How should pragmatists respond to and contribute to the resolution of one of America's greatest and most enduring problems? Given that the most important thinkers of the pragmatist movement—Charles S. Peirce, William James, John Dewey, and George Herbert Mead—said little about the problem of race, how does their distinctly American way of thinking confront the hardship and brutality that characterizes the experience of many African Americans in this country? In 12 thoughtful and provocative essays, contemporary American pragmatists connect ideas with (...) action and theory with practice to come to terms with this seemingly intractable problem. Exploring themes such as racism and social change, the value of the concept of race, the role of education in ameliorating racism, and the place of democracy in dealing with the tragedy of race, the voices gathered in this volume consider how pragmatism can focus new attention on the problem of race. Contributors are Michael Eldridge, Eddie S. Glaude, Jr., Judith M. Green, D. Micah Hester, Donald F. Koch, Bill E. Lawson, David E. McClean, Gregory F. Pappas, Scott L. Pratt, Alfred E. Prettyman, John R. Shook, Paul C. Taylor, and Cornel West. (shrink)

We need guidance in interpreting and evaluating C. S. Peirce. The scope, complexity, and ongoing development of his extensive body of philosophical work call for the location of central themes and arguments. This collection of essays, originally published or written between 1966 and 1995, sets forth those themes that dominate Potter’s thought.

What exactly is a genetic disease? For a phrase one hears on a daily basis, there has been surprisingly little analysis of the underlying concept. Medical doctors seem perfectly willing to admit that the etiology of disease is typically complex, with a great many factors interacting to bring about a given condition. On such a view, descriptions of diseases like cancer as genetic seem at best highly simplistic, and at worst philosophically indefensible. On the other hand, there is clearly some (...) practical value to be had by classifying diseases according to their predominant cause when this can be accomplished in a theoretically satisfactory manner. The question therefore becomes exactly how one should go about selecting a single causal factor among many to explain the presence of disease. When an attempt to defend such causal selection is made at all, the standard accounts offered (Koch's postulates, Hill's epidemiological criteria, manipulability) are all clearly inadequate. I propose, however, an epidemiological account of disease causation which walks the fine line between practical applicability and theoretical considerations of causal complexity and attempts to compromise between patientcentered and population-centered concepts of disease. The epidemiological account is the most basic framework consistent with our strongly held intuitions about the causal classification of disease, yet it avoids the difficulties encountered by its competitors. (shrink)

We argue that Koch’s postulates are best understood within an interventionist account of causation, in the sense described in Woodward. We show how this treatment helps to resolve interpretive puzzles associated with Koch’s work and how it clarifies the different roles the postulates play in providing useful, yet not universal criteria for disease causation. Our paper is an effort at rational reconstruction; we attempt to show how Koch’s postulates and reasoning make sense and are normatively justified within (...) an interventionist framework and more difficult to understand within alternative frameworks for thinking about causation. (shrink)

What exactly is a genetic disease? For a phrase one hears on a daily basis, there has been surprisingly little analysis of the underlying concept. Medical doctors seem perfectly willing to admit that the etiology of disease is typically complex, with a great many factors interacting to bring about a given condition. On such a view, descriptions of diseases like cancer as geneticseem at best highly simplistic, and at worst philosophically indefensible. On the other hand, there is clearly some practical (...) value to be had by classifying diseases according to theirpredominant cause when this can be accomplished in a theoretically satisfactory manner. The question therefore becomes exactly how one should go about selecting a single causal factor among many to explain the presence of disease. When an attempt to defend such causal selection is made at all, the standard accounts offered (Koch's postulates, Hill's epidemiological criteria, manipulability) are all clearly inadequate. I propose, however, an epidemiological account of disease causation which walks the fine line between practical applicability and theoretical considerations of causal complexity and attempts to compromise between patient-centered and population-centered concepts of disease. The epidemiological account is the most basic framework consistent with our strongly held intuitions about the causal classification of disease, yet it avoids the difficulties encountered by its competitors. (shrink)

