The inner ear of mammals uses neurosensory cells derived from the embryonic ear for mechanoelectric transduction of vestibular and auditory stimuli (the hair cells) and conducts this information to the brain via sensory neurons. As with most other neurons of mammals, lost hair cells and sensory neurons are not spontaneously replaced and result instead in age‐dependent progressive hearing loss. We review the molecular basis of neurosensory development in the mouse ear to provide a blueprint for possible enhancement of therapeutically useful (...) transformation of stem cells into lost neurosensory cells. We identify several readily available adult sources of stem cells that express, like the ectoderm‐derived ear, genes known to be essential for ear development. Use of these stem cells combined with molecular insights into neurosensory cell specification and proliferation regulation of the ear, might allow for neurosensory regeneration of mammalian ears in the near future. BioEssays 28: 1181–1193, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Experiential evidence shows that pain is associated with common meanings. These include a meaning of threat or danger, which is experienced as immediately distressing or unpleasant; cognitive meanings, which are focused on the long-term consequences of having chronic pain; and existential meanings such as hopelessness, which are more about the person with chronic pain than the pain itself. This interdisciplinary book - the second in the three-volume Meanings of Pain series edited by Dr Simon van Rysewyk - aims to better (...) understand pain by describing experiences of pain and the meanings these experiences hold for the people living through them. The lived experiences of pain described here involve various types of chronic pain, including spinal pain, labour pain, rheumatic pain, diabetic peripheral neuropathic pain, fibromyalgia, complex regional pain syndrome, endometriosis-associated pain, and cancer-related pain. Two chapters provide narrative descriptions of pain, recounted and interpreted by people with pain. Language is important to understanding the meaning of pain since it is the primary tool human beings use to manipulate meaning. As discussed in the book, linguistic meaning may hold clues to understanding some pain-related experiences, including the stigmatisation of people with pain, the dynamics of patient-clinician communication, and other issues, such as relationships between pain, public policy and the law, and attempts to develop a taxonomy of pain that is meaningful for patients. Clinical implications are described in each chapter. This book is intended for people with pain, their family members or caregivers, clinicians, researchers, advocates, and policy makers. (shrink)

The theoretical and empirical link between leadership and workplace bullying needs further elaboration. The aim of the study is to examine the relationship between quality of leadership and the occurrence of workplace bullying 2 years later. Furthermore, we aim to examine a possible mechanism from leadership to bullying using social community at work as mediator. Using survey data that were collected at two different points in time among 1664 workers from 60 Danish workplaces, we examined the total, direct and indirect (...) effects between quality of leadership and workplace bullying. Our results indicate that quality of leadership plays a role in establishing working conditions that lead to workplace bullying. Furthermore, social community at work fully mediates the effect of poor quality of leadership on workplace bullying. This longitudinal study adds to previous cross-sectional studies on the substantial role played by leaders in the bullying process. Within the leadership–bullying relationship, social community at work acts as a full mediator, adding a significant contribution to the discussion of mechanisms involved in the bullying process. Plausible explanations of this mechanism and practical implications are discussed. (shrink)

There is scarce research on the interaction between psychosocial working conditions and being a target of workplace bullying with individual characteristics as a moderator. We therefore examined 3,363 employees from 60 Danish workplaces to test whether sense of coherence moderates the relationship between the job demand-control model and bullying. This work is exploratory in nature, as no previous study to assess this moderation was found. Hierarchical linear regressions showed that demand-control model was significantly associated with bullying. Sense of coherence displayed (...) a significant though practically negligible moderating effect. This suggests that negative psychosocial working conditions are associated with bullying independently of personal characteristics, at least in terms of sense of coherence. (shrink)

Problem: Medical student mistreatment, as well as patient and staff mistreatment by all levels of medical trainees and faculty, is still prevalent in U.S. clinical training. Largely missing in interventions to reduce mistreatment is acknowledgement of the abuse of power produced by the hierarchical structure in which medicine is practiced. Approach: Beginning in 2001, Yale School of Medicine has held annual “Power Day” workshops for third year medical students and advanced practice nursing students, to define and analyse power dynamics within (...) the medical hierarchy and hidden curriculum using literature, guest speakers, and small groups. During rotations, medical students write narratives about the use of power witnessed in the wards. In response to student and small group leader feedback, workshop organizers have developed additional activities related to examining and changing the use of power in clinical teams. Outcome: Emerging narrative themes included the potential impact of small acts and students feeling “mute” and “complicit” in morally distressing situations. Small groups provided safe spaces for advice, support, and professional identity formation. By 2005, students recognized residents that used power positively with Power Day awards and alumni served as keynote speakers on the use of power in medicine. By 2010, departments including OB/GYN, surgery, psychiatry, and paediatrics, had added weekly team Power Hour discussions. Next Steps: The authors highlight barriers, benefits, and lessons learned. Barriers include the notion of clinical irrelevance and resistance to the word “power” due to perceived accusation of abuse. Benefits include promoting open dialogue about power, fostering inter-professional collaboration, rewarding positive role modelling by residents and faculty, and creating a network of trainee empowerment and leadership. Furthermore, faculty have started to ask that issues of power be addressed in a more transparent way at their level of the hierarchy as well. (shrink)

