This paper examines a looming reproducibility crisis in the core of the hard sciences. Namely, it concentrates on molecular modeling and simulation (MMS), a family of methods that predict properties of substances through computing interactions on a molecular level and that is widely popular in physics, chemistry, materials science, and engineering. The paper argues that in order to make quantitative predictions, sophisticated models are needed which have to be evaluated with complex simulation procedures that amalgamate theoretical, technological, and social factors (...) – leading to problems with reproducibility. Thus, for methodological reasons, the predictive success causes a reproducibility problem. (shrink)

Bayesian epistemology addresses epistemological problems with the help of the mathematical theory of probability. It turns out that the probability calculus is especially suited to represent degrees of belief (credences) and to deal with questions of belief change, confirmation, evidence, justification, and coherence. Compared to the informal discussions in traditional epistemology, Bayesian epis- temology allows for a more precise and fine-grained analysis which takes the gradual aspects of these central epistemological notions into account. Bayesian epistemology therefore complements traditional epistemology; it (...) does not re- place it or aim at replacing it. (shrink)

It is argued that those who defend the Everett, or ‘many-worlds’, interpretation of quantum mechanics should embrace what we call the general quantum theory of open systems (GT) as the proper framework in which to conduct foundational and philosophical investigations in quantum physics. GT is a wider dynamical framework than its alternative, standard quantum theory (ST). This is true even though GT makes no modifications to the quantum formalism. GT rather takes a different view, what we call the open systems (...) view, of the formalism; i.e., in GT, the dynamics of systems whose physical states are fundamentally represented by density operators are represented as fundamentally open as specified by an in general non-unitary dynamical map. This includes, in principle, the dynamics of the universe as a whole. We argue that the more general dynamics describable in GT can be physically motivated, that there is as much prima facie empirical support for GT as there is for ST, and that GT could be fully in the spirit of the Everett interpretation—that there might, in short, be little reason for an Everettian not to embrace the more general theoretical landscape that GT allows one to explore. (shrink)

It is often claimed that the greatest value of the Bayesian framework in cognitive science consists in its unifying power. Several Bayesian cognitive scientists assume that unification is obviously linked to explanatory power. But this link is not obvious, as unification in science is a heterogeneous notion, which may have little to do with explanation. While a crucial feature of most adequate explanations in cognitive science is that they reveal aspects of the causal mechanism that produces the phenomenon to be (...) explained, the kind of unification afforded by the Bayesian framework to cognitive science does not necessarily reveal aspects of a mechanism. Bayesian unification, nonetheless, can place fruitful constraints on causal–mechanical explanation. 1 Introduction2 What a Great Many Phenomena Bayesian Decision Theory Can Model3 The Case of Information Integration4 How Do Bayesian Models Unify?5 Bayesian Unification: What Constraints Are There on Mechanistic Explanation?5.1 Unification constrains mechanism discovery5.2 Unification constrains the identification of relevant mechanistic factors5.3 Unification constrains confirmation of competitive mechanistic models6 ConclusionAppendix. (shrink)

Fundamentality plays a pivotal role in discussions of ontology, supervenience, and possibility, and other key topics in metaphysics. However, there are two different ways of characterising the fundamental: as that which is not grounded, and as that which is the ground of everything else. I show that whether these two characterisations pick out the same property turns on a principle—which I call “Dichotomy”—that is of independent interest in the theory of ground: that everything is either fully grounded or not even (...) partially grounded. I then argue that Dichotomy fails: some facts have partial grounds that cannot be complemented to a full ground. Rejecting Dichotomy opens the door to recognising a bifurcation in our notion of fundamentality. I sketch some of the far-reaching metaphysical consequences this might have, with reference to big-picture views such as Humeanism. Since Dichotomy is entailed by the standard account of partial ground, according to which partial grounds are subpluralities of full grounds, a non-standard account is needed. In a technical “Appendix”, I show that truthmaker semantics furnishes such an account, and identify a semantic condition that corresponds to Dichotomy. (shrink)

Addresses ‘too-odd-not-to-be-true’ reasoning in the assessment of testimony. This is the curious phenomenon that an initially less plausible report from multiple independent witnesses may elicit more confidence than an initially more plausible report.