Human microbiome research makes causal connections between entire microbial communities and a wide array of traits that range from physiological diseases to psychological states. To evaluate these causal claims, we first examine a well-known single-microbe causal explanation: of Helicobacter pylori causing ulcers. This apparently straightforward causal explanation is not so simple, however. It does not achieve a key explanatory standard in microbiology, of Koch’s postulates, which rely on manipulations of single-microorganism cultures to infer causal relationships to disease. When (...) class='Hi'>Koch’s postulates are framed by an interventionist causal framework, it is clearer what the H. pylori explanation achieves and where its explanatory strengths lie. After assessing this ‘simple’, single-microbe case, we apply the interventionist framework to two key areas of microbiome research, in which obesity and mental health states are purportedly explained by microbiomes. Despite the experimental data available, interventionist criteria for explanation show that many of the causal claims generated by microbiome research are weak or misleading. We focus on the stability, specificity and proportionality of proposed microbiome causal explanations, and evaluate how effectively these dimensions of causal explanation are achieved in some promising avenues of research. We suggest some conceptual and explanatory strategies to improve how causal claims about microbiomes are made. (shrink)

Human microbiome research makes causal connections between entire microbial communities and a wide array of traits that range from physiological diseases to psychological states. To evaluate these causal claims, we first examine a well-known single-microbe causal explanation: of Helicobacter pylori causing ulcers. This apparently straightforward causal explanation is not so simple, however. It does not achieve a key explanatory standard in microbiology, of Koch’s postulates, which rely on manipulations of single-microorganism cultures to infer causal relationships to disease. When (...) class='Hi'>Koch’s postulates are framed by an interventionist causal framework, it is clearer what the H. pylori explanation achieves and where its explanatory strengths lie. After assessing this ‘simple’, single-microbe case, we apply the interventionist framework to two key areas of microbiome research, in which obesity and mental health states are purportedly explained by microbiomes. Despite the experimental data available, interventionist criteria for explanation show that many of the causal claims generated by microbiome research are weak or misleading. We focus on the stability, specificity and proportionality of proposed microbiome causal explanations, and evaluate how effectively these dimensions of causal explanation are achieved in some promising avenues of research. We suggest some conceptual and explanatory strategies to improve how causal claims about microbiomes are made. (shrink)

Human microbiome research makes causal connections between entire microbial communities and a wide array of traits that range from physiological diseases to psychological states. To evaluate these causal claims, we first examine a well-known single-microbe causal explanation: of Helicobacter pylori causing ulcers. This apparently straightforward causal explanation is not so simple, however. It does not achieve a key explanatory standard in microbiology, of Koch’s postulates, which rely on manipulations of single-microorganism cultures to infer causal relationships to disease. When (...) class='Hi'>Koch’s postulates are framed by an interventionist causal framework, it is clearer what the H. pylori explanation achieves and where its explanatory strengths lie. After assessing this ‘simple’, single-microbe case, we apply the interventionist framework to two key areas of microbiome research, in which obesity and mental health states are purportedly explained by microbiomes. Despite the experimental data available, interventionist criteria for explanation show that many of the causal claims generated by microbiome research are weak or misleading. We focus on the stability, specificity and proportionality of proposed microbiome causal explanations, and evaluate how effectively these dimensions of causal explanation are achieved in some promising avenues of research. We suggest some conceptual and explanatory strategies to improve how causal claims about microbiomes are made. (shrink)

The objective of the present review on the evolution of Green Chemistry, since its emergence until 2016, aimed an integrated vision of its progress along the three phases of its development: emergence, divulgation and consolidation. The methodology involved the analysis of a selection of bibliography on the evolution of GC collected from issues of the ACS symposia series; editorials in specialized GC journals; and commemorative birthday papers/editorials of these journals and of the GC itself. The analysis allowed to identify and (...) discuss the characteristics and conceptions of GC agents about fundamental concepts and procedures, in order to visualize and better understand the state of knowledge and the subject areas that make up the field. The main alterations identified in the evolution of GC were: it acquired a better defined identity, with more participation of academy and increased scope; was progressively framed in sustainability; has been aspiring to a holistic frame and to a change on the nature of the innovation for its implementation, from incremental to transformative. The analysis suggests that for supporting expansion and consolidation of GC the following aspects deserve attention: full validation of chemical greenness by metrics; better characterization of the frontiers of GC research areas/themes; increased integration between academy and industry; and penetration in chemistry curricula. Its basic philosophy being the practice of a chemistry more focused on the environment preservation, GC means a new stage in nature and in the history of Chemistry. (shrink)

