Friendly persuasion, in contrast to deterrent measures like tax audits and penalties on underreported taxes, is a positive and possibly a cost effective method of increasing taxpayer compliance. However, prior studies have failed to show that friendly persuasion has a significant impact on compliance (Blumenthal et al., 2001; McGraw and Scholz, 1991). In our study, in contrast to prior studies, we examine the impact of generating and reading reasons supporting compliance as friendly persuasion on individuals' income reporting behavior as well (...) as control for gender effects. Specifically, we predict an interaction effect between friendly persuasion and gender on compliance behavior. We carried out a 2 (friendly persuasion and control) × 2 (men and women) full factorial experiment, where participants earned $30 by completing two questionnaires. Participants in the friendly persuasion group were required first to generate and second to read a list of reasons why they should comply fully. Afterwards, participants in both groups were asked to report the income they earned and pay tax on the reported income. The results show a significant main effect for gender as well as a significant interaction effect between gender and friendly persuasion on income reported. Women in the friendly persuasion group reported significantly higher income compared to men in that group. Other comparisons were not significant. Policy implications for increasing taxpayers' ethics and compliance are highlighted. (shrink)

This study examines social desirability bias in the context of ethical decision-making by accountants. It hypothesizes a negative relation between social desirability bias and ethical evaluation. It also predicts an interaction effect between religiousness and gender on social desirability bias. An experiment using five general business vignettes was carried out on 121 accountants (63 males and 58 females). The results show that social desirability bias is higher (lower) when the situation encountered is more (less) unethical. The bias has religiousness and (...) gender main effects as well as an interaction effect between these two independent variables. Women who were more religious recorded the highest bias scores relative to less religious women and men regardless of their religiousness. (shrink)

An educated healthcare professional or student is sensitive and able to make good judgements, understanding existential challenging issues. It is argued that the ideas within phenomenology and hermeneutics can function as a basis for comprehension. This article focuses on how choice of perspective and knowledge is of importance to what we do in practice. However, education does not consist of mere accumulation of knowledge and ways of explanation. We do not become competent practitioners by being able to reproduce philosophical ideas. (...) These are merely perspectives by means of which we can seek to go beyond what we take for granted, or what we assume to know, thus enabling us to take a new direction understanding problems and issues that until now may have been hidden to us. In other words, understanding is of an existential character, whereas an observing healthcare professional must be aware and open to the mental aspects of life. It is therefore important to attune ourselves to being sensitive to and aware of experiences from our lifeworld, understanding what they imply. It is argued that literature provides insight into human nature through the written depiction of real or imagined experiences. To develop such narrative imagination, it is suggested that literature should be part of the curriculum of various educations. This is relevant to healthcare professionals who thereby can get an important insight into human nature and begin to develop the self‐awareness and sensitivity to others that is so central to care. (shrink)

Although there is a growing acknowledgement of the potential of a more nuanced healthcare paradigm and practice, the discourses of health promotion—and with that nursing and other healthcare professionals’ practice—still tend to focus on the medical diagnosis, disease and the rationale of biomedicine. There is a need for shifting to a human practice that draws on a broader perspective related to illness. This requires a transformation of practices which can be constructed within a narrative understanding. A narrative approach appreciates the (...) importance of emotion and intersubjective relation in the telling and listening that occur in the clinical encounter. The essence of nursing lies in the creative imagination, the sensitive spirit and the intelligent understanding of the individuals’ possibilities of becoming empowered in his or her own life. This entails that the focus of the use of patients’ narratives is, ultimately, not the story itself, but the nurses’ and other healthcare professionals’ ability to support the patients in finding useful meaning in their stories. Herein, it is of particular importance to let the patients narrate about what is sparkling moments or events in the lived life. Stories with such focus can open up for patients’ hopes and dreams, which gives inspiration for finding meaningful ways to cope in life empowering personal recovery. It is, therefore, crucial to transform clinical settings into places that acknowledge the need for imagination and creativity, aiming at creating the opportunity for sensibility and vision essential to encouraging a narrative approach and thereby the ability to reflect upon and promote a healing process. (shrink)

