Falls are frequent in Myotonic Dystrophy type 1, but the pathophysiology of the balance impairment needs further exploration in this disease. The current work aims to provide a richer understanding of DM1 imbalance. Standing balance in 16 patients and 40 controls was tested in two posturographic tests. In the Sensory Organization Test, standstill balance was challenged by combining visual and environmental conditions. In the “react” test, reflexes induced by sudden shifts in the support base were studied. Oscillations of the body (...) centre of mass were measured. In the SOT, COM sway was larger in patients than controls in any condition, including firm support with eyes open. On sway-tuned support, COM oscillations when standing with closed eyes were larger in patients than controls even after taking into account the oscillations with eyes open. In the “react” paradigm, balance reflexes were delayed in patients. Results in both experimental paradigms are consistent with leg muscle weakness. This, however, is not a sufficient explanation. The SOT test highlighted that patients rely on vision more than controls to maintain static balance. Consistently enough, evidence is provided that an impairment of proprioceptive and vestibular systems contributes to falls in DM1. Rehabilitation programs targeted at reweighting sensory systems may be designed to improve safe mobility in DM1. (shrink)

An analysis of how capitalism today produces subjectivity like any other “good,” and what would allow us to escape its hold. “Capital is a semiotic operator”: this assertion by Félix Guattari is at the heart of Maurizio Lazzarato's Signs and Machines, which asks us to leave behind the logocentrism that still informs so many critical theories. Lazzarato calls instead for a new theory capable of explaining how signs function in the economy, in power apparatuses, and in the production of (...) subjectivity. Moving beyond the dualism of signifier and signified, Signs and Machines shows how signs act as “sign-operators” that enter directly into material flows and into the functioning of machines. Money, the stock market, price differentials, algorithms, and scientific equations and formulas constitute semiotic “motors” that make capitalism's social and technical machines run, bypassing representation and consciousness to produce social subjections and semiotic enslavements. Lazzarato contrasts Deleuze and Guattari's complex semiotics with the political theories of Jacques Rancière, Antonio Negri and Michael Hardt, Paolo Virno, and Judith Butler, for whom language and the public space it opens still play a fundamental role. Lazzarato asks: What are the conditions necessary for political and existential rupture at a time when the production of subjectivity represents the primary and perhaps most important work of capitalism? What are the specific tools required to undo the industrial mass production of subjectivity undertaken by business and the state? What types of organization must we construct for a process of subjectivation that would allow us to escape the hold of social subjection and machinic enslavement? In addressing these questions, Signs and Machines takes on a task that is today more urgent than ever. (shrink)

The debtor-creditor relation, which is at the heart of this book, sharpens mechanisms of exploitation and domination indiscriminately, since, in it, there is no distinction between workers and the unemployed, consumers and producers, working and non-working populations, between retirees and welfare recipients. They are all "debtors," guilty and responsible in the eyes of capital, which has become the Great, the Universal, Creditor.--from The Making of the Indebted Man Debt -- both public debt and private debt Has become a major concern (...) of economic and political leaders. In The Making of the Indebted Man, Maurizio Lazzarato shows that, far from being a threat to the capitalist economy, debt lies at the very core of the neoliberal project. Through a reading of Karl Marx's lesser-known youthful writings on John Mill, and a rereading of writings by Friedrich Nietzsche, Gilles Deleuze, Felix Guattari, and Michel Foucault, Lazzarato demonstrates that debt is above all a political construction, and that the creditor/debtor relation is the fundamental social relation of Western societies.Debt cannot be reduced to a simple economic mechanism, for it is also a technique of "public safety" through which individual and collective subjectivities are governed and controlled. Its aim is to minimize the uncertainty of the time and behavior of the governed. We are forever sinking further into debt to the State, to private insurance, and, on a more general level, to corporations. To insure that we honor our debts, we are at once encouraged and compelled to become the "entrepreneurs" of our lives, of our "human capital." In this way, our entire material, psychological, and affective horizon is upended and reconfigured. How do we extricate ourselves from this impossible situation? How do we escape the neoliberal condition of the indebted man? Lazzarato argues that we will have to recognize that there is no simple technical, economic, or financial solution. We must instead radically challenge the fundamental social relation structuring capitalism: the system of debt. (shrink)

Biopower agregates no longer families distributed on land but mobile individuals. How can power count forces and take energy from them, if they differ from each other, if they are free? Power comes from beneath, from strategic relations between subjects.

