Consolidation of long-term memory is a highly and precisely regulated multistep process. The transcription regulator cAMP response element-binding protein (CREB) plays a key role in initiating memory consolidation. With time processing, first the cofactors are changed and, secondly, CREB gets dispensable. This ultimately changes the expressed gene program to genes required to maintain the memory. Regulation of memory consolidation also requires epigenetic mechanisms and control at the RNA level. At the neuronal circuit level, oscillation in the activity of CREB and (...) downstream factor define engram cells. Together the combination of all regulation mechanisms allows correct memory processing while keeping the process dynamic and flexible to adjust to different contexts. Also see the video abstract here https://youtu.be/BhSCSmorpEc. (shrink)

The evolutionary origin of synapses and neurons is an enigmatic subject that inspires much debate. Non-bilaterian metazoans, both with and without neurons and their closest relatives already contain many components of the molecular toolkits for synapse functions. The origin of these components and their assembly into ancient synaptic signaling machineries are particularly important in light of recent findings on the phylogeny of non-bilaterian metazoans. The evolution of synapses and neurons are often discussed only from a metazoan perspective leaving a considerable (...) gap in our understanding. By taking an integrative approach we highlight the need to consider different, but extremely relevant phyla and to include the closest unicellular relatives of metazoans, the ichthyosporeans, filastereans and choanoflagellates, to fully understand the evolutionary origin of synapses and neurons. This approach allows for a detailed understanding of when and how the first pre- and postsynaptic signaling machineries evolved. The evolutionary origin of synapses and neurons is an enigmatic subject that inspires much debate. Most of our knowledge and recent discussions are biased towards a metazoan perspective, leaving a considerable gap in our understanding. Recent work has now revealed important insights into the emergence and co-regulation of complex synaptic signaling machineries from studies in the closest unicellular relatives of metazoans. (shrink)

The acoel worm Symsagittifera roscoffensis, an early offshoot of the Bilateria and the only well‐studied marine acoel that lives in a photosymbiotic relationship, exhibits a centralized nervous system, brain regeneration, and a wide repertoire of complex behaviors such as circatidal rhythmicity, photo/geotaxis, and social interactions. While this animal can be collected by the thousands and is studied historically, significant progress is made over the last decade to develop it as an emerging marine model. The authors here present the feasibility of (...) culturing it in the laboratory and describe the progress made on different areas, including genomic and tissue architectures, highlighting the associated challenges. In light of these developments, and on the ability to access abundant synchronized embryos, the authors put forward S. roscoffensis as a marine system to revisit questions in the areas of photosymbiosis, regeneration, chronobiology, and the study of complex behaviors from a molecular and evolutionary perspective. (shrink)

Ruling Passions is about human nature. It is an invitation to see human nature a certain way. It defends this way of looking at ourselves against competitors, including rational choice theory, modern Kantianism, various applications of evolutionary psychology, views that enchant our natures, and those that disenchant them in the direction of relativism or nihilism. It is a story centred upon a view of human ethical nature, which it places amongst other facets of human nature, as just one of the (...) elements which give us the manifold objects of our concerns and cares. (shrink)

From political scandals at the highest levels to inflated repair bills at the local garage, we are seemingly surrounded with unethical behavior, so why should we behave any differently? Why should we go through life anchored down by rules no one else seems to follow? Writing with wit and elegance, Simon Blackburn tackles such questions in this lively look at ethics, highlighting the complications and doubts and troubling issues that spring from the very simple question of how we ought (...) to live. Blackburn dissects many common reasons why we are skeptical about ethics. Drawing on all-too-familiar examples from history, politics, religion and everyday personal experience, he shows how cynicism and self-consciousness can paralyze us into considering ethics a hopeless pursuit. But ethics is neither futile nor irrelevant, he assures us, but an intimate part of the nitty gritty issues of living--of birth, death, happiness, desire, freedom, pleasure, justice. Indeed, from moral dilemmas about abortion and euthanasia, to our obsession with personal rights, to our longing for a sense of meaning in life, our everyday struggles are rife with ethical issues, whether we notice it or not. Blackburn distills the arguments of Hume, Kant and Aristotle down to their essences, to underscore the timeless relevance of our voice of conscience, the pitfalls of complacency, and our concerns about truth, knowledge and human progress. Blackburn's rare combination of depth, rigor and sparkling prose, and his distinguished ranking among contemporary philosophers, mark Being Good as an important statement on our current disenchantment with ethics. It challenges us to take a more thoughtful reading of our ethical climate and to ponder more carefully our own standards of behavior. (shrink)

