Modeling metastasis in animal systems has been an important focus for developing cancer therapeutics. Xenopus laevis is a well‐established model, known for its use in identifying genetic mechanisms underlying diseases and disorders in humans. Prior literature has suggested that the drug, ivermectin, can be used in Xenopus to induce melanocytes to convert into a metastatic melanoma‐like state, and thus could be ideal for testing possible melanoma therapies in vivo. However, there are notable inconsistencies between ivermectin studies in Xenopus and the (...) application of ivermectin in mammalian systems, that are relevant to cancer and melanoma research. In this review, we examine the ivermectin‐induced phenotypes in Xenopus, and we explore the current uses of ivermectin in human research. We conclude that while ivermectin may be a useful drug for many biomedical purposes, it is not ideal to induce a metastatic melanocyte phenotype in Xenopus for testing the effects of potential melanoma therapeutics. (shrink)

This paper presents a feminist analysis of corporate social responsibility in a male-dominated industry within a developing country context. It seeks to raise awareness of the silencing of women’s voices in CSR reports produced by mining companies in Tanzania. Tanzania is one of the poorest countries in Africa, and women are often marginalised in employment and social policy considerations. Drawing on work by Hélène Cixous, a post-structuralist/radical feminist scholar, the paper challenges the masculinity of CSR discourses that have repeatedly masked (...) the voices and concerns of ‘other’ marginalised social groups, notably women. Using interpretative ethnographic case studies, the paper provides much-needed empirical evidence to show how gender imbalances remain prevalent in the Tanzanian mining sector. This evidence draws attention to the dynamics faced by many women working in or living around mining areas in Tanzania. The paper argues that CSR, a discourse enmeshed with the patriarchal logic of the contemporary capitalist system, is entangled with tensions, class conflicts and struggles which need to be unpacked and acknowledged. The paper considers the possibility of policy reforms in order to promote gender balance in the Tanzanian mining sector and create a platform for women’s concerns to be voiced. (shrink)

This is a defence of the claim that names are predicates with a demonstrative element in their singular use.

Aristotle connects modality and time in ways strange and perplexing to modern readers. In this book the author proposes a new solution to this exegetical problem. Although primarily expository, this work explores topics of central concern for current investigations into causality, time, and change.

I begin by proposing and explicating a plausible articulation of the view that morality is overriding. I then argue that it would be desirable for this thesis to be sustained. However, the prospects for its vindication will depend crucially on which moral theory we adopt. I examine some schematic moral theories in order to bring out which are friendly and which unfriendly to moral overridingness. In light of the reasons to hope that the overridingness thesis can be sustained, theories apparently (...) incompatible with it – I argue that consequentialism is one – have a count against them. (shrink)

In philosophical inquiry into the mind, the metaphor of ‘transparency’ has been attractive to many who are otherwise in deep disagreement. It has thereby come to have a variety of different and mutually incompatible connotations. The mind is said to be transparent to itself, our perceptual experiences are said to be transparent to the world, and our beliefs are said to be transparent to – a great many different things. The first goal of this essay is to sort out the (...) different uses of the notion of transparency in the context of the philosophy of mind. The remainder of the essay will then be devoted to examining so-called Transparency theories of self-knowledge, or how we know our own minds. This type of theory has attracted a great deal of interest in recent years, but its prospects hinge on answers to unresolved questions concerning the epistemological details of the account and the scope of its ambitions. (shrink)

Justice, Gender and the Politics of Multiculturalism explores the tensions that arise when culturally diverse democratic states pursue both justice for religious and cultural minorities and justice for women. Sarah Song provides a distinctive argument about the circumstances under which egalitarian justice requires special accommodations for cultural minorities while emphasizing the value of gender equality as an important limit on cultural accommodation. Drawing on detailed case studies of gendered cultural conflicts, including conflicts over the 'cultural defense' in criminal law, (...) aboriginal membership rules and polygamy, Song offers a fresh perspective on multicultural politics by examining the role of intercultural interactions in shaping such conflicts. In particular, she demonstrates the different ways that majority institutions have reinforced gender inequality in minority communities and, in light of this, argues in favour of resolving gendered cultural dilemmas through intercultural democratic dialogue. (shrink)

This chapter considers whether our moral entitlement to manifest certain kinds of partiality stems from a morally basic permission to be partial, or whether it can be accounted for in some other way. In particular, it explores the possibility of justifying partial conduct via a general moral prerogative to pursue our own projects. On this approach, in contexts of plural agency, where two or more people together pursue a joint project, we would have permission to favour our co-agents — but (...) only in ways that relate to our joint project. While this approach might limit the scope of morally permissible partiality, it seems more faithful to the concerns that animate the partiality debates than the alternative of claiming an unrestricted basic right to be partial to whomsoever we wish. (shrink)

