If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

Breaking Bad, hailed by Stephen King, Chuck Klosterman, and many others as the best of all TV dramas, tells the story of a man whose life changes because of the medical death sentence of an advanced cancer diagnosis. The show depicts his metamorphosis from inoffensive chemistry teacher to feared drug lord and remorseless killer. Driven at first by the desire to save his family from destitution, he risks losing his family altogether because of his new life of crime. In (...) defiance of the tradition that viewers demand a TV character who never changes, Breaking Bad is all about the process of change, with each scene carrying forward the morphing of Walter White into the terrible Heisenberg. Can a person be transformed as the result of a few key life choices? Does everyone have the potential to be a ruthless criminal? How will we respond to the knowledge that we will be dead in six months? Is human life subject to laws as remorseless as chemical equations? When does injustice validate brutal retaliation? Why are drug addicts unsuitable for operating the illegal drug business? How can TV viewers remain loyal to a series where the hero becomes the villain? Does Heisenberg's Principle of Uncertainty rule our destinies? In Breaking Bad and Philosophy, a hand-picked squad of professional thinkers investigate the crimes of Walter White, showing how this story relates to the major themes of philosophy and the major life decisions facing all of us. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:F. R. Leavis (Modern Cultural Theorists)Stephen OgdenF. R. Leavis (Modern Cultural Theorists), by Anne Samson; x & 196 pp. Toronto: University of Toronto Press, 1992, $45.00 cloth, $16.95 paper.If it is an overstatement to say that the waves of change currently disturbing the teaching of English in universities originated from the splash made by F. R. Leavis at Cambridge beginning in 1933, Anne Samson’s account of the theorist’s (...) influence scarcely admits it. Her chapter titles—“Leavis and the Growth of English Studies,” “English as a University Subject,” “Literary ‘Theory’ and Constituting the Canon”—indicate not only the range of issues connected with F. R. Leavis’s name but also his significant involvement in their genesis.Samson’s book portrays Leavis as the efficient cause in the establishment of university English as a critical, or more accurately a diagnostic, enterprise. At an early professional cost (he was denied faculty appointment at Cambridge for five years), Leavis helped cut English curricula free from philology, languages, and classical studies; a responsibility Samson partially excuses by connecting Leavis’s motivating principles back through Matthew Arnold to Dickens and Carlyle and even to one “Reverend H. J. Rose, a leading figure in the founding of King’s College, London... declaring in a sermon delivered in 1826 that literature teaches ‘the wisdom of men better and wiser than ourselves’ and prepares for the ‘examination of those moral and intellectual truths which are not only the worthiest exercise of our reason, but most concern our future destiny’” (p. 12).This moralism Samson sees as the central and redeeming principle in Leavis’s system. Specifically, she identifies the Condition of England debate—over the state of culture and economics in a “‘technologico-Benthamite world’” (p. 63)—as the key to Leavis’s literary criticism, his influential journal Scrutiny, and his wide-ranging reform endeavors. “Literature mattered to Leavis because he believed it to be the means, above all others, of combating the ills of a mechanised, constantly changing world and of restoring the heritage of those dispossessed by the machine” (p. 3).Professionally asserting the primacy of criticism over scholarship, then in his writings making no distinction between the literary and the social, Leavis ultimately refused any separation between literature and life. Samson carefully [End Page 360] traces this development in Leavis’s general theory in order to bring out its easily-overlooked implication for the social position of a literary academic. She quotes this crucial passage from Leavis: “The critic... is as much concerned with the health of the mind as any doctor with the health of the body. To set up as a critic is to set up as a judge of values... For the arts are inevitably and quite apart from any intentions of the artist an appraisal of existence” (pp. 15–16). No longer a mere scholar, or the type of irrelevant empiric Leavis so hated in the person of C. P. Snow, the Leavisite theorist is the grand physician diagnosing all society’s ills. Literary artists and their writings, so far from forming the most important part of literature, become perfectly irrelevant—“quite apart”—with the medicocritic prescribing universally “of existence.”Samson’s treatment of Leavis is analytical, though enjoyably and consistently biographical. For instance, her final, and largest, chapter shows the moralist model of the literary critic (the “judge of values”) in action by detailing the history of Leavis’s complete reversal of estimation between T. S. Eliot and D. H. Lawrence. Leavis originally gave Eliot “hero-worship” (p. 162) and dismissed Lawrence as “mechanical” (p. 157). But concurrent with Eliot’s progress to Anglo-Catholicism, Leavis’s moral judgments overturned and, true to type, he increasingly censured Eliot’s writings by diagnosing problems in the man, while he grew to idolize Lawrence; ironically for “rescuing life from... inner mechanisation” (p. 169).Such inconstancy, here expressed in every word, Samson sees as an historical mark of character which places Leavis among the “Great Men of Ideas” (p. 172).Stephen OgdenSimon Fraser UniversityCopyright © 1995 The Johns Hopkins University Press... (shrink)

