This paper aims to identify the key characteristics of model organisms that make them a specific type of model within the contemporary life sciences: in particular, we argue that the term “model organism” does not apply to all organisms used for the purposes of experimental research. We explore the differences between experimental and model organisms in terms of their material and epistemic features, and argue that it is essential to distinguish between their representational scope and representational target. We also examine (...) the characteristics of the communities who use these two types of models, including their research goals, disciplinary affiliations, and preferred practices to show how these have contributed to the conceptualization of a model organism. We conclude that model organisms are a specific subgroup of organisms that have been standardized to fit an integrative and comparative mode of research, and that it must be clearly distinguished from the broader class of experimental organisms. In addition, we argue that model organisms are the key components of a unique and distinctively biological way of doing research using models.Keywords: Experimental organism; Genetics; Model organism; Modeling; Philosophy of biology; Representation. (shrink)

Kant's Critique of Judgment has often been interpreted by scholars as comprising separate treatments of three uneasily connected topics: beauty, biology, and empirical knowledge. Rachel Zuckert's book interprets the Critique as a unified argument concerning all three domains. She argues that on Kant's view, human beings demonstrate a distinctive cognitive ability in appreciating beauty and understanding organic life: an ability to anticipate a whole that we do not completely understand according to preconceived categories. This ability is necessary, moreover, for (...) human beings to gain knowledge of nature in its empirical character as it is, not as we might assume it to be. Her wide-ranging and original study will be valuable for readers in all areas of Kant's philosophy. (shrink)

This Element presents a philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying this understanding. We contend that model organisms are key components of a distinctive way of doing research. We focus on what makes model organisms an important type of model, (...) and how the use of these models has shaped biological knowledge, including how model organisms represent, how they are used as tools for intervention, and how the representational commitments linked to their use as models affect the research practices associated with them. This title is available as Open Access on Cambridge Core. (shrink)

Epistemologists of testimony have focused almost exclusively on the epistemic dynamics of simple testimony. We do sometimes testify by ways of simple, single sentence assertions. But much of our testimony is narratively structured. I argue that narrative testimony gives rise to a form of epistemic dependence that is far richer and more far reaching than the epistemic dependence characteristic of simple testimony.

Our aesthetic judgments are embedded in and shaped by unjust social orders. But can our aesthetic judgments themselves—“this is beautiful; that is not”—be unjust? This article argues that they can. Admitting that this is so does not require us to be unduly revisionary with respect to our concept of justice. Rather, the thought that aesthetic judgments are unjust flows naturally from familiar egalitarian constraints.

Increasingly, metaphors are the target of political critique: Jewish groups condemn Holocaust imagery; mental health organizations, the metaphorical exploitation of psychosis; and feminists, “rape metaphors.” I develop a novel model for making sense of such critiques of metaphor.

Hate speech and misinformation are rife. How to respond? Counterspeech proposals say: with more and better speech. This paper considers the treatment of counterspeech in Maxime Lepoutre’s Democratic Speech In Divided Times. Lepoutre provides a nuanced defence of counterspeech. Some counterspeech, he grants, is flawed. But, he says: counterspeech can be debugged. Once we understand why counterspeech fails – when fail it does – we can engineer more effective counterspeech strategies. Lepoutre argues that the failures of counterspeech can be theorised (...) using the ideology of salience. Negative counterspeech fails because it reinforces the salience of the very ideas or associations that it contests. His solution? Positive counterspeech – a form of counterspeech which avoids the salience trap. I argue that the salience paradigm is ill-suited to theorise the failures of counterspeech. I suggest some alternatives. Further, I show that these alternative paradigms make importantly different practical recommendations – recommendations concerning how we ought to engineer our counterspeech – from those issued by the salience paradigm. (shrink)

What happens when we consider transformative experiences from the perspective of gender transitions? In this paper I suggest that at least two insights emerge. First, trans* persons’ experiences of gender transitions show some limitations to L.A. Paul’s (forthcoming) decision theoretic account of transformative decisions. This will involve exploring some of the phenomenology of coming to know that one is trans, and in coming to decide to transition. Second, what epistemological effects are there to undergoing a transformative experience? By connecting some (...) experiences of gender transitions to feminist standpoint epistemology, I argue that radical changes in one’s identity and social location also radically affects one’s access to knowledge in ways not widely appreciated in contemporary epistemology. (shrink)