A collection of papers to illustrate new waves in Philosophy of Language: -/- "Linguistic Puzzles and Semantic Pretence" by B. Armour-Garb & J. Woodbridge; "Minimal Semantics and the Nature of Psychological Evidence" by E. Borg; "A Naturalistic Approach to the Philosophy of Language" by J. Collins; "In Praise of our Linguistic Intuitions" by A. Everett; "Phenomenal Continua and Secondary Properties" by P. Greenough; "Semantic Oughts in Context" by A. Hattiangadi; "Content Force and Semantic Norms" by M. Kolbel; "Linguistic Competence and (...) Propositional Knowledge" by G. Longworth; "Expressives and Beyond" by S. Predelli; "Analyticity in Externalist Languages" by G. Russell ; "Names as Predicates" by S. Sawyer; "The Epistemic Reading of Counterfactual Conditionals" by K. Schulz; "Introduction, Transmission, and the Foundations of Meaning" by J. Speaks. (shrink)

The possibility that human cerebral organoids (HCOs) develop consciousness is one of the main concerns driving current ethical discourse. Evaluating existing evidence, Zilio and Lavazza (2023) in t...

With the last Holocaust survivors quietly passing away, one might also expect to see accountability debates slowing to a trickle. Surprisingly, however, recent years show an upswing in corporate World War II-related atonement debates. Interest in corporate participation in mass atrocity has expanded worldwide; yet what constitutes ethical corporate behavior during and after war remains understudied. This article considers these questions through a study of the French National Railways’ roles during the German occupation and its more recent struggle to make (...) amends. This study demonstrates that ethical business leadership requires taking responsibility for past as well as current decisions. Most executives grappling with complex corporate histories work in isolation, in part because the scholarship on business ethics fails to provide guidance. Without such guidance, corporations often respond to accusations about their pasts with carefully crafted statements and legal strategies rather than deep expressions of moral leadership. To assist in remedying this tendency, this paper simultaneously encourages companies to engage in deeper reflection on corporate history, while urging scholars to help guide corporations through critical ethical conversations. (shrink)

The topics of equity, diversity, inclusion, decolonization, and Indigenization have been neglected in academic and research integrity. In this article, I offer examples of how these issues are being addressed and argue that academic integrity networks and organizations ought to develop intentional strategies for equity, diversity and inclusion, and decolonization in terms of leadership, scholarship, and professional opportunities. I point out that existing systems perpetuate the conditions that allow for overrepresentation of reporting among particular student groups including international students, students (...) of colour, and those for whom English is an additional language. I conclude with concrete recommendations for action. (shrink)

The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently proposed (...) compensatory mechanism involving nonsense-mediated RNA degradation. Duplicated genes are often inactivated to become pseudogenes, and it is proposed that such is the fate of the USP15 gene of zebrafish, a commonly used model system. As it is reviewed here, these observations have implications not only for the interpretation of model system phenotypes but also for therapeutic interventions designed to target DUBs. (shrink)

In English, two deictic space-time metaphors are in common usage: the Moving Ego metaphor conceptualizes the ego as moving forward through time and the Moving Time metaphor conceptualizes time as moving forward toward the ego . Although earlier research investigating the psychological reality of these metaphors has typically examined spatial influences on temporal reasoning , recent lines of research have extended beyond this, providing initial evidence that personality differences and emotional experiences may also influence how people reason about events in (...) time . In this article, we investigate whether these relationships have force in real life. Building on the effects of individual differences in self-reported conscientiousness and procrastination found by Duffy and Feist , we examined whether, in addition to self-reported conscientiousness and procrastination, there is a relationship between conscientious and procrastinating behaviors and temporal perspective. We found that participants who adopted the Moving Time perspective were more likely to exhibit conscientious behaviors, while those who adopted the Moving Ego perspective were more likely to procrastinate, suggesting that the earlier effects reach beyond the laboratory. (shrink)

In this paper, we theorize that the anticipation of guilt plays an important role in ethically questionable consumer situations. We propose an ethical decision-making framework incorporating anticipated guilt as partial mediator between consumers’ ethical beliefs (anteceded by ethical ideology) and intentions. In the first study, we compared several models using structural equation modeling and found empirical support for our research model. A second experiment was set up to illustrate how these new insights may be applied to prevent consumers from taking (...) advantage of the seller. Results showed that enhancing the anticipation of guilt (by making the interpersonal consequences of the unethical act more salient) increased consumers’ ethical intentions, controlling for ethical beliefs. Together these two studies might have important theoretical and managerial contributions. (shrink)