It is not an exaggeration to say that Allan Gibbard is one of the most significant contributors to philosophy over the last five decades. Gibbard's work covers an impressive number of subfields within philosophy, including ethics, philosophy of language, decision theory, epistemology, and metaphysics. It also engages with, and makes significant contributions to, work from the natural and social sciences. This volume is not a collection of artifacts from past decades of philosophy. Instead, it is a collection of essays that (...) each make a significant contribution to contemporary work in philosophy. This reflects the fact that Gibbard's work has not only had a massive influence on past discussion in philosophy but also continues to influence new directions of philosophical research. With contributions from: Sara Aronowitz, Simon Blackburn, Paul Boghossian, David Braddon-Mitchell, Nate Charlow, Stephen Darwall, Jamie Dreier, Billy Dunaway, Melissa Fusco, Sona Ghosh, Allan Gibbard, Bill Harper, Paul Horwich, Zoë Johnson King, Tristram McPherson, Howard Nye, Lauren Olin, Caleb Perl, David Plunkett, Peter Railton, Connie Rosati, Mark Schroeder, Alex Silk, Daniel J. Singer, Brian Skyrms, and Seth Yalcin. (shrink)

Lockdown measures in response to the COVID-19 pandemic involve placing huge burdens on some members of society for the sake of benefiting other members of society. How should we decide when these policies are permissible? Many writers propose we should address this question using cost-benefit analysis, a broadly consequentialist approach. We argue for an alternative non-consequentialist approach, grounded in contractualist moral theorising. The first section sets up key issues in the ethics of lockdown, and sketches the apparent appeal of addressing (...) these problems in a CBA frame. The second section argues that CBA fundamentally distorts the normative landscape in two ways: first, in principle, it allows very many morally trivial preferences—say, for a coffee—might outweigh morally weighty life-and-death concerns; second, it is insensitive to the core moral distinction between victims and vectors of disease. The third section sketches our non-consequentialist alternative, grounded in Thomas Scanlon’s contractualist moral theory. On this account, the ethics of self-defence implies a strong default presumption in favour of a highly restrictive, universal lockdown policy: we then ask whether there are alternatives to such a policy which are justifiable to all affected parties, paying particular attention to the complaints of those most burdened by policy. In the fourth section, we defend our contractualist approach against the charge that it is impractical or counterintuitive, noting that actual CBAs face similar, or worse, challenges. (shrink)

`On the Marxist Imaginary...' is an excerpt from a larger work that uses the history of Socialisme ou Barbarie (1949-67) to examine the role of the problem of praxis in Cornelius Castoriadis's more political writings. The present article examines the schema his revolutionary group Socialisme ou Barbarie developed between 1952 and 1956 to link working-class experience, autonomous strikes, and possibilities for revolution and socialism.