En este artículo analizaré dos importantes aproximaciones contemporáneas a la democracia ateniense. Se trata de las interpretaciones enfrentadas de dos helenistas que han arrojado nueva luz sobre el conocimiento de la democracia clásica. Mogens H. Hansen se ha centrado especialmente en el estudio de las instituciones como fundamento del poder democrático, mientras Josiah Ober, basándose en los textos retóricos, pretende reconstruir la ideología popular a la que hace responsable del dominio político del dêmos sobre la elite. Intentaré, a su (...) vez, trazar las líneas de filiación teórica de ambas posturas y, para ello, abordaré una segunda cuestión, la de qué es la polis griega, un estado o una sociedad sin estado. Mi conclusión es que la lectura de Hansen está muy cercana a la historiografía liberal de G. Grote, mientras que la de Ober no es ajena a las lecturas antropológicas y comunitaristas. (shrink)

Is Plato’s philosophy still relevant for current issues in politics and political science? In order to answer this question, the contributions to this volume endeavour to re-read the Platonic dialogues and to interpret them in terms of textual hermeneutics on the one hand. On the other hand, they refer to Plato from a systematic point of view and apply his philosophy, in particular the method of Socratic dialogue, to discussions on contemporary political issues. The volume is dedicated to Barbara Zehnpfennig, (...) whose works aim at making Socratic–Platonic philosophy fruitful for the present on the basis of a new interpretation of Plato’s philosophy. With contributions by Anke Adamik, Sarah Al-Taher, Viktoria Bachmann, Philip Breuer, Johanna Falk-Seifert, Bettina Fröhlich, Benjamin A. Hahn, Hendrik Hansen, Thomas Haslböck, Raul Heimann, Johannes Frank Hoerlin, Vanessa Jansche, Peter Kainz, Christina Kast, Eva-Maria Kaufmann, Ulrich Kühn, Laura Martena, Julian Obenauer, Victor Peneff und Thomas Wimmer. (shrink)

: Although "brain death" and the dead donor rule—i.e., patients must not be killed by organ retrieval—have been clinically and legally accepted in the U.S. as prerequisites to organ removal, there is little data about public attitudes and beliefs concerning these matters. To examine the public attitudes and beliefs about the determination of death and its relationship to organ transplantation, 1351 Ohio residents ≥18 years were randomly selected and surveyed using random digit dialing (RDD) sample frames. The RDD telephone survey (...) was conducted using computer-assisted telephone interviews. The survey instrument was developed from information provided by 12 focus groups and a pilot study of the questionnaire. Three scenarios based on hypothetical patients were presented: "brain dead," in a coma, or in a persistent vegetative state (PVS). Respondents provided personal assessments of whether the patient in each scenario was dead and their willingness to donate that patient's organs in these circumstances. More than 98 percent of respondents had heard of the term "brain death," but only one-third (33.7%) believed that someone who was "brain dead" was legally dead. The majority of respondents (86.2%) identified the "brain-dead" patient in the first scenario as dead, 57.2 percent identified the patient in a coma as dead (Scenario 2), and 34.1 percent identified the patient in a PVS as dead (Scenario 3). Nearly one-third (33.5%) were willing to donate the organs of patients they classified as alive for at least one scenario, in seeming violation of the dead donor rule. Most respondents were not willing to violate the dead donor rule, although a substantial minority was. However, the majority of respondents were unaware, misinformed, or held beliefs that were not congruent with current definitions of "brain death." This study highlights the need for more public dialogue and education about "brain death" and organ donation. (shrink)