Most, if not all, psychologists have served as teaching or research assistants during graduate school, been instructed by teaching assistants, or both. As both faculty and students themselves, graduate assistants are faced with several dilemmas for which they typically have little preparation or guidance. These issues are explored in the context of the existing literature on multiple relationships in academic settings. Recommendations are made for graduate assistants, their faculty supervisors or mentors, and administrators to proactively address and confront these challenges (...) in a manner consistent with the profession of psychology's ethics code and to minimize the potential for harm to those we are entrusted to teach. (shrink)

The current paper highlights a new, interactive Shiny App that can be used to aid in understanding and teaching the important task of conducting a prior sensitivity analysis when implementing Bayesian estimation methods. In this paper, we discuss the importance of examining prior distributions through a sensitivity analysis. We argue that conducting a prior sensitivity analysis is equally important when so-called diffuse priors are implemented as it is with subjective priors. As a proof of concept, we conducted a small simulation (...) study, which illustrates the impact of priors on final model estimates. The findings from the simulation study highlight the importance of conducting a sensitivity analysis of priors. This concept is further extended through an interactive Shiny App that we developed. The Shiny App allows users to explore the impact of various forms of priors using empirical data. We introduce this Shiny App and thoroughly detail an example using a simple multiple regression model that users at all levels can understand. In this paper, we highlight how to determine the different settings for a prior sensitivity analysis, how to visually and statistically compare results obtained in the sensitivity analysis, and how to display findings and write up disparate results obtained across the sensitivity analysis. The goal is that novice users can follow the process outlined here and work within the interactive Shiny App to gain a deeper understanding of the role of prior distributions and the importance of a sensitivity analysis when implementing Bayesian methods. The intended audience is broad and can include those with limited exposure to Bayesian methods or the specific model presented here. (shrink)

Artificial insemination was the first conceptive technology to be widely used in agriculture. Whereas at the beginning of the twentieth century all cows in England and Wales were mated to bulls, by the end of the 1950s 60% conceived through artificial insemination. By then a national network of ‘cattle breeding centres’ brought AI within the reach of every farmer. In this paper I explore how artificial insemination, which had few supporters in the 1920s and 1930s, was transformed into an ‘indispensable’ (...) method for reproducing cattle. I discuss the factors that made organised AI possible , including changes in cultures of cattle breeding, novel State involvement in bovine reproduction, the rise of new ‘animal breeding research’ centres at Cambridge, Edinburgh and Reading universities, war preparations and central planning by the Milk Marketing Board . I go on to show that the unprecedented focus on bovine reproduction set in motion by the AI centres effectively generated new networks of reproductive research, through these the ‘biopower’ of the farm was incorporated into the clinic. The example of AI shows that by combining the history of reproductive technology in agriculture and medicine we can give a richer account of modern reproduction. (shrink)

This study seeks to understand the ways in which men who pledge sexual abstinence until marriage negotiate and assert masculine identities before and after marriage. Using longitudinal qualitative data, this work traces the ways in which men who pledge abstinence until marriage manage a tension between both “sacred” and “beastly” discourses surrounding sexuality. The situational and interactional gendered practices of these men highlight their attempts to resolve the incongruity between practices of sexual purity and hegemonic definitions of masculinity. I argue (...) that a decision to pledge sexual abstinence until marriage is an example of hybrid masculinities in that the postmarriage transition to a more hegemonically masculine status suggests that such practices are not challenging current gendered systems of power and inequality. These findings underscore the potential fallacy in using cross-sectional data to illustrate changes in gender relations, and demonstrate the importance of incorporating life course perspectives when theorizing masculinities. (shrink)

The study explores the use of Graphic Novels as an innovative form of training that may improve an individual’s ethical efficacy. A quantitative comparison of the graphic novel method and the traditional written case study is analyzed. The literature on ethics, graphic novels, and training are brought together from theories of narrative and literature perspective to formulate a study. The study uses a 2 × 2 repeated-measure MANOVA to analyze the participant’s reaction to bribery situations based on varying levels of (...) ‘grayness.’ The overall study finds that ethical efficacy increases with the use of the graphic novel method. The greatest improvements are in the individual’s level of self-efficacy and understanding of principle-based ethical issues. In addition, the participant’s level of industry experience may play a factor in applying the graphic novel technique. Finally, guidelines on how to effectively utilize the graphic novel method are stated. Improving ethical efficacy through business ethics training may help improve an individual’s self-efficacy, involvement and principle-based understanding. The study explores the use of Graphic Novels as an innovative form of training that may improve an individual’s ethical efficacy. A quantitative comparison of the graphic novel method and the traditional written case study are analyzed. Literature on ethics, graphic novels, and training are brought together with theories of narrative and literature perspective to formulate a study. The study uses a 2 × 2 repeated-measure MANOVA to analyze the participant’s reaction to bribery ethical situations based on varying levels of ‘grayness.’ The overall study finds that ethical efficacy increases with the use of the graphic novel method. The greatest improvements are in the individual’s level of self-efficacy and understanding of principle-based ethical issues. In addition, the participant’s level of industry experience may play a factor in applying the graphic novel technique. Finally, guidelines on how to effectively utilize the graphic novel method is set forth. (shrink)

