The hemolysin toxin (HlyA) is secreted across both the cytoplasmic and outer membranes of pathogenic Escherichia coli and forms membrane pores in cells of the host immune system, causing cell dysfunction and death. The processes underlying the interaction of HlyA with the bacterial and mammalian cell membranes are remarkable. Secretion of HlyA occurs without a periplasmic intermediate and is directed by an uncleaved C‐terminal targetting signal and the HlyB and HlyD translocator proteins, the former being a member of a transporter (...) superfamily central to import and export of a wide range of substrates by prokaryotic and eukaryotic cells. The separate process by which HlyA is targetted to mammalian cell membranes is dependent upon fatty acylation of a non‐toxic precursor, proHlyA. This is achieved by a novel mechanism directed by the activator protein HlyC, which binds to an internal proHlyA recognition sequence and provides specificity for the transfer of fatty acid from cellular acyl carrier protein. (shrink)

We investigate how epistemic injustice can manifest itself in mathematical practices. We do this as both a social epistemological and virtue-theoretic investigation of mathematical practices. We delineate the concept both positively—we show that a certain type of folk theorem can be a source of epistemic injustice in mathematics—and negatively by exploring cases where the obstacles to participation in a mathematical practice do not amount to epistemic injustice. Having explored what epistemic injustice in mathematics can amount to, we use the concept (...) to highlight a potential danger of intellectual enculturation. (shrink)

Until recently, discussion of virtues in the philosophy of mathematics has been fleeting and fragmentary at best. But in the last few years this has begun to change. As virtue theory has grown ever more influential, not just in ethics where virtues may seem most at home, but particularly in epistemology and the philosophy of science, some philosophers have sought to push virtues out into unexpected areas, including mathematics and its philosophy. But there are some mathematicians already there, ready to (...) meet them, who have explicitly invoked virtues in discussing what is necessary for a mathematician to succeed. In both ethics and epistemology, virtue theory tends to emphasize character virtues, the acquired excellences of people. But people are not the only sort of thing whose excellences may be identified as virtues. Theoretical virtues have attracted attention in the philosophy of science as components of an account of theory choice. Within the philosophy of mathematics, and mathematics itself, attention to virtues has emerged from a variety of disparate sources. Theoretical virtues have been put forward both to analyse the practice of proof and to justify axioms; intellectual virtues have found multiple applications in the epistemology of mathematics; and ethical virtues have been offered as a basis for understanding the social utility of mathematical practice. Indeed, some authors have advocated virtue epistemology as the correct epistemology for mathematics (and perhaps even as the basis for progress in the metaphysics of mathematics). This topical collection brings together several of the researchers who have begun to study mathematical practices from a virtue perspective with the intention of consolidating and encouraging this trend. (shrink)

Pragmatism is America's best-known native philosophy. It espouses a practical set of beliefs and principles that focus on the improvement of our lives. Yet the split between classical and contemporary pragmatists has divided the tradition against itself. Classical pragmatists, such as John Dewey and William James, believed we should heed the lessons of experience. Neopragmatists, including Richard Rorty, Hilary Putnam, and Jürgen Habermas, argue instead from the perspective of a linguistic turn, which makes little use of the idea of experience. (...) Can these two camps be reconciled in a way that revitalizes a critical tradition? -/- Colin Koopman proposes a recovery of pragmatism by way of "transitionalist" themes of temporality and historicity which flourish in the work of the early pragmatists and continue in contemporary neopragmatist thought. "Life is in the transitions," James once wrote, and, in following this assertion, Koopman reveals the continuities uniting both phases of pragmatism. Koopman's framework also draws from other contemporary theorists, including Michel Foucault, Pierre Bourdieu, Bernard Williams, and Stanley Cavell. By reflecting these voices through the prism of transitionalism, a new understanding of knowledge, ethics, politics, and critique takes root. Koopman concludes with a call for integrating Dewey and Foucault into a model of inquiry he calls genealogical pragmatism, a mutually informative critique that further joins the analytic and continental schools. (shrink)

