In vertebrates it is often found that if one considers a group of genes clustered on a certain chromosome, then the homologues of those genes often form another cluster on a different chromosome. There are four explanations, not necessarily mutually exclusive, to explain how such homologous clusters appeared. Homologous clusters are expected at a low probability even if genes are distributed at random. The duplication of a subset of the genome might create homologous clusters, as would a duplication of the (...) entire genome. Alternatively, it may be adaptive for certain combinations of genes to cluster, although clearly the genes must have duplicated prior to rearrangement into clusters. Molecular phylogenetics provides a means to examine the origins of homologous clusters, although it is difficult to discriminate between the different explanations using current data. However, with more extensive sequencing and mapping of vertebrate genomes, especially those of the early diverging chordates, it should soon become possible to resolve the origins of homologous clusters. BioEssays 21:697–703, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

This book is intended to be a standard reference work on the frontal lobes for researchers, clinicians, and students in the fields of neurology, neuroscience, ...

Thomas Friedman’s best-selling The World is Flat has exerted much influence in the west by providing both an accessible analysis of globalisation and its economic and social effects, and a powerful cultural metaphor for globalisation. In this review, we more closely examine Friedman’s notion of the social contract, the moral centre of his hopeful vision of a globalised world. While Friedman’s social contract holds a more generous view of social and state obligation than his neoliberal economic analysis might otherwise allow, (...) his fallacious assumptions about education rest on poorly argued claims about the nature of human beings, the proper aims of schooling, and meanings of justice in a globalised world. (shrink)

Attention research with prefrontal patients supports Merker's argument regarding the crucial role for the midbrain in higher cognition, through largely overlooked and misunderstood prefrontotectal connectivity. However, information theoretic analyses reveal that both exogenous (i.e., collicular) and endogenous (prefrontal) sources of information are responsible for large-scale context-sensitive brain dynamics, with prefrontal cortex being at the top of the hierarchy for cognitive control. (Published Online May 1 2007).

Aggleton & Brown argue that a hippocampal-anterior thalamic system supports the “recollection” of contextual information about previous events, and that a separate perirhinal-medial dorsal thalamic system supports detection of stimulus “familiarity.” Although there is a growing body of human literature that is in agreement with these claims, when recollection and familiarity have been examined in amnesics using the process dissociation or the remember/know procedures, the results do not seem to provide consistent support. We reexamine these studies and describe the results (...) of an additional experiment using a receiver operating characteristic (ROC) technique. The results of the reanalysis and the ROC experiment are consistent with Aggleton & Brown's proposal. Patients with damage to both regions exhibit severe deficits in recollection and smaller, but consistent, deficits in familiarity. (shrink)

An example is given of a complete theory with minimal models of arbitrarily large minimality rank.

Name der Zeitschrift: Neue Zeitschrift für Systematische Theologie und Religionsphilosophie Jahrgang: 57 Heft: 1 Seiten: 138-154.

A set X is prime bounding if for every complete atomic decidable (CAD) theory T there is a prime model U of T decidable in X. It is easy to see that $X = 0\prime$ is prime bounding. Denisov claimed that every $X <_{T} 0\prime$ is not prime bounding, but we discovered this to be incorrect. Here we give the correct characterization that the prime bounding sets $X \leq_{T} 0\prime$ are exactly the sets which are not $low_2$ . Recall that (...) X is $low_2$ if $X\prime\prime$ $\leq_{T} 0\prime$ . To prove that a $low_2$ set X is not prime bounding we use a $0\prime$ -computable listing of the array of sets { Y : Y $\leq_{T}$ X } to build a CAD theory T which diagonalizes against all potential X-decidable prime models U of T. To prove that any $non-low_{2}$ ; X is indeed prime bounding, we fix a function f $\leq_T$ X that is not dominated by a certain $0\prime$ -computable function that picks out generators of principal types. Given a CAD theory T. we use f to eventually find, for every formula $\varphi (\bar{x})$ consistent with T, a principal type which contains it, and hence to build an X-decidable prime model of T. We prove the prime bounding property equivalent to several other combinatorial properties, including some related to the limitwise monotonic functions which have been introduced elsewhere in computable model theory. (shrink)

BackgroundJunior medical doctors have a key role in discussions and decisions about treatment and end-of-life care for people with dementia in hospital. Little is known about junior doctors’ decision-making processes when treating people with dementia who have advance care directives, or the factors that influence their decisions. To describe among junior doctors in relation to two hypothetical vignettes involving patients with dementia: their legal compliance and decision-making process related to treatment decisions; the factors influencing their clinical decision-making; and the factors (...) associated with accurate responses to one hypothetical vignette. MethodA cross-sectional survey of junior doctors, including trainees, interns, registrars and residents, on clinical rotation in five public hospitals located in one Australian state. The anonymous, investigator-developed survey was conducted between August 2018 and June 2019. Two hypothetical vignettes describing patients with dementia presenting to hospital with an ACD and either: bacterial pneumonia; or suspected stroke were presented in the survey. Participants were asked to indicate whether they would commence treatment, given the ACD instructions described in each vignette.ResultsOverall, 116 junior doctors responded. In Vignette 1, 58% of respondents selected the legally compliant option. Participants who chose the legally compliant option perceived ‘following patient wishes’ and ‘legal requirements to follow ACDs’ as equally important reasons for complying with the ACD. The most common reason for not selecting the legally compliant option in Vignette 1 was the ‘ACD is relevant in my decision-making process, but other factors are more relevant’. In Vignette 2, 72% of respondents indicated they would commence treatment and 18% selected they would not commence treatment.. Similar reasons influenced participant decision-making in Vignette 2, a less legally certain scenario.ConclusionsThere are critical gaps in junior doctors’ compliance with the law as it relates to the implementation of ACDs. Despite there being differences in relation to the legal answer and its certainty, clinical and ethical factors guided decision-making over and above the law in both vignettes. More education and training to guide junior doctors’ clinical decision-making and ensure compliance with the law is required. (shrink)

