Recent studies of early development in a number of ivertebrate and vertebrate species have suggested that growth factors and their receptors may play important roles in differentiation as well as cell proliferation. In the mouse embryo, the expression of the receptors for insulin and insulin‐like growth factors I and II (IGF‐I and ‐II) are temporally regulated. The ontogeny of receptor and ligand expression within the insulin and IGF gene family suggests that the very earliest stages of mammalian embryogenesis may be (...) subject to regulation by autocrine and paracrine factors from maternal and embryonic sources. (shrink)

This paper argues that the various approaches to ethics that bioethicists rely on are not adequate to provide effective moral guidance in how to avoid a series of looming human catastrophes (associated with such threats as environmental degradation, war, extreme poverty, and pandemics). It proposes development of a new approach to ethics, dubbed public ethics, that simultaneously investigates moral responsibilities at multiple levels of human organization from the individual to international bodies. It argues that feminist relational theory can provide guidance (...) to development of this new type of ethics, and it warns against obstacles bioethicists face in its pursuit. (shrink)

This book presents the first full translation of the correspondence of Leo Strauss and Gerhard Krüger, showing for each the development of key and influential ideas, along with seven interpretative essays by leading Strauss scholars. During the early to mid-1930’s, Leo Strauss carried on an intense, and sometimes deeply personal, correspondence with one of the leading intellectual lights among Heidegger’s circle of recent students and younger associates. A fellow traveler in the effort to “return to Plato” and reject neo-Kantian conventions (...) of the day, Krüger was also a serious student of Rudolf Bultmann and the neo-orthodox movement in which Strauss also took an early interest. During the most intense years of their correspondence, each underwent significant intellectual development: in Krüger’s case, through a penetrating series of studies of Kant and Descartes, respectively, ultimately leading to Krüger’s conversion to Catholicism; and, in Strauss’s case, through the complex stages of what he subsequently called his “reorientation,” involving what he for the first time calls “political philosophy.” Readers interested in tracing the development of Strauss’s thoughts regarding a theological alternative that he found helpfully challenging—if not ultimately compelling—will find this correspondence to be an accessible point of entry. (shrink)

The book is an investigation of the semantics of numericals, counting and measuring, and its connection to the mass/count distinction from a theoretical and crosslinguistic perspective. It reviews some recent major linguistic results in these topics, and presents the author's new research including in-depth case studies of a number of typologically unrelated languages.

Polygamy, forced marriage, female genital mutilation, punishing women for being raped, differential access for men and women to health care and education, unequal rights of ownership, assembly, and political participation, unequal vulnerability to violence. These practices and conditions are standard in some parts of the world. Do demands for multiculturalism — and certain minority group rights in particular — make them more likely to continue and to spread to liberal democracies? Are there fundamental conflicts between our commitment to gender equity (...) and our increasing desire to respect the customs of minority cultures or religions? In this book, the eminent feminist Susan Moller Okin and fifteen of the world’s leading thinkers about feminism and multiculturalism explore these unsettling questions in a provocative, passionate, and illuminating debate. Okin opens by arguing that some group rights can, in fact, endanger women. She points, for example, to the French government’s giving thousands of male immigrants special permission to bring multiple wives into the country, despite French laws against polygamy and the wives’ own bitter opposition to the practice. Okin argues that if we agree that women should not be disadvantaged because of their sex, we should not accept group rights that permit oppressive practices on the grounds that they are fundamental to minority cultures whose existence may otherwise be threatened. In reply, some respondents reject Okin’s position outright, contending that her views are rooted in a moral universalism that is blind to cultural difference. Others quarrel with Okin’s focus on gender, or argue that we should be careful about which group rights we permit, but not reject the category of group rights altogether. Okin concludes with a rebuttal, clarifying, adjusting, and extending her original position. These incisive and accessible essays — expanded from their original publication in Boston Review and including four new contributions — are indispensable reading for anyone interested in one of the most contentious social and political issues today. The diverse contributors, in addition to Okin, are Azizah al-Hibri, Abdullahi An-Na’im, Homi Bhabha, Sander Gilman, Janet Halley, Bonnie Honig, Will Kymlicka, Martha Nussbaum, Bhikhu Parekh, Katha Pollitt, Robert Post, Joseph Raz, Saskia Sassen, Cass Sunstein, and Yael Tamir. (shrink)