This study examines whether truth-telling in the form of honest reporting is associated with cognitive moral development. Conventional agency theory assumes that people are self-interested and willing to tell a lie to increase their personal payoffs, while recent empirical evidence shows that some people give up monetary rewards to tell the truth. The social psychology literature suggests that cognitive moral development influences individuals’ ethical decisions. We carried out an experiment whereby participants submitted managerial reports in which truth-telling decreased their monetary (...) payoff. Despite the fact that their decisions were not subject to monitoring, auditing, or reputation effects, some participants reported honestly or partially honestly. We find the relationship between honest reporting and cognitive moral development to be both positive and linear. Compared with those at lower stages of cognitive moral development, participants at higher stages of cognitive moral development were more likely to submit an honest report and give up potential monetary gains from lying. We further examine the economic impact of honest reporting on the firm’s profit. With the assumption of self-interest and profit maximization, Antle and Eppen suggest that a contract with a hurdle-rate feature reduces managers’ information rent. We find that in comparison with the expected outcome of a hurdle contract, the firm can yield higher profits with a trust contract by hiring managers with a P-score higher than 16.67. (shrink)

In this article, I focus on possibly impaired self-determination in addiction. After some methodological reflections, I introduce a phenomenological description of the experience of being self-determined. I argue that being self-determined implies effectivity of agency regarding three different behavioural domains. Such self-referential agency shall be called ‘self-effectivity’ in this article. In a second step, I will use this phenomenological description to understand the impairments of self-determination in addiction. While addiction does not necessarily imply a basic lack of control over one’s (...) life, this can well be the case during certain periods of time or in special situations. Addiction is herein described as an embodied custom—highly effective with respect to changing one’s lived experience—which is learned and developed while becoming addicted. Such a repeatedly performed custom, called a ‘psychotropic technique’, implies deep changes in one’s personal identity and alters an agent’s ‘self-effectivity’. In the closing section, I discuss the possible implications of a phenomenological approach to personal responsibility. (shrink)

Phenomenological descriptions of depressed mental life offer a profound understanding of depression from the first-person perspective. In this paper, such descriptions are developed by drawing on the work by Ludwig Binswanger and on the autobiographical report of depression by Piet C. Kuiper . I will argue that Binswanger’s central claim in his phenomenological description of the depressed state of mind fails due to crucial misunderstandings of Edmund Husserl’s phenomenology. Nonetheless, by drawing on Kuiper’s first-hand account, I will develop a phenomenological (...) description of depressed mental life, highlighting the altered manner of pre-reflective valuing in depression and introducing the concept of a ‘depressive habituality.’ This term refers to the acquisition of a new set of habitualisations, especially on the foundational levels of automatic mental life. It offers explanations for the fact that it is not easy to recover from depression and that people may more easily become depressed again. (shrink)

In this paper phenomenological descriptions of the experiential structures of suicidality and of self-determined behaviour are given; an understanding of the possible scopes and forms of lived self-determination in suicidal mental life is offered. Two possible limits of lived self-determination are described: suicide is always experienced as minimally self-determined, because it is the last active and effective behaviour, even in blackest despair; suicide can never be experienced as fully self-determined, even if valued as the authentic thing to do, because no (...) retrospective re-evaluation from some future vantage is possible. The phenomenological descriptions of the possible scope of lived self-determination in suicidality, presented in this paper, should prove to be extremely helpful in three different fields of interest: (a) ethical debates regarding the pros and cons of autonomous or heteronomous suicide; (b) clinical day-to-day practice with respect to treating suicidal people; (c) people who suffered a suicidal crisis, attempted suicide or lost loved ones through suicides. (155 words). (shrink)