This chapter demonstrates how early modern male and female thinkers alike were concerned not only with ethical, religious, and political liberty, but also with the liberty to philosophize, or libertas philosophandi. It is argued that while men’s interests in this latter kind of liberty tended to lie with the liberty to philosophize differently from their predecessors, women were more concerned with the liberty to philosophize at all. For them, the idea that women should be free to think was foundational. This (...) chapter shows how some women thinkers of the period, such as Damaris Cudworth Masham (1658–1708) and Mary Astell (1666–1731), followed through on the general trend of thinking about liberty in terms of freedom of the mind, to thinking about liberty for women in wider ethical and political terms. To support this point, the chapter explores their views on education, female rationality, and moral philosophy. (shrink)

: Contextualism in epistemology has been proposed both as a way to avoid skepticism and as an explanation for the variability found in our use of "knows." When we turn to contextualism to perform these two functions, we should ensure that the version we endorse is well suited for these tasks. I compare two versions of epistemic contextualism: attributor contextualism and methodological contextualism. I argue that methodological contextualism is superior both in its response to skepticism and in its mechanism for (...) changing contexts. However, methodological contextualism still faces two challenges: explaining why we are solidly committed to some contexts, and explaining why knowledge within a context is valuable. I propose virtue contextualism as a useful extension of methodological contextualism, focusing on the way that our virtues depend on our social roles. My proposed virtue contextualism retains the benefits of methodological contextualism while explaining both our commitment to particular contexts and the value of knowledge held within those contexts. (shrink)

Throughout his works, John Dewey makes deep and intriguing connections between democracy, education, and daily life. His ideas have contributed to both the theory and practice of participatory democracy and, although he actually “had surprisingly little to say about democratic citizenship” directly, his scholarship has influenced the ideas of others working on citizenship education and has provided rich notions of democracy, education, experience, and public life underlying it.1 However, Dewey commentators Michael Eldridge and Robert Westbrook worry that, although Dewey promoted (...) deeper ways of participating in democracy and engaging in social life, he failed to fully explain how to achieve his vision.2 Instead, he .. (shrink)

One of the most important lessons the work of Marilyn Strathern has taught us about knowledge practices is how they stand alone or intersect according to their context. In turn, this has helped us to develop a more dynamic account of knowledge formations as they both travel and stand still. Indeed it is the vacillation between movement and stasis that explains how essentialisms can either anchor cultural systems of thought or become unmoored – a process Strathern has tracked across both (...) cultural and epistemological contexts. In this paper I use the biological sciences as a context in which to track the process by which analogies ‘travel back’ to remake both their object and its epistemology, or ‘habits of thought’. Indeed, context itself can change, and be changed by, what I am calling analogic return – something we might also consider in relation to scale or perception, or as one of the world-making practices out of which we constantly remake ourselves, now more literally than ever in the context of new genetic technologies and stem cell science. (shrink)

Burge's thesis is the thesis that certain second-order self-ascriptionsare self-verifying in virtue of their self-referential form. The thesis hasrecently come under attack on the grounds that it does not yield a theory ofself-knowledge consistent with semantic externalism, and also on the groundsthat it is false. In this paper I defend Burge's thesis against both charges,in particular against the arguments of Bernecker, Gallois and Goldberg. Thealleged counterexamples they provide are merely apparent counterexamples, andthe thesis is adequate to its proper task. To (...) think otherwise is simply tomisunderstand the thesis. (shrink)

Abstract In this paper I criticise a recent account of fictional discourse proposed by Nathan Salmon. Salmon invokes abstract artifacts as the referents of fictional names in both object- and meta-fictional discourse alike. He then invokes a theory of pretence to forge the requisite connection between object-fictional sentences and meta-fictional sentences, in virtue of which the latter can be assigned appropriate truth-values. I argue that Salmon's account of pretence renders his appeal to abstract artifacts as the referents of fictional names (...) in object-fictional discourse explanatorily redundant. I further argue that his account is therefore no improvement over those he criticises, thus leaving his own account unmotivated. (shrink)