Patriarchal theologies which obstruct women’s leadership in the Anglican Church and impede ‘collaborative’ ministry prompt this exploration of the reluctance to relinquish male metaphors for God, even when intimate relationship rather than gender is stressed as the crucial concept of Trinitarian theology. Despite the ambiguities of using female terms for the divine and of establishing the oft-neglected Holy Spirit as female imaginary in the Godhead, Father-idolatry and sub-ordinationism in the Trinity need to be challenged. ‘Midwife’ is suggested as a feminine (...) term for the 3rd Person, signifying non-gendered action but retaining personhood. This would creatively renew Trinitarian doctrine, the Church and its leadership as reflections of the perichoretic Godhead. (shrink)

This Element examines the entirety of Kant's Critique of Taste with particular emphasis on its political and moral aims. Kant's critical treatment of aesthetic judgment is both an extended theoretical response to influential predecessors and contemporaries, including Rousseau and Herder, and a practical intervention in its own right meant to nudge history forward at a time of civilizational crisis. Attention to these themes helps resolve a number of puzzles, both textual and philosophic, including the normative force and meaning of judgments (...) of taste, and the relation between natural and artful beauty. (shrink)

Two decades of literature and discussion on the topic of therapist-client sexual relationships have revealed much about the nature and consequences of these relationships and have produced an explicit prohibition against such relationships in American Psychological Association (APA) Ethical Principle 6a. This article reviews the literature as it relates to the ethically gray area of sex with former clients. The relative lack of an empirical basis for extending the prohibition of Principle 6a to posttermination relationships is noted. This article describes (...) concepts from three theoretical perspectives about psychotherapy that support an extension of the prohibition to sexual relationships with ex-clients. (shrink)

Leading scholars continue the debate over whether consciousness causes behavior or plays no functional role in it, discussing the question in terms of neuroscience, philosophy, law, and public policy.

Conversations on Consciousness is just that - a series of twenty lively and challenging conversations between Sue Blackmore and some of the world's leading philosophers and scientists. Written in a colloquial and engaging style the book records the conversations Sue had when she met these influential thinkers, whether at conferences in Arizona or Antwerp, or in their labs or homes in Oxford or San Diego. The conversations bring out their very different personalities and styles and reveal a wealth of fascinating (...) detail about their theories and beliefs. Why is consciousness such a special and difficult issue for twenty-first century science? Sue, herself a researcher into this controversial and difficult topic, begins by asking each of her colleagues this simple question and is immediately plunged into the depths of the debate: How do the subjective experiences we call consciousness arise from the physical brain? Is this even the right question to ask? Can zombies - people who behave outwardly just like others but have no inner mental life - exist? What can dreams tell us about consciousness? Should we all be learning to meditate? Do we have free will, and if not is it possible to live without it? With an introduction setting out the broad structure of the debate on consciousness, and an extensive glossary, this book provides an engaging and accessible account of the most challenging problem of all, through the words of some of the leading figures involved in seeking to solve it. (shrink)

Written in a colloquial and engaging style the book records the conversations Sue had when she met these influential thinkers, whether at conferences in Arizona ...

ABSTRACT The welcome expansion of kairos beyond its traditional locus in public debate to a broad range of discourse forms and persuasive actions has not been matched by a reevaluation of the temporal logic of kairos, which is still seen as located in teleologic time. This article suggests that Walter Benjamin’s understanding of time could refigure kairos as a nonteleological relationship among past, present, and future. Benjamin provides a theoretical rationale for kairotic action that is distributed in time and space (...) and accounts for kairos of objects, places, technologies, and works of art. These temporal affordances, usually developed separately in contemporary theory, are deeply connected in Benjamin’s writing; his understanding of time therefore integrates currently unconnected lines of research and supports a fluid but coherent understanding of kairotic agency. (shrink)

