It is traditionally believed that cerebral activation (the presence of low voltage fast electrical activity in the neocortex and rhythmical slow activity in the hippocampus) is correlated with arousal, while deactivation (the presence of large amplitude irregular slow waves or spindles in both the neocortex and the hippocampus) is correlated with sleep or coma. However, since there are many exceptions, these generalizations have only limited validity. Activated patterns occur in normal sleep (active or paradoxical sleep) and during states of anesthesia (...) and coma. Deactivated patterns occur, at times, during normal waking, or during behavior in awake animals treated with atropinic drugs. Also, the fact that patterns characteristic of sleep, arousal, and waking behavior continue in decorticate animals indicates that reticulo-cortical mechanisms are not essential for these aspects of behavior. (shrink)

Søren Kierkegaard’s (1813-1855) works have as their starting point, aside from a couple of newspaper articles published around the middle of the decade of the 1830s, a literary review of a novel written by a contemporary of his who was to achieve international fame still in life, viz. the writer Hans Christian Andersen (1805-1875). Notwithstanding, I argue that what was meant to be a literary review hides a vigorous anticipation of a problem that was meant to interest Kierkegaard throughout his (...) entire production, that is, the problem of nihilism. In this sense, the present article is based on a reading of both Andersen’s novel as well as Kierkegaard’s review, which leads me to explore the more profound connotations of Kierkegaard’s critique of the former also in terms of the context these works were produced. In sum, my argument is that both Andersen and Kierkegaard were dealing with the first signs of the arrival of nihilism in Denmark. (shrink)

This article reviews the strengths and limitations of five major paradigms of medical computer-assisted decision making (CADM): (1) clinical algorithms, (2) statistical analysis of collections of patient data, (3) mathematical models of physical processes, (4) decision analysis, and (5) symbolic reasoning or artificial intelligence (Al). No one technique is best for all applications, and there is recent promising work which combines two or more established techniques. We emphasize both the inherent power of symbolic reasoning and the promise of artificial intelligence (...) and the other techniques to complement each other. (shrink)

Parents of children with terminal illness may try many different types of alternative and unproven treatment, not all recognised by the medical establishment. When active participation is requested difficult ethical dilemmas may arise. We present one such case, a child of five years with an inoperable posterior fossa brain tumour.