Simulation techniques, especially those implemented on a computer, are frequently employed in natural as well as in social sciences with considerable success. There is mounting evidence that the "model-building era" (J. Niehans) that dominated the theoretical activities of the sciences for a long time is about to be succeeded or at least lastingly supplemented by the "simulation era". But what exactly are models? What is a simulation and what is the difference and the relation between a model and a simulation? (...) These are some of the questions addressed in this article. I maintain that the most significant feature of a simulation is that it allows scientists to imitate one process by another process. "Process" here refers solely to a temporal sequence of states of a system. Given the observation that processes are dealt with by all sorts of scientists, it is apparent that simulations prove to be a powerful interdisciplinarily acknowledged tool. Accordingly, simulations are best suited to investigate the various research strategies in different sciences more carefully. To this end, I focus on the function of simulations in the research process. Finally, a somewhat detailed case-study from nuclear physics is presented which, in my view, illustrates elements of a typical simulation in physics. (shrink)

The emerging consensus in the philosophy of cognition is that cognition is situated, i.e., dependent upon or co-constituted by the body, the environment, and/or the embodied interaction with it. But what about emotions? If the brain alone cannot do much thinking, can the brain alone do some emoting? If not, what else is needed? Do (some) emotions (sometimes) cross an individual's boundary? If so, what kinds of supra-individual systems can be bearers of affective states, and why? And does that make (...) emotions ?embedded? or ?extended? in the sense cognition is said to be embedded and extended? Section 2 shows why it is important to understand in which sense body, environment, and our embodied interaction with the world contribute to our affective life. Section 3 introduces some key concepts of the debate about situated cognition. Section 4 draws attention to an important disanalogy between cognition and emotion with regard to the role of the body. Section 5 shows under which conditions a contribution by the environment results in non-trivial cases of ?embedded? emotions. Section 6 is concerned with affective phenomena that seem to cross the organismic boundaries of an individual, in particular with the idea that emotions are ?extended? or ?distributed.? (shrink)

According to orthodoxy, there are two basic moods of supposition: indicative and subjunctive. The most popular formalizations of the corresponding norms of suppositional judgement are given by Bayesian conditionalization and Lewisian imaging, respectively. It is well known that Bayesian conditionalization can be generalized (via Jeffrey conditionalization) to provide a model for the norms of partial indicative supposition. This raises the question of whether imaging can likewise be generalized to model the norms of ‘partial subjunctive supposition’. The present article casts doubt (...) on whether the most natural generalizations of imaging are able to provide a plausible account of the norms of partial subjunctive supposition. (shrink)

Nancy Cartwright is one of the most distinguished and influential contemporary philosophers of science. Despite the profound impact of her work, there is neither a systematic exposition of Cartwright’s philosophy of science nor a collection of articles that contains in-depth discussions of the major themes of her philosophy. This book is devoted to a critical assessment of Cartwright’s philosophy of science and contains contributions from Cartwright's champions and critics. Broken into three parts, the book begins by addressing Cartwright's views on (...) the practice of model building in science and the question of how models represent the world before moving on to a detailed discussion of methodologically and metaphysically challenging problems. Finally, the book addresses Cartwright's original attempts to clarify profound questions concerning the metaphysics of science. With contributions from leading scholars, such as Ronald N. Giere and Paul Teller, this unique volume will be extremely useful to philosophers of science the world over. (shrink)

Bayes nets are a powerful tool for researchers in statistics and artificial intelligence. This chapter demonstrates that they are also of much use for philosophers and psychologists interested in (Bayesian) rationality. To do so, we outline the general methodology of Bayes nets modeling in rationality research and illustrate it with several examples from the philosophy and psychology of reasoning and argumentation. Along the way, we discuss the normative foundations of Bayes nets modeling and address some of the methodological problems it (...) raises. (shrink)