Sometimes, states face emergencies: situations where many individuals face an imminent threat of serious harm. Some believe that in such cases certain sorts of actions which are normally morally prohibited might be permissible. In this paper, I discuss this view as it applies in both the contexts of war and of public health policy. I suggest that the deontologist can best understand emergencies by analogy with the distinction between act- and rule consequentialism. In real world cases, we must often make (...) decisions in ‘epistemically murky’ situations, such that the application of deontological principles to particular cases is unclear. I suggest that we develop conventions to deal with such cases in a manner which we think is most likely to approximate the demands of abstract deontological principles across time. I claim that we can best understand ‘supreme emergencies’ as situations which ‘epistemic murkiness’ is resolved. In such cases, there may be a conflict between what would be valid application of abstract deontological principles and the conventions which normally guide us in epistemically murky situations. (shrink)

This paper explores some of the ethical issues around offering COVID-19 vaccines to children. My main conclusion is rather paradoxical: the younger we go, the stronger the grounds for justified parental hesitancy and, as such, the stronger the arguments for enforcing vaccination. I suggest that this is not thereductio ad absurdumit appears, but does point to difficult questions about the nature of parental authority in vaccination cases. The first section sketches the disagreement over vaccinating teenagers, arguing that the UK policy (...) was permissible. The second section outlines a problem for this policy, that it faces justified vaccine hesitancy. The third section discusses three strategies for responding to this problem, arguing that there may be no simple way of overcoming parents’ reasons to resist vaccinations. (shrink)

Like many, I find the idea of relying on patient preference predictors in life-or-death cases ethically troubling. As part of his stimulating discussion, Sharadin1 diagnoses such unease as a worry that using PPPs disrespects patients’ autonomy, by treating their most intimate and significant desires as if they were caused by their demographic traits. I agree entirely with Sharadin’s ‘debunking’ response to this concern: we can use statistical correlations to predict others’ preferences without thereby assuming any causal claim. However, I suspect (...) that, for at least some of us, our unease about PPPs stems from a different kind of ‘autonomy’ concern. In this commentary, then, I will explore this concern, and show how it relates to Sharadin’s work. Very many of our preferences are caused, ultimately, by facts which are outside our control, such as our demographic features. However, I suggest that we can still act autonomously on the basis of such preferences, when they are preferences which we endorse. Imagine, for example, that Jane has grown up in a church-growing environment, which has shaped many of her preferences, …. (shrink)

This anthology has been significantly expanded for this edition to include a wider range of contemporary issues.

Zen-Buddhist nothingness is the nowhere is there something that is I, or conversely: the I that is the nowhere is there something. (Hisamatsu, FN, 25-26; quoted and trans. in Stambaugh, FS, 76)... it is empty of being. That means that it is beyond all measure ....... it is empty without emptiness. That means that it does not cling to itself.... it possesses nothing. That means that it doesn't possess and also cannot be possessed. (Hisamatsu, FN, 31; quoted and trans. in (...) Stambaugh, FS, 77-8)The emptiness of what is called "emptiness" is referred to as "the emptiness of emptiness" (ʼsūnyatāʼsūnyatā), and it is explained in this way for the purpose of controverting any understanding of emptiness as a[n ontological reference to] "being." (Candrakīrti, EMW, 180)A skillful Zen student will strive to be awakened to an identity with all phenomena, the student him- or herself emptyand continually changing as the phenomena come forth. (Codiga, ZPSP, 108)Zen practice is a means for the enlightenment of bushes and grasses, an activity that has no beginning or end in the vastness of any empty universe. (p. 110). (shrink)

LOCALITY AND JUDGMENT THE GENERAL THEMES OF THE VIEW OF PRACTICE I will develop here are expressed in the triangle of locality, inexhaustibility, ...

Possession is preeminently the form in which the other becomes the same, by becoming mine. (Levinas, TI, 46)If perceptions are distinct existences, they form a whole only by being connected together. But no connexions among distinct existences are ever discoverable by human understanding. We only feel a connexion or determination of the thought to pass from one object to another. It follows, therefore, that the thought alone feels personal identity, when reflecting on the train of past perceptions that compose a (...) mind, the ideas of them are felt to be connected together, and naturally introduce each other. (Burne, T, App., 635)The I think must accompany all my representations, for otherwise something would be represented in me which could not be thought: .... they must conform to the condition under which alone they can exist altogether in a common self-consciousness, because otherwise they would not all without exception belong to me. (Kant, CPR, 76-7). (shrink)