This paper aims to argue for the thesis that it is not a priori morally justified that the first phase of space colonisation is based on sexual reproduction. We ground this position on the argument that, at least in the first colonisation settlements, those born in space may not have a good chance of having a good life. This problem does not depend on the fact that life on another planet would have to deal with issues such as solar radiation (...) or with the decrease or entire absence of the force of gravity. These issues could plausibly be addressed given that the planets or settlements we will feasibly colonise could be completely transformed through geoengineering processes. Likewise, the ability of humans to live in space could be enhanced through genetic modification interventions. Even if, however, the problems concerning survival in space were solved, we think that, at least in the first period of colonisation of space or other planets, giving birth to children in space could be a morally irresponsible choice since we argue, the life we ​​could give them might not be good enough. We contend that this is the case since when we decide to have a baby. We argue that it is not morally right to be content that our children have a minimally sufficient life worth living; before we give birth to children in space, we should make sure we can give them a reasonable chance of having a good life. This principle applies both on Earth - at least where you can choose - and for space travel. (shrink)

We propose a mentalistic and nativist view of human early mental and social life and of the ontogeny of mindreading. We define the mental state of sharedness as the primitive, one-sided capability to take one's own mental states as mutually known to an i nteractant. We argue that this capability is an innate feature of the human mind, which the child uses to make a subjective sense of the world and of her actions. We argue that the child takes all (...) of her mental states as shared with her caregivers. This a llows her to interact with her caregivers in a mentalistic way from the very beginning and provides the grounds on which the later maturation of mindreading will build. As the latter process occurs, the child begins to understand the mental world in terms of differences between the mental states of different agents; subjectively, this also corresponds to the birth of privateness. ? (shrink)

Nationalism and patriotism are two of the most powerful forces shaping world history. In this paperback edition of a highly successful, wide-ranging study, Maurizio Viroli shows exactly why patriotism is a political virtue and nationalism a political vice.

This book studies a central but hitherto neglected aspect of Rousseau's political thought: the concept of social order and its implications for the ideal society which he envisages. The antithesis between order and disorder is a fundamental theme in Rousseau's work, and the author takes it as the basis for this study. In contrast with a widely held interpretation of Rousseau's philosophy, Professor Viroli argues that natural and political order are by no means the same for Rousseau. He explores the (...) differences and interrelations between the different types of order which Rousseau describes, and shows how the philosopher constructed his final doctrine of the just society, which can be based only on every citizen's voluntary and knowing acceptance of the social contract and on the promotion of virtue above ambition. The author also shows the extent of Rousseau's debt to the republican tradition, and above all to Machiavelli, and revises the image of Rousseau as a disciple of the natural-law school. (shrink)

This paper draws from Foucault’s analysis of liberalism and neoliberalism to reconstruct the mechanisms and the means whereby neoliberalism has transformed society into an ‘enterprise society’ based on the market, competition, inequality, and the privilege of the individual. It highlights the role of financialization, neglected by Foucault, as a key apparatus in achieving this transformation. It elaborates the strategies of individualization, insecuritization and depoliticization used as part of neoliberal social policy to undermine the principles and practices of mutualization and redistribution (...) that the Welfare State and Fordism had promoted. It shows that the aim of neoliberal politics is the restoration of the power of capital to determine the distribution of wealth and to establish the enterprise as dominant form; this requires that it target society as a whole for a fundamental reconstruction, putting in place new mechanisms to control individual conduct. The analysis refers to the case of workers in the culture industry to illustrate the operation of these mechanisms in practice. It also outlines the main elements of the analytical apparatus that makes visible the new role of the state as an ensemble of apparatuses constituting the conditions for neoliberal market capitalism and the new type of individual appropriate for it. The paper thus adds a new dimension to Foucault’s analysis. (shrink)

The Italian philosopher Maurizio Lazzarato reveals the underpinnings of contemporary subjectivity in the aesthetics and politics of mass media. This book discloses the conceptual groundwork of Lazzarato's thought as a whole for a time when his writings have become increasingly influential.