For years, moral language has been the province of the Right, as the Left has consoled itself with rudderless pragmatism. In this profound and powerful book, Susan Neiman reclaims the vocabulary of morality--good and evil, heroism and nobility--as a lingua franca for the twenty-first century. In constructing a framework for taking responsible action on today's urgent questions, Neiman reaches back to the eighteenth century, retrieving a series of values--happiness, reason, reverence, and hope--held high by Enlightenment thinkers. In this thoroughly (...) updated edition, Neiman reflects on how the moral language of the 2008 presidential campaign has opened up new political and cultural possibilities in America and beyond. (shrink)

This research paper explores the implications of emotional intelligence and the Big Five personality model on virtual team effectiveness. It illustrates how emotional intelligence and Big Five personality traits help team members better understand interpersonal relationships and develop constructive virtual teams. The widespread use of virtual team meetings for collaborative work over in-person interaction with diverse personalities creates discord and trust among team members, limiting overall productivity. A quantitative analysis approach is used, with hypotheses tested and a series of multiple (...) linear regression analyses performed on data collected from relevant industries using convenient sampling. The findings show that the Big Five personality affects the virtual team's trust and collaboration parameters. However, the relationship between personality traits and team effectiveness is mediated by emotional intelligence. Also, it is explored that having control over emotional intelligence or developing emotional intelligence would improve team performance while managing and working with a diverse group of people. (shrink)

This book features the full scope of Susan Petrilli's important work on signs, language, communication, and of meaning, interpretation, and understanding. Although readers are likely familiar with otherness, interpretation, identity, embodiment, ecological crisis, and ethical responsibility for the biosphere—Petrilli forges new paths where other theorists have not tread. This work of remarkable depth takes up intensely debated topics, exhibiting in their treatment of them what Petrilli admires—creativity and imagination. Petrilli presents a careful integration of divergent thinkers and diverse perspectives. (...) While she abandons hope of attaining a final synthesis or an unqualifiedly comprehensive outlook, there remains a drive for coherence and detailed integration. The theory of identity being advocated in this book will provide the reader with an aid to appreciating the identity of the theorizing undertaken by Petrilli in her confrontation with an array of topics. Her theory differentiates itself from other offerings and, at the same time, is envisioned as a process of self-differentiation. Petrilli's contribution is at once historical and theoretical. It is historical in its recovery of major figures of language; it is theoretical in its articulation of a comprehensive framework. She expertly combines analytic precision and moral passion, theoretical imagination and political commitment. (shrink)

The Republic’s political discussion begins with the construction of two contrasting cities: a ‘healthy’ city and a ‘city with a fever’; one defined by environmentally sustainable subsistence practices and the other by ‘luxurious’ over consumption that exceeds the carrying capacity of its land. Plato’s characters proceed to cure the inflamed city of its fever, resulting in the delineation of the ideal political constitution, the Kallipolis, which recovers the virtues of the original, healthy city in an altered form. This paper develops (...) an ecological reading of the Republic, highlighting Plato’s optimism regarding humans’ ability to limit their material consumption in accordance with the limits of the natural world. The conventional interpretation of the Republic’s first city, known as ‘the city of pigs’, is reconsidered in light of new socio-ecological research on traditional resource management systems. (shrink)

This book explores the meaning and import of neurophenomenology and the philosophy of enactive or embodied cognition for psychology. It introduces the psychologist to an experiential, non-reductive, holistic, theoretical, and practical framework that integrates the approaches of natural and human science to consciousness. In integrating phenomenology with cognitive science, neurophenomenology provides a bridge between the natural and human sciences that opens an interdisciplinary dialogue on the nature of awareness, the ontological primacy of experience, the perception of the observer, and the (...) mind-brain relationship, which will shape the future of psychological theory, research, and practice.​​. (shrink)