This paper reassesses Robert Koch’s work on tropical infections of humans and cattle as being inspired by an underlying interest in epidemiology. Such an interest was developed from the early 1890s when it became clear that an exclusive focus on pathogens was insufficient as an approach to explain the genesis and dynamics of epidemics. Koch, who had failed to do so before, now highlighted differences between infection and disease and described the role of various sub-clinical states of disease (...) in the propagation and—consequently—in the control of epidemics. Studying pathologies of men and cattle in tropical countries eventually facilitated the application of such measures in Europe through the screening of healthy carriers of typhoid, which was carried out in 1902. The concept of the carrier state can be understood as a spin-off from tropical medicine into the study and control of infectious disease in Europe. With it travelled assumptions that were typical for colonial and veterinary medicine where the health of indigenous individuals or cattle would be a secondary objective compared to the control of diseases in populations. (shrink)

One of Ludwik Fleck’s ideas about the development of scientific knowledge is that—once a system of interpretation is in place—the process that follows can be characterised as one of inertia: any new evidence comes under a strong pressure to be incorporated into the established frame. This can result in what Fleck called a harmony of illusions when contradictory evidence becomes almost invisible or is incorporated into the established frame only by huge efforts.The paper analyses early explanations of the tuberculin reaction (...) as a case study of Fleck’s argument. For Robert Koch, who had presented tuberculin in 1890, the compound was supposed to be a diagnostic tool and a cure for tuberculosis. His conception of its effect was rather peculiar, but strictly in line with ideas on the pathogenesis of infectious diseases he had developed much earlier. After tuberculin was released in late 1890, whether Koch’s conception was convincing depended on the place that a given observer had in the medical world in late-nineteenth-century Germany. Inside Koch’s group, the status of the tuberculin reaction remained stable and tuberculin retained its value as a diagnostic and curative tool. On the other hand, observers from outside that thought collective, and in particular from clinical medicine, soon pointed to flaws in its conception. These critics developed a rather different picture of tuberculin as a mysterious and dangerous drug. No reconciliation followed and what we find instead in German medicine around the year 1900 is the presence of rather contradictory concepts and practices surrounding Koch’s wonder cure. (shrink)

An able and clear defense of Bradley's principal theses and the underlying conception of metaphysical enterprise. "This is a book about a metaphysician, about metaphysics, and, most importantly, it attempts to develop elements of a metaphysical position long the lines of what is called Absolute Idealism." The Introduction takes up the Verificationists [[sic]] argument and two recent accounts of metaphysics. Part I devotes ten Chapters to the elucidation and defense of Bradley's conception of reality. It culminates in examining three alternative (...) accounts of "Real". Part II considers "the major philosophical theories of the self in order to defend Bradley's Theory of the self within his metaphysical scheme."--A. S. C. (shrink)

Unlike its predecessors, this systematic survey of the law of Athens is based on explicit discussion of how the subject might be studies, incorporating topics such as the democratic political system and social structure. Technical and legal terms are explained in a comprehensive glossary.

§1. The origins of recursion theory. In dedicating a book to Steve Kleene, I referred to him as the person who made recursion theory into a theory. Recursion theory was begun by Kleene's teacher at Princeton, Alonzo Church, who first defined the class of recursive functions; first maintained that this class was the class of computable functions ; and first used this fact to solve negatively some classical problems on the existence of algorithms. However, it was Kleene who, in his (...) thesis and in his subsequent attempts to convince himself of Church's Thesis, developed a general theory of the behavior of the recursive functions. He continued to develop this theory and extend it to new situations throughout his mathematical career. Indeed, all of the research which he did had a close relationship to recursive functions.Church's Thesis arose in an accidental way. In his investigations of a system of logic which he had invented, Church became interested in a class of functions which he called the λ-definable functions. Initially, Church knew that the successor function and the addition function were λ-definable, but not much else. During 1932, Kleene gradually showed1 that this class of functions was quite extensive; and these results became an important part of his thesis 1935a. (shrink)