Two central assumptions of current models of language acquisition were addressed in this study: (1) knowledge of linguistic structure is "mapped onto" earlier forms of non-linguistic knowledge; and (2) acquiring a language involves a continuous learning sequence from early gestural communication to linguistic expression. The acquisition of the first and second person pronouns ME and YOU was investigated in a longitudinal study of two deaf children of deaf parents learning American Sign Language (ASL) as a first language. Personal pronouns in (...) ASL are formed by pointing directly to the addressee (YOU) or self (I or ME), rather than by arbitrary symbols. Thus, personal pronouns in ASL resemble paralinguistic gestures that commonly accompany speech and are used prelinguistically by both hearing and deaf children beginning around 9 months. This provides a means for investigating the transition from prelinguistic gestural to linguistic expression when both gesture and language reside in the same modality.\nThe results indicate that deaf children acquired knowledge of personal pronouns over a period of time, displaying errors similar to those of hearing children despite the transparency of the pointing gestures. The children initially (ages 10 and 12 months) pointed to persons, objects, and locations. Both children then exhibited a long avoidance period, during which one function of the pointing gesture (pointing to self and others) dropped out completely. During this period their language and cognitive development were otherwise entirely normal, and they continued to use other types of pointing (e.g., to objects). When pointing to self and others returned, it was marked with errors typical of hearing children; one child exhibited consistent pronoun reversal errors, thinking the YOU point referred to herself, while the other child exhibited reversal errors inconsistently. Evidence from experimental tasks conducted with the first child revealed that pronoun errors occurred in comprehension as well. Full control of the ME and YOU pronouns was not achieved until 25-27 months, around the same time when hearing children master these forms. Thus, the study provides evidence for a discontinuity in the child's transition from prelinguistic to linguistic communication. It is argued that aspects of linguistic structure and its acquisition appear to involve distinct, language-specific knowledge. (shrink)

In the dominant metaphor for organ transplantation, the organ is the ultimate gift, the dying donor's life‐giving bequest, conveyed and made possible by a heroic transplant team. The metaphor encourages donation and enforces recipients’ compliance with post‐transplant treatment. It is also inaccurate and sometimes deeply damaging for the recipient.

This paper defends a direct reference view of names including empty names. The theory says that empty names literally have no meaning and cannot be used to express truths. Names, including empty names, are associated with accompanying descriptions that are implicated in pragmati‐cally imparted truths when empty names are used. This view is defended against several important objections having to do with differences in names, descriptions associated with the names, and considerations of modality. The view is shown to be superior (...) to an alternative theory treating empty names as the “descriptive names” of Kripke and Evans. (shrink)

This paper defends a direct reference view of names including empty names. The theory says that empty names literally have no meaning and cannot be used to express truths. Names, including empty names, are associated with accompanying descriptions that are implicated in pragmati‐cally imparted truths when empty names are used. This view is defended against several important objections having to do with differences in names, descriptions associated with the names, and considerations of modality. The view is shown to be superior (...) to an alternative theory treating empty names as the “descriptive names” of Kripke and Evans. (shrink)

Through examination of a case study of Liberian refugee participation in the Truth and Reconciliation Commission of Liberia, this article highlights concerns about the lack of opportunity for refugee participation in peacebuilding generally. The experience of the authors working with refugees in the Buduburam Settlement near Accra, Ghana, demonstrates the overwhelming desire of refugees to participate in the processes that directly impact their lives, as well as the future of their home and host countries. The article concludes with the suggestion (...) that the Liberian Truth and Reconciliation Commission’s work with refugees can serve as a model of how refugee participation can be enhanced in similar processes in the future. (shrink)

The fifth edition of this classic introduction to Christian ethics via the case method approach, utilizing case studies of contemporary ethical issues.

Transplantation experiments have shown that developing metazoan organs carry intrinsic information about their size and shape. Organ and body size are also sensitive to extrinsic cues provided by the environment, such as the availability of nutrients. The genetic and molecular pathways that contribute to animal size and shape are numerous, yet how they cooperate to control growth is mysterious. The recent identification and characterization of several mutations affecting growth in Drosophila melanogaster promises to provide insights. Many of these mutations affect (...) the extrinsic control of animal size; others affect the organ‐intrinsic control of pattern and size. In this review, we summarize the characteristics of some of these mutations and their roles in growth and size control. In addition, we speculate about possible connections between the extrinsic and intrinsic pathways controlling growth and pattern. BioEssays 24:54–64, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

There are both externalist and internalist theories of the phenomenal content of conscious experiences. Externalists like Dretske and Tye treat the phenomenal content of conscious states as representations of external properties. Internalists think that phenomenal conscious states are reducible to electrochemical states of the brain in the style of the type-type identity theory. In this paper, we side with the representationalists and visit a dispute between them over the test case of Swampman. Does Swampman have conscious phenomenal states or not? (...) Dretske and Tye disagree on this issue. We try to settle the dispute in favor of Dretske's theory. (shrink)

Journal Name: Cognitive Linguistics Issue: Ahead of print.