The ownership condemned with such rigor by the mystics, and often called impurity, is only the search for one's own solace and one's own interest in the jouissance of the gifts of God, at the expense of the jealousy of the pure love that wants everything for God and nothing for the creature .... Ownership, of course, is nothing but self-love or pride, which is the love of one's own excellence insofar as it is one's own, and which, instead of (...) coming back completely and uniquely to God, still to a small extent brings the gifts of God back to the self so that it can takepleasure in them. (Fénelon: quoted in Nancy, SL, 94)Love defines itself as the absolute opposite and as the destruction of self-love. Self-love is not simply the love of the self; .... One can love oneself with a real love, and it might even be that one must do so .... But self-love, understood according to the signification the spiritual authors gave to it, .... is the love (which, from this moment on, is no longer one) of possession. It is the love of the self as property. (pp. 94-5). (shrink)

Strong social identity does not lead to lack of accountability and “bad” behavior in groups and crowds but rather causes group behavior to be driven by group norms. The solution to problematic group behavior is therefore not to individualize the group but rather to change group norms, as underlined by the relational dynamics widely studied in the SIDE tradition.

“This is my major thesis. Mystery is inherent in both the nature of things and the nature of rationality. I will sustain this thesis by a review of some of the central issues of philosophy to elucidate their mysterious qualities. More important, however, I will develop in detail an explanation of mystery and trace some of its important ramifications.” “I will argue that an ordinal metaphysics, with its associated theory of query, provides an account of mystery that no other theory (...) can provide. “While the theory presented here is a theory of philosophical mystery, it has fundamental implications for all branches of knowledge, including the physical and social sciences. “In short, I speak against a simplistic view of the world and of experience based on a simplistic and narrow conception of understanding and rationality. Mystery calls not for veneration and awe, but for a full and complex activity of mind, broaching all established conditions in its pursuit of answers....Reason is fulfilled as completely in mysteries which persevere throughout our efforts to resolve them as in mysteries which are resolved and dissipated, passing into new questions to which we must find new answers, in an unterminating process of rational interrogation.” — From the Preface by Stephen David Ross. (shrink)

This book contains remarkable photographs taken on the ‘lost’ fifth floor of Lewis’s by photographer Stephen King. They capture the remarkable history and former glory.

The general theory of art and aesthetic value developed in this book is based on the notions of inexhaustibility and contrast and has important forebears in Kant, Coleridge, and Whitehead.

How does one desire forgetting? How does one desire not to keep?How does one desire mourning (assuming that to mourn, to work at mourning does not amount to keeping . . .)? (Derrida, GT, 36)Jacques Derrida died Friday night, October 8–9, 2004.

Dasein is authentically itself only to the extent that, as concernful Being-alongside and solicitous Being-with, it projects itself upon its ownmost potentiality-for-Being rather than upon the possibility of the they-self. (Heidegger, BT, 308)The more I return to myself, the more I divest myself, under the traumatic effect of persecution, of my freedom as a constituted, willful, imperialist subject, the more I discover myself to be responsible; the more just I am, the more guilty I am. I am "in myself" through (...) the others. (Levinas, OB, 112)these singular beings [Daseins] are themselves constituted by sharing, they are distributed and placed, or rather spaced, by the sharing that makes them others: other for one another, and other, infinitely other for the Subject of their fusion, which is engulfed in the sharing, in the ecstasy of the sharing "communicating" by not "communing." ... Thus, the communication of sharing would be this very dis-location. (Nancy, IC, 25)What defines the "self" is precisely what defines us as personsnamely, the various roles and relationships that link us to others. (Bockover, ERS, 56). (shrink)

Explores the idea of human and natural kinds, pursuing an ethics of the earth responsive to social, political, and environmental issues.

The Limits of Language concerns itself with the nature and limits of language at a time when our understanding of the world and of ourselves is intimately related to what we understand of language.

