Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

This paper defends a theory of fictional truth. According to this theory, there is a fact of the matter concerning the number of hairs on Sherlock Holmes' head, and likewise for any other meaningful question one could ask about what's true in a work of fiction. We argue that a theory of this form is needed to account for the patterns in our judgments about attitude reports that embed fictional claims. We contrast our view with one of the dominant approaches (...) to fictional truth, which originates with David Lewis. Along the way we explore the relationship between fiction, counterfactuals, and vagueness. (shrink)

Harry Chalmers argues that monogamy involves restricting one’s partner’s access to goods in a morally troubling way that is analogous to an agreement between partners to have no additional friends. Chalmers finds the traditional defenses of monogamy wanting, since they would also justify a friendship-restricting agreement. I show why three traditional defenses of monogamy hold up quite well and why they don’t, for the most part, also justify friendship-restricting agreements. In many cases, monogamy can be justified on grounds of practicality, (...) specialness, or jealousy. (shrink)

The Ideal Worlds Account of Desire says that S wants p just in case all of S’s most highly preferred doxastic possibilities make p true. The account predicts that a desire report ⌜S wants p⌝ should be true so long as there is some doxastic p-possibility that is most preferred. But we present a novel argument showing that this prediction is incorrect. More positively, we take our examples to support alternative analyses of desire, and close by briefly considering what our (...) cases suggest about the logic of desire. (shrink)

A single mother is a person who is accountable for raising their children alone because they do not have a husband or live-in partner. Single mothers claim to have no co-parenting relationships at all, comparing single parents to those who are married, cohabiting, or without children, single parents experience the worst work-life balance. A single parent may feel overwhelmed by the demands of juggling child care, a career, paying bills, and maintaining household responsibilities. Single-parent households frequently deal with several extra (...) obligations and possible complications that other families would not. The study also emphasizes the difficulties and coping mechanisms faced by contractual single parents as well as their lived experiences. The study's findings, which were based on an Interpretative Phenomenological Analysis, were as follows: (1) Work-life balance can be difficult for single parents. They struggle to keep their jobs while taking care of their family because they are the only ones in charge of the children. (2) Single contractual mothers face particular difficulties due to a lack of resources for basic expenses. (3) Contractual single women lean on their kids, the good people in their lives, and their faith in God to get through problems. (shrink)

The analysis of desire ascriptions has been a central topic of research for philosophers of language and mind. This work has mostly focused on providing a theory of want reports, that is, sentences of the form ‘S wants p’. In this paper, we turn from want reports to a closely related but relatively understudied construction, namely hope reports, that is, sentences of the form ‘S hopes p’. We present two contrasts involving hope reports and show that existing approaches to desire (...) fail to explain these contrasts. We then develop a novel account that combines some of the central insights in the literature. We argue that our theory provides an elegant account of our contrasts and yields a promising analysis of hoping. (shrink)

In this paper, we present two puzzles involving desire reports concerning series of events. What does a person want to happen in the first event – is it the event with the highest expected return, or the event that is the initial part of the best series? We show that existing approaches fail to resolve the puzzles around this question and develop a novel account of our own. Our semantics is built around three ideas. First, we propose that desire ascriptions (...) are evaluated relative to a contextually supplied set of propositions, or alternatives. The semantic value of an ascription ‘S wants p’ is determined by S's preference ordering over these alternatives. Second, we propose that desire reports carry a requirement to the effect that the prejacent of the ascription must be suitably related to the background set of alternatives. Finally, we suggest that desire reports carry a dominance condition concerning the subject's ranking of the alternatives. Overall, we argue that our theory provides us with an elegant resolution of our puzzles, and yields a promising approach to desire. (shrink)