In Ethics–Politics–Subjectivity, Simon Critchley takes up three questions at the centre of contemporary theoretical debate: What is ethical experience? What can be said of the subject who has this experience? What, if any, is the relation of ethical experience to politics? Through spirited confrontations with major thinkers, such as Lacan, Nancy, Rorty, and, in particular, Levinas and Derrida, Critchley finds answers in a nuanced “ethics of finitude” and defends the political possibilities of deconstruction. Democracy, economics, friendship, and technology are (...) all considered anew in Critchley’s bold excursions on the meaning and value of recent French philosophy. (shrink)

I argue that alternative-denoting expressions interact with their semantic context by taking scope. With an empirical focus on indefinites in English, I show how this approach improves on standard alternative-semantic architectures that use point-wise composition to subvert islands, as well as on in situ approaches to indefinites more generally. Unlike grammars based on point-wise composition, scope-based alternative management is thoroughly categorematic, doesn’t under-generate readings when multiple sources of alternatives occur on an island, and is compatible with standard treatments of binding. (...) Unlike all in situ treatments of indefinites, relying on a true scope mechanism prevents over-generation when an operator binds into an indefinite. My account relies only on function application, some mechanism for scope-taking, and two freely-applying type-shifters: the first is Karttunen’s :3–44, 1977. https://doi.org/10.1007/BF00351935) proto-question operator, aka Partee’s Studies in discourse representation theory and the theory of generalized quantifiers, Foris, Dordrecht, 1986) IDENT, and the second can be factored out of extant approaches to the semantics of questions in the tradition of Karttunen. These type-shifters form a decomposition of LIFT, the familiar function mapping values into scope-takers. Exceptional scope of alternative-generating expressions arises via scopal pied-piping: indefinites take scope over their island, which then itself takes scope. (shrink)

How should we choose on behalf of groups of agents who violate expected utility theory by being risk averse or risk seeking? Unfortunately, we sometimes have to choose either acts that everyone disprefers or acts that are sure to turn out worse than another act. This observation is particularly troubling for risk-expected utility theorists: neither option sits comfortably with their view.

An original study of the philosophical problems associated with inductive reasoning. Like most of the main questions in epistemology, the classical problem of induction arises from doubts about a mode of inference used to justify some of our most familiar and pervasive beliefs. The experience of each individual is limited and fragmentary, yet the scope of our beliefs is much wider; and it is the relation between belief and experience, in particular the belief that the future will in some respects (...) resemble the past and the unobserved the observed, which forms the subject of this book. Dr Blackburn's first aim is to state the problem of induction properly, to show that there does exist a genuine problem immune to the solutions in vogue at present, yet no tin principle insoluble. He gives an extended and original account of the concept of a reason and goes on to discuss prediction. In the end Dr Blackburn produces a rationale for belief in certain short-term predictions based on his reinterpretation of the classical principle of indifference. He claims that a justification for induction can be found along the lines he has suggested and must indeed be found there if anywhere. (shrink)

Levinas's idea of ethics as a relation of responsibility to the other person has become a highly influential and recognizable position across a wide range of academic and non-academic fields. Simon Critchley's aim in this book is to provide a less familiar, more troubling, and truer account of Levinas's work. He proposes a new dramatic method for reading Levinas, where the fundamental problem of his work is seen as the attempt to escape from the tragedy of Heidegger's philosophy and (...) the way in which that philosophy shaped political events in the last century. (shrink)

In this paper I discuss the shapelessnesss hypothesis, which is often referred to and relied on by certain sorts of ethical and evaluative cognitivist, and which they use primarily in arguing against a certain, influential form of noncognitivism. I aim to (i) set out exactly what the hypothesis is; (ii) show that its original and traditional use is left wanting; and (iii) show that there is some rehabilitation on offer that might have a chance of convincing neutrals.