Fundamental theories are hard to come by. But even if we had them, they would be too complicated to apply. Quantum chromodynamics is a case in point. This theory is supposed to govern all strong interactions, but it is extremely hard to apply and test at energies where protons, neutrons and ions are the effective degrees of freedom. Instead, scientists typically use highly idealized models such as the MIT Bag Model or the Nambu Jona-Lasinio Model to account for phenomena in (...) this domain, to explain them and to gain nderstanding. Based on these models, which typically isolate a single feature of QCD and disregard many others, scientists attempt to get a better understanding of the physics of strong interactions. But does this practice make sense? Is it justified to use these models for the purposes at hand? Interestingly, these models do not even provide an accurate description of the mass spectrum of protons, neutrons and pions and their lowest lying excitations well - despite several adjustable parameters. And yet, the models are heavily used. I'll argue that a qualitative story, which establishes an explanatory link between the fundamental theory and a model, plays an important role in model acceptance in these cases. (shrink)

I suggest a way of extending Stalnaker’s account of assertion to allow for centered content. In formulating his account, Stalnaker takes the content of assertion to be uncentered propositions: entities that are evaluated for truth at a possible world. I argue that the content of assertion is sometimes centered: the content is evaluated for truth at something within a possible world. I consider Andy Egan’s proposal for extending Stalnaker’s account to allow for assertions with centered content. I argue that Egan’s (...) account does not succeed. Instead, I propose an account on which the contents of assertion are identified with sets of multi-centered worlds. I argue that such a view not only provides a plausible account of how assertions can have centered content, but also preserves Stalnaker’s original insight that successful assertion involves the reduction of shared possibilities. (shrink)

Effective field theories have been a very popular tool in quantum physics for almost two decades. And there are good reasons for this. I will argue that effective field theories share many of the advantages of both fundamental theories and phenomenological models, while avoiding their respective shortcomings. They are, for example, flexible enough to cover a wide range of phenomena, and concrete enough to provide a detailed story of the specific mechanisms at work at a given energy scale. So will (...) all of physics eventually converge on effective field theories? This paper argues that good scientific research can be characterised by a fruitful interaction between fundamental theories, phenomenological models and effective field theories. All of them have their appropriate functions in the research process, and all of them are indispensable. They complement each other and hang together in a coherent way which I shall characterise in some detail. To illustrate all this I will present a case study from nuclear and particle physics. The resulting view about scientific theorising is inherently pluralistic, and has implications for the debates about reductionism and scientific explanation. (shrink)

A commonly held idea regarding the nature of time is that the future is open and the past is fixed or closed. This article investigates the notion that there is an asymmetry in openness between the past and the future. The following questions are considered: How exactly is this asymmetry in openness to be understood? What is the relation between an open future and various ontological views about the future? Is an open future a branching future? What is the relation (...) between an open future and the question of whether contingent statements about the future are true or false? Is an open future compatible with a single determinate future? (shrink)

Theoretical models are an important tool for many aspects of scientific activity. They are used, i.a., to structure data, to apply theories or even to construct new theories. But what exactly is a model? It turns out that there is no proper definition of the term "model" that covers all these aspects. Thus, I restrict myself here to evaluate the function of models in the research process while using "model" in the loose way physicists do. To this end, I distinguish (...) four kinds of models. These are (1) models as special theories, (2) models as a substitute for a theory, (3) toy models and (4) developmental models. I argue that models of the types (3) and (4) are considerably useful in the process of theory construction. This will be demonstrated in an extended case-study from High-Energy Physics. (shrink)

Science strives for coherence. For example, the findings from climate science form a highly coherent body of knowledge that is supported by many independent lines of evidence: greenhouse gas emissions from human economic activities are causing the global climate to warm and unless GHG emissions are drastically reduced in the near future, the risks from climate change will continue to grow and major adverse consequences will become unavoidable. People who oppose this scientific body of knowledge because the implications of cutting (...) GHG emissions—such as regulation or increased taxation—threaten their worldview or livelihood cannot provide an alternative view that is coherent by the standards of conventional scientific thinking. Instead, we suggest that people who reject the fact that the Earth’s climate is changing due to greenhouse gas emissions oppose whatever inconvenient finding they are confronting in piece-meal fashion, rather than systematically, and without considering the implications of this rejection to the rest of the relevant scientific theory and findings. Hence, claims that the globe “is cooling” can coexist with claims that the “observed warming is natural” and that “the human influence does not matter because warming is good for us.” Coherence between these mutually contradictory opinions can only be achieved at a highly abstract level, namely that “something must be wrong” with the scientific evidence in order to justify a political position against climate change mitigation. This high-level coherence accompanied by contradictory subordinate propositions is a known attribute of conspiracist ideation, and conspiracism may be implicated when people reject well-established scientific propositions. (shrink)

