Any theory of information needs to comply with what we call the implementation, formalization, and representation constraints. These constraints are justified by basic considerations concerning scientific modelling and methodology. In the first part of this paper, we argue that the implementation and formalization constraints cannot be satisfied because the relation between Shannon information and IIT must be clarified. In the second part of the paper, we focus on the representation constraint. We argue that IIT cannot succeed in satisfying this constraint (...) for semantic contents without offering models for concepts, conceptual roles, and context sensitivity. In the final part of the paper, further complications are raised with respect to the distinction between consciousness and attention, which apply more specifically to the representation constraint. We conclude with some recommendations as to how IIT may succeed in solving these problems, highlighting the advantages and enormous potential of IIT as a scientific theory. (shrink)

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

The enormous destructive power of present stocks of nuclear weapons poses the greatest threat to public health in human history. Technical changes in weapons design are leading to an increased emphasis on the ability to fight a nuclear war, eroding the concept of deterrence based on mutually assured destruction and increasing the risk of nuclear war. Medical planning and civil defence preparations for nuclear war have recently been increased in several countries although there is little evidence that they will be (...) of significant value in the aftermath of a nuclear conflict. These developments have raised new ethical dilemmas for those in health professions. If there is any risk of use of weapons of mass destruction, then support for deterrence with these weapons as a policy for national or global security appears to be incompatible with basic principles of medical ethics and international law. The primary medical responsibility under such circumstances is to participate in attempts to prevent nuclear war. (shrink)

Residency training in the Netherlands is to be restructured over the coming years. To this end a general competence profile for medical specialists has been introduced. This profile is nearly the same as the Canadian CanMEDS 2000 model, which describes seven general areas of medical specialist competence, one of which is professionalism. In order to establish a training programme for residents and their instructors based on this competence, it is necessary to develop a vision that does justice to everyday medical (...) practice. The two most prevailing views of professionalism—as personal, or as a behavioural characteristic—fall short of this. Only when professionalism is understood as reflective professionalism does it encompass the fundamental contextuality of medical treatment. This means that the focus of training and assessment must be shifted to accountability for treatment. (shrink)

The present paper draws on climate science and the philosophy of science in order to evaluate climate-model-based approaches to assessing climate projections. We analyze the difficulties that arise in such assessment and outline criteria of adequacy for approaches to it. In addition, we offer a critical overview of the approaches used in the IPCC working group one fourth report, including the confidence building, Bayesian and likelihood approaches. Finally, we consider approaches that do not feature in the IPCC reports, including three (...) approaches drawn from the philosophy of science. We find that all available approaches face substantial challenges, with IPCC approaches having as a primary source of difficulty their goal of providing probabilistic assessments. (shrink)

Was Metaphysik ist, läßt sich nicht apriorisch bestimmen, sondern zeigt sich erst in den denkerischen Entwürfen eines Ersten und Grundlegenden. Metaphysik ist, wie Philosophie überhaupt, von ihrer Geschichte nicht trennbar. Die philosophische Bedeutung der Periode des Mittelalters für den Gang der abendländischen Metaphysik ist in den letzten Jahrzehnten durch zwei klassische Studien herausgestellt worden.

This book constitutes the thoroughly refereed post-conference proceedings of the 10th International Conference on Quantum Interaction, QI 2016, held in San Francisco, CA, USA, in July 2016. The 21 papers presented in this book were carefully reviewed and selected from 39 submissions. The papers address topics such as: Fundamentals; Quantum Cognition; Language and Applications; Contextuality and Foundations of Probability; and Quantum-Like Measurements.

Im Jahrgang LXV der Recherches de Théologie et Philosophie médiévales wurde die Reihe «Entretiens» inauguriert, in der angesehene Forscher auf dem Gebiet der mittelalterlichen Theologie und Philosophie zu ihrem persönlichen Werdegang als Forscher, zu ihren Forschungsschwerpunkten und zur Zukunft der Mittelalterforschung Auskunft geben. Das zweite Interview führten Jan A. Aertsen und Andreas Speer mit Wolfgang Kluxen, emeritierter Ordinarius für Philosophie in Bonn, von 1972 bis 1982 Präsident, später président d’honneur der Société Internationale pour l’Étude de la Philosophie Médiévale.

The South African-Dutch research group responsible for this article started its activities in 2012 by looking at religious tolerance as a means of addressing the tendency for religious intolerance, extremism and fundamentalism. While tolerance seemed to be a promising way to counter religious intolerable behaviour, some shortcomings also became apparent. For example, the concept of tolerance includes an aspect of passivity towards others who adhere to another religion. The concept also does not appear to be able to respond to attitudes (...) and values such as respect, human rights and diversity. Accurate investigation of this problem, both conceptually and empirically, led to the understanding that hospitality is a concept that embodies more active adaptation to those who are different. Hospitality, therefore, seems to be a more promising concept than tolerance for reducing religious tension between individuals and groups. The inner contradiction discovered by Derrida in the notion of hospitality does not detract from the concept of being defined from a Biblical point of view. Hospitality can also be taught to young people. Although there are no formal provisions for hospitality in the national curricula, an analysis of the Dutch and South African national curricula shows that there is room for hospitality education. (shrink)

Products of particlelike representations of the homogeneous Lorentz group are used to construct the degrees of spin angular momentum of a composite system of protons and neutrons. If a canonical labeling system is adopted for each state, a shell structure emerges. Furthermore the use of the Dirac ring ensures that the spin is characterized by half-angles in accord with the neutron-rotation experiment. It is possible to construct a Clebsch-Gordan decomposition to reduce a state of complex angular momentum into simpler states (...) which can be identified with α and β particles, multipole operators, etc. Finally, ground-state energy levels are calculated for all the even-even nuclei by using a differentiable manifold that is spin-graded and gauge-invariant by construction. It is shown that this manifold is Grassmann. (shrink)