Like all of Nagel's work, this is a book with a message: an apparently clear, simple message, forcefully presented and repeated. The message is that there is a limit to the extent to which we can "get outside" fundamental forms of thought, including logical, mathematical, scientific, and ethical thought. "Getting outside" means taking up a biological or psychological or sociological or economic or political view of ourselves as thinkers. It also inclines many people to talk of the contingency or subjectivity (...) or arbitrariness or "relativity" of our thoughts. Nagel believes that the standpoint is impossible, and the relativism it is apt to engender is self-refuting: "we cannot criticize some of our own claims of reason without employing reason at some point to formulate and support those criticisms". The general message is that first-order thoughts, the elementary certainties of mathematics, logic, science, and ethics, "dominate" any attempt to displace them. The book ends with the peroration: "Even if we distance ourselves from some of our thoughts and impulses, and regard them from outside, the process of trying to place ourselves in the world leads eventually to thoughts that we cannot think of as merely `ours'. If we think at all, we must think of ourselves, individually and collectively, as submitting to the order of reasons rather than creating it.". (shrink)

The article proposes a novel approach to the much discussed question of which symmetries have ‘direct empirical significance’ and which do not. The approach is based on a development of a recently proposed framework by Hilary Greaves and David Wallace, who claim that, contrary to the standard folklore among philosophers of physics, ‘local’ symmetries may have direct empirical significance no less than ‘global’ ones. Partly vindicating the standard folklore, a result is derived here from a number of plausible assumptions, that (...) states that local symmetries can indeed have no direct empirical significance. Ways to interpret the result are considered and possible morals are outlined. 1 Introduction2 Greaves and Wallace on Interior versus Non-interior Symmetries3 Elaborating on the Greaves/Wallace Framework4 The Result5 Problems with ’t Hooft’s Beam Splitter6 Summary and Conclusion. (shrink)

Dialog is a joint action at different levels. At the highest level, the goal of interlocutors is to align their mental representations. This emerges from joint activity at lower levels, both concerned with linguistic decisions (e.g., choice of words) and nonlinguistic processes (e.g., alignment of posture or speech rate). Because of the high‐level goal, the interlocutors are particularly concerned with close coupling at these lower levels. As we illustrate with examples, this means that imitation and entrainment are particularly pronounced during (...) interactive communication. We then argue that the mechanisms underlying such processes involve covert imitation of interlocutors’ communicative behavior, leading to emulation of their expected behavior. In other words, communication provides a very good example of predictive emulation, in a way that leads to successful joint activity. (shrink)

In recent years, there has been an intense public debate about whether and, if so, to what extent investments in nuclear energy should be part of strategies to mitigate climate change. Here, we address this question from an ethical perspective, evaluating different strategies of energy system development in terms of three ethical criteria, which will differentially appeal to proponents of different normative ethical frameworks. Starting from a standard analysis of climate change as arising from an intergenerational collective action problem, we (...) evaluate whether contributions from nuclear energy will, on expectation, increase the likelihood of successfully phasing out fossil fuels in time to avert dangerous global warming. For many socio-economic and geographic contexts, our review of the energy system modeling literature suggests the answer to this question is “yes.” We conclude that, from the point of view of climate change mitigation, investments in nuclear energy as part of a broader energy portfolio will be ethically required to minimize the risks of decarbonization failure, and thus the tail risks of catastrophic global warming. Finally, using a sensitivity analysis, we consider which other aspects of nuclear energy deployment, apart from climate change, have the potential to overturn the ultimate ethical verdict on investments in nuclear energy. Out of several potential considerations, we suggest that its potential interplay — whether beneficial or adverse — with the proliferation of nuclear weapons is the most plausible candidate. (shrink)