The concept of supervenience and a regimented concept of grounding are often taken to provide rival explications of pre-theoretical concepts of dependence and determination. Friends of grounding typically point out that supervenience claims do not entail corresponding grounding claims. Every fact supervenes on itself, but is not grounded in itself, and the fact that a thing exists supervenes on the fact that its singleton exists, but is not grounded in it. Common lore has it, though, that grounding claims do entail (...) corresponding supervenience claims. In this article, I show that this assumption is problematic. On one way of understanding it, the corresponding supervenience claim is just an entailment claim under a different name. On another way of understanding it, the corresponding claim is a distinctive supervenience claim, but its specification gives rise to what I call the "reference type problem": to associate the classes of facts that are the relata of grounding with the types of facts that are the relata of supervenience. However it is understood, supervenience rules out prima facie possibilities: alien realizers, blockers, heterogeneous realizers, floaters, and heterogeneous blockers. Instead of being rival explications of one and the same pre-theoretical concept, grounding and supervenience may be complementary concepts capturing different aspects of determination and dependence. (shrink)

In this discussion note, we explain how to relax some of the standard assumptions made in Garber-style solutions to the Problem of Old Evidence. The result is a more general and explanatory Bayesian approach.

The aggregation of consistent individual judgments on logically interconnected propositions into a collective judgment on those propositions has recently drawn much attention. Seemingly reasonable aggregation procedures, such as propositionwise majority voting, cannot ensure an equally consistent collective conclusion. The literature on judgment aggregation refers to that problem as the discursive dilemma. In this paper, we motivate that many groups do not only want to reach a factually right conclusion, but also want to correctly evaluate the reasons for that conclusion. In (...) other words, we address the problem of tracking the true situation instead of merely selecting the right outcome. We set up a probabilistic model analogous to Bovens and Rabinowicz (2006) and compare several aggregation procedures by means of theoretical results, numerical simulations and practical considerations. Among them are the premise-based, the situation-based and the distance-based procedure. Our findings confirm the conjecture in Hartmann, Pigozzi and Sprenger (2008) that the premise-based procedure is a crude, but reliable and sometimes even optimal form of judgment aggregation. (shrink)

Current orthodoxy in modal logic and metaphysics has it that actuality is non-contingent in the following sense: for all p, if actually, p, then necessarily, actually, p. Call this thesis (Actuality) Necessitism and its negation (Actuality) Contingentism. Thus, according to Contingentism, there is at least one proposition p which is actually true but which could have been actually false. In another paper, one of us (Glazier 2023) has recently defended Contingentism. The present paper explores the logic of actuality under Contingentism. (...) After informally introducing Contingentism and outlining what we take to be the main motivations for accepting it, we consider how contingent actuality should be taken to be. We argue that the nature, or essence, of actuality imposes certain limits on the extent to which actuality could have been different, and these then inform our view of the logic of actuality. Turning to the formal study of the logic of contingent actuality, we specify a formal language and a possible world semantics for that language and distinguish a number of natural notions of validity and consequence to which it gives rise. We present axiomatizations of the different resulting logics and examine the variety of iterated modalities in our systems. We establish soundness and completeness results. (shrink)

Discussions about a replicability crisis in science have been driven by the normative claim that all of science should be replicable and the empirical claim that most of it isn’t. Recently, such crisis talk has been challenged by a new localism, which argues a) that serious problems with replicability are not a general occurrence in science and b) that replicability itself should not be treated as a universal standard. The goal of this article is to introduce this emerging strand of (...) the debate and to discuss some of its implications and limitations. I will in particular highlight the issue of demarcation that localist accounts have to address, i.e. the question of how we can distinguish replicable science from disciplines where replicability does not apply. (shrink)