Adopting the methods of Ethnomethodology and Conversation Analysis, this article aims to add to our knowledge of the dynamics and resistance in professional-client encounters. It does this by examining the argumentative function of second-hand assessments in the setting of vocational rehabilitation. In the situated negotiation of appropriate work-targeted initiatives, the practice of reporting second-hand assessments functions either as ‘opposing’ the professional’s investigations, or, when used in initiating turns, as ‘promoting’ the client’s case. Regarding the first, second-hand assessments provide opportunities to (...) oppose and redirect the institutional agenda. That is, the issue introduced by the professional is fended off more or less openly through second-hand accounts, which provide a presumptive better grasp on the matter at hand. (shrink)

Understanding the mental life of persons with psychosis/schizophrenia has been the crucial challenge of psychiatry since its origins, both for scientific models as well as for every therapeutic encounter between persons with and without psychosis/schizophrenia. Nonetheless, a preliminary understanding is always the first step of phenomenological as well as other qualitative research methods addressing persons with psychotic experiences in their life-world. In contrast to Rashed's assertions, in order to achieve such understanding, phenomenological psychopathologists need not necessarily adopt the transcendental-phenomenological attitude, (...) which, however, is often required if performing phenomenological philosophy. Additionally, in the course of these scientific endeavors, differences between persons with psychosis/schizophrenia and so-called normal people seem to have a methodological function and value driving the scientist in her enterprise. Yet, these differences do not extend to ethical dimensions, and therefore, do not by any means touch ethical equality. (shrink)

In this paper, I develop a phenomenological description of lived autonomy and describe possible alterations of lived autonomy associated with chronic depression as they relate to specific psychopathological symptoms. I will distinguish between two types of lived autonomy, a pre-reflective type and a reflective type, which differ with respect to the explicitness of the action that is willed into existence; and I will relate these types to the classical distinction between freedom of intentional action and freedom of the will. I (...) will then describe how a chronically depressed person habitually discloses her experiential workspace with an impaired scope of perceivable action-properties, and pre-reflectively values many of these perceived action-properties as demanding or devalues these properties as well as her own abilities and drive to perform the respective actions. These alterations, typically experienced in a passive manner, imply an impairment of both types of lived autonomy. Drawing on first-hand accounts, I will then argue that small islands of lived autonomy, even of the reflective type, are possible if the afflicted identifies with at least some of her ‘depressive disabilities’. Lastly, I will compare this manner of life-conduct with the constellation of includence, as described by Tellenbach, and discuss the limitations of this study. (shrink)

We present a proof for a conjecture previously formulated by Dzhafarov et al.. The conjecture specifies a measure for the degree of contextuality and a criterion for contextuality in a broad class of quantum systems. This class includes Leggett–Garg, EPR/Bell, and Klyachko–Can–Binicioglu–Shumovsky type systems as special cases. In a system of this class certain physical properties \ are measured in pairs \ \); every property enters in precisely two such pairs; and each measurement outcome is a binary random variable. Denoting (...) the measurement outcomes for a property \ in the two pairs it enters by \ and \, the pair of measurement outcomes for \ \) is \ \). Contextuality is defined as follows: one computes the minimal possible value \ for the sum of \ ) that is allowed by the individual distributions of \ and \; one computes the minimal possible value \ for the sum of \ across all possible couplings of the entire set of random variables \ in the system; and the system is considered contextual if \ ). This definition has its justification in the general approach dubbed Contextuality-by-Default, and it allows for measurement errors and signaling among the measured properties. The conjecture proved in this paper specifies the value of \ in terms of the distributions of the measurement outcomes \ \). (shrink)

Modern slavery is a major topic of concern in international law and global governance, in civil society, and in academic debates. Yet, what does modern slavery mean, and can its highly different forms be covered in a single concept? This paper discusses these questions in three steps: First, it develops common definitions of modern slavery. Second, it discusses critical rejections of these definitions. The two camps that adhere to the definitions of modern slavery, and that reject them, respectively, face certain (...) limits. In a third step, the paper takes up with the limits and the strengths of both. It suggests that the limits of definitions of modern slavery can be overcome by critical approaches; and that the limits of critical approaches can be overcome by definitions of modern slavery. The key is their integration into a human rights frame. Ultimately, the paper proposes an approach to modern slavery that neither relies on a binary distinction between slavery and non-slavery, nor does it strive for the abolishment of the concept of modern slavery. Rather, the paper calls for a normatively and contextually embedded approach within the human rights frame. (shrink)