[ES] La posibilidad de definir una ontología del arte —indagando, por tanto, cuál género de cosas sería un objeto de arte— recorre dos horizontes alternativos: aquél de una metafísica prescriptiva y aquél de una metafísica descriptiva. [EN] The possibility of defining an ontology of art —asking, therefore, which kind of things would be a work of art— follows two alternative horizons: that of a prescriptive Metaphysics, and that of a descriptive Metaphysics.

In the wide critical reviews that the enterprise of Begriffsgeschichte has triggered, the difficult relationship that conceptual history – in its Koselleckian declination – entertains with systemic theory has remained maybe underexposed until now. Moving from the tension between experience and historicity in Koselleck, the article reflects on the tensions that the historical-conceptual structure reveals as soon as it comes into contact with the problems of historical semantics that accompany the Luhmannian attempt of operating, in the register of second order (...) observation, a temporal dislocation and a de-paradoxification of the paradox activated by Derrida’s différance, as constitutive of historicity. The blind spot at the bottom of Luhmannian gaze cuts out the borders of the “history” continent along the lines of the shipwreck of the classic semantics of modernity. (shrink)

Sex robots are already a reality: in this provocative text, Maurizio Balistreri explores the fascinating world of future sex, exploring the ethical questions raised by the existence of a sex robot industry.

In this book, Esposito presents a historiography of organicist and holistic thought through an examination of the work of leading biologists from Britain and America. He shows how this work relates to earlier Romantic tradition and sets it within the wider context of the history and philosophy of the life sciences.

There is a growing body of scholarship that is addressing the ethics, in particular, the bioethics of space travel and colonisation. Naturally, a variety of perspectives concerning the ethical issues and moral permissibility of different technological strategies for confronting the rigours of space travel and colonisation have emerged in the debate. Approaches ranging from genetically enhancing human astronauts to modifying the environments of planets to make them hospitable have been proposed as methods. This paper takes a look at a critique (...) of human bioenhancement proposed by Mirko Garasic who argues that the bioenhancement of human astronauts is not only functional but necessary and thus morally permissible. However, he further claims that the bioethical arguments proposed for the context of space do not apply to the context of Earth. This paper forwards three arguments for how Garasic’s views are philosophically dubious: (1) when he examines our responsibility towards future generations he refers to a moral principle (which we will call the principle of mere survival) which, besides being vague, is not morally acceptable; (2) the idea that human bioenhancement is not natural is not only debatable but morally irrelevant; and (3) it is not true that the situations that may arise in space travel cannot occur on Earth. We conclude that not only is the (bio)enhancement of humans on Earth permissible but perhaps even necessary in certain circumstances. (shrink)

: The doctrines on human nature and moral development maintained in ancient China by Gaozi, Mencius, and Xunzi, respectively, have been interpreted mostly as a contradiction within the Confucian school. It is argued here that they represent distinct, yet possible and congruous, modes of interpreting and re-elaborating Confucius' teachings, two opposing yet largely complementary currents that have developed within the Confucian school.

The world economy, already launched toward the globalization of markets, is strenuously searching for nonrenewable natural resources, to exploit in the productive processes to satisfy the demands of a world population in continuous growth. In such a context ecological taxation can contribute to the resolution of environmental problems, stimulating the entrepreneurs to appraise opportunities, not only environmental but also economical, that spring from the introduction of innovations of sustainable processes. With this in mind this article has proceeded with an evolutionary (...) adaptation of the environmental curve of Kuznets, through a three-dimensional re-elaboration inserting as a third variable the sustainable technological component and showing how this can represent a valid tool of environmental politics for the attainment of an acceptable level of pollution for society in developed countries. Therefore, the objective of public governance is to favor research in the field of sustainable technology and to induce, even through the introduction of environmental taxation and facilitations, enterprises to use productive eco-compatible processes with the purpose of improving the general level of the quality of life in harmony with the concept of sustainable development. (shrink)