Community technology design has been deeply affected by paradigm shifts and dominant discourses of its seminal disciplines, such as Human Computer Interaction, Cultural and Design theories, and Community Development as reflected in Community Narratives. A particular distinction of community technology design endeavours has been their cultural stance, which directs the agendas, interactions, and outcomes of the collaboration. Applying different cultural lenses to community technology design, shifts not only practices but also directs the levels of awareness, thereby unfolding fundamentally distinct cultural (...) engagement approaches. Previous community technology design research indulged in cross-, inter-, and multicultural approaches to community engagement; it was occupied with meticulously deconstructing and reconstructing perspectives, interactions, roles, and agendas. We argue that when deeply immersed in joint design activities in long-term collaborations, we look beyond individual cultures and enter a transcultural mode of engagement. A transcultural community technology design endeavour supports a continuous creation and re-creation of new meanings, originating from individual entities yet being diffused and continuously reflected within the existing design space. We suggest that within community technology design, a context with abundant cultural diversity, a heightened awareness becomes a necessity. We exemplify different instantiations of the cultural engagement approaches within our long-term collaborations and technology design projects with indigenous communities in Malaysian Borneo and Namibia. A transcultural approach to indigenous knowledge preservation and digitisation efforts with indigenous communities opens up a controversial debate about protecting versus integrating local epistemologies. (shrink)

This lucidly written book looks at the interpretative audacity of five major "overreaders"—Jacques Derrida, Gilles Deleuze, Emmanuel Levinas, Slavoj Žižek and Stanley Cavell—and asks what is at stake and what is to be gained by their ...

Contemporary theories of civic education frequently appeal to an ideal of mutual respect in the context of ethical, ethical and religious disagreement. This paper critically examines two recently popular criticisms of this ideal. The first, coming from a postmodern direction, charges that the ideal is hypocritical in its effort to be maximally impartial and fair. The second, which I associate with such 'new atheists' as Sam Harris and Richard Dawkins, argues that notions of mutual respect pose a threat to such (...) basic goals of education as the cultivation of critical thinking. (shrink)

This article attempts to assess the claim that the unum necessarium in our time is the general dissemination of scientific knowledge because liberal civilization or the “good society” cannot be had in the presence of traditional religion and “metaphysics.” The paper attempts to place this claim in the context of continuing globalization and related questions such as 9/11, Fundamentalist Islam, Sino-Western relations, “pop” atheism and the prospect of a “post-human” future. The paper describes the continuance of pre-Enlightenment traditions and beliefs (...) even as constant globalizing influences with their attendant secularism, atheism and technologism make their presence felt. The paper canvasses the views of Chet Raymo, C.S. Lewis, Bryan Appleyard, Werner Heisenberg, Stanley Rosen, Henry Adams, Friedrich Nietzsche Martin Heidegger and Francis Fukuyama as a means of assessing the claim that an education rooted in a simple commitment to scientific progressivism will be inadequate to the demands of the 21 st Century. (shrink)

Jason Stanley presents a startling and provocative claim about knowledge: that whether or not someone knows a proposition at a given time is in part determined by his or her practical interests, i.e. by how much is at stake for that person at that time. In defending this thesis, Stanley introduces readers to a number of strategies for resolving philosophical paradox, making the book essential not just for specialists in epistemology but for all philosophers interested in philosophical methodology. (...) Since a number of his strategies appeal to linguistic evidence, it will be of great interest to linguists as well. (shrink)

In the mid-eighteenth century David Hume argued that successful prediction tells us nothing about the truth of the predicting theory. But physical theory routinely predicts the values of observable magnitudes within very small ranges of error. The chance of this sort of predictive success without a true theory suggests that Hume's argument is flawed. However, Colin Howson argues that there is no flaw and examines the implications of this disturbing conclusion; he also offers a solution to one of the (...) central problems of Western philosophy, the problem of induction. (shrink)

How to imagine the imagination is a topic that draws philosophers the way flowers draw honeybees. From Plato and Aristotle to Wittgenstein and Sartre, philosophers have talked and written about this most elusive of topics--that is, until contemporary analytic philosophy of mind developed. Perhaps it is the vast range of the topic that has scared off our contemporaries, ranging as it does from mental images to daydreams. The guiding thread of this book is the distinction Colin McGinn draws between (...) perception and imagination. Clearly, seeing an object is similar in certain respects to forming a mental image of it, but it is also different. McGinn shows what the differences are, arguing that imagination is a sui generis mental faculty. He goes on to discuss the nature of dreaming and madness, contending that these are primarily imaginative phenomena. In the second half of the book McGinn focuses on what he calls cognitive (as opposed to sensory) imagination, and investigates the role of imagination in logical reasoning, belief formation, the understanding of negation and possibility, and the comprehension of meaning. His overall claim is that imagination pervades our mental life, obeys its own distinctive principles, and merits much more attention. (shrink)