The essay is about the “Preliminary Expectoration” of Kierkegaard’s Fear and Trembling. It argues that “the absurd” there refers primarily to the practical paradox that in faith (so it is claimed) one must simultaneously renounce and gladly accept a loved object. In other words it is about a problem of detachment as a feature of religious life. The paper goes on to interpret, and discuss critically, the views expressed in the book about both renunciation (infinite resignation) and the nature of (...) faith. (shrink)

Batman ist einer der komplexesten und ambivalentesten Charaktere der Comic-Welt. Um ihn und sein Tun drehen sich eine Menge Fragen: Welchen philosophischen Belastungen und Herausforderungen muss er sich beim Schutz von Gotham City stellen? Was treibt seine Gegenspieler an? Ist Batman in seiner Menschlichkeit besser als Superman? Die Philosophie bei Batman bietet unterhaltsame Antworten und Einblicke in Batmans Welt. Das Buch zeigt wie der Dark Knight zum Beispiel mit ethischen Fragen, moralischer Verantwortung, seinem Wunsch nach Rache an den Mördern (...) seiner Eltern und seiner geheimen Identität ringt. Dabei beschäftigen sich die Autoren mit bekannten Philosophen wie Plato, Aristoteles, Kant, Nietzsche und Kierkegaard. (shrink)

Robert Pippin reviews Slavoj Žižek’s Less than Nothing, a serious attempt to re-actualize Hegel in the light of Lacanian metapsychology. But does Žižek’s attempt to think Hegel with Lacan produce, as Žižek hopes, a political figuration adequate to the present? Or does it land us rather in the Hegelian zoo, along with such well-known specimens as the Beautiful Soul, the Unhappy Consciousness, and The Knight of Virtue?

Was treibt seine Gegenspieler an? Ist Batman in seiner Menschlichkeit besser als Superman? Die Philosophie bei Batman bietet unterhaltsame Antworten und Einblicke in Batmans Welt.

Following Zizek's insight that the blockbuster can constitute the ideal terrain for mapping out the ideological and political dilemmas of our conjuncture, this piece takes a Zizekian look awry at two recent depictions of revolutionary crowds/movements in "The Dark Knight Rises" and "Argo". Viewed through the genealogical lens of representations of the “people” in philosophy and literature, what we find in both films is a (distorted, dispersed) staging not only of our own time and situation, a strange figuration of (...) capital and an ultimately justified revolutionary struggle over the city (or, surplus). (shrink)

Why doesn't Batman just kill the Joker and end everyone's misery? Can we hold the Joker morally responsible for his actions? Is Batman better than Superman? If everyone followed Batman's example, would Gotham be a better place? What is the Tao of the Bat? Batman is one of the most complex characters ever to appear in comic books, graphic novels, and on the big screen. What philosophical trials does this superhero confront in order to keep Gotham safe? Combing through seventy (...) years of comic books, television shows, and movies, Batman and Philosophy explores how the Dark Knight grapples with ethical conundrums, moral responsibility, his identity crisis, the moral weight he carries to avenge his murdered parents, and much more. How does this caped crusader measure up against the teachings of Plato, Aristotle, Kant, Kierkegaard, and Lao Tzu? (shrink)

"The great value of the book lies in the manner in which May relates the expansionist urge to the "symbolic" differences emerging between the North and the South. The result is a balanced account that contributes to the efforts of historians to understand the causes of the Civil War."--Journal of American History "The most ambitious effort yet to relate the Caribbean question to the larger picture of southern economic and political anxieties, and to secession. The core of this superbly documented (...) book is a detailed description of expansionist ideology and activities during the 1850s."--Civil War History A path-breaking work when first published in 1973, The Southern Dream remains the standard work on attempts by the South to spread American slavery into the tropics--Cuba, Mexico, and Central America in particular--before the Civil War. Robert May shows that the South's expansionists had no more success than when they tried to extend slavery westward. As one after another of their plots failed, southern imperialists lost hope that their labor system might survive in the Union. Blaming northern Democrats and antislavery Republicans alike for their disappointed dreams, alienated southerners embraced secession as an alternative means to achieving the tropical slave empire that they craved. Had war not erupted at Fort Sumter, Confederates might have attempted to conquer the Caribbean basin. May's book serves as an important reminder that foreign policy cannot be divorced from the writing of American history, even in regard to seemingly domestic matters like the causes of the Civil War. Contending that America's Manifest Destiny became "sectionalized" in the 1850s, he explains why southerners considered Caribbean expansion so important and shows how southerners used their clout in Washington to initiate diplomatic schemes like the notorious Ostend Manifesto and presidential attempts to buy the slaveholding island of Cuba from Spain. He also describes southern filibustering plots against Latin American domains, such as the aborted designs on Mexico of the colorful Knights of the Golden Circle and the actual invasions of Central America by native Tennessean William Walker. Walker struck a major blow for the expansion of slavery when he legalized it during his occupation of Nicaragua. Most important, May relates how Caribbean plots affected American public opinion and ignited sectional friction in congressional debates. May argues that President-elect Abraham Lincoln might have saved the Union in the winter of 1860-61, had he agreed to last minute concessions facilitating slavery's future expansion towards the tropics. May's fascinating and often surprising account internationalized the causes of the Civil War. It should be read by anyone who wishes to understand the complex reasons why Americans came to blows with each other in 1861. This reprinting features a new preface by the author, which addresses the latest research on the Caribbean question. Robert E. May is professor of history at Purdue University. (shrink)