We argue that individual and institutional caregivers have a defeasible moral duty to provide dependent children with plant-based diets and related education. Notably, our three arguments for this claim do not presuppose any general duty of veganism. Instead, they are grounded in widely shared beliefs about children’s interests and caregivers’ responsibilities, as well as recent empirical research relevant to children’s moral development, autonomy development, and physical health. Together, these arguments constitute a strong cumulative case against inculcating in children the dietary (...) practice of regularly eating meat (and other animal products) — a practice we call ‘carnism’. (shrink)

In this paper I present my proposal for the central norm governing the practice of assertion, which I call the Supportive Reasons Norm of Assertion (SRNA). The critical features of this norm are that it's highly sensitive to the context of assertion, such that the requirements for warrantedly asserting a proposition shift with changes in context, and that truth is not a necessary condition for warrantedly asserting. In fact, I argue that there are some cases where a speaker may warrantedly (...) assert something she knows to be false. Only SRNA seems able to account for such cases. (shrink)

In this paper, we explore the recent creation of “iBlastoids,” which are 3-D structures that resemble early human embryos prior to implantation which formed via self-organization of reprogrammed ad...

The biological sciences have become increasingly reliant on so-called 'model organisms'. I argue that in this domain, the concept of a descriptive model is essential for understanding scientific practice. Using a case study, I show how such a model was formulated in a preexplanatory context for subsequent use as a prototype from which explanations ultimately may be generated both within the immediate domain of the original model and in additional, related domains. To develop this concept of a descriptive model, I (...) focus on use of the nematode worm Caenorhabditis elegans and the wiring diagrams that were developed as models of its neural structure. In addition, implications of the concept of a descriptive model, particularly its relevance for the data-phenomena distinction as well as its relation to long-standing debates on realism, are briefly examined. (shrink)

Through an examination of the actual research strategies and assumptions underlying the Human Genome Project (HGP), it is argued that the epistemic basis of the initial model organism programs is not best understood as reasoning via causal analog models (CAMs). In order to answer a series of questions about what is being modeled and what claims about the models are warranted, a descriptive epistemological method is employed that uses historical techniques to develop detailed accounts which, in turn, help to reveal (...) forms of reasoning that are explicit, or more often implicit, in the practice of a particular field of scientific study. It is suggested that a more valid characterization of the reasoning structure at work here is a form of case-based reasoning. This conceptualization of the role of model organisms can guide our understanding and assessment of these research programs, their knowledge claims and progress, and their limitations, as well as how we educate the public about this type of biomedical research. (shrink)

Ambiguity in our experience of embodiment online has prevented us from confidently extending existing scholarship to the domain of online sociality. In recent decades, research across the disciplines has been undergirded by themes related to embodiment, restoring to prominence a theme previously neglected in part thanks to the rise of feminist scholars within the academy. We have not, however, adequately appealed to this corpus when theorizing forms of life happening online. In this paper I hope to bridge this gap by (...) bringing forward phenomenological evidence about the nature of online embodiment. This paper presents the findings from a research project that used phenomenological interviews to elicit descriptions of lived embodiment from participants singing in online choirs during the COVID-19 pandemic. I argue that these descriptions reveal anchoring and discounting as central features of their experience, two dynamics of the body schema as described by Merleau-Ponty in the Phenomenology of Perception that underpin participant experiences of sensory disjunction. I furthermore take pains to show how the form of embodiment operative in the online choirs has the characteristics of intercorporeality, a reciprocal two-sided form of embodied subjectivity. After explaining how Husserl and Merleau-Ponty each define intercorporeality, I suggest that what I am calling an auditory intercorporeality underlies reported features of participant experience in the choirs, such as we-experience and coordination. (shrink)

Philosophy and Phenomenological Research, EarlyView.