The relationship between construal and redundancy has not been previously explored empirically. Russian aspect allows speakers to construe situations as either Perfective or Imperfective, but it is not clear to what extent aspect is determined by context and therefore redundant. We investigate the relationship between redundancy and open construal by surveying 501 native Russian speakers who rated the acceptability of both Perfective and Imperfective verb forms in complete extensive authentic contexts. We find that aspect is largely redundant in 81% of (...) uses, and in 17% of contexts aspect is relatively open to construal. We contend that anchoring in redundant contexts likely facilitates the independence of construal in contexts with less redundancy. However further research is needed to discover what makes contexts redundant since known cues for aspect are absent in the majority of such contexts. Native speakers are fairly consistent in giving the original aspect high ratings, but less consistent in rating the non-original aspect, indicating potential problems in testing the reactions of speakers to non-authentic data. (shrink)

Medical advances in transplantation techniques have driven an exponential increase in the demand for transplantable organs. Unfortunately, policy efforts to bolster the organ supply have been less than effective, failing to provide a stopgap for ever-increasing numbers of patients who await organ transplantation. The number of registrations on waiting lists exceeded 65,245 in early 1999, a 325% increase over the 20,000 that existed 11 years earlier in 1988. Regrettably, more than 4,000 patients die each year while awaiting transplantation.

I propose that human experience of matter provides the source domain for the metaphor that motivates the grammatical category of aspect in Russian. This model is a version of the universal TIME IS SPACE metaphor, according to which SITUATIONS ARE MATERIAL ENTITIES, and, more specifically, PERFECTIVE IS A DISCRETE SOLID OBJECT versus IMPERFECTIVE IS A FLUID SUBSTANCE. The contrast of discrete solid objects with fluid substances reveals a rich array of over a dozen properties; the isomorphism observed between those properties (...) and the complex uses of aspect in Russian is compelling. This model presents a more finely articulated account of Russian aspect than feature analysis can achieve. Although some of these properties overlap significantly with the count versus mass distinction often associated with aspect, the properties provide more detail and ground the metaphor to concrete experience. Properties of matter can be divided into three groups: inherent properties such as edges, shape, and integrity (which correspond to inherent situation aspect); interactional properties such as juxtaposition, dynamism, and salience (which correspond to discourse phenomena of aspect); and human interactional properties such as graspability and impact (which correspond to pragmatic phenomena of aspect). The interactional and human interactional properties can be used to motivate subjective construal, whereas the inherent properties serve as default motivators. The model will be demonstrated in detail using Russian data, followed by a survey comparing Russian with the other Slavic languages, which will show that deviations consist of either non-implementation of a given property, or the implementation of an inherent (default) property in place of an interactional or human interactional property. This model will be contrasted with a brief discussion of a selection of non-Slavic languages. The specific metaphor in this model does not apply beyond Slavic, but perhaps it will encourage investigation into the source domain of aspect in other languages. There appears to be a correlation between the relatively heavy morphological investment Slavic languages make in nominal individuation and the individuation of situations presented in this metaphorical model. (shrink)

Strategies for Successful Animal Shelters is the first book to assess the relationship between shelter traits, activities and critical outcome variables, such as live release or save rates. This book provides a data-based evaluation of shelter processes and practices with explicit recommendations for improved shelter activities. Using a survey of licensed animal shelters, case studies, and data on state inspections, complaints, and save rates, this book provides an assessment of the activities, processes, and procedures that are most likely to lead (...) to positive outcomes for a variety of animal shelters. The book also contributes to community debate around animal sheltering and provides best practices, methods and means to assess local shelters to ensure the highest level of animal welfare. It is a valuable resource for animal shelter professionals and rescue groups, as well as students in disciplines such as animal science, animal welfare and shelter medicine."--Back cover. (shrink)

Gendered barriers to women’s advancement in STEM disciplines are subtle, often the result of gender practices, gender stereotypes, and gendered occupational cultures. Professional socialization into scientific cultures encourages and rewards gender practices that help to maintain gendered barriers. This article focuses more specifically on how individual women scientists’ gender practices potentially sustain gender barriers. Findings based on interview data from thirty women in academic STEM fields reveal that women draw on gendered expectations and norms within their disciplines to discursively distance (...) themselves from other women they perceive as having deviated from such norms and expectations. The types of distancing in which these respondents engage reflect and support gendered structures, cultures, and practices that ultimately disadvantage women and obscure gender inequality. I conclude by discussing the implications of women scientists’ distancing practices for efforts to change the gendered cultures of STEM disciplines. (shrink)