This paper is about two requirements on wish reports whose interaction motivates a novel semantics for these ascriptions. The first requirement concerns the ambiguities that arise when determiner phrases, such as definite descriptions, interact with ‘wish’. More specifically, several theorists have recently argued that attitude ascriptions featuring counterfactual attitude verbs license interpretations on which the determiner phrase is interpreted relative to the subject’s beliefs. The second requirement involves the fact that desire reports in general require decision-theoretic notions for their analysis. (...) The current study is motivated by the fact that no existing account captures both of these aspects of wishing. I develop a semantics for wish reports that makes available belief-relative readings but also allows decision-theoretic notions to play a role in shaping the truth conditions of these ascriptions. The general idea is that we can analyze wishing in terms of a two-dimensional notion of expected utility. (shrink)

A growing number of epistemologists have endorsed the Ignorance Norm for Inquiry. Roughly, this norm says that one should not inquire into a question unless one is ignorant of its answer. I argue that, in addition to ignorance, proper inquiry requires a certain kind of knowledge. Roughly, one should not inquire into a question unless one knows it has a true answer. I call this the Knowledge Norm for Inquiry. Proper inquiry walks a fine line, holding knowledge that there is (...) an answer in the left hand and ignorance of the answer in the right. (shrink)

This paper presents a puzzle involving embedded attitude reports. We resolve the puzzle by arguing that attitude verbs take restricted readings: in some environments the denotation of attitude verbs can be restricted by a given proposition. For example, when these verbs are embedded in the consequent of a conditional, they can be restricted by the proposition expressed by the conditional’s antecedent. We formulate and motivate two conditions on the availability of verb restrictions: a constraint that ties the content of restrictions (...) to the “dynamic effects” of sentential connectives and a constraint that limits the availability of restriction effects to present tense verbs with first-person subjects. However, we also present some cases that make trouble for these conditions, and outline some possible ways of modifying the view to account for the recalcitrant data. We conclude with a brief discussion of some of the connections between our semantics for attitude verbs and issues concerning epistemic modals and theories of knowledge. (shrink)

Although much has been written about the truth-conditions of de re attitude reports, little attention has been paid to certain ‘ultra-liberal’ uses of those reports. We believe that if these uses are legitimate, then a number of interesting consequences for various theses in philosophical semantics follow. The majority of the paper involves describing these consequences. In short, we argue that, if true, ultra-liberal reports: bring counterexamples to a popular approach to de re attitude ascriptions, which we will call ‘descriptivism’; and (...) combine with independently plausible principles about the logic of belief to imply that subjects can achieve omniscience about what exists from the armchair. Although we are not committed to the view that ultra-liberal reports are false, in the final part of the paper we discuss the prospects of pursuing a line according to which the acceptability of such reports ought not be taken at face value. We conclude by arguing that those who are sympathetic with this move might have reason to doubt the truth of an even broader class of acceptable de re attitude reports, namely those that have been taken to undermine orthodox accounts of de re attitude ascriptions. (shrink)

I give an account of the compositional semantics of unconditionals that explains their relationship to if -conditionals in the Lewis/Kratzer/Heim tradition. Unconditionals involve an alternative-denoting adjunct that supplies domain restrictions pointwise to a main-clause operator such as a modal. The differences from if -clauses follow from the structure of the adjuncts; both are conditionals in the Lewisian sense. In the course of treating unconditionals, I provide a concrete implementation of conditionals where conditional adjuncts in general are a species of correlative, (...) and show what detaching this hypothesis from if involves. (shrink)

In this paper, I raise a problem for standard precisifications of the Relational Analysis of attitude reports. The problem I raise involves counterfactual attitude verbs. such as ‘wish’. In short, the trouble is this: there are true attitude reports ‘ S wishes that P ’ but there is no suitable referent for the term ‘that P ’. The problematic reports illustrate that the content of a subject’s wish is intimately related to the content of their beliefs. I capture this fact (...) by moving to a framework in which ‘wish’ relates subjects to sets of pairs of worlds, or paired propositions, rather than—as is standardly assumed—sets of worlds. Although other types of counterfactual attitude reports, for example those involving ‘imagine’, may be similarly problematic, at this stage it is unclear whether they can be handled the same way. (shrink)

In this paper, we propose a novel account of desire reports, i.e. sentences of the form 'S wants p'. Our theory is partly motivated by Phillips-Brown's (2021) observation that subjects can desire things even if those things aren't best by the subject's lights. That is, being best isn't necessary for being desired. We compare our proposal to existing theories, and show that it provides a neat account of the central phenomenon.