In this article, I will discuss two prominent views on the relevance and irrelevance of ontological investigations for the social sciences, namely, ontological foundationalism and anti-ontological pragmatism. I will argue that both views are unsatisfactory. The subsequent part of the article will introduce an alternative role for ontological projects in the philosophy of the social sciences that fares better in this respect by paying attention to the ontological assumptions of actual social scientific theories, models, and related explanatory practices. I will (...) illustrate and support this alternative through discussion of three concrete cases. (shrink)

In this journal Andy Egan argued that, contrary to what I have claimed, quasi-realism is committed to a damaging asymmetry between the way a subject regards himself and the way he regards others. In particular, a subject must believe it to be a priori that if something is one of his stable or fundamental beliefs, then it is true. Whereas he will not hold that this is a priori true of other people. In this paper I rebut Egan's argument, and (...) give further consideration to the correct way to think about our own fallibility. (shrink)

Cancer is a singular cellular state, the emergence of which destabilises the homeostasis reached through the evolution to multicellularity. We present the idea that the onset of the cellular disobedience to the metazoan functional and structural architecture, known as the cancer phenotype, is triggered by changes in the cell's external environment that occur with ageing: what ensues is a breach of the social contract of multicellular life characteristic of metazoans. By integrating old ideas with new evidence, we propose that with (...) ageing the environmental information that maintains a multicellular organisation is eroded, rewiring internal processes of the cell, and resulting in an internal shift towards an ancestral condition resulting in the pseudo‐multicellular cancer phenotype. Once that phenotype emerges, a new local social contract is built, different from the homeostatic one, leading to tumour formation and the foundation of a novel local ecosystem. (shrink)

Does humour make us human, or do the cats and dogs laugh along with us? On Humour is a fascinating, beautifully written and funny book on what humour can tell us about being human. Simon Critchley skilfully probes some of the most perennial but least understood aspects of humour, such as our tendency to laugh at animals and our bodies, why we mock death with comedy and why we think it's funny when people act like machines. He also looks (...) at the darker side of humour, as rife in sexism and racism and argues that it is important for reminding us of people we would rather not be. (shrink)

Trust is a natural mechanism by which an autonomous party, an agent, can deal with the inherent uncertainty regarding the behaviours of other parties and the uncertainty in the information it shares with those parties. Trust is thus crucial in any decentralised system. This paper builds on recent efforts to use argumentation to reason about trust. Specifically, a set of schemes is provided, and abstract patterns of reasoning that apply in multiple situations geared towards trust. Schemes are described in which (...) one agent, A, can establish arguments for trusting another agent, B, directly, as well as schemes that A can use to construct arguments for trusting C, where C is trusted by B. For both sets of schemes, a set of critical questions is offered that identify the situations in which these schemes can fail. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:diacritics 34.1 (2004) 3-17 [Access article in PDF] Universal Shylockery Money and Morality in The Merchant of Venice Simon Critchley Tom McCarthy What if Nietzsche were a Jew, and a mean-minded Venetian Jew at that? We'd like to begin with the thought experiment of imagining The Merchant of Venice as a genealogy of morality and imagining Shylock as Nietzsche. What is The Merchant of Venice about? What is (...) at stake in this oddly inside-out drama, where a piece of good old Elizabethan comic Jew-baiting rotates 180 degrees into a devastating study of Christian anti-Semitism only to flip back into what it seemed to deny? Our initial hypothesis is that it is nothing less than an inquiry into the origin of our moral concepts of justice, good and bad, and more particularly guilt, law, mercy, and love. It is here that a link with Nietzsche suggests itself, particularly with the Second Essay of On the Genealogy of Morals.* * *How do we breed an animal with the right to make promises? For Nietzsche, the human being is an originally forgetful creature, like a young child. To make this originally forgetful creature remember requires physical discipline; it behooves punishment. The teaching of morality is never gentle; it never droppeth from heaven like gentle rain. On the contrary, if something is to be retained in memory, it must be burned in. The origin of memory lies in pain and cruelty: "Man could never do without blood, torture and sacrifices when he felt the need to create a memory for himself" [GM 61]. Nietzsche's first, astonishing hypothesis in the Second Essay is that the origin of concepts like responsibility and conscience lies in cruelty—cruelty administered and maintained through a corporal and corporeal regime. Further, as religions are systems of cruelty, all forms of asceticism originate in the same painful place. "Consider the German punishments," Nietzsche proposes—and we all know that there's nothing quite like the German punishments: stoning, breaking on the wheel, piercing with stakes, tearing apart or trampling with horses, boiling in oil, flaying alive, cutting straps from the flesh, smearing the wrongdoer with honey and leaving him to the flies in the blazing sun. As Nietzsche quips, with magnificent understatement, "With the aid of such images and procedures one finally remembers five or six 'I will not's'" [GM 62]. It is on the basis of this burned-in memory of cruelty that good, decent, upright burghers such as ourselves acquired the habit of moral reasoning:Ah, reason, seriousness, mastery over affects, the whole sombre thing called reflection, all these prerogatives and showpieces of man: how dearly they have been bought! How much blood and cruelty lie at the bottom of all "good things." [GM 62] [End Page 3]"Dearly bought": let's hold onto that trope of purchasing. In another extraordinary passage of the Second Essay, Nietzsche explains the origin of thinking itself in terms of economic activity:Setting prices, determining values, contriving equivalences, exchanging—these preoccupied the earliest thinking of man to so great an extent that in a sense they are thinking [das Denken ist]. [GM 70] In the beginning was trade. Human activity begins with exchange, with the to and fro of buying and selling, which are forms of life older than all other social alliances and organization. It is from here, Nietzsche insists, that human beings arrive at the first moral canon of justice:"Everything has its price; all things can be paid for"—the oldest and most naïve moral canon of justice, the beginning of all "good-naturedness," all "fairness," all "good will," all "objectivity" on earth. [GM 70] Which brings us to the origin of das Bewusstsein der Schuld and schlechte Gewissen, the consciousness of guilt and bad conscience. Nietzsche's hypothesis here, and our theme is beginning to come into focus, is that the origin of guilty conscience lies in the relation between a creditor and debtor, Glaubiger und Schuldner. The spiritual concept of guilt, Schuld, originates in the very material concept of Schulden... (shrink)