Models are of central importance in many scientific contexts. The centrality of models such as the billiard ball model of a gas, the Bohr model of the atom, the MIT bag model of the nucleon, the Gaussian-chain model of a polymer, the Lorenz model of the atmosphere, the Lotka-Volterra model of predator-prey interaction, the double helix model of DNA, agent-based and evolutionary models in the social sciences, or general equilibrium models of markets in their respective domains are cases in point. (...) Scientists spend a great deal of time building, testing, comparing and revising models, and much journal space is dedicated to introducing, applying and interpreting these valuable tools. In short, models are one of the principal instruments of modern science. -/- Philosophers are acknowledging the importance of models with increasing attention and are probing the assorted roles that models play in scientific practice. The result has been an incredible proliferation of model-types in the philosophical literature. Probing models, phenomenological models, computational models, developmental models, explanatory models, impoverished models, testing models, idealized models, theoretical models, scale models, heuristic models, caricature models, didactic models, fantasy models, toy models, imaginary models, mathematical models, substitute models, iconic models, formal models, analogue models and instrumental models are but some of the notions that are used to categorize models. While at first glance this abundance is overwhelming, it can quickly be brought under control by recognizing that these notions pertain to different problems that arise in connection with models. For example, models raise questions in semantics (what is the representational function that models perform?), ontology (what kind of things are models?), epistemology (how do we learn with models?), and, of course, in philosophy of science (how do models relate to theory?; what are the implications of a model based approach to science for the debates over scientific realism, reductionism, explanation and laws of nature?). (shrink)

This paper explores various functions of idealizations in quantum field theory. To this end it is important to first distinguish between different kinds of theories and models of or inspired by quantum field theory. Idealizations have pragmatic and cognitive functions. Analyzing a case-study from hadron physics, I demonstrate the virtues of studying highly idealized models for exploring the features of theories with an extremely rich structure such as quantum field theory and for gaining some understanding of the physical processes in (...) the system under consideration. (shrink)

Belief in substance dualism, the idea that mind and matter are two different kinds of substances, has been found to be a strong predictor of belief in free will. Why? Here, we test whether believing that mind and matter are different kinds of substance correlates with differences in how people think of free will and/or differences in how people interpret the scenarios used to test their conceptions. We provided participants (N = 515) with two hypothetical scenarios where the world was (...) presented either as deterministic or not and asked them whether they thought that a given decision could be free in that world. Incompatibilist free will requires that determinism, the idea that at any instant only one possible future can follow from the state of the world, is false. Compatibilists hold that free will is possible even if determinism is true. In this study, we investigate if substance dualists are more compatibilist. We find that they are not, and that both dualists and physicalists agree that free will is incompatible with determinism. In addition, we show that dualists and physicalists are equally likely to commit bypassing, i.e., to misinterpret determinism as excluding mental causation. We also show that dualists have a stronger tendency to commit intrusion, i.e., to misinterpret determinism by importing indeterministic metaphysics into their interpretation of deterministic descriptions. (shrink)

Models are of central importance in many scientific contexts. The roles the MIT bag model of the nucleon, the billiard ball model of a gas, the Bohr model of the atom, the Gaussian-chain model of a polymer, the Lorenz model of the atmosphere, the Lotka- Volterra model of predator-prey interaction, agent-based and evolutionary models of social interaction, or general equilibrium models of markets play in their respective domains are cases in point.

The aggregation of consistent individual judgments on logically interconnected propositions into a collective judgment on the same propositions has recently drawn much attention. Seemingly reasonable aggregation procedures, such as propositionwise majority voting, cannot ensure an equally consistent collective conclusion. The literature on judgment aggregation refers to such a problem as the \textit{discursive dilemma}. In this paper we assume that the decision which the group is trying to reach is factually right or wrong. Hence, we address the question of how good (...) the various approaches are at selecting the right conclusion. We focus on two approaches: distance-based procedures and a Bayesian analysis. They correspond to group-internal and group-external decision-making, respectively. We compare those methods in a probabilistic model, demonstrate the robustness of our results over various generalizations and discuss their applicability in different situations. The findings vindicate (i) that in judgment aggregation problems, reasons should carry higher weight than conclusions and (ii) that considering members of an advisory board to be highly competent is a better strategy than to underestimate their advice.". (shrink)

This paper is an essay review of Steven French and Harmke Kamminga (eds.), Correspondence, Invariance and Heuristics. Essays in Honour of Heinz Post (Dordrecht: Kluwer, 1993). I distinguish a varity of correspondence relations between scientific theories (exemplified by cases from the book under review) and examine how one can make sense of the the prevailing continuity in scientific theorizing.