All around the world in March, due to COVID-19, competitive sport calendars were suddenly canceled, jeopardizing the training programs of athletes. Moreover, in Italy, the government banned all non-essential travel across the entire country from the beginning of March. Consequently, Italian cyclists were banned from leaving their homes and therefore unable to perform their ordinary training activities. The Italian Association of Professional Cyclists early on during that period noticed that several cyclists were experiencing a worrying decrease in their mental well-being (...) and asked the authors to set up an online Sport Psychology Intervention during lockdown to enhance the athletes' mental health. Through a number of unprecedented events and considerations, the aim of the current investigation was to assess the Italian cyclists' mental health during the lockdown and its changes after the SPI. We validated the Italian version of the Sport Mental Health Continuum Short Form —presented in Study 1—and then applied it to a sample of Italian professional cyclists—presented in Study 2—prior to and after the SPI. To achieve these objectives, the reliability and construct validity of the Italian version of the Sport MHC-SF were tested in Study 1. RM-MANOVA tests were run to evaluate the effect of SPI on cyclists in Study 2. A total of 185 Italian athletes were involved in the validation of the MHC in Study 1 and 38 professional cyclists in Study 2. Results from Study 1 suggested a three-factor higher order model of Sport MHC-SF [Model fit: χ2 = 471.252, p < 0.000; CFI = 0.951; RMSEA = 0.049; RMR= 0.048]. MCFA showed that the default model kept invariance among groups of athletes. Results from Study 2 highlighted that professional cyclists who followed the SPI were able to cope better with psychological stressors, showing improved well-being compared to the athletes that did not. No significant differences were found for emotional and social well-being. The present multi-study paper contributes to the theoretical field with a validated measure of Sport MHC-SF translated in the Italian language and culture. It also provides practical implications related to cases of reduced mental health due to injury, illness, or similar situations of home confinement in the future. (shrink)

The translation of this work has been funded by SEPS - Segretariato Europeo per le Pubblicazioni Scientifiche.

The rise of molecular epigenetics over the last few years promises to bring the discourse about the sociality and susceptibility to environmental influences of the brain to an entirely new level. Epigenetics deals with molecular mechanisms such as gene expression, which may embed in the organism “memories” of social experiences and environmental exposures. These changes in gene expression may be transmitted across generations without changes in the DNA sequence. Epigenetics is the most advanced example of the new postgenomic and context-dependent (...) view of the gene that is making its way into contemporary biology. In my article I will use the current emergence of epigenetics and its link with neuroscience research as an example of the new, and in a way unprecedented sociality of contemporary biology. After a review of the most important developments of epigenetic research, and some of its links with neuroscience, in the second part I reflect on the novel challenges that epigenetics presents for the social sciences for a re-conceptualization of the link between the biological and the social in a postgenomic age. Although epigenetics remains a contested, hyped, and often uncritical terrain, I claim that especially when conceptualized in broader non-genecentric frameworks,. (shrink)

This book presents a critical examination of Machiavelli's thought, combining an accessible, historically-informed account of his work with a reassessment of his central ideas and arguments. Viroli challenges the accepted interpretations of Machiavelli's work, insisting that his republicanism was based not on a commitment to virtue, greatness, and expansion, but to the ideal of civic life protected by the shield of fair laws. His detailed study of how Machiavelli composed The Prince offers a number of new interpretations and he further (...) contends that the most challenging--and underestimated--aspect of Machiavelli's thought is his philosophy of life, in particular his conceptions of love, women, irony, God, and the human condition. (shrink)

Chapter 1st of the book. This chapter explores the fundamental ambiguity of the concept of plasticity – between openness and determination, change and stabilization of forms. This pluralism of meanings is used to unpack different instantiations of corporeal plasticity across various epochs, starting from ancient and early modern medicine, particularly humouralism. A genealogical approach displaces the notion that plasticity is a unitary phenomenon, coming in the abstract, and illuminates the unequal distribution of different forms of plasticities across social, gender, and (...) ethnic groups. Taking a longer view of the plastic body as a ubiquitous belief in traditions predating and coexisting with modern medicine will help contextualize the seeming radicalism of today’s turn to permeability and the exceptionalism of Western findings. By highlighting the complex biopolitical usages of plasticity in the past, the chapter warns against simplistic appropriations of the term in contemporary body/world configurations driven by findings in neuroscience, epigenetics and microbiomics. (shrink)

In this paper I address the conflict of interest (CoI) issue from a legal point of view at a European level. We will see that the regulatory framework that exists in Europe does state the need for the independence of ethics committee involved in authorisation of research and clinical trials. We will see that CoI is an element that has to be closely monitored at National and International level. Therefore, Member States and Newly Associated States do have to address CoI (...) in the authorisation process of research and clinical protocols of biomedicine. (shrink)