This paper summarizes the longstanding debate over psychology's fragmentation by illustrating two principal impediments to the fostering of consensus and unity. The paper then discusses the important benefits of past dialogue concerning these issues, suggesting that some progress has been made in dealing with problems of disunity and fragmentation, particularly at the metatheoretical and philosophical levels. This general discussion then forms the backdrop for the following articles, which together form a single argument in favor of a hermeneutic approach to the (...) problem of fragmentation. (shrink)

In this paper I argue that RadicalInterpretation (RI), taken to be a methodological doctrine regarding the conditions under which an interpretation of an utterance is both warranted and correct, has unacceptable implications for the conditions on (ascriptions of) understanding. The notion of understanding at play is that which underwrites the testimonial transmission of knowledge. After developing this notion I argue that, on the assumption of RI, hearers will fail to have such understanding in situations in which we should want to (...) maintain otherwise. The overall effect of the argument is to provide a heretofore unexamined source of motivation for anti-individualistic approaches to the semantics of utterances. (shrink)

This is a comprehensive and appreciative account of Dewey’s philosophy of value. It succeeds in rectifying certain current misconceptions of Dewey’s aims and contributions to moral philosophy, and in clearly presenting a coherent theory of value. Gouinlock begins his account by laying stress upon Dewey’s Experience and Nature as a key to Dewey’s thought. Chapter 1 is devoted to this task. It is held that "Dewey develops and articulates an inclusive philosophy by characterizing such things as art, science, and value (...) with a common set of concepts denoting the generic traits of experience." There is also a discussion of Dewey’s philosophic method and the uses and abuses of experience. Chapter 2 deals with man and nature and Dewey’s critical response to bifurcation between mind and body, and the relation between individual and society. Chapter 3 begins with Nature and Value. Here one finds a good discussion of ends-in-view and values. A great stress is laid on Dewey’s use of metaphysical concepts in value analysis, in particular the needed stress on the inclusive unity of means and end. (shrink)

This target article draws together two groups of experimental studies on the control of human movement through peripheral feedback and centrally generated signals of motor commands. First, during natural movement, feedback from muscle, joint, and cutaneous afferents changes; in human subjects these changes have reflex and kinesthetic consequences. Recent psychophysical and microneurographic evidence suggests that joint and even cutaneous afferents may have a proprioceptive role. Second, the role of centrally generated motor commands in the control of normal movements and movements (...) following acute and chronic deafferentation is reviewed. There is increasing evidence that subjects can perceive their motor commands under various conditions, but that this is inadequate for normal movement; deficits in motor performance arise when the reliance on proprioceptive feedback is abolished either experimentally or because of pathology. During natural movement, the CNS appears to have access to functionally useful input from a range of peripheral receptors as well as from internally generated command signals. The unanswered questions that remain suggest a number of avenues for further research. (shrink)

Plutarch's essay de fortuna Romanorum has attracted divergent judgements. Ziegler dismissed it as ‘eine nicht weiter ernst zu nehmende rhetorische Stilübung’. By Flacelière it was hailed as ‘une ébauche de méditation sur le prodigieux destin de Rome’. It is time to consider the work afresh and to discover whether there is common ground between these two views. Rather than offering a general appreciation, my treatment will take the work chapter by chapter, considering points of interest as they arise. This method (...) will enable us to compare what Plutarch says on particular subjects and themes in de fort. Rom. with what he says or does not say about them elsewhere. We shall thus be able to see clearly that for the most part the ideas he presents in the essay correspond with his thoughts about the rôle of fortune expressed in more serious writing, and that, where there is no correspondence, this is attributable to the rhetorical background. I do not intend to address directly the frequently discussed but insoluble question of whether we have in de fort. Rom. only one of two original works, that is whether there was once a de virtute Romanorum which Plutarch composed or answered. De fort. Rom. itself in fact gives almost as much prominence to άρετή as to τúχη, and their competing roles will be carefully evaluated. Nor do I look at the dating of the work. (shrink)