A foundational goal of cognitive linguistics is to explain linguistic phenomena in terms of general cognitive strategies rather than postulating an autonomous language module (Langacker 1987: 12–13). Metonymy is identified among the imaginative capacities of cognition (Langacker 1993: 30, 2009: 46–47). Whereas the majority of scholarship on metonymy has focused on lexical metonymy, this study explores the systematic presence of metonymy in word-formation. I argue that in many cases, the semantic relationships between stems, affixes, and the words they form can (...) be analyzed in terms of metonymy, and that this analysis yields a better, more insightful classification than traditional descriptions of word-formation. I present a metonymic classification of suffixal word-formation in three languages: Russian, Czech, and Norwegian. The system of classification is designed to maximize comparison between lexical and word-formational metonymy. This comparison supports another central claim of cognitive linguistics, namely that grammar (in this case word-formation) and lexicon form a continuum (Langacker 1987: 18–19), since I show that metonymic relationships in the two domains can be described in nearly identical terms. While many metonymic relationships are shared across the lexical and grammatical domains, some are specific to only one domain, and the two domains show different preferences for source and target concepts. Furthermore, I find that the range of metonymic relationships expressed in word-formation is more diverse than what has been found in lexical metonymy. There is remarkable similarity in word-formational metonymy across the three languages, despite their typological differences, though they all show some degree of language-specific behavior as well. Although this study is limited to three Indo-European languages, the goal is to create a classification system that could be implemented (perhaps with modifications) across a wider spectrum of languages. (shrink)

: This paper reviews current and suggested policies designed to increase organ donation in the United States and indicates the problems inherent to these approaches for increasing organ donation by African Americans. Data from a population-based study assessing attitudes and beliefs about organ donation among white and African-American respondents are presented and discussed. We pose the question of whether it is reasonable to maintain the existing system or whether we should institute a system that uses policies based on the attitudes (...) and beliefs of a minority group that is in greater need than the majority. In light of the discussion, we suggest that the current policies guiding the organ procurement system are not adequate to address existing concerns within the African-American community and that a different set of assumptions may be needed to drive organ procurement policy. (shrink)

The stories we tell of psychiatric disability1 and gender play a crucial role not only in the experience of psychiatric disorders, but in who disordered individuals are in the most literal sense. Recent theories of the self—so-called narrative self-constitution views, or “narrative theories”—contend that the self is, fundamentally, constituted by a narrative one tells about oneself. Furthermore, this narrative almost certainly absorbs elements from surrounding cultural scripts. Thus, narrative self-constitution views can shed light on some of the ways in which (...) cultural... (shrink)

A primary intention of our original manuscript was to provide examples of both harmful and helpful influences of one cultural artifact—depression memoirs—on who female readers take their selves to be, and who they may actually end up being. Bradley Lewis beautifully articulated our strategy as “chart[ing] out … conflicting vectors” : that is, delineating select examples of how certain outer narratives conveyed in depression memoirs may kindle sexist and sanist modes of being. Our hope was that making these vectors explicit (...) could ultimately be liberating for some individuals by “opening up... (shrink)

We propose the “grammatical profile” as a means of probing the aspectual behavior of verbs. A grammatical profile is the relative frequency distribution of the inflected forms of a word in a corpus. The grammatical profiles of Russian verbs provide data on two crucial issues: a) the overall relationship between perfective and imperfective verbs and b) the identification of verbs that characterize various intersections of aspect, tense and mood (TAM) with lexical classes. There is a long-standing debate over whether Russian (...) aspectual “pairs” are formed only via suffixation (the Isacenko hypothesis) or whether they are formed via both suffixation and prefixation (the traditional view). We test the Isacenko hypothesis using data on the corpus frequency of inflected forms of verbs. We find that the behavior of perfective and imperfective verbs is the same regardless of whether the aspectual relationship is marked by prefixes or suffixes; our finding thus supports the traditional view. Introspective descriptions of Russian aspect have often connected the use of particular inflectional forms with certain uses of aspect; for example, the use of imperative forms with the imperfective aspect to produce expressions that are very polite. Grammatical profiles make it possible to identify verbs that behave as outliers, presenting unusually large proportions of usage in parts of the paradigm. This analysis both gives substance to and extends previous introspective descriptions by identifying the verbs most involved in certain TAM-category interactions. On a methodological level, this study contributes to current discussions on the use of inflected forms vs. lemmas in corpus studies. Newman (Aiming low in linguistics: Low-level generalizations in corpus-based research: National Chiao Tung University, 2008) finds valuable information at the level of the inflectional form, and Gries (forthcoming) argues that inflectional forms do not necessarily provide a better basis for analysis than lemmas. We agree with them that the appropriate level of granularity is determined by both the language and the linguistic phenomenon under analysis. (shrink)