Practical philosophy and ethics -- Practical tortise raising -- Truth, beauty, and goodness -- Dilemmas: dithering, plumping, and grief -- Group minds and expressive harm -- Trust, cooperation, and human psychology -- Must we weep for sentimentalism? -- Through thick and thin -- Perspectives, fictions, errors, play -- The steps from doing to saying -- Success semantics -- Wittgenstein's irrealism -- Circles, finks, smells, and biconditionals -- The absolute conception: Putnam vs. Williams -- Julius Caesar and George Berkeley play leapfrog (...) -- The majesty of reason -- Fiction and conviction. (shrink)

This study analyses the sensitivity of public goods contributions through the lens of psychological motives. We report the results of a public goods experiment in which subjects were induced with the motives of care and anger through autobiographical recall. Subjects’ preferences, beliefs, and perceptions under each motive are compared with those of subjects experiencing a neutral autobiographical recall control condition. We find, but only for those subjects with the highest comprehension of the game, that care elicits significantly higher contributions than (...) anger, with the control treatment in between. This positive influence of the care motive on unconditional giving is accounted for partly by preferences for giving and partly by beliefs concerning greater contributions by others. Anger also affects attention to own and other’s payoffs and perceptions of the game’s incentive structure. (shrink)

Gopal Sreenivasan’s “hybrid theory” states that a moral duty is directed toward an individual because her interests justify the assignment of control over the duty. An alternative “plain theory” states that the individual’s interests justify the duty itself. I argue that a strong moral status constraint explains Sreenivasan’s instrumentalization objection to a Razian plain theory but that his own model violates this constraint. I suggest how both approaches can be reformulated to satisfy the constraint, and I argue that a reformulated (...) plain theory can also avoid an insufficiency objection. The hybrid approach consequently has no clear advantage over the plain approach. (shrink)

This paper argues that research on normative issues in the life sciences will benefit from a tighter integration of philosophy of science. We examine research on ethical, legal and social issues in the life sciences (“ELSI”) and discuss three illustrative examples of normative issues that arise in different areas of the life sciences. These examples show that important normative questions are highly dependent on epistemic issues which so far have not been addressed sufficiently in ELSI, RRI and related areas of (...) research. Accordingly, we argue for the integration of research on the epistemic aspects of the relevant areas of science into ELSI research to provide a better basis for addressing normative questions. (shrink)

Drawing on philosophy, psychology, literature, history, and popular culture, this book looks at the good and bad aspects of vanity and self-love, from the myth of Narcissus and the Christian story of the Fall to today's self-esteem industry.