Inheritance is the principle that deontic `ought' is closed under entailment. This paper is about a tension that arises in connection with Inheritance. More specifically, it is about two observations that pull in opposite directions. One of them raises questions about the validity of Inheritance, while the other appears to provide strong support for it. We argue that existing approaches to deontic modals fail to provide us with an adequate resolution of this tension. In response, we develop a positive analysis, (...) and show that this proposal provides a satisfying account of our intuitions. (shrink)

In this paper, I draw attention to comparative preference claims, i.e. sentences of the form \S prefers p to q\. I show that preference claims exhibit interesting patterns, and try to develop a semantics that captures them. Then I use my account of preference to provide an analysis of desire. The resulting entry for desire ascriptions is independently motivated, and finds support from a wide range of phenomena.

Several theorists have observed that attitude reports have what we call “revisionist” uses. For example, even if Pete has never met Ann and has no idea that she exists, Jane can still say to Jim ‘Pete believes Ann can learn to play tennis in ten lessons’ if Pete believes all 6-year-olds can learn to play tennis in ten lessons and it is part of Jane and Jim’s background knowledge that Ann is a 6-year-old. Jane’s assertion seems acceptable because the claim (...) she reports Pete as believing is entailed by Pete’s beliefs if they are revised in light of Jane and Jim’s background knowledge. We provide a semantic theory of revisionist reports based on this idea. We observe that the admissible “revisions” are limited in a striking way. Jane cannot say ‘Pete thinks Ann is a 6-year-old and can play tennis in ten lessons’ in the same context that she can say ‘Pete believes Ann can learn to play tennis ten lessons’, even though this too follows from Jane and Jim’s background knowledge together with what Pete believes. Our theory predicts the infelicity of these latter reports. It also has the resources to predict the truth of “exported” attitude reports and casts the relationship between these reports and “singular thought” in a new light. We conclude by discussing how revisionist reports make trouble for a simplistic view of the connection between the relations expressed by attitude verbs in natural language and the relations of most interest to philosophers of mind and cognitive science. (shrink)

Kriegel has revived adverbialism as a theory of consciousness. But recent attacks have shed doubt on the viability of the theory. To save adverbialism, I propose that the adverbialist take a stance on the nature of adverbial modification. On one leading theory, adverbial modification turns on the instantiation by a substance of a psychological type. But the resulting formulation of adverbialism turns out to be a mere notational variant on the relationalist approaches against which Kriegel dialectically situates adverbialism. By contrast, (...) I argue that the way to be an adverbialist is to adopt an event ontology, emphasizing the active contribution of the mind to the phenomenology of experience. My close examination of the semantics of adverbial modification throws this metaphysical distinction into sharp relief. The event-based semantics overcomes recent objections in a way superior to the methods that would have been obviously available in the absence of a sophisticated semantics. (shrink)

Although many people choose to sign consent forms and participate in research, how many thoroughly read a consent form before signing it? Across 3 experiments using 348 undergraduate student participants, we examined whether personality characteristics as well as consent form content, format, and delivery method were related to thorough reading. Students repeatedly failed to read the consent forms, although small effects were found favoring electronic delivery methods and traditional format forms. Potential explanations are discussed and include participant apathy, participants trying (...) to save time by not reading the consent form, and participant assumptions about consent forms. (shrink)