We propose an action-oriented understanding of emotion. Emotions are modifications of a basic form of goal-oriented striving characteristic of human life. They are appetitive orientations: pursuits of the good, avoidances of the bad. Thus, emotions are not truly distinct from, let alone opposed to, actions -- as erroneously suggested by the classical understanding of emotions as 'passions'. In the present paper, we will outline and defend this broadly enactive approach and motivate its main claims. Our proposal gains plausibility from a (...) literature- and interview-based investigation of emotional changes characteristic of clinical depression. Much narrative evidence from patient reports points towards the conclusion that many of those changes might result from a catastrophic alteration of the basic form of goal-pursuit at the root of human emotionality. The experience of profound depression could in this respect be a kind of inverted image of non-pathological emotionality--a highly unnatural passivity, giving rise to a profound -- and quite horrifying -- sense of incapacity. (shrink)

There are various ways to reach a group decision on a factual yes–no question. One way is to vote and decide what the majority votes for. This procedure receives some epistemological support from the Condorcet Jury Theorem. Alternatively, the group members may prefer to deliberate and will eventually reach a decision that everybody endorses—a consensus. While the latter procedure has the advantage that it makes everybody happy, it has the disadvantage that it is difficult to implement, especially for larger groups. (...) Besides, the resulting consensus may be far away from the truth. And so we ask: Is deliberation truth-conducive in the sense that majority voting is? To address this question, we construct a highly idealized model of a particular deliberation process, inspired by the movie Twelve Angry Men, and show that the answer is ‘yes’. Deliberation procedures can be truth-conducive just as the voting procedure is. We then explore, again on the basis of our model and using agent-based simulations, under which conditions it is better epistemically to deliberate than to vote. Our analysis shows that there are contexts in which deliberation is epistemically preferable and we will provide reasons for why this is so. (shrink)

The life sciences are said to be in the midst of a replication crisis because a majority of published results are irreproducible, and scientists rarely replicate existing data. Here I argue that point 2 of this assessment is flawed because there is a hitherto unidentified form of replication in the experimental life sciences, which I call ‘microreplications’. Using a case study from biochemistry, I illustrate how MRs depend on a key element of experimentation, namely, experimental controls. I end by reflecting (...) on what MRs mean for the broader debate about the replication crisis. (shrink)

The aim of this paper is to explore how children learn to form new relationships with nature. It draws on a longitudinal case study of children participating in a stewardship project involving the conservation of salamanders during the school day in Stockholm, Sweden. The qualitative method includes two waves of data collection: when a group of 10-year-old children participated in the project (2015) and two years after they participated (2017). We conducted 49 interviews with children as well as using participant (...) observations and questionnaires. We found indications that children developed sympathy for salamanders and increased concern and care for nature, and that such relationships persisted two years after participation. Our rich qualitative data suggest that whole situations of sufficient unpredictability triggering free exploration of the area, direct sensory contact and significant experiences of interacting with a species were important for children’s development of affective relationships with the salamander species and with nature in an open-ended sense. Saving the lives of trapped animals enabled direct sensory interaction, feedback, increased understanding, and development of new skills for dynamically exploring further ways of saving species in an interactive process experienced as deeply meaningful, enjoyable and connecting. The behavioural setting instilled a sense of pride and commitment, and the high degree of responsibility given to the children while exploring the habitat during authentic situations enriched children’s enjoyment. The study has implications for the design of education programmes that aim to connect children with nature and for a child-sensitive urban policy that supports authentic nature situations in close spatial proximity to preschools and schools. (shrink)