Diagnosing the Diagnostic and Statistical Manual of Mental Disorders (Karnac, 2014) evaluates the latest edition of the D.S.M.The publication of D.S.M-5 in 2013 brought many changes. Diagnosing the Diagnostic and Statistical Manual of Mental Disorders asks whether the D.S.M.-5 classifies the right people in the right way. It is aimed at patients, mental health professionals, and academics with an interest in mental health. Issues addressed include: How is the D.S.M. affected by financial links with the pharmaceutical industry? To what extent (...) were and should patients involved in revising the classification? How are diagnoses added to the D.S.M.? Does medicalization threaten the idea that anyone is normal? What happens when changes to diagnostic criteria mean that people lose their diagnoses? How important will the D.S.M. be in the future? (shrink)

Kevin Dorst has recently provided a novel argument for the KK principle. In this paper I sketch a rejoinder.

This essay takes up two questions. First, what does it mean to say that someone creates her own luck? At least colloquially speaking, luck is conceived as something out of an agent's control. So how could an agent increase or decrease the likelihood that she'll be lucky? Building on some recent work on the metaphysics of luck, the essay argues that there is a sense in which agents can create their own luck because people with more skill tend to have (...) more opportunities to benefit from luck. Second, what implications does this conception of luck have for related topics such as how we evaluate performances (like shooting an arrow), including coming to know something? The ubiquitous presence of luck in our actions is often underappreciated. The essay argues that when we combine an expected outcomes view of luck with a counterfactual view of causation, the distinction between environmental and intervening veritic luck seems to disappear. We need a more nuanced view of how luck sometimes undermines credit for success in agents' actions. The upshot of this view is that while luck may undermine the creditworthiness of an agent's success, it only partially undermines creditworthiness. (shrink)

I argue that we are sometimes morally responsible for having and using (or not using) our concepts, despite the fact that we generally do not choose to have them or have full or direct voluntary control over how we use them. I do so by extending an argument of Angela Smith's; the same features that she says make us morally responsible for some of our attitudes also make us morally responsible for some of our concepts. Specifically, like attitudes, concepts can (...) be (a) conceptually and rationally connected to our evaluative judgments, (b) in principle subject to rational revision (reasons‐responsive), and (c) the basis for actual and potential moral assessments of people that we have good reasons to endorse. Thus, we are open to moral appraisal on the basis of having and using (or not using) our concepts when they reflect our evaluative judgments, though even then it is not always appropriate to praise or blame us on that basis. (shrink)

The tradition of immanent critique promises a lot. It promises to be critical of the existing social order without appealing to ‘external’ normative standards. I argue that the prospects for immanent criticism are bleak: they must either commit to an implausible social ontology, a flawed meta-normative theory, or both.

This essay critically examines the evolving relationship between chemistry and ecology, challenging the historical view of chemistry as purely mechanistic. It argues for a new perspective that recognises the dynamic and agentised qualities of matter. Drawing from diverse scientific and philosophical sources, it is argued that modern chemical theories can reshape how we understand life, agency, and intelligence within the material world. These insights are explored in the context of future technological innovations and ecological sustainability, emphasising the potential of ‘agentised (...) chemistry’ as a strategy for creating circular impacts. By viewing chemistry as an active agent in shaping the world, rather than a passive tool for innovation, this approach offers a more symbiotic and negotiated relationship between human development and nature, supporting a transition towards a more ecologically sustainable future. (shrink)

Pyrrhonian sceptics claim, notoriously, to assent to the appearances without making claims about how things are. To see whether this is coherent we need to consider the philosophical history of ‘appearance’(phainesthai)-talk, and the closely related concept of an impression (phantasia). This history suggests that the sceptics resemble Plato in lacking the ‘non-epistemic’ or ‘non-doxastic’ conception of appearance developed by Aristotle and the Stoics. What is distinctive about the Pyrrhonian sceptic is simply that the degree of doxastic commitment involved in his (...) assent to an impression is asymptotally low. (shrink)

What consciousness exactly is remains an unsettled issue among both philosophers and biologists. Three aspects of consciousness are generally recognized: awareness consciousness (through connection...