The purpose of this exploratory study is to examine the use of an ethical intervention strategy - counterexplanation - on individuals' ethical decision-Making. As opposed to providing reasons to support a decision in the case of explanation, counterexplanation is the provision of reasons that either speak against or provide evidence against a chosen course of action. The number of explanations and/or counterexplanations provided by the participants is expected to have a significant effect on ethical evaluation and intention. The number of (...) explanations is expected to be negatively related to ethical decision-making while the number of counterexplanations is expected to be positively related to ethical decision-making. The experiment, that made use of five ethical vignettes, manipulated four treatment groups - explanation, counterexplanation, explanation/counterexplanation, and counterexplanation/explanation. Participants were randomly assigned to one of the four reatments. They performed the requirements of their treatment before recording their ethical evaluations and intentions. As expected, larger numbers of explanations led to less ethical decision-making and larger numbers of counterexplanations led to more ethical decision-making. However, when both types of explanations are required, the order of counterexplaining before explaining is more desirable as it leads to more ethical decision-making. The study also reports that individuals with high social desirability bias may generate less counterexplanations. Implications of the findings are explained in the paper. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Diacritics 30.3 (2000) 53-71 [Access article in PDF] Ghostly Politics Jann Matlock [Figures]The failure of the Second Republic, as we know well, thanks to Marx, was a matter of ghostly politics.1 Successful revolutions succeeded—claimed Marx—in "waking the dead" in order to glorify the new struggles. Unsuccessful revolutions parodied, as in 1848, the old ones. The Second Republic failed to find again "the spirit of revolution" ("den Geist der Revolution"); (...) instead, it made its "ghost walk about again" ["Der 18te Brumaire" 116].2The "conjurations of the dead" ("Totenbeschwörungen") [115] of the failed Second Republic—and of the Second Empire, which crowned its disastrous experiment—were nowhere more apparent than in the obsession that swept France in 1853 within months after Louis-Napoléon declared himself Emperor in the spectral shadow of his great-uncle, as contemporary Louis Figuier described:Suddenly—it was near the last days of April 1853—Paris woke up prey to the [Table-]turning epidemic, and the newspapers, which finally had to break the silence, informed us that [the epidemic] had simultaneously burst forth in Strasbourg, in Marseille, in Bordeaux, in Toulouse, and in all our other great population centers. For the public, it was, at first, only a simple amusement to which people everywhere surrendered themselves amidst great bursts of laughter. Pedestal tables [guéridons], [other kinds of] tables, hats, plates and washbasins—everything that was within reach—were called into service. Some people succeeded. Others—and these were the greater number—failed at the experiment; they accused the successful of deception [supercherie], and the successful, in their turn, accused the unsuccessful of failing to believe. "They turn; they donít turn": that summed up all the debates on this subject, and these were the only two terms through which, among the vulgar, the question of the tables was thrashed about. In our country, always quite frivolous about serious matters, though sometimes extreme in its credulousness and sometimes absurd in its skepticism, the tables were for the larger share of people only an amusement, only a way to kill time in society. Quarrels were frequent [End Page 53] on this subject. People denied. People confirmed. People laughed—when they were not losing their tempers.Nevertheless, the phenomenon soon appeared to make progress, and this was quite another story. Not only did the tables turn, but they spoke and wrote; they rose up and held themselves in the air without any strings—or at least without any visible ones. The tables gave consultations, discovered secrets buried in the most profound mystery, put the world of the living in communication with the world of the dead, and finally, behaved in such a way to let people believe they were haunted by spirits [hantées par des esprits]. [294-95] The Baron Du Potet, editor of the Journal du magnétisme, remarked in the summer of 1853 that "The tables are making one hell of a noise! —Enter into the porter's lodge, you'll see him make his table turn; go to the home of a judge, of a lawyer, of an archbishop even, and their tables are turning—after dinner, of course. It seems that they are even interrogating tables in palaces" [643]. Alexandre Erdan, author of an 1855 book on "the religious excentricities" of contemporary France, denounced the table turning as "a universal monomania" and declared it the "the characteristic event" of the year 1853, "that memorable period of universal mental estrangement" [71]. Daumier honored the trend in May and June 1853 with a series of a dozen caricatures called La Fluidomanie.3 Caricaturist Cham continued to ridicule its believers well into the year 1853 [Fig. 1].4 Louis Huart, author of a series of satirical articles in the opposition newspaper Le Charivari recounted a debate between two scholars on the subject: "Sir, are you for tables turning or for tables not turning," asked the first. The second replied, "It's all the same to me so long as the table is well served and it doesn't turn while I'm eating." Huart's conclusion, not dissimilar to that of most... (shrink)