Quantum aesthetics fosters what might be called a general thesis of metaphysical intimacy. There is no place left, even in nature, where uninterpreted events can hide. With regard to the work of Niels Bohr and Heisenberg, this condition of unavoidable interpretation is referred to as the “indivisibility of the quantum action.” Accordingly, talking about any privileged or pristine considerations involves contradictions that, according to advocates of quantum aesthetics, must be overcome. Now, every facet of existence has a voice that has (...) a human origin and must be correctly deciphered. Even nature is not simply confronted, but must be explored in terms of its cultural nuances. (Caro and Murphy, eds., WQC, 182). (shrink)

The fundamental faith of the metaphysicians is the faith in opposite values. . . .For one may doubt, first, whether there are any opposites at all, and secondly whether these popular valuations and opposite values on which the metaphysicians put their seal, are not perhaps merely foreground estimates, only provisional perspectives, perhaps even from some nook, perhaps from below, frog perspectives, as it were, to borrow an expression painters use. For all the value that the true, the truthful, the selfless (...) may deserve, it wouldstill be possible that a higher and more fundamental value for life might have to be ascribed to deception, selfishness, and lust. . . .Maybe! (Nietzsche, BGE, #2). (shrink)

there is something else to which we are witness, and which we might describe as an insurrection of subjugated knowledges. (Foucault, 2L, 81)a whole set of knowledges that have been disqualified as inadequate to their task or insufficiently elaborated: naive knowledges, . . . . (82)What emerges out of this is something one might call a genealogy, or rather a multiplicity of genealogical researches, a painstaking rediscovery of struggles together with the rude memory of their conflicts. (83)Let us give the (...) term genealogy to the union of erudite knowledge and local memories which allows us to establish a historical knowledge of struggles and to make use of this knowledge tactically today. (83)If we were to characterise it in two terms, then “archaeology” would be the appropriate methodology of this analysis of local discursivities, and “genealogy” would be the tactics whereby, on the basis of the descriptions of these local discursivities, the subjected knowledges which were thus released would be brought into play. (85). (shrink)

The disaster ruins everything, all the while leaving everything intact. It does not touch anyone in particular; “I” am not threatened by it, but spared, left aside. It is in this way that I am threatened;. . . .The disaster is separate; that which is most separate.When the disaster comes upon us, it does not come. The disaster is its imminence, but since the future, as we conceive of it in the order of lived time, belongs to the disaster, the (...) disaster has always already withdrawn or dissuaded it; there is no future for the disaster, just as there is no time or space for its accomplishment. (Blanchot, WD, 1–2). (shrink)

The image sees.The image feels.The image acts. (Bennett, CB, 195)The image gives.The image is given.The image proliferates.The image betrays.The image for gives.The image is for giving.The image is for exposition.The image is for beauty.The image is from the good.The image is mother, and is father, is both mother and father, and neither mother nor father; for it is the child. The image is the parent, and the children, both parent and children, and neither parent nor children.

Memory is, therefore, neither perception nor conception, but a state or affection of one of these, conditioned by lapse of time. As already observed, there is no such thing as memory of the present while present; for the present is object only of perception, and the future, of expectation, but the object of memory is the past. All memory, therefore, implies a time elapsed; consequently only those animals which perceive time remember, and the organ whereby they perceive time is also (...) that whereby they remember. (Aristotle, OM, 449b24–30). (shrink)

[T]here is that theory which you have often described to us—that what we call learning is really just recollection (anamnēsis). If that is true, then surely what we recollect now we must have learned at some time before, which is impossible unless our souls existed somewhere before they entered this human shape. So in that way too it seems likely that the soul is immortal. (Plato, Phaedo, 72e–73a)Thus the soul, since it is immortal and has been born many times, and (...) has seen all things both here and in the other world, has learned everything that is. So we need not be surprised if it can recall the knowledge of virtue or anything else which, as we see, it once possessed. (Plato, Meno, 81cd). (shrink)

I wish to take up the subject ... in relation to a set of practices in late antiquity. Among the Greeks, these practices took the form of a precept: epimeleisthai sautou, "to take care of yourself," to take "care of the self," "to be concerned, to take care of yourself."The precept of the "care of the self" [souci de soi] was, for the Greeks, one of the main principles of cities, one of the main rules for social and personal conduct (...) and for the art of life. For us now, this notion is rather obscure and faded. (Foucault, TS, 19). (shrink)