Fictionalist approaches to ontology have been an accepted part of philosophical methodology for some time now. On a fictionalist view, engaging in discourse that involves apparent reference to a realm of problematic entities is best viewed as engaging in a pretense. Although in reality, the problematic entities do not exist, according to the pretense we engage in when using the discourse, they do exist. In the vocabulary of Burgess and Rosen (1997, p. 6), a nominalist construal of a given discourse (...) is revolutionary just in case it involves a “reconstruction or revision” of the original discourse. Revolutionary approaches are therefore prescriptive. In contrast, a nominalist construal of a given discourse is hermeneutic just in case it is a nominalist construal of a discourse that is put forth as a hypothesis about how the discourse is in fact used; that is, hermeneutic approaches are descriptive. I will adopt Burgess and Rosen’s terminology to describe the two different spirits in which a fictionalist hypothesis in ontology might be advanced. Revolutionary fictionalism would involve admitting that while the problematic discourse does in fact involve literal reference to nonexistent entities, we ought to use the discourse in such a way that the reference is simply within the pretense. The hermeneutic fictionalist, in contrast, reads fictionalism into our actual use of the problematic discourse. According to her, normal use of the problematic discourse involves a pretense. According to the pretense, and only according to the pretense, there exist the objects to which the discourse would commit its users, were no pretense involved. My purpose in this paper is to argue that hermeneutic fictionalism is not a viable strategy in ontology. My argument proceeds in two steps. First, I discuss in detail several problematic consequences of any interesting application of hermeneutic fictionalism. Of course, if there is good evidence that hermeneutic fictionalism is correct in some cases, then some of these drastic consequences would have to be accepted.. (shrink)

Aimed at philsophy graduates this book investigates mental content in a systematic way and advances a number of claims about how mental content states are related to the body and the world. Internalism is the thesis that they are; externalism is the theory that they are not.

The Blackwell Companion to Christian Ethics presents a comprehensive and systematic exposition of Christian ethics, seen through the lens of Christian worship.

The epistemic position of an agent often depends on their position in a larger network of other agents who provide them with information. In general, agents are better off if they have diverse and independent sources. Sullivan et al. [19] developed a method for quantitatively characterizing the epistemic position of individuals in a network that takes into account both diversity and independence; and presented a proof-of-concept, closed-source implementation on a small graph derived from Twitter data [19]. This paper reports on (...) an open-source reimplementation of their algorithm in Python, optimized to be usable on much larger networks. In addition to the algorithm and package, we also show the ability to scale up our package to large synthetic social network graph profiling, and finally demonstrate its utility in analyzing real-world empirical evidence of ‘echo chambers’ on online social media, as well as evidence of interdisciplinary diversity in an academic communications network. (shrink)

McGinn's latest brings together moral philosophy and literary analysis in a way that illuminates both. Setting out to enrich the domain of moral reflection by showing the value of literary texts as sources of moral illumination, McGinn starts by setting out an uncompromisingly realist ethical theory, arguing that morality is an area of objective truth and genuine knowledge. He goes on to address such subjects as the nature of goodness, evil character, and the meaning of monstrosity in the context of (...) an aesthetic theory of virtue, which maintains that goodness of character is the same thing as beauty of soul. Looking at such literary works as Billy Budd, Lolita, The Picture of Dorian Gray, and Frankenstein, as well as examples from film and painting, Ethics, Evil, and Fiction is an original and compelling book by a leading philosopher who is also a critic and novelist. (shrink)

In the past two decades, much work on Kant has aimed to delimit and evaluate the bedrock assumptions of Kant's mature Critical philosophy. This volume brings together leading Kant scholars to address this issue in conversation with each other, articulating and interrogating Kant's critical assumptions.

In this study of the nature of philosophy, Colin McGinn shows us how philosophy can maintain its connection to the past while looking forward to a bright future.