In this paper I propose a new interpretation of the British evolutionary synthesis. The synthetic work of J. B. S. Haldane, R. A. Fisher and J. S. Huxley was characterized by both an integration of Mendelism and Darwinism and the unification of different biological subdisciplines within a coherent framework. But it must also be seen as a bold and synthetic Darwinian program in which the biosciences served as a utopian blueprint for the progress of civilization. Describing the futuristic visions of (...) these three scientists in their synthetic heydays, I show that, despite a number of important divergences, their biopolitical ideals could be biased toward a controlled and regimented utopian society. Their common ideals entailed a social order where liberal and democratic principles were partially or totally suspended in favor of bioscientific control and planning for the future. Finally, I will argue that the original redefinition of Darwinism that modern synthesizers proposed is a significant historical example of how Darwinism has been used and adapted in different contexts. The lesson I draw from this account is a venerable one: that, whenever we wish to define Darwinism, we need to recognize not only its scientific content and achievements but expose the other traditions and ideologies it may have supported. (shrink)

In recent years, the persuasion that Niccolò Machiavelli was a cynical, irreligious devious, ambitious, deceitful, and misogynous man has been gaining remarkable consensus among scholars. The most...

ExcerptAs Jürgen Habermas has recently pointed out, scientific naturalism represents one of the “two countervailing trends that mark the intellectual tenor of our age,” the other being religious worldviews.1 In a broader intellectual landscape dominated by research programs in neuro- and cognitive science, evolutionary psychology, behavioral genetics and so on, contemporary naturalism symbolizes not only the meta-philosophical framework of these leading intellectual enterprises, but more fundamentally a sort of zeitgeist for our epoch. This is true not only at an epistemological (...) level, characterized today by the efforts of an entire generation of philosophers to “naturalize” knowledge, the mind, consciousness, and…. (shrink)

ArgumentD’Arcy Thompson has often been portrayed as a loner. His science of form has frequently been labeled anachronistic, idiosyncratic, and unconnected to his contemporary biology. This article aims to challenge this interpretation. Thompson's representation as a loner did not lie in the idiosyncrasies of his science, but in our own historiography. Through the use of unedited archival sources, this study shows that Thompson's biology was well-connected to an international research program – a program mainly shared by developmental biologists, physiologists, and (...) morphologists. In addition, this article also aims to propose a new interpretation of Thompson'sOn Growth and Form. Drawing on his private correspondence and published sources, the paper re-contextualizes the contents and conclusions of Thompson's seminal work. We will see that Thompson defended a particular kind of organismal biology. The bio-science he supported stemmed not only from Aristotle's zoology or Pythagorean mathematics, but had many allies among twentieth-century naturalists. (shrink)

Our understanding of body–world relations is caught in a curious contradiction. On one side, it is well established that many concepts that describe interaction with the outer world – ‘plasticity’ or ‘metabolism’- or external influences on the body - ‘environment’ or ‘milieu’ – appeared with the rise of modern science. On the other side, although premodern science lacked a unifying term for it, an anxious attentiveness to the power of ‘environmental factors’ in shaping physical and moral traits held sway in (...) nearly all medical systems before and alongside modern Europe. In this article, I build on a new historiography on the policing of bodies and environments in medieval times and at the urban scale to problematize Foucault’s claim about biopolitics as a modern phenomenon born in the European eighteenth-century. I look in particular at the collective usage of ancient medicine and manipulation of the milieu based on humoralist notions of corporeal permeability (Hippocrates, Galen, Ibn Sīnā) in the Islamicate and Latin Christendom between the 12th and the 15th century. This longer history has implications also for a richer genealogy of contemporary tropes of plasticity, permeability and environmental determinism beyond usual genealogies that take as a starting point the making of the modern body and EuroAmerican biomedicine. (shrink)

The modern family has developed in its configuration, assuming different features from the traditional family typical of the first part of last century. The typologies of family that currently exist are several and include households with a single parent, others with more than two parents, others with two different ethnicities within them, and so on. Irrespective of its structure, however, each family can be accepted as valid if fulfills the development tasks of all its members. In particular is the coexistence (...) of clearly identifiable functions and roles that can ensure children a peaceful growth. (shrink)