ArgumentWe examine the criteria used to validate the use of nonhuman organisms in North-American alcohol addiction research from the 1950s to the present day. We argue that this field, where the similarities between behaviors in humans and non-humans are particularly difficult to assess, has addressed questions of model validity by transforming the situatedness of non-human organisms into an experimental tool. We demonstrate that model validity does not hinge on the standardization of one type of organism in isolation, as often the (...) case with genetic model organisms. Rather, organisms are viewed as necessarily situated: they cannot be understood as a model for human behavior in isolation from their environmental conditions. Hence the environment itself is standardized as part of the modeling process; and model validity is assessed with reference to the environmental conditions under which organisms are studied. (shrink)

What does it feel like to encounter ourselves and one another as implicated subjects, both in our everyday lives and in the context of our work as clinicians, and how does this matter? With contributions from a diverse group of relational psychoanalytic thinkers, this book reads Michael Rothberg's concept of the implicated subject - the notion that we are continuously implicated in injustices even when not perpetrators - as calling us to elaborate what it feels like to inhabit such subjectivities (...) in relation to others both similarly and differently situated. Implication and anti-Black racism are central to many chapters, with attention given to the unique vulnerability of racial minority immigrants, to Native American genocide, and to the implication of ordinary Israelis in the oppression of Palestinians. The book makes the case that the therapist's ongoing openness to learning of our own implication in enactments is central to a Relational sensibility and to a progressive psychoanalysis. As a contribution to the necessary and long-overdue conversation within the psychoanalytic field about racism, social injustice, and ways to move toward a just society, this book will be essential for all relational psychoanalysts and psychotherapists. (shrink)

This chapter offers phenomenological ethics of intimacy for experiences of isolation, reduced haptic relations, and periods when we must hold each other at a distance. How can we practice an ethics of intimacy from a space of separation and suspended activities involving bodily proximity and touch? By drawing on Luce Irigaray’s identification of a “caress before the caress,” I locate a queer, feminist ethics of intimacy born from the experience of undetermined desire or “erotic suspension.” The reduction and disruption of (...) touching, brought about by a crisis such as a pandemic, magnifies the experience of ethical or epistemological uncertainty surrounding haptic relations. But I argue that the experience of erotic suspension before the caress underlies all forms of being-together. One’s relationship to this moment before the caress is critical because it informs and transforms the way we are together. The disruption of our usual forms of being-together may be an opportunity for transformed ethical relations, the expansion of intimacy, and heightened sensation and pleasure. (shrink)

The so-called "biometric-Mendelian controversy" has received much attention from science studies scholars. This paper focuses on one scientist involved in this debate, Arthur Dukinfield Darbishire, who performed a series of hybridization experiments with mice beginning in 1901. Previous historical work on Darbishire's experiments and his later attempt to reconcile Mendelian and biometric views describe Darbishire as eventually being "converted" to Mendelism. I provide a new analysis of this episode in the context of Darbishire's experimental results, his underlying epistemology, and his (...) influence on the broader debate surrounding the rediscovery and acceptance of Mendelism. I investigate various historiographical issues raised by this episode in order to reflect on the idea of "conversion" to a scientific theory. Darbishire was an influential figure who resisted strong forces compelling him to convert prematurely due to his requirements that the new theory account for particularly important anomalous facts and answer the most pressing questions in the field. (shrink)