In _The Eudaimonist Ethics of al-Fārābī and Avicenna_, Janne Mattila provides the first comprehensive account of the ethical thought of al-Fārābī and Avicenna.

The purpose of this exploratory study is to examine the use of an ethical intervention strategy – counterexplanation – on individuals’ ethical decision-making. As opposed to providing reasons to support a decision in the case of explanation, counterexplanation is the provision of reasons that either speak against or provide evidence against a chosen course of action. The number of explanations and/or counterexplanations provided by the participants is expected to have a significant effect on ethical evaluation and intention. The number of (...) explanations is expected to be negatively related to ethical decision-making while the number of counterexplanations is expected to be positively related to ethical decision-making. The experiment, that made use of five ethical vignettes, manipulated four treatment groups – explanation, counterexplanation, explanation/counterexplanation, and counterexplanation/explanation. Participants were randomly assigned to one of the four reatments. They performed the requirements of their treatment before recording their ethical evaluations and intentions. As expected, larger numbers of explanations led to less ethical decision-making and larger numbers of counterexplanations led to more ethical decision-making. However, when both types of explanations are required, the order of counterexplaining before explaining is more desirable as it leads to more ethical decision-making. The study also reports that individuals with high social desirability bias (a tendency to present oneself in a culturally acceptable manner) may generate less counterexplanations. Implications of the findings are explained in the paper. (shrink)

In welfare encounters, clients may from time to time report about other peoples’ doings in ways that are heard as more or less downgrading. This article examines how these reports are brought off in Norwegian vocational rehabilitation encounters, and especially, how the professional party aligns. Do such practices represent what Levinson calls ‘allowable contributions’ in the vocational rehabilitation meeting or are they treated as matter out of place? The analysis of five data extracts suggests that it is very important for (...) the reception that the report is well contextualized and attuned to the institutional agenda. The counsellors displayed a neutral but cooperative alignment to reports integrated neatly in the business-at-hand in a top-down fashion. Here, the reports served as a tool to inform the recipient about the client’s own character and/or her experience of the rehabilitation process. However, in the two latter cases, where the client had a more initiating role, the reports appeared to have a more humorous or entertaining function. In response, the counsellors did not display alignment but searched for institutional relevance before re-contextualizing the report into a proper context. This suggests that out-of-frame reports about other people delivered on a humorous footing do not straightforwardly fall into the category of ‘allowable contributions’ in this setting. (shrink)

Nudging refers to the subtle design of the context of choice in a way that mobilises the unconscious mind and alters human behaviour predictably. Nudging has been criticised for entailing numerous practical and ethical problems, including manipulation, elitism and cultural insensitivity. To respond to the problems, participatory and deliberative procedures have been proposed that would enable the questioning of the power relations embedded in behavioural governance. Yet participation and deliberation are themselves characterised by unconscious behavioural influences. I argue that awareness (...) of the prevalence of unconscious behavioural influences in environmental governance is a prerequisite for tackling the complex practical and ethical issues of nudging. I show that unconscious behavioural influences permeate environmental governance and outline analytical approaches for revealing them. (shrink)

This paper explores the prospects of a combinatorial account of modality. We argue against David M. Armstrong’s version of combinatorialism, which seeks to do without modal primitives, on the grounds, among other things, that Armstrong’s basic ontological categories are themselves subject to non-contingent constraints on recombination. We outline an alternative version, which acknowledges the necessity of modal primitives, at the level of ontology, and not just of our concepts.