Engaging with the challenging and controversial reading of Spinoza presented by Gilles Deleuze in Expressionism in Philosophy (1968), this book focuses on Deleuze's redeployment of Spinozist concepts within the context of his own philosophical project of constructing a philosophy of difference as an alternative to the Hegelian dialectical philosophy. Duffy demonstrates that a thorough understanding of Deleuze's Spinozism is necessary in order to fully engage with Deleuze's philosophy of difference.

The Moral Conscience principle claims that a conflict between the demands of a law and the demands of an individual’s sincere moral conscience provides her with a defeasible moral entitlement to an exemption. This chapter argues that this principle is vulnerable to an unfairness objection. There is nothing special about moral conscience that would justify granting an exemption, it claims, that is not shared by a variety of non-moral projects. Thus, there is no principled moral reason for a defeasible entitlement (...) to moral conscience-based exemptions that is not an equally good reason for a defeasible entitlement to non-moral project-based exemptions. Since the chapter assumes that people are not defeasibly entitled to such project-based exemptions, it advocates scepticism about the Moral Conscience principle. (shrink)

Research highlights several risk and resilience factors at multiple ecological levels that influence individuals’ mental health and wellbeing in their everyday lives and, more specifically, in disaster or outbreak situations. However, there is limited research on the role of these factors in the early days of the COVID-19 crisis. The present study examined if and how potential risk factors and resilience factors are associated with mental health and well-being outcomes, and whether these resilience factors buffer the associations between risk factors (...) and said outcomes. One to two weeks after the government recommended preventative measures, 1,122 Canadian workers completed an online questionnaire, including multiple wellbeing outcome scales in addition to measures of potential risk and resilience factors. Structural equation models were tested, highlighting that overall, the considered risk factors were associated with poorer wellbeing outcomes, except social distancing which was associated with lower levels of stress. Each of the potential resilience factors was found to have a main effect on one or more of the wellbeing outcomes. Moderation analysis indicated that in general these resilience factors did not, however, buffer the risk factors. The findings confirm that the COVID-19 crisis encompasses several stressors related to the virus as well as to its impact on one’s social, occupational, and financial situation, which put people at risk for lower wellbeing as early as one to two weeks after the crisis began. While several resilience factors emerged as positively related to wellbeing, such factors may not be enough, or sufficiently activated at that time, to buffer the effects of the numerous life changes required by COVID-19. From an ecological perspective, while mental health professionals and public health decision-makers should offer/design services directly focused on mental health and wellbeing, it is important they go beyond celebrating individuals’ inner potential for resilience, and also support individuals in activating their environmental resources during a pandemic. (shrink)

The Derrida Dictionary is a comprehensive and accessible guide to the world of Jacques Derrida, the founder of deconstruction and one of the most important and influential European thinkers of the twentieth century. Meticulously researched and extensively cross-referenced, this unique book covers all his major works, ideas and influences and provides a firm grounding in the central themes of Derrida's thought. Students will discover a wealth of useful information, analysis and criticism. A-Z entries include clear definitions of all the key (...) terms used in Derrida's writings and detailed synopses of his key works. The Dictionary also includes entries on Derrida's major philosophical influences and those he engaged with, such as Kant, Hegel, Husserl, Freud, Heidegger, Foucault, Lacan and Levinas. It covers everything that is essential to a sound understanding of Derrida's philosophy, offering clear and accessible explanations of often complex terminology. The Derrida Dictionary is the ideal resource for anyone reading or studying Derrida, deconstruction or modern European philosophy more generally. (shrink)