Jealousy is an emotion that arises in diverse circumstances and is experienced in phenomenologically diverse ways. In part because of this diversity, evaluations of jealous subjects tend to be conflicting and ambiguous. Thus philosophers who are interested in the moral status of jealousy face a challenge: to explain how, despite the diversity of jealous subjects and experiences of jealousy, our moral evaluations of those subjects in light of those experiences might be unified. In this project, I confront and respond to (...) this challenge, which I call the challenge of heterogeneity. -/- In Part I, I refine and expand on existing descriptive accounts of jealousy, defending an account with three necessary but not sufficient conditions. On my view, if one is jealous: -/- A. One desires that oneself stand in some relation to a specific, non-replicable good. B. One has in mind a (possibly imagined) rival and regards the rival’s having the good as logically or causally inconsistent with the satisfaction of this desire C. One has in mind some (possibly imagined) set of circumstances in which this desire would be satisfied. -/- In discussing this view I emphasize the role that relationships play in giving rise to jealousy, since its connections to relationships make jealousy descriptively and normatively unique. -/- In Part II, I develop an account of jealousy’s moral significance. To do so, I divide cases of jealousy into three types: those involving jealous desires relating to (1) caring relationships, (2) non-caring relationships, and (3) material goods or personal qualities. I argue that in all three types of cases, jealousy undermines the actual or potential moral value of the jealous subjects’ relationships, and that this undermining provides the paradigmatic moral reason to criticize jealous subjects. Thus I respond to the challenge of heterogeneity without simply portraying jealous subjects as selfish or insecure. -/- After doing so, I consider multiple arguments for the claim that a person’s being jealous sometimes constitutes a moral reason to praise that person. I critique each of those arguments and conclude that we have good reasons to see jealous subjects as worthy of moral criticism but not moral praise. (shrink)

Schütz’ tuning-in relationship designates sharing time as the ground of we-experiences, but the Husserlian account of time that he relies upon for this argument seems to undermine the very possibility of doing so. I argue that Merleau-Ponty’s conception of temporality offers a more plausible account of shared time via the ‘transferability’ of the body schema. Disability theorists and critical phenomenologists, however, would remind us that any account of we-experiences must recognize bodily difference. I argue that bodies of diverse motilities can (...) come to share a body schema without risk of ‘forced time compliance’ if we jettison synchronization and embrace improvisation as a paradigm for schematic sharing: I use the example of collective free improvisation to illustrate flexible, emergent, and bidirectional body schemas that, I claim, circumvent the assimilationist tendencies looming in any account of we-experiences premised upon bodily sameness. (shrink)

A generally ignored feature of Aristotle’s famous function argument is its reliance on the claim that practitioners of the crafts (technai) have functions: but this claim does important work. Aristotle is pointing to the fact that we judge everyday rational agency and agents by norms which are independent of their contingent desires: a good doctor is not just one who happens to achieve his personal goals through his work. But, Aristotle argues, such norms can only be binding on individuals if (...) human rational agency as such is governed by objective teleological norms.
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This paper argues that Hegel’s account of subjectivity and agency as historically coined is essential to an accurate understanding of his theory of tragedy. Focusing on Sophocles’ Oedipus the King, I argue that Hegel’s historical account of agency is necessary for understanding his theory of the ancient tragic hero. Although Hegel’s theory of ancient tragedy is often described in terms of a conflict between ethical spheres embodied in two individuals, the conflict in Oedipus is between Oedipus’ deeds and his later (...) knowledge of what has actually occurred. I show how this seemingly subjective conflict is in keeping with Hegel’s theory. Further, while Hegel sees Oedipus as wrong to take full moral accountability for the consequences of his deeds, at the same time, for Hegel, this is the right action for a tragic hero, and the very thing that renders Oedipus timelessly and tragically heroic, rather than a mere victim of fate. (shrink)

Qualitative research provides rigorous methods not only for investigating behavioral or social issues, but can also be used for exploring epistemic issues related to science and its practices. There is growing scholarly awareness that important aspects of science can be best understood through qualitative analyses and cannot be captured using more traditional textual sources such as publications or archival documents or via more quantitative or formalized methodologies such as citation analysis or bibliometrics. Reflecting on our own research on the philosophy (...) of scientific practices, particularly on the role of model organisms in biology, we discuss some of the challenges associated with the design and conduct of qualitative research in the philosophy of science. We then explore three issues in more detail: The extent to which qualitative methods support the identification of media and spaces for the study of epistemic questions in science; the investigation of social structures particularly relevant to scientific practices and reasoning; and the conceptual and interpretative significance of analytic choices in empirical research on science. In closing, we reflect on the value of qualitative research methods for understanding scientific practices as ways to identify novel research directions, refine and augment philosophically motivated research questions, investigate the rationales and procedures through which particular scientific choices become ingrained in research, and question the implications of such habits as norms for what counts as “best practice” in particular scientific fields, all of which are topics that deserve more attention from philosophers and other scholars interested in scientific practices. (shrink)