This article presents, discusses and analyses data from a Danish empirical study of authentic job interviews. Drawing on critical discourse analysis and sociolinguistics, as well as other fields, the author explores the relationship between success in job interviews and communicative style. The recontextualization of lifeworld resources is approached through both qualitative and quantitative analyses of spoken language. The author demonstrates that certain communicative styles and recontextualizations formed by a combination of lifeworld and job-related perspectives are more successful in job interviews; (...) on the basis of sociolinguistic evidence, he argues that these styles and recontextualizations are products of general processes of socialization rather than products of formal education. (shrink)

International studies investigate the governance authority of state versus non-state actors in terms of their public or private authority. However, the public–private distinction does not sufficiently capture the variety of governance actors, or the forms of their authority, beyond that distinction. Focussing on businesses, this paper argues that certain governance actors assume public and private roles, as well as a third category of roles it calls ‘societal’ that transcend notions of public and private. To understand these roles and how they (...) affect governance authority, this paper treats the public–private relationship as mediated and extends it with the ‘societal’ category, then translates it into the concept of business authority, which constitutes a particular form of governance authority alongside public and private authority. It does so by operationalising governance authority as a triadic concept composed of power, legitimacy and a connection to public interests. In all three components, business authority escapes the binary distinction between public and private without simply merging the two. (shrink)

I discuss some problems related to extreme mathematical realism, focusing on a recently proposed “shut-up-and-calculate” approach to physics. I offer arguments for a moderate alternative, the essence of which lies in the acceptance that mathematics is a human construction, and discuss concrete consequences of this—at first sight purely philosophical—difference in point of view.

In this paper the question of autonomy in delusional disorders is investigated using a phenomenological approach. I refer to the distinction between freedom of intentional action, and freedom of the will, and develop phenomenological descriptions of lived autonomy, taking into account the distinction between a pre-reflective and a reflective type. Drawing on a case report, I deliver finely-grained phenomenological descriptions of lived autonomy and experienced self-determination when acting on delusions. This analysis seeks to demonstrate that a person with delusions can (...) be described as responsible for her behaviour on a ‘framed’ level (level of freedom of intentional action), even though she is not autonomous on a higher (‘framing’) level (level of freedom of the will), if, and only if, the goods of agency for herself and others are respected. In these cases the person with delusions is very nearly comparable to people in love, who are also not free to choose their convictions, and who could also be rightly held responsible for the behaviour flowing from their convictions. (shrink)

The legal and normative openness of human rights allows for the integration of new subjects, arenas, violators, and protectors of human rights. Indigenous movements manage to use this flexibility and implement their claims within the human rights system. Yet, indigenous rights cause manifold discussions and ambiguities, all of which are related to the question of the concept of indigeneity. In spite of the endeavor for pragmatic and flexible approaches, scopes and implications of concepts of indigeneity need to be dealt with. (...) This paper discusses both scope and implications, starting from hegemonic criteria for a working definition of indigeneity. It shows how indigenous identity is inextricably linked to its non-indigenous other. Subsequently, indigenous human rights entail specific repercussions in indigeneity being a resource and an imperative. Those repercussions stem from indigeneity being simultaneously a source and target of indigenous human rights claims and from the self-referential duplication of the right to indigeneity for indigenes, respectively. The provided tools for an analysis of the ambiguities of indigenous human rights contribute to their further and more just development, implementation, and monitoring. (shrink)