Frege maintains that there are not two distinct acts, assertion and denial; rather, denying p is one and the same as asserting not-p. Wittgenstein appears not to recognise this identity in Frege, attributing to him the contrary view that a proposition may have one of two verbs, "is true" or "is false". This paper explains Wittgenstein’s attribution as a consequence of Frege’s treatment of content as theoretically prior to the act of judgment. Where content is prior to judgment, the denial (...) of p—what is rejected in asserting p—is distinct from the assertion of not-p. Wittgenstein’s own embrace of Frege’s identity is then considered, an embrace explained in part by his repudiation of Frege’s theoretical order. (shrink)

ABSTRACT Greek historical accounts of ancient eclipses were an important, if peculiar, focus of scientific attention in the nineteenth century. Victorian-era astronomers tried to correct the classical histories using scientific methods, then used those histories as data with which to calibrate their lunar theories, then rejected the histories as having any relevance at all. The specific dating of these eclipses—apparently a simple exercise in celestial mechanics—became bound up with tensions between scientific and humanistic approaches to the past as well as (...) with wider social debates over the power and authority of science in general. The major figures discussed here, including G. B. Airy, Simon Newcomb, and T. H. Huxley, argued that the critical question was whether science could speak authoritatively about the past. To them, the ability of science to talk about the past indicated its power to talk about the future; it was also the fulcrum of fierce boundary disputes among science, history, and religion. (shrink)

ABSTRACT Greek historical accounts of ancient eclipses were an important, if peculiar, focus of scientific attention in the nineteenth century. Victorian-era astronomers tried to correct the classical histories using scientific methods, then used those histories as data with which to calibrate their lunar theories, then rejected the histories as having any relevance at all. The specific dating of these eclipses—apparently a simple exercise in celestial mechanics—became bound up with tensions between scientific and humanistic approaches to the past as well as (...) with wider social debates over the power and authority of science in general. The major figures discussed here, including G. B. Airy, Simon Newcomb, and T. H. Huxley, argued that the critical question was whether science could speak authoritatively about the past. To them, the ability of science to talk about the past indicated its power to talk about the future; it was also the fulcrum of fierce boundary disputes among science, history, and religion. (shrink)

Schopenhauer repeatedly claims that suicide is both foolish and futile. But while many commentators have expressed sympathy for his charge of foolishness, most regard his charge of futility as indefensible even within his own system. In this paper, I offer a defense of Schopenhauer’s futility charge, based on metaphysical and psychological considerations. On the metaphysical front, Schopenhauer’s view implies that psychological connections extend beyond death. Drawing on Parfit’s discussion of personal identity, I argue that those connections have personal significance, such (...) that suicide does not allow one, as Hamlet hopes, simply “not to be.” On the psychological front, I argue that a distinction between agents’ intentions and underlying desires makes room for Schopenhauer to claim that paradigmatic suicidal agents ultimately desire the opposite of what suicide accomplishes. I conclude by showing how the resulting account of futility can buttress the charge of foolishness as well. My interpretation still leaves Schopenhauer vulnerable to certain objections, but shows that his account is significantly more defensible than previous commentators have realized. (shrink)

The Oxford-educated philosopher serves up his trenchant survey of his academic discipline, offering his commentary on Descartes, Anselm Bertrand Russell, Sartre ...

This article focuses on Barth's explication of Anselm's Proslogion 2-4 in his book on Anselm and attempts to show how Anselm helped clarify for Barth the ontological nature of his own early theology, in particular what he meant by the “is” in his affirmation “God is God.” My contention is that Barth's continual pointing to Anselm's Fides Quaerens Intellectum as a vital key to his own theology should not be overlooked. In fact, I argue that only by returning Barth to (...) Anselm in this way is it possible to understand more thoroughly Barth's relevance to contemporary onto-theological debates. (shrink)

The long eighteenth century is a crucial period in the history of ethics, when our moral relations to God, ourselves and others were minutely examined and our duties, rights and virtues systematically and powerfully presented. Colin Heydt charts the history of practical morality - what we ought to do and to be - from the 1670s, when practical ethics arising from Protestant natural law gained an institutional foothold in England, to early British responses to the French Revolution around 1790. (...) He examines the conventional philosophical positions concerning the content of morality, and utilizes those conventions to reinterpret the work of key figures including Locke, Hume, and Smith. Situating these positions in their thematic and historical contexts, he shows how studying them challenges our assumptions about the originality, intended audience, and aims of philosophical argument during this period. His rich and readable book will appeal to a range of scholars and students. (shrink)

Introductory remarks about the problem of the self -- The epistemological self : the self of neural instantiation -- The ontological self : the self of first-person subjectivity -- The epistemological and ontological selves : a brief "summing up" -- Empirical evidence and the ontological and epistemological selves -- Some final thoughts.