This paper presents an account of akrasia, drawn from the work of William James, that sees akrasia as neither a rational failing (as with most philosophical accounts) nor a moral failing (as with early Christian accounts), but rather a necessary by-product of our status as biological beings. By examining James’s related accounts of motivation and action, I argue that akratic actions occur when an agent attempts to act against her settled habits, but fails to do so. This makes akrasia a (...) product of the agent’s practical failure to adequately structured her environment to bring about her desired action. Akratic action performs the vital function of revealing to the agent the exact point at which her cognitive effort was insufficient for bringing about her intended action. It also reveals that future improvement is within her control. As such, akratic action is the very foundation of James’s meliorism. (shrink)

In some sentences, demonstratives can be substituted with definite descriptions without any change in meaning. In light of this, many have maintained that demonstratives are just a type of definite description. However, several theorists have drawn attention to a range of cases where definite descriptions are acceptable, but their demonstrative counterparts are not. Some have tried to account for this data by appealing to presupposition. I argue that such presuppositional approaches are problematic, and present a pragmatic account of the target (...) contrasts. On this approach, demonstratives take two arguments and generally require that the first, covert argument is non-redundant with respect to the second, overt argument. I derive this condition through an economy principle discussed by Schlenker (2005). (shrink)

One of the central topics in semantic theory over the last few decades concerns the nature of local contexts. Recently, theorists have tried to develop general, non-stipulative accounts of local contexts (Schlenker, 2009; Ingason, 2016; Mandelkern & Romoli, 2017a). In this paper, we contribute to this literature by drawing attention to the local contexts of subclausal expressions. More specifically, we focus on the local contexts of quantificational determiners, e.g. `all', `both', etc. Our central tool for probing the local contexts of (...) subclausal elements is the principle Maximize Presupposition! (Percus, 2006; Singh, 2011). The empirical basis of our investigation concerns some data discussed by Anvari (2018b), e.g. the fact that sentences such as `All of the two presidential candidates are crooked' are unacceptable. In order to explain this, we suggest that the local context of determiners needs to contain the information carried by their restrictor. However, no existing non-stipulative account predicts this. Consequently, we think that the local contexts of subclausal expressions will likely have to be stipulated. This result has important consequences for debates in semantics and pragmatics, e.g. those around the so-called "explanatory problem" for dynamic semantics (Soames, 1982; Heim, 1990; Schlenker, 2009). (shrink)

Point-of-care evidence-based medicine websites allow physicians to answer clinical queries using recent evidence at the bedside. Despite significant research into the function, usability and effectiveness of these programmes, little attention has been paid to their ethical issues. As many of these sites summarise the literature and provide recommendations, we sought to assess the role of conflicts of interest in two widely used websites: UpToDate and Dynamed. We recorded all conflicts of interest for six articles detailing treatment for the following conditions: (...) erectile dysfunction, fibromyalgia, hypogonadism, psoriasis, rheumatoid arthritis and Crohn's disease. These diseases were chosen as their medical management is either controversial, or they are treated using biological drugs which are mostly available by brand name only. Thus, we hypothesised that the role of conflict of interest would be more significant in these conditions than in an illness treated with generic medications or by strict guidelines. All articles from the UpToDate articles demonstrated a conflict of interest. At times, the editor and author would have a financial relationship with a company whose drug was mentioned within the article. This is in contrast with articles on the Dynamed website, in which no author or editor had a documented conflict. We offer recommendations regarding the role of conflict of interest disclosure in these point-of-care evidence-based medicine websites. (shrink)

A long line of epistemologists including Sosa (2021), Feldman (2002), and Chisholm (1977) have argued that, at least for a certain class of questions that we take up, we should (or should aim to) close inquiry iff by closing inquiry we would meet a unique epistemic standard. I argue that no epistemic norm of this general form is true: there is not a single epistemic standard that demarcates the boundary between inquiries we are forbidden and obligated to close. In short, (...) such norms are false because they are insensitive to the potentially ambitious epistemic goals that agents may permissibly bring to bear on an inquiry. Focusing particularly on knowledge-oriented versions of the norm, I argue that ignorance has a positive role to play in epistemic life by licensing prolonged inquiry into questions that we especially care about. (shrink)

For the first time, this book brings Kierkegaard into a dialogue with various postmodern forms of Christianity, on topics like revelation and the Bible, the atonement and moralism, and the church as an apologetic of witness.