An argument with roots in ancient Greek philosophy claims that only humans are capable of a certain class of thought termed conceptual, as opposed to perceptual thought, which is common to humans, the higher animals, and some machines. We outline the most detailed modern version of this argument due to Mortimer Adler, who in the 1960s argued for the uniqueness of the human power of conceptual thought. He also admitted that if conceptual thought were ever manifested by machines, such an (...) achievement would contradict his conclusion. We revisit Adler’s criterion in the light of the past five decades of artificial-intelligence research, and refine it in view of the classical definitions of perceptual and conceptual thought. We then examine two well-publicized examples of creative works produced by AI systems and show that evidence for conceptual thought appears to be lacking in them. Although clearer evidence for conceptual thought on the part of AI systems may arise in the near future, especially if the global neuronal workspace theory of consciousness prevails over its rival, integrated information theory, the question of whether AI systems can engage in conceptual thought appears to be still open. (shrink)

We propose that emotion psychology would significantly gain from including narrative(s) and the conversational negotiation of appropriateness. Using the example of anger, we argue that narrators need to construct plausible narratives of emotional events to achieve validating responses by listeners. We argue first that narrators attempt to demonstrate that the appraisal conditions for their emotion are given so that the emotion fits the narrated events. Second, we argue that this in turn explains why narratives of specific emotions exhibit specific forms. (...) Third, we argue that coping with emotional experiences is helped by narrating such that the fittingness of emotions is demonstrated. We conclude that narrative plays an important role for identifying, processing, communicating, and eliciting emotions. (shrink)

The reported birth of genetically modified twins in late 2018 has given new fuel to debates about the ethics of germline genome editing (GGE). There is a broad consensus among stakeholders that clinical uses of GGE should be temporarily banned as the technology is not yet deemed safe for use in humans. However, the idea of a complete ban is dismissed by many based on the expectation that more research will eventually allow scientists to make the technology safe without having (...) to put humans at risk first. In this article, I will analyse this assumption and argue that it is undermined by recent developments in the postgenomic life sciences. In particular, I will argue that in a postgenomic view of germline editing a complete ban on specific uses of the technology is warranted, because the research needed to assess the safety of these interventions would not be morally defensible. (shrink)

In 2015 scientists called for a partial ban on genome editing in human germline cells. This call was a response to the rapid development of the CRISPR–Cas9 system, a molecular tool that allows researchers to modify genomic DNA in living organisms with high precision and ease of use. Importantly, the ban was meant to be a trust-building exercise that promises a ‘prudent’ way forward. The goal of this paper is to analyse whether the ban can deliver on this promise. To (...) do so the focus will be put on the precedent on which the current ban is modelled, namely the Asilomar ban on recombinant DNA technology. The analysis of this case will show (a) that the Asilomar ban was successful because of a specific two-step containment strategy it employed and (b) that this two-step approach is also key to making the current ban work. It will be argued, however, that the Asilomar strategy cannot be transferred to human genome editing and that the current ban therefore fails to deliver on its promise. The paper will close with a reflection on the reasons for this failure and on what can be learned from it about the regulation of novel molecular tools. (shrink)

Several theories of emergence will be distinguished. In particular, these are synchronic, diachronic, and weak versions of emergence. While the weaker theories are compatible with property reductionism, synchronic emergentism and strong versions of diachronic emergentism are not. Synchronice mergentism is of particular interest for the discussion of downward causation. For such a theory, a system's property is taken to be emergent if it is irreducible, i.e., if it is not reductively explainable. Furthermore, we have to distinguish two different types of (...) irreducibility with quite different consequences: If, on the one hand, a system's property is irreducible because of the irreducibility of the system's parts' behavior on which the property supervenes, we seem to have a case of "downward causation". This kind of downward causation does not violate the principle of the causal closure of the physical domain. If, on the other hand, a systemic property is irreducible because it is not exhaustively analyzable in terms of its causal role, downward causation is not implied. Rather, it is dubitable how unanalyzable properties might play any causal role at all. Thus, epiphenomenalism seems to be implied. The failure to keep apart the two kinds of irreducibility has muddled recent debate about the emergence of properties considerably. (shrink)

This article focuses on existential feelings. To begin with, it depicts how they differ from other affective phenomena and what type of intentionality they manifest. Furthermore, a detailed analysis shows that existential feelings can be subdivided, first, into elementary and nonelementary varieties, and second, into three foci of primary relatedness: oneself, the social environment, and the world as such. Eventually, five strategies of emotion regulation are examined with respect to their applicability to existential feelings. In the case of harmful existential (...) feelings, it turns out that none seems fitting except one, attentional deployment. (shrink)