Variability in the symptom experience in patients diagnosed with chronic conditions may be related to social determinants of health (SDoH). The purpose of this critical review was to (1) summarize the existing literature on SDoH and symptom clusters (i.e., multiple, co‐occurring symptoms) in patients diagnosed with common chronic conditions, (2) evaluate current variables and measures used to represent SDoH, (3) identify gaps in the evidence base, and (4) provide recommendations for the incorporation of SDoH into future symptom cluster research. We (...) identified 118 articles including information on SDoH in chronic condition symptom cluster research. Articles primarily focused on cancer populations. Few articles had the explicit purpose of investigating relationships between SDoH and symptom clusters, and the inclusion of SDoH was often limited to variables used to describe samples. Future studies should be designed to “move beyond Table 1” in their utilization of SDoH as variables and examine relationships between SDoH and symptom clusters. Attention should be paid to the appropriateness of measures being used to collect information on SDoH, and analysis methods that estimate causal connections between variables should be considered. Research regarding the relationship of SDoH with symptom clusters in patients with chronic conditions has the potential to reveal mechanisms of symptom disparities and guide changes to alleviate these disparities. (shrink)

Our urban problem is how to revive the reality of the outside as a dimension of human experience.Richard Sennett.

This book provides a fascinating and critical insight into familiar and less familiar mixed legal systems, taking the reader on a voyage of discovery from St Lucia and Guyana to the islands of the Seychelles and Mauritius. It considers those mixed systems which share boundaries with unmixed ones, such as Scotland and Quebec, and those located off-shore of major and dominant jurisdictions such as Jersey off the coasts of France’s civil law and England’s common law system, as well as Cyprus, (...) situated between the influences of Europe and those of the Middle East. (shrink)

Debunks cherished theories of mainstream consensus and reveals the deeper mysteries of the science of the unseen.

Mathematical argument in the elementary grades : what and why? -- Elementary students as mathematicians -- The teaching model -- Using the lesson sequences : what the teacher does -- Mathematical argument in the elementary classroom : impact on students and teachers.

Language is the species-specific human version of the animal system of communication. In contrast to non-human animals, language enables humans to invent a plurality of possible worlds; reflect upon signs; be responsible for our actions; gain conscious awareness of our inevitable mutual involvement in the network of life on this planet; and be responsibly involved in the destiny of the planet. The author looks at semiotics, the study of signs, symbols, and communication as developing sequentially rather than successively, more synchronically (...) than diachronically. She discusses the contemporary phenomenon that people in today's society have witnessed and participated in, as part of the development of semiotics. Although there is a long history preceding semiotics, in a sense the field is, as a phenomenon, more "of our time" than of any time past. Its leading figures, whom Petrilli examines, belong to the twentieth and twenty-first century. Semiotics is associated with a capacity for listening. This capacity is also the condition for reconnecting to and recovering the ancient vocation of semiotics as that branch of medical science relating to the interpretation of signs or symptoms. The pragmatic aspect of global semiotics studies the impact of language or signs on those who use them, and looks for consequences in actual practice. In this respect, Petrilli theorizes that the task for semiotics in the era of globalization is nothing less than to take responsibility for life in its totality. (shrink)

The duration of “now” is shown to be important not only for an understanding of how conscious beings sense duration, but also for the validity of the phenomenological enterprise as Husserl conceived it. If “now” is too short, experiences can not be described before they become memories, which can be considered to be transcendent rather than immanent phenomena and therefore inadmissible as phenomenological data. Evidence concerning (a) the objective duration of sensations in various sensory modalities, (b) the time necessary for (...) sensations to enter consciousness and (c) the variability in the subjective sense of time's passing under different conditions is used to conclude that the duration of “now” can actually vary under normal conditions from about 10 ms to several seconds and in extreme cases up to several hours. Thus the immanent moment can be long enough to encompass a report of the contents of consciousness, making phenomenology a viable project. A further speculation from the evidence described is that consciousness takes discrete samples of the external world, at a rate inversely proportional to the duration of the “now” moment. (shrink)

The first priority of this response is to address Libet's rebuttal of my reinterpretation of his data. Then, because many authors have commented on various aspects of the debate, the rest of the response is organized in terms of subject matter, not as replies to each individual commentator. First, I reply to an objection expressed by two separate commentators to part of my reinterpretation of those of Libet's data supposedly supporting backward referral. This leads to a brief discussion of the (...) whole concept of backward referral. The relevance of the flash-lag illusion to possible measurement errors in the Libet/Trevena and Miller paradigm is addressed next. Finally, I have a few words to say on the relationship between quantum mechanical ontology and free will. (shrink)