Stanley Rosen's book is the first full-length study of the Sophist in English and one of the most complete in any language. He follows the stages of the dialogue in sequence and offers an exhaustive analysis of the philosophical questions that come to light as Theaetetus and the Eleatic Stranger pursue the sophist through philosophical debate. Rosen finds the central problem of the dialogue in the relation between original and image; he shows how this distinction underlies all subsequent technical (...) themes and analyzes in detail such problems as non-being or negation and false statement. Arguing that the dialogue must be treated as a dramatic unity, he pays careful attention throughout to the setting, the events, the language used, and the relations between the natures of the speakers and the topics under discussion. (shrink)

This chapter begins with an overview of John Rawls's four‐stage sequence account of how to apply justice as fairness to institutions. It focuses on the facets of institutional design: (i) How should basic democratic institutions and processes be structured so as to realize the fair value of the basic political liberties? (ii) What kinds of educational and health institutions are needed to secure fair equality of opportunity? (iii) How do principles of justice apply to the family? (iv) What implications does (...) the difference principle have for the structure of a market economy? Rawls's extension of the original position via the four‐stage sequence proceeds against the background of three kinds of pluralism. According to Rawls, occupational choice means that there is a diversity of positions open to all citizens, and no one is forced to hold or pursue specific kinds of employment. (shrink)

Plato’s Theaetetus, Sophist, and Statesman exhibit several related dialectical methods relevant to Platonic education: maieutic in Theaetetus, bifurcatory division in Sophist and Statesman, and non-bifurcatory division in Statesman, related to the ‘god-given’ method in Philebus. I consider the nature of each method through the letter or element paradigm, used to reflect on each method. At issue are the element’s appearances in given contexts, its fitness for communing with other elements like it in kind, and its own nature defined through its (...) relations to others. These represent stages of inquiry for the Platonic student inquiring into the sources of knowledge. (shrink)

The British Idealist movement flourished between the 1860s and 1920s and exerted a very significant influence in the USA, India and Canada, most notably on John Dewey and Josiah Royce. The movement also laid the groundwork for the thought of Oakeshott and Collingwood. Its leading figures – particularly Green and Caird – have left a number of complete or near complete manuscripts in various British university archives, many of which remain unpublished. This important collection widens access to this unpublished material (...) by transcribing, editing and then publishing the most significant pieces. The project focuses on the moral, political, and religious writings – the areas of most interest to scholars. This annotated, critical edition opens them up to the academic community. (shrink)

Based on the author's ethnographic research in India, the book explores the psychology of Hinduism, and offers an innovative synthesis of psychoanylsis with modern anthropological theories of cultural difference. Stanley N. Kurtz offers a new interpretation of the multiple "mother goddesses" of Hinduism, and explores how this multiplicity is key to understanding early childhood experience in which a child is raised by many "mothers" in the Hindu joint family. Arguing that traditional psychoanalytic approaches to Indian culture have applied Western (...) models without regard to differing cultural circumstances, Kurtz suggests that immersion in a joint family plays a central role in the development of feelings and needs which are carried over into adult life. The book concludes with a briefr comparison of mothering in India and contemporary America. _All the Mothers Are One_ makes a significant contribution to the growing debate concerning the role of psychoanalysis in the interpretation of culture and the study of cross-cultural human development. (shrink)

Plato's great attempt to define the nature of the sophist -- the false image of the philosopher -- has perplexed readers from classical times to the present. The dialogue has been central in the ongoing debate about the theory of forms, and it remains a crucial text for Plato scholars in both the analytical and the phenomenological traditions. Stanley Rosen's book is the first full-length study of the Sophist in English and one of the most complete in any language. (...) He follows the stages of the dialogue in sequence and offers an exhaustive analysis of the philosophical questions that come to light as Theaetetus and the Eleatic Stranger pursue the sophist through philosophical debate. Rosen finds the central problem of the dialogue in the relation between original and image; he shows how this distinction underlies all subsequent technical themes and analyzes in detail such problems as non-being or negation and false statement. Arguing that the dialogue must be treated as a dramatic unity, he pays careful attention throughout to the setting, the events, the language used, and the relations between the natures of the speakers and the topics under discussion. Rosen's new approach to the technical issues in the dialogue will be of interest to Plato scholars of all schools, and his analysis of the sophistical dimension of the world will engage all who have puzzled over what it means to be a philosopher. (shrink)

"This collection is obviously a labor of love. Fortunately, it is also a labor of editorial care and precision.