During recovery from psychosis (diagnosed as schizophrenia) things must often be done slower than normally expected. The tempo of the socially shared reality is often experienced as being too fast for the recovering person. We will describe how this impairment stems from the pre-reflective mental structure underlying psychosis and how it can be transferred into an active skill supporting recovery, often including social retreat. In this paper, co-written by a psychiatrist and a person experienced in psychosis (= participatory health research), (...) we will draw on personal experiences, (participatory) qualitative research and first-hand accounts for our arguments. We will sketch out the process and three crucial building blocks of recovery: laid-back situations, switch-off skills, places to talk. We will then describe the acquired skill of slowing-down as an amalgam of the building blocks ‘switch-off skill’ and ‘laid-back situation’, since slowing-down answers the situation in a laid-back manner and enforces a slow behavioral pace on it. While this might be okay in private and in some situations shared with others (i.e. during serene situations), it may be tantalizing for others in many everyday situations resulting in stigma or exclusion (i.e. during work). Slowing-down therefore challenges the surrounding others and demonstrates the necessity to synchronize private and public tempos. This is most challenging while living in two realities at once, being the second and often a long-lasting stage of recovery (stage of double realities). (shrink)

This article explores the concept of trust put forth by Niklas Luhmann and Talcott Parsons. It shows the outline of Luhmann's theory of trust and its connections to his autopoietic systems theory. It also deliberates upon the role of trust in the Luhmannian research of future society as well as examines the role of trust in risk society and shows why norms, values and familiarity play only a peripheral role in today's society. Trust is a way to control everyday interaction (...) of the future. But what are the challenges and limits of Luhmann's concept of trust? (shrink)

The genetic component of variations in human responses to pharmacological agents is called pharmacogenetics while the molecular basis for these variations are most often identified as pharmacogenomics. Pharmacogenomics as a field of scientific endeavor is so new that in the scientific literature the two terms are often used interchangeably. In fact, the search for new drugs at the molecular level start with the identification of variations in DNA sequences whose products produce alterations in the amino acid structure of the active (...) portion of a protein which are then identified with the clinical disorder in question. This process is just the reverse of standard pharmaceutical approaches which begin with exploration of the physiological and potentially the biochemical basis of the specific disorder under study. The completion of the first draft of the human genome in the first months of the new millenium has increased expectations that molecular genetic approaches to drug disovery and development will significantly shorten the time-frame of new drug testing, significantly reduce the level of adverse events and anable the design of drugs to treat those with unique disorders.Based on such rosy expectations and the potential economic opportunities afforded by those who obtain such patents, there has been a rush of patent applications both in the United States and in Europe by private industry and university laboratories conducting genomic research to secure the rights to specific DNA sequences and federal agencies attempting to place the control of such information in the public domaine. This paper will document and discuss from a historic prospective the public policy and bioethical issues associated with the availability of patents for drug development. (shrink)

In one of his meetings with members of the Vienna Circle, Wittgenstein discusses Hermann Weyl’s brief conversion to intuitionism and criticizes his arguments against applying the law of the excluded middle to generalizations over the natural numbers. Like Weyl, however, Wittgenstein rejects the classical model theoretic conception of generality when it comes to infinite domains. Nonetheless, he disagrees with him about the reasons for doing so. This paper provides an account of Wittgenstein’s criticism of Weyl that is based on his (...) differing understanding of what a general statement over infinite domains consists in. This difference in their conception of generality is argued to be central to the middle Wittgenstein’s overall stance on intuitionism as well. While Weyl (and other intuitionists) reject the law of the excluded middle on grounds of constructivity, Wittgenstein argues that general statements over infinite domains do not express propositions in the first place. The origin of this position as well as its consequences for contemporary debates on generality are further assessed. (shrink)

Kant's first antinomy uses a notion of infinity that is tied to the concept of (finitary) successive synthesis. It is commonly objected that (i) this notion is inadequate by modern mathematical standards, and that (ii) it is unable to establish the stark ontological assumption required for the thesis that an infinite series cannot exist. In this paper, I argue that Kant's notion of infinity is adequate for the set-up and the purpose of the antinomy. Regarding (i), I show that contrary (...) to appearance, the Critique can even accommodate a modern notion of infinity without consequences for the antinomy; and regarding (ii), that the ‘ontological’ consequence indeed follows once its covertly epistemic character is adequately understood. (shrink)