Findings from two experiments argue in favor of the superiority of default, preferred interpretations over non-default less favored counterparts, outshining degree of non-salience, non-literalness, contextual strength, and negation. They show that, outside of a specific context, the default interpretation of specific negative constructions is a non-salient interpretation 1; their non-default interpretation is a salience-based alternative. In contrast, the default interpretation of the affirmative counterparts is a salience-based interpretation ; their non-default interpretation is a non-salient alternative. When in equally strongly supportive (...) contexts, default yet non-salient negative sarcasm is processed faster than non-default, non-salient yet affirmative sarcasm and faster than non-default yet salience-based negativ.. (shrink)

It is increasingly argued that there is a single unified constitutive norm of both assertion and practical reasoning. The most common suggestion is that knowledge is this norm. If this is correct, then we would expect that a diagnosis of problematic assertions should manifest as problematic reasons for acting. Jennifer Lackey has recently argued that assertions epistemically grounded in isolated second-hand knowledge (ISHK) are unwarranted. I argue that decisions epistemically grounded in premises based on ISHK also seem inappropriate. I finish (...) by suggesting that this finding has important implications for the debates regarding the norms of assertion and practical reasoning. (shrink)

The food sovereignty movement calls for a reversal of the neoliberal globalization of food, toward an alternative development model that supports peasant production for local consumption. The movement holds an ambiguous stance on peasant production for export markets, and clearly prioritizes localized trade. Food sovereignty discourse often simplifies and romanticizes the peasantry—overlooking agrarian class categories and ignoring the interests of export-oriented peasants. Drawing on 8 months of participant observation in the Andean countryside and 85 interviews with indigenous peasant farmers, this (...) paper finds that export markets are viewed as more fair than local markets. The indigenous peasants in this study prefer export trade because it offers a more stable and viable livelihood. Feeding the national population through local market intermediaries, by contrast, is perceived as unfair because of oversupply and low, fluctuating prices. This perspective, from the ground, offers important insight to movement actors and scholars who risk oversimplifying peasant values, interests, and actions. (shrink)

Semifactual thinking about what might have been the same, e.g., ''even if Philip had not chosen the chocolate ice-cream sundae, he would have developed an allergic reaction'' has been neglected compared to counterfactual thinking about what might have been different, e.g., ''if only Philip had not chosen the chocolate ice-cream sundae, he would not have developed an allergic reaction''. We report the first systematic comparison of the two sorts of thinking in two experiments. The first experiment showed that counterfactual ''if (...) only'' thoughts about an antecedent event lead people to judge the event to be more causally related to the outcome, whereas semifactual ''even if'' thoughts lead people to judge the antecedent event to be less causally related to the outcome. In addition, the experiment showed that generating counterfactual ''if only'' thoughts increases emotional reactions such as regret, whereas generating semifactual ''even if'' thoughts decreases such reactions. The second experiment, along with a replication experiment, showed that when people complete ''if only'' and ''even if'' sentence stems, they focus on different alternative antecedents to the outcome: ''if only'' thoughts focus on alternatives that would undo the outcome whereas ''even if'' thoughts focus on alternatives that would not undo it, from among a set of available alternative antecedents in which either all, some, or none would undo the outcome. The implications of the results for theories of thinking about what might have been are discussed. (shrink)

In Fredericks (2018b), I argued that we can be morally responsible for our concepts if they are mental representations. Here, I make a complementary argument for the claim that even if concepts are abstract objects, we can be morally responsible for coming to grasp and for thinking (or not thinking) in terms of them. As before, I take for granted Angela Smith's (2005) rational relations account of moral responsibility, though I think the same conclusion follows from various other accounts. My (...) strategy is to focus on the relations that can obtain between concepts (understood as abstract objects) and morally responsible agents. I conclude by discussing some of the reasons why my arguments matter, which have to do with consequential choices between conceptual options, purposefully seeking out concepts that are new to us, and moral education. (shrink)