Zipf famously stated that, if natural language lexicons are structured for efficient communication, the words that are used the most frequently should require the least effort. This observation explains the famous finding that the most frequent words in a language tend to be short. A related prediction is that, even within words of the same length, the most frequent word forms should be the ones that are easiest to produce and understand. Using orthographics as a proxy for phonetics, we test (...) this hypothesis using corpora of 96 languages from Wikipedia. We find that, across a variety of languages and language families and controlling for length, the most frequent forms in a language tend to be more orthographically well‐formed and have more orthographic neighbors than less frequent forms. We interpret this result as evidence that lexicons are structured by language usage pressures to facilitate efficient communication. (shrink)

Hypocrites are often thought to lack the standing to blame others for faults similar to their own. Although this claim is widely accepted, it is seldom argued for. We offer an argument for the claim that nonhypocrisy is a necessary condition on the standing to blame. We first offer a novel, dispositional account of hypocrisy. Our account captures the commonsense view that hypocrisy involves making an unjustified exception of oneself. This exception-making involves a rejection of the impartiality of morality and (...) thereby a rejection of the equality of persons, which we argue grounds the standing to blame others. (shrink)

Recent work by philosophers such as Harry Chalmers and Hallie Liberto has called into question the moral permissibility of monogamy. In this article, I defend monogamy on a number of grounds, including practical reasons and reasons relating to commitment, specialness, and jealousy. I also attempt to reframe the debate about monogamy as not just relating to the permissibility of restricting one’s partner but as equally about one’s freedom to leave a relationship. Finally, I make a case against Liberto’s claim that (...) monogamous agreements are over-extensive. (shrink)

Schlenker (Semant Pragmat 2(3):1–78, 2009; Philos Stud 151(1):115–142, 2010a; Mind 119(474):377–391, 2010b) provides an algorithm for deriving the presupposition projection properties of an expression from that expression’s classical semantics. In this paper, we consider the predictions of Schlenker’s algorithm as applied to attitude verbs. More specifically, we compare Schlenker’s theory with a prominent view which maintains that attitudes exhibit belief projection, so that presupposition triggers in their scope imply that the attitude holder believes the presupposition (Karttunen in Theor Linguist 34(1):181, (...) 1974; Heim in J Semant 9(3):183–221, 1992; Sudo in The art and craft of semantics: a festschrift for Irene Heim, MIT Press, 2014). We show that Schlenker’s theory does not predict belief projection, and discuss several consequences of this result. (shrink)

The development of artificial intelligence will require systems of ethical decision making to be adapted for automatic computation. However, projects to implement moral reasoning in artificial moral agents so far have failed to satisfactorily address the widespread disagreement between competing approaches to moral philosophy. In this paper I argue that the proper response to this situation is to design machines to be fundamentally uncertain about morality. I describe a computational framework for doing so and show that it efficiently resolves common (...) obstacles to the implementation of moral philosophy in intelligent machines. (shrink)

This paper defends a new norm of assertion: Assert that p only if you are in a position to know that p. We test the norm by judging its performance in explaining three phenomena that appear jointly inexplicable at first: Moorean paradoxes, lottery propositions, and selfless assertions. The norm succeeds by tethering unassertability to unknowability while untethering belief from assertion. The PtK‐norm foregrounds the public nature of assertion as a practice that can be other‐regarding, allowing asserters to act in the (...) best interests of their audience when psychological pressures would otherwise prevent them from communicating the knowable truth. (shrink)

