomedical research and the resulting benefits to the health of participants, it is imperative that practical solutions be found to the problems associated with the management of biobanks: namely, protecting the integrity of the research participants, as well as guaranteeing the security and confidentiality of the participant's information. Methods We aimed to devise a practical and efficient model for the management of biobanks in biomedical research where a medical archivist plays the pivotal role as a data-protection officer. The model had to reduce the burden placed on REBs responsible for the evaluation of genetics projects and, at the same time, maximize the protection of research participants. Results The proposed model includes the following: 1) a means of protecting the information in biobanks, 2) offers ways to provide follow-up information requested about the participants, 3) protects the participant's confidentiality and 4) adequately deals with the ethical issues at stake in biobanking. Conclusion Until a governmental governance body is established in Quebec to guarantee the protection of research participants and establish harmonized guidelines for the management of biobanks in medical research, it is definitely up to REBs to find solutions that the present lack of guidelines poses. The model presented in this article offers a practical solution on a day-to-day basis for REBs, as well as researchers by promoting an archivist to a pivotal role in the process. It assures protection of all participants who altruistically donate their samples to generate and improve knowledge for better diagnosis and medical treatment. (shrink)