The nearly omnipotent character known only as “Q” dramatically enters the Star Trek universe when he puts all humanity in the person of Captain Jean‐Luc Picard, on trial in the first episode of TNG. Acting as self‐professed prosecutor, judge, and jury, Q promises Picard an “absolutely equitable” trial, only to coerce Picard into pleading “guilty” by threatening to kill his crew. Q could be like the “Leviathan” of Thomas Hobbes (1588‐1679), an absolute sovereign who has the power to keep people (...) from warring with each other, but who can't be held accountable or subject to any civil law in the use of that power. Enlisting Hobbes and Locke, this chapter examines the motives behind Q's enigmatic actions and sees what Q, deep down, might believe about justice. Hobbes begins with a basic right of nature that all people possess: our liberty to ensure the preservation of our own life. (shrink)

In this paper, I challenge the traditional narrative that William James’s arguments against determinism were primarily motivated by his personal struggles with depression. I argue that James presents an alternative argument against determinism that is motivated by his commitment to sound scientific practice. James argues that determinism illegitimately extrapolates from observations of past events to predictions about future events without acknowledging the distinct metaphysical difference between them. This occupation with futurity suggests that James’s true target is better understood as logical (...) determinism rather than causal determinism. This has consequences for James’s proposed alternative, which I call his probabilistic underdeterminism, a conception of the universe that is built on chance, choice, and a local teleology. All of this forms part of a broader criticism of the scientific practices of his day based on their widespread failure to acknowledge the distorting effects of observation on that which is observed. (shrink)

This paper is about conjunctions and disjunctions in the scope of non-doxastic atti- tude verbs. These constructions generate a certain type of ignorance implicature. I argue that the best way to account for these implicatures is by appealing to a notion of contex- tual redundancy (Schlenker, 2008; Fox, 2008; Mayr and Romoli, 2016). This pragmatic approach to ignorance implicatures is contrasted with a semantic account of disjunctions under `wonder' that appeals to exhausti cation (Roelofsen and Uegaki, 2016). I argue that (...) exhausti cation-based theories cannot handle embedded conjunctions, so a pragmatic account of ignorance implicatures is superior. (shrink)

I argue that popular understandings of white nationalist double speak strategies do not fully represent the practice of these strategies, and identify a linguistic tactic used by white nationalists that I call sugar-coating. Sugar-coating works by packing an otherwise unacceptable utterance together with some kind of reward, thereby promoting uptake. I contrast this with existing notions of double speak, such as figleaves (Saul 2017, 2021), dogwhistles (Haney-López 2014), and bullshit (Kenyon and Saul 2022). I argue that sugar-coating more accurately reflects (...) the practice of white nationalist recruitment rhetoric, as described in the Daily Stormer Style Guide. (shrink)

Common‐sense morality seems to dictate that newborn babies strictly outrank non‐human animals on an ordered list of subjects of moral consideration. This is best described as the view that newborn babies have a higher moral status than any non‐human animal. In this article, I will argue that this common‐sense claim about the special moral status of newborn babies makes it hard to avoid the conclusion that fetuses, including pre‐conscious fetuses, also have a higher moral status than any non‐human animal—indeed, as (...) high as newborn babies. While this conclusion does not quite entail that abortion is generally seriously immoral, it does seem to follow that it would be no less difficult to justify (even relatively early) abortion than it would be to justify killing a newborn. (shrink)

This article argues that, propaedeutic to the construction of an Objectivist aesthetics, scholars must refute the irrational/immoral philosophical premises that have been destroying the philosophy of art. Due to the troubling combination of its contemporaneity, extremism, and considerable influence, poststructuralism, which, since the 1960s, has served as the default philosophical foundation for philosophers of art, is the target of this article. This article contends that the road to an Objectivist aesthetics must first be cleared of philosophical debris like poststructuralism before (...) we can hope to go back to the world of art. (shrink)